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http://dx.doi.org/10.3746/pnf.2012.17.1.014

Effect of Persimmon Leaf Extract on Phthalic Anhydride-induced Allergic Response in Mice  

Mok, Ji-Ye (Jeonju University Atopy & Health Research Institute)
Jeon, In-Hwa (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University)
Cho, Jung-Keun (Department of Radiological Science, College of Alternative Medicine, Jeonju University)
Park, Ji-Min (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University)
Kim, Hyeon-Soo (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University)
Kang, Hyun-Ju (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University)
Kim, Hyung-Soon (Moakgol Association)
Jang, Seon-Il (Jeonju University Atopy & Health Research Institute)
Publication Information
Preventive Nutrition and Food Science / v.17, no.1, 2012 , pp. 14-21 More about this Journal
Abstract
The purpose of this study was to investigate the anti-allergy activities of persimmon leaf extract (PLE) on a phthalic anhydride (PA)-induced allergic mouse model. A human leukemic mast cell line (HMC-1) was used to examine the inhibitory activity of PLE on the histamine release by human leukemic mast cells. PLE inhibited histamine release from HMC-1 cells in response to cross-linkage of high-affinity IgE receptor-${\alpha}$ ($Fc{\varepsilon}RI{\alpha}$). Additionally, a PA-induced allergic mouse model was used to investigate the effects of PLE in vivo. Mice were orally administrated with or without PLE of single dose (250 mg/kg/day) for 31 days. Oral intake of PLE significantly inhibited passive cutaneous reactions. Oral administration of PLE to PA-induced allergic mice also led to a striking suppression of the development of contact dermatitis, ear swelling and lymph node weight. In addition, PA-specific IL-4 production of draining lymph node cells was markedly diminished by PLE oral administration, but not IFN-${\gamma}$. Furthermore, PLE treatment suppressed PA-induced thymus and activation-regulated chemokine (CCL17) and cutaneous T cell-attracting chemokine (CCL27) expressions in ear tissues. Based on these results, we suggest that PLE may have therapeutic potential as an effective material for management of irritant contact dermatitis or related inflammatory diseases.
Keywords
persimmon leaf extract; phthalic anhydride; contact dermatitis; IgE; chemokines;
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