[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.15616/BSL.2018.24.3.263

Inhibition of 5α-reductase of de novo Generation of Short Anti-oxidant Peptides

Lee, Sung-Gyu (Department of Medical Laboratory Science, College of Health Science, Dankook University)
Kang, Hyun (Department of Medical Laboratory Science, College of Health Science, Dankook University)

Abstract

This study aims to investigate the biological activities related to hair loss of short anti-oxidant peptides (DK peptides) $5{\alpha}$ -reductase inhibition and anti-oxidation. The series of DK peptides were generated amphipathic helical properties using leucines, lysines and tryptophan residues. Cell viability and free radical scavenging activities were performed using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium bromide (MTT) and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay, respectively. The DK peptides were investigated for inhibitory activity against $5{\alpha}$ -reductase. Antioxidant activities were determined by means of, 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assays. All peptides could inhibit $5{\alpha}$ -reductase in lipopolysaccharide-stimulated macrophage. In conclusion, DK peptides was suggested as the most attractive ingredients for improving hair loss, because of the high inhibitory against $5{\alpha}$ -reductase inhibition.

Keywords

$5{\alpha}$ -reductase; Anti-oxidant peptides; Hair loss;

Citations & Related Records

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