• Title/Summary/Keyword: HER2

Search Result 2,751, Processing Time 0.032 seconds

Meta-analysis of Six Randomized Control Trials of Chemotherapy Plus Anti-HER Monoclonal Antibody for Advanced Gastric and Gastroesophageal Cancer

  • Luo, Huai-Qing;Han, Li;Jiang, Yan
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.15 no.13
    • /
    • pp.5343-5348
    • /
    • 2014
  • Background: A meta-analysis was performed to examine the benefit/risk ratio for the addition of anti- HER MoAbs to chemotherapy in patients with advanced gastric and gastroesophageal cancer from six randomized phase II/III trials. Materials and Methods: We searched relative trials from Pubmed, EMBASE, Cochrane library databases, China National Knowledge Infrastructure databases, Google Scholar and the NIH ClinicalTrials. Primary outcomes were overall response rate (ORR), progression-free survival (PFS), overall survival (OS). Secondary outcomes were toxicities. All analyses were performed using STATA 12.0. Results: This meta-analysis included six randomized controlled trials (RCTs) with 2, 297 patients and we demonstrated that the anti-HER MoAbs arm did have a positive effect on ORR in the anti-HER MoAbs arm (OR 1.28, 95% CI 1.00-1.64, p=0.01). There was an increasing benefit regarding OS (HR 0.74, 95% CI 0.60-0.88, p<0.05) and PFS (HR 0.72, 95% CI 0.60-0.84, p<0.05) in the anti-HER2 subgroup, but a reduction of OS (HR 1.11, 95% CI 0.87-1.36, p<0.05) and PFS (HR 1.13, 95% CI 0.98 -1.28, P<0.05) in anti-EGFR subgroup. Some grade 3-4 toxicity had a significantly higher incidence in the anti-HER MoAbs arm. There was no significant publication bias for all endpoints. Conclusions: The addition of trstuzumab MoAb to chemotherapy for gastric and gastroesophageal cancer significantly improved outcome of OS and PFS endpoints, while other MoAbs led to no improvement in results. Some adverse events were increased in anti-HER MoAbs arm compared with the control.

Breast Cancer in Men: a Report from the Department of Radiation Oncology in Kermanshah Province, Iran

  • Amirifard, Nasrin;Sadeghi, Edris
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.17 no.5
    • /
    • pp.2593-2596
    • /
    • 2016
  • Background: Male breast cancer (MBC) is a rare disease that accounts for less than 1% of all cancers in men and less than 1% of all diagnosed breast cancers. In this study, we retrospectively evaluated the clinicopathological features, treatment options and overall survival in Kurdish MBC cases. Materials and Methods: Seventeen MBC were referred to Department of Radiation Oncology in Imam Reza Hospital, Kermanshah, Iran, between 2010 and 2016. Immunohistochemical analysis was performed for ER, PR and Her2 biomarkers and FISH for those with Her2 2+. Median follow-up period was 30 months (2-65 months). We excluded from the study patients who did not have follow-up after initial diagnosis. Treatment methods were chemotherapy, radiotherapy, hormonal therapy, target therapy and palliative care. Survival was estimated by the Kaplan Meier method (Prism 5). Results: The mean age at diagnosis was $49.24{\pm}17$ years (range, 24-85 years). Grade II was the most grade in MBC (65%). Fourteen patients (82%) had invasive ductal carcinoma, one (6%) had ductal carcinoma in situ and 2 (12%) had invasive papillary. ER, PR and Her2 were significantly positive in 14/17, 8/17 and 2/17 cases, respectively. The treatment included modified radical mastectomy for most patients. Chemotherapy with TAC and CEF regimens was delivered to 15/17 cases. Tamoxifen therapy was delivered to 14/17 cases. Three stage IV patients received Avestin and two with Her2 3+ were given Trastuzumab (Herceptin). Patients received adjuvant radiotherapy following surgery and chemotherapy. The site of metastasis was the bone in 2 cases, lung in 1 case and liver in 1 case. Zoledronic acid (Zometa) was prescribed for patients with bone metastasis. Five-year overall survival rate was 64%. Conclusions: MBC is rare. Thus, we need larger studies are in collaboration with several research centers in the field of breast cancer. ER positive, grade II of invasive ductal carcinoma, stage II and right side happened more with MBC. Overall survival is similar to other studies.

Lived experience of mothers who have child with cerebral palsy (뇌성마비아 어머니의 경험)

  • Lee Hwa Za;Kim Yee Soon;Lee Gee Won;Gwan Soo Za;Kang In Soon;An Hea Gyung
    • Child Health Nursing Research
    • /
    • v.2 no.1
    • /
    • pp.93-111
    • /
    • 1996
  • The purpose of the study is to identify the lived experience of mothers who have children with cerebral palsy in order to understand their agony. Moreover, the result of study was to find some nursing intervention for disabled children and their mothers. For this purpose, ten mothers who are willing to cooperate with this research were selected at random from those who have children with the cerebral palsy, currently using the municipal facilities for the handicapped with cerebral malfunction. Data collection was done from October 4, 1994 th December 31, 1994. The data were collected by asking the mothers mentioned above with some unstructured open-ended questions, recorded on the tapes with permission by the interviewee in order to prevent missing of the interviewed contents. These collected data have been substantiated and properly analyzed on the basis of phenomenological approach initiated by Colaizzi's method. The results and validity are proved to be credible by means of the individual checking of the interviewed mothers. The results of this study are as follows : 1. When the mother is first informed of the diagnosis of cerebral palsy on her child, she usually misses the crucial timing needed for proper treatment of the child's disorder because she is notified through the doctor's indifference and his apparently inactive, matter-of-fact attitude. At first she suspects the doctor's diagnosis and tries to attribute it to the unknown cause from a certain genetic problem and then she quickly wants to deny the whole situation that her child is really suffering from the cerebral palsy. The reality is too much for her to accept as it is and she would not believe her child is abnormal. Therefore, she even attempts depend on the power of God for its solution. 2. The mother, who goes thorough this kind of uncommon experiences, is totally devoted to the treatment and care of the child and completely ignores her own life and happiness. At the same time, she feels sorry for her other normal children she believes having not enough care and concern. Also, she feels sorry for the sick child when the child's brothers or sisters show special concern for the patient out of sympathy. It is sorry and not satisfied for her that the child is growing with abnormality and neighbor other around have inappropriate attitudes. Likewise, she is discontent with her husband's lack of concern about the child's treatment. She believes that the health care system in this society isn't fulfilling its due purpose. In the state of her utmost distress and anxiety, she always feels the need of competent consultants, and is angry about that her child is treated as an abnormal being, she is trying to hide the child from other people and to make him or her disappear, if possible. Although she doesn't have harmonious relation with her husband, she id happy when he shows his affection for the child and she feels relieved and thankful when the relatives don't mention about the child's condition Since the child's overall status of health is continuously in unstable conditions, requiring her all-time readiness for an emergency, she feels guilty of her child's illness toward the fEmily members as if it was her own fault to have borne such an abnormal child and she feels responsible for the child morally and financially if necessary Because her life is centered on taking care of the child, she cannot afford to enjoy her own life and happiness. She is a lonely mother, fatigued, with no proper relationship with other people around her. With this sense of guilt and responsibility as a mother of an unusual disease, she has no choice but to grieve her destiny from which she is not allowed to escape. 3. Nevertheless, the mother with the child suffering from the cerebral palsy does not easily give up the hope of getting her child cured and she believes that in the long run, though slower than hoped, her abnormal son or daughter will be eventually cured to become a normal sibling someday. This kind of hope is sustained by the mother's strong faith coming from observing the progress of other similar children getting better. Sometimes she is encouraged to have this faith by other mothers who share the same painful experiences, believing that her child will improve even more rapidly than others with the same palsy. Full of hope, she painstakingly waits for the child's healing. Moreover, she plans to have another child. she thinks that the patient child's brothers and sisters only can truly understand and look after the patients. However, when she notices that the progress of other children under the treatment does not look so hopeful, she is distressed by the thoughts that her child may never get well. Too, she is worried that the patient's brother or sister will be born as the same invalid with the cerebral disease. She is discouraged to have another baby as much as she is encouraged to. She is also troubled by the thought that in case she has another baby, she will have to be forced. to neglect the patient child, especially when she does have an extra hand or some reliable person to help her with taking care of the patient.

  • PDF

A Study on the RuO2 Electrode Catalyst Prepared by Colloidal Method (콜로이드법으로 합성한 RuO2 전극촉매의 연구)

  • PARK, JIN-NAM
    • Transactions of the Korean hydrogen and new energy society
    • /
    • v.30 no.3
    • /
    • pp.193-200
    • /
    • 2019
  • $RuO_2$, $PtO_2$, and various $(Ru,Pt)O_2$ colloidal solution were prepared using modified Watanabe method. Electrodes were manufactured by dipping of Ni mesh into the colloidal solution. Manufactured electrodes were characterized by XRD, SEM, and EDS. $(Ru,Pt)O_2$ electrodes showed $RuO_2$ crystal structure and high roughness. The hydrogen evolution reaction (HER) activities were evaluated by Linear Sweep Voltammetry. 1Ru2Pt electrode showed similar activity with commercial electrode, HER potentials are -0.9 V for both.

Nine months versus 12 months of adjuvant trastuzumab for patients with HER2-positive breast cancer

  • El-Enbaby, Ashraf Mahmoud;El Moneim, Nadia Ahmed Abd;Khedr, Gehan Abd El atti;Elwany, Yasmine Mohamed Nagy
    • Korean Journal of Clinical Oncology
    • /
    • v.14 no.2
    • /
    • pp.108-115
    • /
    • 2018
  • Purpose: This study aimed to compare the results of treatment with adjuvant trastuzumab for 9 months versus 12 months in human epidermal growth factor 2 (HER2)-positive breast cancer patients. The primary endpoint was disease-free survival. Secondary endpoints included cardiac safety, tolerability, and overall survival. Methods: The study included 60 non-metastatic HER2-positive breast cancer patients. All study patients underwent surgery, received adjuvant chemotherapy, radiotherapy and hormonal therapy if indicated. Thirty patients were randomized in each group. Group I patients received adjuvant trastuzumab for 12 months, while group II patients received adjuvant trastuzumab for 9 months. Patients were assessed by clinical examination and Echocardiography during treatment. Results: After median follow-up of 12 months, 90% of the patients in group I were disease free and 83.3% of patients in group II were disease free (P=0.402). All studied population in both groups I and II were alive at the end of the 1-year follow-up period after the completion of adjuvant trastuzumab treatment thus overall survival is 100%. Conclusion: Trastuzumab is tolerable and its side effects are reversible. Nine months of adjuvant trastuzumab treatment is more cost effective than the standard 12 months.

A Regressional Study on the Relation between Marriage Variables and Fertility (결혼관련 요인의 출산력에 미치는 영향 연구)

  • 김성혜;김초강
    • Korean Journal of Health Education and Promotion
    • /
    • v.8 no.1
    • /
    • pp.87-97
    • /
    • 1991
  • The purpose of this study is to identify the important marriage variables influencing fertilty. The data on which this study is based was selected from the survey data which was nation-widely collected from 2,824 married women in 1989 as the Korean. Family Function Study performed by the Korea Institute for Population and Health. The data was analyzed by the methods such as Cross Tabulation, Pearson's Correlation, and Multiple Regression. And the data analysis was processed by SPSS. The results are as follows. 1. There are differences in fertility according to the socioeconomic factor. The higher the educational level of a married woman is the lower the fertility level. And if the decision of marriage was made by herself, the fertility level is significantly low. As the duration of living in a large city is longer and the educational level of her husband is higher, the fertility level is low. 2. There are differences is fertility according to the demographic factor. As the first marriage age of her and her husband, the fertility level was low. And when a couple doesn't live with the husband's parents and the size of a family is small, the fertility level is low. 3. Finally the factors affecting fertility were analyzed by the Stepwised Multiple Regression. The result shows that as the educational level of a married woman is higher, she herself decides the marriage, the first marriage level of her is higher, the size of a family is small, her husband is higher, the fertility level is low.

  • PDF

A Clinical Case of Soeumin Abnormal Uterine Bleeding from Endometriosis with Onbaek-won (자궁내막증으로 인한 소음인(少陰人) 붕루(崩漏)환자의 온백원(溫白元)을 이용한 치험1례)

  • Lee, Pil-Jae;Kim, Seong-Ki;Song, Eun-Young;Lim, Eun-Chul;Seo, Young-Min
    • Journal of Sasang Constitutional Medicine
    • /
    • v.22 no.2
    • /
    • pp.108-114
    • /
    • 2010
  • 1. Objectives: The purpose of this case is to report the effect of Onbaek-won(溫白元) which is based on Sasang Constitutional Medicine for abnormal uterine bleeding from Endometriosis in Soeumin. 2. Methods: We treated Soeumin patient that had abnormal uterine bleeding from endometriosis. We prescribed Onbaek-won(溫白元) for her physical symptoms. The improvement of her disease was checked her bleeding volume and other physical symptoms. 3. Results: After the Sasang constitutional medication of Onbaek-won(溫白元) was given, her bleeding volume and her physical symptoms was improved. 4. Conclusions: This case study show an efficient result of using Onbaek-won(溫白元) in abnormal uterine bleeding from endometriosis of Soeumin. Onbaek-won(溫白元) was used instead of Semen Tiglii(巴豆).

A Study on BRCA1/2 Mutations, Hormone Status and HER-2 Status in Korean Women with Early-onset Breast Cancer (젊은 한국인 유방암 환자에서 BRCA1/2 돌연변이와 호르몬 수용체, HER-2 상태에 관한 연구)

  • Choi, Doo-Ho;Jin, So-Young;Lee, Dong-Wha;Kim, Eun-Seog;Kim, Yong-Ho
    • Radiation Oncology Journal
    • /
    • v.26 no.1
    • /
    • pp.65-73
    • /
    • 2008
  • Purpose: Women with breast cancer diagnosed at an age of 40 years or younger have a greater prevalence of germline BRCA1 and BRCA2 mutations than the prevalence of women with breast cancer diagnosed at older ages. Several immunohistochemical characteristics have been identified in breast cancers from studies of Caucasian women with BRCA1/2 mutations having familial or early-onset breast cancers. The aim of this study is to determine whether early-onset breast cancer in BRCA1 or BRCA2 mutation carriers, who were not selected from a family history, could be distinguished by the use of immunohistochemical methods and could be distinguished from breast cancer in women of a similar age without a germline BRCA1 or BRCA2 mutation. We also analyzed the prognostic difference between BRCA1/2 related and BRCA1/2 non-related patients by the use of univariate and multivariate analysis. Materials and Methods: Breast cancer tissue specimens from Korean women with early-onset breast cancers were studied using a tumor tissue microarray. Immunohistochemical staining of estrogen receptor(ER), progesterone receptor(PR) and HER-2, as well as the histology and grade of these specimens, were compared. The prognostic impact of immunohistochemical and histological factors as well as the BRCA1/2 mutation status was investigated separately. Results: There were 14 cases and 16 deleterious BRCA1/2 mutations among 101 patients tested. A family history(4/14) and bilateral breast cancers(3/9) were high risk factors for BRCA1/2 mutations. BRCA1/2-associated cancers demonstrated more expression of ER-negative(19.4% versus 5.1%, p=0.038) and HER-2 negative than BRCA1/2 negative tumors, especially for tumors with BRCA1 tumors The BRCA1/2 mutation rate for patients with triple negative tumors(negative expression of ER, PR and HER-2) was 24.2%. Tumor size, nodal status, and HER-2 expression status were significantly associated with disease free survival, as determined by univariate and multivariate analysis, but the BRCA1/2 status was not a prognostic factor. Conclusion: Breast cancer that occurs in women with a germline BRCA1 or BRCA2 mutations have recognizable immunohistochemical features, which may be useful in identifying individuals that are more likely to carry germline mutations. Although the BRCA1/2 mutation status was not a prognostic factor in Korean women with early-onset breast cancer, more cases with a longer follow-up period are needed for further study.

Communication Between Mother and her Adolescents (어머니와 정년기여자와의 커뮤니케이션에 관한 연구)

  • 김진숙;유영주
    • Journal of Families and Better Life
    • /
    • v.3 no.1
    • /
    • pp.77-91
    • /
    • 1985
  • This study was carried out to learn about the contents of communication between mother and her adolescents in this country, and possible differences in the contents of communication with demographic variables. In particular, I wanted to find out the following; 1)contents of communication between mother and her adolescents. 2)Contents of communication between parents with adolescents. 3)Possible differences in the contents of communication with differences in the level of education, employment status, and age of mother, family income level, and sex, and birth order of children. To test these hypotheses, I distributed questionnaires to 600 mothers of selected high school juniors(11th grade) in Seoul. Four hundred and fourty-eight questionnaires were returned, and the results were analyzed using frequency distribution, percentage, and x2-test. The results were as following; 1) In general, mothers communicated well with their adolescents, especially in topics related to studying, friends, school, parents and family, and future career. Communication on sex-education or sex-role, however, was rather limited in contents. ool, parents and family. Communication on sex-education or sex-role of adolescent was almost never attempted. This result showed similarity with 1 above. 3) (1) contents of communication and educational level of mother; contents of communication between mother and her adolescents differed significantly with educational level on all topics except parents and family, indicating that the educational level of mother, the more diverse was contents of communication between mother and her adolescents. (2) Contents of communication and employment status of mother: On all topics except sex-education, communication between mother and her adolescents differed significantly between employed and unemployed mothers, indicating that unemployed mothers communicate on greater number of topics with their adolescents than employed mothers do. (3) contents of communication and family income level; Family income level did not affect contents of communication between mother and her adolescents significantly. (4) contents of communication and age of mother; Age of mother did not affect a contents of communication between mother and her adolescents significantly. (5) contents of communication and sex of adolescent; Thee were significant differences in contents of communication on certain topics; On virginity, sex, marriage, and dating, mother communicate more diversely with daughters than with sons. This result certainly reflects the deep-rooted traditional value system among koreans, with permissive attitude toward males, and far more strict attitude toward females, on sex-related matters. (6) Contents of communication and birth order of adolescents; The birth order of adolescents did not affect contents of communication between mother and her adolescents significantly.

  • PDF

A Study on the Costume and Color Image of the Movie - Focusing on Main Actresses' Costumes - (영화의 복식과 색채 이미지 연구 - 여자주인공 복식을 중심으로 -)

  • Hong, Jin-Hee;Cho, Kyu-Hwa
    • Journal of Fashion Business
    • /
    • v.12 no.2
    • /
    • pp.12-27
    • /
    • 2008
  • The purpose of this study is to study main characters' (Roxie Hart, Velma Kelly) costumes and color images in the movie "Chicago". First, regarding the costumes and color images in characters, Roxie's straight silhouette slip in skin tone reflected her frailty and monotonous routines in reality. On the other hand, a white beaded dress showed her fame-hungry and self-absorption in fantasy. Also, a low waistline blue dress and a see-through black dress with a white collar were to disguise her guilt and draw sympathy to win a suitcase. Black and contrasting colors of red and blue body-suit style dresses expressed Velma's sensual attraction, aggressiveness, and desperation. Second, these images were reinforced by color images in the backgrounds in the film. On the scene of Velma's 'cell block tango', black and red showed her strong character. Contrasting colors of the red and blue expressed Velma's desire and despair in her act of 'the desperation'. As for images of black color on Roxie's stages, they represented her self-absorption and frustration of failing to attract public attention. On the ending of duet performance of Roxie and Velma, the yellow of the background expressed success and joy in life.