• Nutrition Research and Practice
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• v.16 no.6
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• pp.729-744
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• 2022

BACKGROUND/OBJECTIVES: 4-Hydroxy-2-nonenal (HNE) is a biomarker for oxidative stress to induce inflammation. Methionine is an essential sulfur-containing amino acid with antioxidative activity. On the other hand, the evidence on whether and how methionine can depress HNE-derived inflammation is lacking. In particular, the link between the regulation of the nuclear factor-κB (NF-κB) signaling pathway and methionine intake is unclear. This study examined the link between depression from HNE accumulation and the anti-inflammatory function of ⳑ-methionine in rats. MATERIALS/METHODS: Male Wistar rats (3-week-old, weighing 70-80 g) were administered different levels of ⳑ-methionine orally at 215.0, 268.8, 322.5, and 430.0 mg/kg body weight for two weeks. The control group was fed commercial pellets. The hepatic HNE contents and the protein expression and mRNA levels of the inflammatory mediators were measured. The interleukin-10 (IL-10) and glutathione S-transferase (GST) levels were also estimated. RESULTS: Compared to the control group, hepatic HNE levels were reduced significantly in all groups fed ⳑ-methionine, which were attributed to the stimulation of GST by ⳑ-methionine. With decreasing HNE levels, ⳑ-methionine inhibited the activation of NF-κB by up-regulating inhibitory κBα and depressing phosphoinositide 3 kinase/protein kinase B. The mRNA levels of the inflammatory mediators (cyclooxygenase-2, interleukin-1β, interleukin-6, inducible nitric oxide synthase, tumor necrotic factor alpha) were decreased significantly by ⳑ-methionine. In contrast, the protein expression of these inflammatory mediators was effectively down regulated by ⳑ-methionine. The anti-inflammatory action of ⳑ-methionine was also reflected by the up-regulation of IL-10. CONCLUSIONS: This study revealed a link between the inhibition of HNE accumulation and the depression of inflammation in growing rats, which was attributed to ⳑ-methionine availability. The anti-inflammatory mechanism exerted by ⳑ-methionine was to inhibit NF-κB activation and to up-regulate GST.

• Journal of Welding and Joining
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• v.20 no.4
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• pp.423-426
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• 2002

No Abstract, See Full-text

• Proceedings of the KWS Conference
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• 2001.05a
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• pp.3-9
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• 2001

No Abstract, See Full Text

• International Journal of Control, Automation, and Systems
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• v.3 no.2
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• pp.159-165
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• 2005

This paper designs observers for matrix second-order linear systems on the basis of generalized eigenstructure assignment via unified parametric approach. It is shown that the problem is closely related with a type of so-called generalized matrix second-order Sylvester matrix equations. Through establishing two general parametric solutions to this type of matrix equations, two unified complete parametric methods for the proposed observer design problem are presented. Both methods give simple complete parametric expressions for the observer gain matrices. The first one mainly depends on a series of singular value decompositions, and is thus numerically simple and reliable; the second one utilizes the right factorization of the system, and allows eigenvalues of the error system to be set undetermined and sought via certain optimization procedures. A spring-mass system is utilized to show the effect of the proposed approaches.

• Journal of Communications and Networks
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• v.16 no.1
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• pp.92-97
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• 2014

A novel method for extracting frequency slippage signal from radar full pulse sequence is presented. For the radar full pulse sequence received by radar interception receiver, radio frequency (RF) and time of arrival (TOA) of all pulses constitute a two-dimensional information sequence. In a complex and intensive electromagnetic environment, the TOA of pulses is distributed unevenly, randomly, and in a nonstationary manner, preventing existing methods from directly analyzing such time series and effectively extracting certain signal features. This work applies Gaussian noise insertion and structure function to the TOA-RF information sequence respectively such that the equalization of time intervals and correlation processing are accomplished. The components with different frequencies in structure function series are separated using empirical mode decomposition. Additionally, a chaos detection model based on the Duffing equation is introduced to determine the useful component and extract the changing features of RF. Experimental results indicate that the proposed methodology can successfully extract the slippage signal effectively in the case that multiple radar pulse sequences overlap.

• International Journal of Fluid Machinery and Systems
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• v.8 no.3
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• pp.124-131
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• 2015

The good performance of a vortex shedder is defined by strong and stable vortex generated under the condition of most linearity in Strouhal number and low power loss. In this paper, the flow past a bluff body of circular cylinder with a slit normal to the flow has been analyzed focusing on drag coefficient, linearity of Strouhal number and flow resistance (K-factor). The ANSYS/FLUENT package is used for flow simulation and the integration method of computational code to iSIGHT platform is employed for automated design cycle. This study results the design with (0.20~0.267) blockage ratio and 0.10 slit ratio as the best shedder for vortex flowmeter and this results are in well agreement with the experiment. As the combination of GAMBIT, FLUENT, and iSIGHT substitutes the design parameters automatically according to the input data, this method designs effectively the vortex shedder with less design cycle time and low manufacturing cost eliminating the human intervention bottleneck.

• Journal of Power Electronics
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• v.18 no.5
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• pp.1585-1594
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• 2018

The estimation of $LiFePO_4$/graphite battery states suffers from the prominent hysteresis phenomenon between the respective open-circuit voltage curves towards charging and discharging. A lot of hysteresis models have been documented to investigate the hysteresis mechanism. This paper reviews and deeply interprets four non-electrochemical hysteresis models and some improvements. These models can be conveniently incorporated into commonly used equivalent circuit models to reproduce battery behaviors. Through simulation and experimental comparisons of voltage predictions and state-of-charge estimations, the pros and cons of these models are presented.

• Journal of Electrical Engineering and Technology
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• v.8 no.5
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• pp.1096-1106
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• 2013

This paper presents the control of a Permanent Magnet Electric Variable Transmission (PM-EVT) for Hybrid Electric Vehicles (HEVs). Consisting of two electric machines, the EVT realizes the power split function in an electromagnetic way rather than in a mechanical way. A specific PM-EVT has been designed for Toyota Prius II. The control scheme of the entire vehicle is deduced using the Energetic Macroscopic Representation methodology. The energy management strategy yields local control references. A specific attention is paid for the field weakening for wide speed range. Simulation results are provided to illustrate the EVT modeling and control.

• Ocean Systems Engineering
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• v.2 no.1
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• pp.1-16
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• 2012

Offshore wind turbines are complex structural and mechanical systems located in a highly demanding environment. This paper proposes a multi-level system approach for studying the structural behavior of the support structure of an offshore wind turbine. In accordance with this approach, a proper numerical modeling requires the adoption of a suitable technique in order to organize the qualitative and quantitative assessment in various sub-problems, which can be solved by means of sub-models at different levels of detail, both for the structural behavior and for the simulation of loads. Consequently, in a first place, the effects on the structural response induced by the uncertainty of the parameters used to describe the environmental actions and the finite element model of the structure are inquired. After that, a meso-level FEM model of the blade is adopted in order to obtain the detailed load stress on the blade/hub connection.

• Steel and Composite Structures
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• v.22 no.2
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• pp.387-398
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• 2016

In order to evaluate the effects of U shape ultra high performance concrete (UHPC) permanent form on the behaviors of Reinforced Concrete (RC) beam, a full scale RC composite beam is designed and tested with U shape UHPC permanent form and a reference RC beam with same parameters is tested simultaneously for comparison. The effects of the permanent form on the failure mode, cracking strength, ultimate capacity and deformation are studied. Test results shows that the contributions of the U shape UHPC permanent form to the flexural cracking behaviors of RC beam are significant. This study may provide a reference for the design of sustainable RC beam with high durable UHPC permanent form.