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http://dx.doi.org/10.7314/APJCP.2013.14.10.5631

Radiation-induced Cochlea Hair Cell Death: Mechanisms and Protection  

Tan, Pei-Xin (Department of Radiation Oncology, Nanfang Hospital, Southern Medical University)
Du, Sha-Sha (Department of Radiation Oncology, Nanfang Hospital, Southern Medical University)
Ren, Chen (Department of Radiation Oncology, Nanfang Hospital, Southern Medical University)
Yao, Qi-Wei (Department of Radiation Oncology, Nanfang Hospital, Southern Medical University)
Yuan, Ya-Wei (Department of Radiation Oncology, Nanfang Hospital, Southern Medical University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.10, 2013 , pp. 5631-5635 More about this Journal
Abstract
Cochlea hair cell death is regarded to be responsible for the radiation-induced sensorineural hearing loss (SNHL), which is one of the principal complications of radiotherapy (RT) for head and neck cancers. In this mini-review, we focus on the current progresses trying to unravel mechanisms of radiation-induced hair cell death and find out possible protection. P53, reactive oxygen species (ROS) and c-Jun N-terminal kinase (JNK) pathways have been proposed as pivotal in the processes leading to radiation hair cell death. Potential protectants, such as amifostine, N-acetylcysteine (NAC) and epicatechin (EC), are claimed to be effective at reducing radiation-inducedhair cell death. The RT dosage, selection and application of concurrent chemotherapy should be pre-examined in order to minimize the damage to cochlea hair cells.
Keywords
Radiotherapy; sensorineural hearing loss; ototoxicity; hair cell; apoptosis;
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1 Verheij M, Bartelink H (2000). Radiation-induced apoptosis. Cell Tissue Res, 301, 133-42.   DOI   ScienceOn
2 Wang J, Ruel J, Ladrech S, et al (2007). Inhibition of the c-Jun N-terminal kinase-mediated mitochondrial cell death pathway restores auditory function in sound-exposed animals. Mol Pharmacol, 71, 654-66.
3 Xie LH, Tang AZ, Yin SH, Tan SH (2012). [Protective effects of n-acetylcysteine on cochlear damage occuring in guinea pigs exposed to irradiation]. Zhonghua Yi Xue Za Zhi, 92, 989-92.
4 Zine A, van de Water TR (2004). The MAPK/JNK signalling pathway offers potential therapeutic targets for the prevention of acquired deafness. Curr Drug Targets CNS Neurol Disord, 3, 325-32.   DOI
5 Awwad HK (1990). Radiation Oncology: Radiobiological and Physiological Perspectives. Late reacting tissues: radiation damage to central nervous system, The Netherlands: Kluger Academic Publishers.
6 Baker K, Staecker H (2012). Low dose oxidative stress induces mitochondrial damage in hair cells. Anat Rec (Hoboken), 295, 1868-76.   DOI   ScienceOn
7 Bertolaso L, Martini A, Bindini D, et al (2001). Apoptosis in the OC-k3 immortalized cell line treated with different agents. Audiology, 40, 327-35.   DOI
8 Bhandare N, Antonelli PJ, Morris CG, et al (2007). Ototoxicity after radiotherapy for head and neck tumors. Int J Radiat Oncol Biol Phys, 67, 469-79.   DOI   ScienceOn
9 Bohne BA, Marks JE, Glasgow GP (1985). Delayed effects of ionizing radiation on the ear. Laryngoscope, 95, 818-28.
10 De Flora S, Izzotti A, D'Agostini F, Balansky RM (2001). Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smokingrelated endpoints. Carcinogenesis, 22, 999-1013.   DOI   ScienceOn
11 Cheng AG, Huang T, Stracher A, et al (1999). Calpain inhibitors protect auditory sensory cells from hypoxia and neurotrophin-withdrawal induced apoptosis. Brain Res, 850, 234-43.   DOI   ScienceOn
12 Bourhis J, Blanchard P, Maillard E, et al (2011). Effect of amifostine on survival among patients treated with radiotherapy: a meta-analysis of individual patient data. J Clin Oncol, 29, 2590-7.   DOI   ScienceOn
13 Chen WC, Jackson A, Budnick AS, et al (2006). Sensorineural hearing loss in combined modality treatment of nasopharyngeal carcinoma. Cancer, 106, 820-9.   DOI   ScienceOn
14 Cheng AG, Cunningham LL, Rubel EW (2005). Mechanisms of hair cell death and protection. Curr Opin Otolaryngol Head Neck Surg, 13, 343-8.   DOI   ScienceOn
15 Doctrow SR, Lopez A, Schock AM, et al (2012). A synthetic superoxide dismutase/catalase mimetic EUK-207 mitigates radiation dermatitis and promotes wound healing in irradiated rat skin. J Invest Dermatol, 133, 1088-96.
16 Feghali JG, Liu W, Van De Water TR (2001). L-n-acetyl-cysteine protection against cisplatin-induced auditory neuronal and hair cell toxicity. Laryngoscope, 111, 1147-55.   DOI   ScienceOn
17 Ferri KF, Kroemer G (2001). Organelle-specific initiation of cell death pathways. Nat Cell Biol, 3, 255-63.   DOI   ScienceOn
18 Fleury B, Lapeyre M (2010). Tolerance of normal tissues to radiation therapy: ear. Cancer Radiother, 14, 284-9.   DOI   ScienceOn
19 Hitchcock YJ, Tward JD, Szabo A, Bentz BG, Shrieve DC (2009). Relative contributions of radiation and cisplatin-based chemotherapy to sensorineural hearing loss in headand-neck cancer patients. Int J Radiat Oncol Biol Phys, 73, 779-88.   DOI   ScienceOn
20 Hensley ML, Hagerty KL, Kewalramani T, et al (2009). American Society of Clinical Oncology 2008 clinical practice guideline update: use of chemotherapy and radiation therapy protectants. J Clin Oncol, 27, 127-45.
21 Hettinger K, Vikhanskaya F, Poh MK, et al (2007). C-Jun promotes cellular survival by suppression of PTEN. Cell Death Differ, 14, 218-29.   DOI   ScienceOn
22 Honore HB, Zarowski A, Moller K, Grau C (2002). Radiotherapy-induced ear toxicity. Radiother Oncol, 65, 9-16.   DOI   ScienceOn
23 Hua C, Bass JK, Khan R, Kun LE, Merchant TE (2008). Hearing loss after radiotherapy for pediatric brain tumors: effect of cochlear dose. Int J Radiat Oncol Biol Phys, 72, 892-9.   DOI   ScienceOn
24 Iliakis G (1991). The role of DNA double strand breaks in ionizing radiation-induced killing of eukaryotic cells. Bioessays, 13, 641-8.   DOI
25 Jiang H, Sha SH, Forge A, Schacht J (2006). Caspase-independent pathways of hair cell death induced by kanamycin in vivo. Cell Death Differentiation, 13, 20-30.   DOI   ScienceOn
26 Kim CH, Kang SU, Pyun J, et al (2008). Epicatechin protects auditory cells against cisplatin-induced death. Apoptosis, 13, 1184-94.   DOI
27 Linskey ME, Johnstone PA (2003). Radiation tolerance of normal temporal bone structures: implications for gamma knife stereotactic radiosurgery. Int J Radiat Oncol Biol Phys, 57, 196-200.   DOI   ScienceOn
28 Lessa RM, Oliveira JA, Rossato M, Ghilardi Netto T (2009). Analysis of the cytoprotective effect of amifostine on the irradiated inner ear of guinea pigs: an experimental study. Braz J Otorhinolaryngol, 75, 694-700.   DOI
29 Liang J, Wang D, Renaud G, et al (2012). The stat3/socs3a pathway is a key regulator of hair cell regeneration in zebrafish. [corrected]. J Neurosci, 32, 10662-73.   DOI   ScienceOn
30 Li JJ, Guo YK, Tang QL, et al (2010). Prospective study of sensorineural hearing loss following radiotherapy for nasopharyngeal carcinoma. J Laryngol Otol, 124, 32-6.   DOI   ScienceOn
31 Low WK, Fong KW (1998). Long-term hearing status after radiotherapy for nasopharyngeal carcinoma. Auris Nasus Larynx, 25, 21-4.   DOI   ScienceOn
32 Low WK, Kong SW, Tan MG (2010). Ototoxicity from combined Cisplatin and radiation treatment: an in vitro study. Int J Otolaryngol, 2010, 523976.
33 Low WK, Burgess R, Fong KW, Wang DY (2005). Effect of radiotherapy on retro-cochlear auditory pathways. Laryngoscope, 115, 1823-6.   DOI   ScienceOn
34 Low WK, Sun L, Tan MG, Chua AW, Wang DY (2008). L-N-Acetylcysteine protects against radiation-induced apoptosis in a cochlear cell line. Acta Otolaryngol, 128, 440-5.   DOI   ScienceOn
35 Low WK, Michelle GK, Tan. Sun L, et al (2006b). Dose-dependant radiation-induced apoptosis in a cochlear cell-line. Apoptosis, 11, 2127-36.   DOI
36 Mansour HH, Hafez HF, Fahmy NM, Hanafi N (2008). Protective effect of N-acetylcysteine against radiation induced DNA damage and hepatic toxicity in rats. Biochem Pharmacol, 75, 773-80.   DOI   ScienceOn
37 Marchenko ND, Zaika A, Moll UM (2000). Death signal-induced localization of p53 protein to mitochondria: a potential role in apoptotic signaling. J Biol Chem, 275, 16202-12.   DOI   ScienceOn
38 Pyun JH, Kang SU, Hwang HS, et al (2011). Epicatechin inhibits radiation-induced auditory cell death by suppression of reactive oxygen species generation. Neuroscience, 199, 410-20.   DOI   ScienceOn
39 Mikkelsen RB, Wardman P (2003). Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms. Oncogene, 22, 5734-54.   DOI   ScienceOn
40 Petsuksiri J, Sermsree A, Thephamongkhol K, et al (2011). Sensorineural hearing loss after concurrent chemoradiotherapy in nasopharyngeal cancer patients. Radiat Oncol, 6, 19.   DOI   ScienceOn
41 Reliene R, Fischer E, Schiest RH (2004). Effect of N-acetylcysteine on oxidative DNA damage and the frequency of DNA deletions in atm-deficient mice. Cancer Res, 63, 5148-53.
42 Sabapathy K (2012). Role of the JNK pathway in human diseases. Prog Mol Biol Transl Sci, 106, 145-69.   DOI   ScienceOn
43 Seidman MD, Vivek P (2004). Intratympanic treatment of hearing loss with novel and traditional agents. Otolaryngol Clin North Am, 37, 973-90.   DOI   ScienceOn
44 Selzer E, Hebar A (2012). Basic principles of molecular effects of irradiation. Wien Med Wochenschr, 162, 47-54.   DOI   ScienceOn
45 Wang J, Ladrech S, Pujol R (2004). Caspase inhibitors, but not c-Jun NH2-terminal kinase inhibitor treatment, prevent cisplatin-induced hearing loss. Cancer Res, 64, 9217-24.   DOI   ScienceOn
46 Tabuchi K, Nishimura B, Nakamagoe M, et al (2011). Ototoxicity: mechanisms of cochlear impairment and its prevention. Curr Med Chem, 18, 4866-71.   DOI
47 Pan CC, Eisbruch A, Lee JS, et al (2005). Prospective study of inner ear radiation dose and hearing loss in head-and-neck cancer patients. Int J Radiat Oncol Biol Phys, 61, 1393-402.   DOI   ScienceOn
48 Devarajan P, Savoca M, Castaneda MP, et al (2002). Cisplatin-induced apoptosis in auditory cells: role of death receptor and mitochondrial pathways. Hear Res, 174, 45-54.   DOI   ScienceOn
49 Gao F, Fish BL, Szabo A, et al (2012). Short-term treatment with a SOD/catalase mimetic, EUK-207, mitigates pneumonitis and fibrosis after single-dose total-body or whole-thoracic irradiation. Radiat Res, 178, 468-80.   DOI
50 Low WK, Toh ST, Wee J, Fook-Chong SM, Wang DY (2006a). Sensorineural hearing loss after radiotherapy and chemoradiotherapy: a single, blinded, randomized study. J Clin Oncol, 24, 1904-9.   DOI   ScienceOn
51 Sha SH, Taylor R, Forge A, Schacht J (2001). Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals. Hear Res, 155, 1-8.   DOI   ScienceOn