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Immunoregulatory Effects of Water Extracts of Inonotus obliquus in Carbon Tetrachloride-Induced Liver Damage Animal Model  

An, Chi-Sun (College of Biomedical & Health Science, Department of Life Science, Konkuk University)
Jin, Hai-Lan (College of Biomedical & Health Science, Department of Life Science, Konkuk University)
Jeon, Yun-Hui (College of Biomedical & Health Science, Department of Life Science, Konkuk University)
Bak, Jong-Phil (College of Biomedical & Health Science, Department of Life Science, Konkuk University)
Kim, Jong-Dai (Medical & Bio-material Research Center, Kangwon University)
Yoon, Jung-Han (Medical & Bio-material Research Center, Kangwon University)
Lim, Beong-Ou (College of Biomedical & Health Science, Department of Life Science, Konkuk University)
Publication Information
Korean Journal of Medicinal Crop Science / v.18, no.1, 2010 , pp. 1-8 More about this Journal
Abstract
Inonotus obliquus is one of the immune-regulatory substances and is recognized to play the role in the metabolic process of inflammation, allergy and immuntiy. The purpose of this study was to evaluate the effects of water extracts of Inonotus obliquus (IOW) on the liver lymphocyte immune function in the Sprague-Dawley male rats treated with carbon tetrachloride ($CCl_4$) to induce liver damage. Rats were fed with each experimental diet and water for 4 weeks. We found that effects of IOW on interferon-gamma (IFN-$\gamma$), signal transducer and activator of transcription 1 (STAT1), phospho-signal transducer and activator of transcription 1 (pSTAT1) and GATA-binding protein 3 (GATA-3) were decrease in vivo. Interleukin-4 (IL-4), STAT6, pSTAT6 and T-box expressed in T-cells (T-bet) decreased significantly lower in $CCl_4$+IOW group than the $CCl_4$ group. Our data indicated that cytokine protein production were increased in $CCl_4$ group and $CCl_4$+IOW group. As a result of this study, we assume that IOW fed could regulate the immuno-modulating functions through regulate the cytokine production capacity activated by liver damage.
Keywords
Carbon Tetrachloride; Inonotus obliquus; Immunoregulatory;
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Times Cited By KSCI : 5  (Citation Analysis)
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