• Journal of the Korean Society for Industrial and Applied Mathematics
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• 제22권1호
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• pp.29-62
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• 2018

We investigate a class of HIV infection models with two kinds of target cells: $CD4^+$ T cells and macrophages. We incorporate three distributed time delays into the models. Moreover, we consider the effect of humoral immunity on the dynamical behavior of the HIV. The viruses are produced from four types of infected cells: short-lived infected $CD4^+$T cells, long-lived chronically infected $CD4^+$T cells, short-lived infected macrophages and long-lived chronically infected macrophages. The drug efficacy is assumed to be different for the two types of target cells. The HIV-target incidence rate is given by bilinear and saturation functional response while, for the third model, both HIV-target incidence rate and neutralization rate of viruses are given by nonlinear general functions. We show that the solutions of the proposed models are nonnegative and ultimately bounded. We derive two threshold parameters which fully determine the positivity and stability of the three steady states of the models. Using Lyapunov functionals, we established the global stability of the steady states of the models. The theoretical results are confirmed by numerical simulations.

• 성인간호학회지
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• 제26권5호
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• pp.563-572
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• 2014

Purpose: The purpose of this study was to identify the mediating effect of hope and depression applied on the influence of social stigma on suicidal ideation of 108 HIV infected males. Methods: This study was a descriptive, crosssectional design that used a survey approach. Data collection was one-on-one interviews by a counseling nurse from July 2012 to January 2013. The survey included questions about social stigma, hope, depression, and suicidal ideation. Results: Fitness of the hypothetical model was appropriate ($x^2/df=1.97$, TLI=.97, CFI=.98, RMSEA=.07, SRMR=.04). Social stigma had no direct effect on suicidal ideation but had a significant indirect effect on suicidal ideation via hope and depression. Hope had a mediating effect the relationship between stigma and depression but no direct effect on the relationship between stigma and suicidal ideation. Hope had an indirect effect on suicidal ideation via depression. Stigma and hope accounted for 41% of depression was where as suicidal ideation was explained 56.3% by depression, hope, and stigma. Conclusion: In order to reduce depression and suicidal ideation of HIV infected people, stigma improving strategies are required. And hope intervention for HIV infected people may decrease their suicidal ideation and depression.

• 한국간호교육학회지
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• 제27권2호
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• pp.163-174
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• 2021

Purpose: This study aims to identify factors influencing the stigma communication concerning HIV (Human Immunodeficiency Virus)/AIDS (Acquired Immune Deficiency Syndrome) patients between health and medical college students. Methods: In this descriptive study, the participants were 158 college students from a certain university. Data were collected from September 18 to September 30, 2018. Self-reported questionnaires were used to measure AIDS-related knowledge, homosexual awareness, fear of HIV/AIDS patients and stigma communication. The collected data were analyzed with descriptive statistics, an independent t-test, one way analysis of variance, Pearson's correlation and a stepwise multiple regression analysis using the SPSS 23.0 program. Results: The factors influencing the stigma communication between health and medical college students were a fear of HIV/AIDS patients (β=.47, p<.001) and homosexual awareness (β=-.15, p=.040), which together explained 28.0% of the variance in the model. Conclusion: The study findings suggest that an education program for health and medical college students should be developed. Additionally, when designing the education program, it is recommended that the contents for inducing attitude changes should include affective areas as well as knowledge-oriented contents. The study suggests that it is necessary to provide a systematic education program to decrease the stigma for HIV/AIDS patients before health care providers enter clinical practice.

• 한국보건간호학회지
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• 제37권1호
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• pp.136-146
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• 2023

This cross-sectional design study was undertaken to determine the factors associated with suicidal ideation in human immunodeficiency virus (HIV)-infected older adults. Data from a city-wide representative sample collected by the Seoul Metropolitan Government were used. The cross-sectional survey was conducted between February and March 2013. Participants selected and included in the analysis were HIV-infected adults living in Seoul, and aged 50 years and older. The overall adjusted model showed that being unemployed (adjusted odds ratio [aOR], 3.34; 95% confidence interval [CI], 1.16-9.57), a history of depression treatment (aOR, 4.61; 95% CI, 1.02-20.66), perceived belongingness (aOR, 0.63; 95% CI, 0.41-0.99), and psychological functioning (aOR, 0.85; 95% CI, 0.73-0.99) were significantly related to suicidal ideation. Psychosocial features were found to be strongly associated with suicidal ideation among HIV-infected older adults. The findings could be useful for HIV nursing consultants to identify HIV-infected older adults who are vulnerable to suicidal ideation. Comprehensive mental health services should be provided as coping resources for HIV-infected older adults who have suicidal ideation.

• 대한간호학회지
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• 제53권3호
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• pp.295-308
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• 2023

Purpose: This study evaluated the validity and reliability of Shively and colleagues' self-efficacy for HIV disease management skills (HIV-SE) among Korean participants. Methods: The original HIV-SE questionnaire, comprising 34 items, was translated into Korean using a translation and back-translation process. To enhance clarity and eliminate redundancy, the author and expert committee engaged in multiple discussions and integrated two items with similar meanings into a single item. Further, four HIV nurse experts tested content validity. Survey data were collected from 227 individuals diagnosed with HIV from five Korean hospitals. Construct validity was verified through confirmatory factor analysis. Criterion validity was evaluated using Pearson's correlation coefficients with the new general self-efficacy scale. Internal consistency reliability and test-retest were examined for reliability. Results: The Korean version of HIV-SE (K-HIV-SE) comprises 33 items across six domains: "managing depression/mood," "managing medications," "managing symptoms," "communicating with a healthcare provider," "getting support/help," and "managing fatigue." The fitness of the modified model was acceptable (minimum value of the discrepancy function/degree of freedom = 2.49, root mean square error of approximation = .08, goodness-of-fit index = .76, adjusted goodness-of-fit index = .71, Tucker-Lewis index = .84, and comparative fit index = .86). The internal consistency reliability (Cronbach's α = .91) and test-retest reliability (intraclass correlation coefficient = .73) were good. The criterion validity of the K-HIV-SE was .59 (p < .001). Conclusion: This study suggests that the K-HIV-SE is useful for efficiently assessing self-efficacy for HIV disease management.

• 한국콘텐츠학회논문지
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• 제16권8호
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• pp.247-256
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• 2016

본 연구는 HIV 감염인이 지각하는 사회적 지지와 사회적 낙인이 삶의 질에 미치는 영향에서 희망의 매개효과를 검증하기 위해 수행되었다. 연구대상은 HIV 감염인 197명이며, 상담간호사가 일대일 면접을 통해 사회적 낙인, 사회적 지지, 희망, 삶의 질에 대한 자료를 수집하였다. 매개효과의 분석은 AMOS 21.0 프로그램을 이용하여 구조방정식 모형을 통해 수행하였고, 간접효과의 유의성은 붓스트래핑(Bootstrapping) 방법을 사용하여 분석하였다. 연구결과, 첫째, 사회적 지지는 삶의 질에 유의한 정적 영향을 미쳤고, 사회적 낙인은 유의한 부적 영향을 미쳤다. 둘째, 사회적 지지는 희망에 유의한 정적 영향을 미쳤고, 사회적 낙인은 희망에 유의한 부적 영향을 미쳤다. 셋째, 사회적 지지와 사회적 낙인이 삶의 질에 미치는 영향에서 희망은 유의한 매개효과가 있었다. HIV 감염인의 삶의 질을 향상시키기 위하여 낙인적 시선을 개선하고 사회적 지지체계를 형성하기 위한 적극적인 전략이 요구되며, 주요한 매개역할을 하는 희망을 향상시킬 수 있는 중재프로그램을 개발하여 적용하는 것이 필요하다.

• 보건교육건강증진학회지
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• 제30권5호
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• pp.113-124
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• 2013

Objectives: The objective of this study was developing a community-based HIV prevention program to enhance the safe sexual behavior among rural Ethiopian female youth. Methods: A community-based HIV prevention program was developed using the Cox's Interaction Model of Client Health Behavior. The program development was carried out in four phases using a mixed research method: need-assessment which consisted of three steps (secondary-data analysis, key-informant interview, and focused-group interview); identification of preliminary program contents; expert's review of the program contents for the validity and cultural acceptability of the program; and refinement of the proposed program contents. Results: The HIV prevention program developed in this study consisted of three modules; the first module was for enhancing the youth's self-esteem, the second was for providing the youth with information regarding HIV/AIDS and safe sexual behavior, and the third was for improving the youth's communication skills and refusing skills. Conclusions: The need assessment and expert's review was very effective way to reflect sociocultural factors of rural Ethiopia for developing HIV prevention program for female youth. Further research is desirable for verifying the effectiveness of the developedprogram.

• 대한수학회지
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• 제42권5호
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• pp.1071-1086
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• 2005

In this paper, we introduce a discrete time to the model to describe the time between infection of a CD4$^{+}$ T-cells, and the emission of viral particles on a cellular level. We study the effect of the time delay on the stability of the endemically infected equilibrium, criteria are given to ensure that the infected equilibrium is asymptotically stable for all delay. We also obtain the condition for existence of an orbitally asymptotically stable periodic solution.

• Journal of applied mathematics & informatics
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• 제5권3호
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• pp.785-796
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• 1998

In this paper we propose a model of HIv population through method of phases with non-Markovian evolution of immi-gration. The analysis leads to an explicit differnetial equations for the generating functions of the total population size. The detection process of antibodies (against the antigen of virus) is analysed and an explicit expression for the correlation functions are provided. A measure of bunching is also introduced for some particular choice of parameters.

• 대한수학회보
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• 제48권3호
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• pp.555-574
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• 2011

It is well known that the mathematical models provide very important information for the research of human immunodeciency virus type. However, the infection rate of almost all mathematical models is linear. The linearity shows the simple interaction between the T-cells and the viral particles. In this paper, a differential equation model of HIV infection of $CD4^+$ T-cells with Crowley-Martin function response is studied. We prove that if the basic reproduction number $R_0$ < 1, the HIV infection is cleared from the T-cell population and the disease dies out; if $R_0$ > 1, the HIV infection persists in the host. We find that the chronic disease steady state is globally asymptotically stable if $R_0$ > 1. Numerical simulations are presented to illustrate the results.