• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• v.11 no.2
• /
• pp.122-129
• /
• 2008

Purpose: Patients with chronic gastrointestinal disease are at risk for trace element deficiency due to impaired absorption and gastrointestinal loss. The aim of this study was to evaluate the trace element status of patients with gastrointestinal disease by blood and hair analysis, and to determine the usefulness of hair mineral analysis for diagnosing trace element deficiency not detected by a blood test. Methods: An analysis of hair minerals was performed and compared with blood mineral analysis in 13 patients with chronic gastrointestinal disease. The concentration of each element in the hair and blood was compared in the subgroups based on parenteral nutritional support or clinical symptoms. Results: Almost all patients had trace element deficiency. The trace elements deficient in the blood or hair analysis included zinc, selenium and copper. The hair zinc concentration was significantly lower in the group receiving parenteral nutritional support. The hair selenium concentration was statistically associated with the clinical symptoms of hair loss, brittle hair and loss of hair pigmentation. Conclusion: The results of this study suggest that patients with chronic gastrointestinal disease should receive adequate zinc and selenium replacement to avoid trace element deficiency especially when treated with long-term parenteral nutrition. Hair mineral analysis is useful as a complementary tool for the detection of a trace element deficiency.

• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.46 no.2
• /
• pp.89-103
• /
• 2020

A frizz hair is referred to the fly-away hairs that have become bulky or deviated from the regular hair and the cause of that is not clear known. The internal lipids are related to the physical properties of hair such as elasticity and tensile strength and interracial studies have previously conducted to relate the lipid mass and Afrikaan hair, which has a lot of frizzy hair. Although washing hair is the only way to control the hair loss without damage of hair surface, the number of washing and lipid loss are not linearly correlated. In this study, the amount of lipid hair was analyzed by washing the hair with a few different types of shampoos containing various conditioning polymers and oils of different polarities. The results confirmed that the higher the polarity of the oil, the higher the lipid content. This method was applied to Indian frizzy hair to evaluate the degree of frizziness and found that the frizzy volume was more severe for a hair with less lipids. On the other hand, the frizzy hair volume of fly-away hairs was observed more broadly for the hairs with higher lipid contents. In addition, the friction on the surface of the hair did not differ due to the oil treatment. Taken together, it was concluded that hair frizzing was affected by the amount of lipids in the hair rather than by the adhesion between the oils. Thus, this study suggests that controlling the lipid contents in hair may be an important solution in the development of hair anti-frizzy technology.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.10
• /
• pp.5631-5635
• /
• 2013

Cochlea hair cell death is regarded to be responsible for the radiation-induced sensorineural hearing loss (SNHL), which is one of the principal complications of radiotherapy (RT) for head and neck cancers. In this mini-review, we focus on the current progresses trying to unravel mechanisms of radiation-induced hair cell death and find out possible protection. P53, reactive oxygen species (ROS) and c-Jun N-terminal kinase (JNK) pathways have been proposed as pivotal in the processes leading to radiation hair cell death. Potential protectants, such as amifostine, N-acetylcysteine (NAC) and epicatechin (EC), are claimed to be effective at reducing radiation-inducedhair cell death. The RT dosage, selection and application of concurrent chemotherapy should be pre-examined in order to minimize the damage to cochlea hair cells.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.18 no.2
• /
• pp.561-570
• /
• 2004

To screen the effective materials for hair loss treatment, the Gamissanghwa-tang extracts were tested. As a result we found that the Gamissanghwa-tang extracts have the hair growth promoting effect. After topical application of each test materials to the back of CS7BL/6 mice, the earlier conversion of telogen-to-anagen phase was induced. In the experiments of 5α-reductase type II inhibition assay, Radix Paeoniae Alba, Semen Cuscutae showed effective potential to inhibit the activity of 5α-reductase type II. And hair growth index of the Gamissanghwa-tang extracts ranked as 1.2, especially the hair growth index of Fructus Rubi is highest as 1.8. But there were no plant extracts which have effect on the DNA proliferation of hair dermal papilla cell measured by [³H]thymidine incorporation, the expression of growth factors such as IGF-I, KGF, HGF estimated by RT-PCR and protein synthesis of vibrissae hair follicle measured by [/sup 35/S] cysteine incorporation. Cortex Cinnamomi showed anti-bacterial effect on P. ovale, Radix Paeoniae Alba has the highest radical scavening activity and Radix Glycyrrhizae has the highest effects of NO synthesis. These results suggest that Gamissanghwa-tang can be used as a potent treatment agent for helping hair growth stimulation.

• Culinary science and hospitality research
• /
• v.19 no.5
• /
• pp.100-109
• /
• 2013

This study aims to analyze 19 kinds of mineral contents in hair targeting 311 people in Seoul who suffer from hair loss. The results are as follows: 1. The average contents of all kinds of minerals were within the standards. 2. Sodium, potassium, and selenium were more detected in men than in women; calcium, magnesium, copper, and manganese were more detected in women than in men; toxic elements, mercury, antimony, and arsenic were more detected in men than in women, which was statistically significant. 3. As the age increased, potassium (p<.05), iron (p<.01), manganese (p<.05), chromium (p<.01), and mercury (P<0.01) increased gradually, which was statistically significant. In particular, the content of mercury exceeded its standard in those over fifty. 4. Selenium (p<.01), lead (p<.05), aluminum (p<.05), and arsenic (p<.01) were more detected in natural hair than in permanent or colored hair. Calcium (p<.001), magnesium (p<.001), and manganese (p<.01) were more detected in permanent or colored hair than in natural hair. They were all statistically significant.

• Biomedical Science Letters
• /
• v.24 no.3
• /
• pp.263-269
• /
• 2018

This study aims to investigate the biological activities related to hair loss of short anti-oxidant peptides (DK peptides) $5{\alpha}$-reductase inhibition and anti-oxidation. The series of DK peptides were generated amphipathic helical properties using leucines, lysines and tryptophan residues. Cell viability and free radical scavenging activities were performed using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium bromide (MTT) and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay, respectively. The DK peptides were investigated for inhibitory activity against $5{\alpha}$-reductase. Antioxidant activities were determined by means of, 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assays. All peptides could inhibit $5{\alpha}$-reductase in lipopolysaccharide-stimulated macrophage. In conclusion, DK peptides was suggested as the most attractive ingredients for improving hair loss, because of the high inhibitory against $5{\alpha}$-reductase inhibition.

• Prospectives of Industrial Chemistry
• /
• v.22 no.1
• /
• pp.12-22
• /
• 2019

탈모 인구의 증가로 국내 탈모 시장이 빠르게 팽창하고 있으며, 탈모 관련 산업이 성장기에 진입하였다. 탈모시장은 탈모관리제품, 기기, 관리실 및 의료 시술로 세분화되고 있으며 관련 신제품들이 개발되고 있지만 샴푸와 같은 화장품 시장의 규모가 가장 크게 자리 잡고 있는 상황이다. 세계 헤어케어 관련 화장품 시장은 중국의 탈모 관련 미용산업 시장규모가 매우 크며, 국내 기업들도 중국 탈모 시장에 선진출하기 위해 제품개발 및 마케팅을 강화하고 있다. 이러한 시장동향과 더불어 국내에서는 새로운 소재 개발과 함께 안전하고 기능성이 뛰어난 탈모방지 화장품의 요구가 확대되고 있는 추세이다. 따라서 본 기획에서는 현재 기능성 헤어케어 제품들의 시장분석과 동업계 현황, 5-Force 분석을 통한 경쟁상황, 수요전망 등에 대하여 소개하고, 향후 탈모방지 화장품시장의 발전 가능성과 향후 전략 방안을 제시하고자 한다.

• The Korean Journal of Food And Nutrition
• /
• v.32 no.5
• /
• pp.553-559
• /
• 2019

To investigate the effects of antioxidant activities and hair loss prevention of extracts from Platycodon grandiflorum, we've prepared chloroform (CF) and ethylacetate fractions (EA) extracted from P. grandiflorum. In the results of DPPH radical scavenging assay, the two fractions showed dose-dependent antioxidant activities. Furthermore, in the ABTS assay, the two fractions exhibited the inhibitory effect over 90% at 10, 50, 100, 200 mg/mL. To investigate the inflammation inhibitory effect, we used RAW264.7 cells, these extracts were inhibited inflammatory reaction by suppressing the production of nitric oxide (NO) and prostaglandin $E_2$ ($PGE_2$) in dose-dependent manner. In the assay of HaCaT cells' proliferation, the 24 hr treatment of the extracts significantly accelerarted cell proliferation in the range of concentrations used. The two fractions inhibited the proliferation of Malssezia furfur, the bacteria induce the dandruff. Finally, the CF could significantly inhibit the DHT production at 1, 10, 50, $100{\mu}g/mL$, but EA showed the inhibitory effect at the concentration over $50{\mu}g/mL$. The overall results of this study suggest that the chloroform (CF) and ethylacetate fractions (EA) from P. grandiflorum could be a useful raw material for the hair loss prevention products.

• Fashion & Textile Research Journal
• /
• v.9 no.3
• /
• pp.341-346
• /
• 2007

This research is the hair damage as treating a perm before and after that is compared the change of surface characteristics of human hair. On the basis of this, we would to show a basic data for hair damage prevention and hair improvement to keep the beautiful and healthy hair. Results are as follows; For the change of formational characteristics of hair surface, untreated hair before the perm treatment had smooth appearance overall and undamaged scale that is in pattern and finely folded was observed but damaged hair and extremely hair had uneven edge and damages throughout along with the dissolution of scale which the border of epidermal gap is unclear. Hair after a perm treatment caused cortical exposures due to extensive loss of scale during the treatment and even bubble effect. Protein perm, regular perm, soft perm, and direct heating perm, in that order, had the most damages to the hair.

• Korea Journal of Cosmetic Science
• /
• v.1 no.1
• /
• pp.11-18
• /
• 2019

Caffeine is widely used in cosmetics and hair care products. Although its efficacy in stimulating hair growth has been confirmed in recent studies, its mechanism of action remains unelucidated. The present study aimed to determine the effects of caffeine on hair growth, with a focus on intracellular hair follicle activity. Experiments included in vitro and ex vivo tests, and a clinical study. Caffeine enhanced the cellular activity and potassium channel opening. It also promoted human hair follicle elongation. Immunohistochemical staining showed that the Ki-67 signal was significantly higher in cells treated with caffeine. These efficacies of caffeine were comprehensively demonstrated in clinical results, wherein caffeine-containing shampoo improved hair density after 24 weeks of testing. Collectively, the results of this study demonstrated that caffeine promoted hair growth and inhibited the progression of hair loss by enhancing intracellular activity of hair follicles.