• 한국콘텐츠학회논문지
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• 제6권10호
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• pp.114-125
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• 2006

이전 논문은 자바 프로그램에서 논리적인 오류를 찾기 위한 기술로 HDT를 제안했었다. HDT는 알고리즈믹 프로그램 디버깅 기술을 이용하여 실행트리에서 오류를 포함하고 있는 메소드를 찾고, 단계적 프로그램 디버깅 기술을 이용하여 오류를 포함하고 있는 메소드에서 오류가 있는 문장을 찾아낸다. 이 기술은 전통적인 디버깅 기술보다 자바 프로그램에서 프로그래머가 디버깅하는 횟수를 줄였다. 그러나 최근에는 프로그램 크기가 증가하고 메소드의 수가 증가하고 있기 때문에 아직까지 HDT는 디버깅하는 횟수가 많다. 이 논문은 HDT에 프로그램 분할 기술을 적용하는 HDTS를 제안한다. 이 방법은 자바 프로그램을 디버깅할 때, HDT보다 프로그래머가 디버깅하는 횟수를 줄여 줄 수 있다. 특히, HDTS는 메소드와 문장의 수가 증가할수록 효율성이 증가한다.

• 혜화의학회지
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• 제9권1호
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• pp.143-153
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• 2000

To evaluate the antitumor activity and antimetastatic effects of Hongsam -daibotang(HDT-C), studies were done experimentally. The results were obtained as follows: 1. In cytotoxicity against A549, SK-OV-3 and B16-BL6 concentration inhibi ting cell growth up to below 30% of control was recognized at $10^{-3}g/ml$ of HDT-C. 2. The T/C% was 145.4% in HDT-C treated group in S-180 bearing ICR mice. 3. In Inhibitory effect on activity of DNA topoisomerase I, the $IC_{50}$ was shown $100-200{\mu}g/ml$ of HDT-C. 4. The expressing $TNF-{\alpha}$ was increased in HDT-C treated group as compared with control. 5. The expressing MMP-9 was decreased in HDT-C treated group as compared with control. 6. HDT-C extracts exhibited efficient adhesive effect of A549, B16-BL6 cell to complex extracellular matrix. 7. In CAM assays, angiogenesis was significantly inhibited in HDT-C treated group than control group. 8. In pumonary colonization assay, a number of colonies in the lungs were decreased significantly in HDT-C treated group as compared with control group. 9. In hematological changes in B16-BL6 injected C57BL/6, numbers of WBC and were decreased insignificantly and also those of platelet were increased insignificantly in HDT-C treated group as compared with control. 10. In the histological changes of lung in B16-BL6 injected mice, infiltration of cancer cells were inhibited effectively in HDT-C treated groups whereas many cancer cells were infiltrated into erivascular and peribronchiol of control group. These results suggested that HDT-C extracts might be usefully applied for prevention and treatment of cancer.

• 동의생리병리학회지
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• 제22권2호
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• pp.307-314
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• 2008

Handayeolso-Tang(HDT) has been used as traditional medicine for the treatment of Taeumin TaeYang-Hanguel. The present study was conducted to investigate the anti-allergic activity of Handayeolso-Tang(HDT). We investigated the anti-allergic effects of HDT in RBL-2H3 basophilic leukemia cells by compound48/80, a mast cell degranulator and compound 48/80 induced anaphylactic shock in mice. HDT significantly inhibited ${\beta}-hexosaminidase$ and histamine release from compound 48/80 stimulated RBL-2H3 cells. In addition, HDT effectively inhibited anaphylactic shock in mice by 45% at a dose 120 mg/mouse versus PBS treated control after the I.p injection(8 mg/kg) of compound 48/80. The in vitro anti-inflammatory activities of HDT in LPS-stimulated RAW 264.7 cells were investigated. HDT inhibited NO production in LPS-stimulated RAW 264.7 cells and effectively dowregulated the expression of iNOS mRNA and iNOS protein expression in LPS -stimulated RAW 264.7 cells. These result provide evidences that HDT may be beneficial in the treatment of allergic inflammtory disease.

• 대한한방소아과학회지
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• 제27권1호
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• pp.59-68
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• 2013

Objectives The aim of this study is to investigate whether hwang-ryun-haedok-tang (HDT) affect proliferations of androgen-dependent LNCaP prostate cancer cells, androgen-independent PC-3, DU-145 prostate cancer cells, MCF-7 human breast cancer cells, A549, NCI-H292 human pulmonary cancer cells and K-562 human chronic myelogenous leukemia cells. Materials and Methods Effects of HDT on proliferations of each cancer cell line were investigated. 20,000 cells/well were plated in each well of 96-well culture plate. After 24 hrs, 0.01-10% of HDT in culture medium was added to cancer cells. The number of cells was counted by using SRB assay or direct cell counting method after 72 hours from drug treatment. Effect of baicalein or berebrine on proliferation was assessed according to the same method. Results (1) HDT inhibited proliferations of LNCaP, PC-3 and DU-145 prostate cancer cells. (2) HDT inhibited proliferation of MCF-7 breast cancer cells. (3) HDT also inhibited proliferations of A549, NCI-H292 pulmonary cancer cells and K-562 chronic myelogenous leukemia cells. (4) Baicalein and berberine also showed inhibitory effects on proliferations of prostate and breast cancer cells. Conclusion : HDT inhibited proliferations of human prostate, breast, pulmonary and blood cancer cells. These results suggest us the potential use of HDT as a chemopreventive or chemotherapeutic agent. Effect of HDT on human cancer should be further investigated using in vivo experimental models that can reflect pathophysiology of human cancer through another studies.

• Molecules and Cells
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• 제41권7호
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• pp.665-675
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• 2018

Rice is a facultative short-day (SD) plant in which flowering is induced under SD conditions or by other environmental factors and internal genetic programs. Overexpression of Histone Deacetylase 701 (HDT701) accelerates flowering in hybrid rice. In this study, mutants defective in HDT701 flowered late under both SD and long-day conditions. Expression levels of florigens Heading date 3a (Hd3a) and Rice Flowering Locus T1 (RFT1), and their immediate upstream floral activator Early heading date 1 (Ehd1), were significantly decreased in the hdt701 mutants, indicating that HDT701 functions upstream of Ehd1 in controlling flowering time. Transcript levels of OsINDETERMINATE SPIKELET 1 (OsIDS1), an upstream repressor of Ehd1, were significantly increased in the mutants while those of OsGI and Hd1 were reduced. Chromatin-immunoprecipitation assays revealed that HDT701 directly binds to the promoter region of OsIDS1. These results suggest that HDT701 induces flowering by suppressing OsIDS1.

• 항공우주기술
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• 제8권1호
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• pp.207-214
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• 2009

본 연구는 미세중력 모델인 머리하향기울기(Head Down Tilt; HDT) 자세에서 운동 중저산소호흡이 심혈관계 반응에 미치는 영향을 알아보는데 있었다. 8명의 건강한 남성($23{\pm}2$ 세, 신장 $176{\pm}4$ cm, 체중 $75{\pm}8$ kg)은 4가지 조건(앉은 자세에서 정상공기 호흡: SN, 앉은 자세에서 13% 산소호흡; SH, HDT 자세에서 정상공기 호흡; SH, HDT 자세에서 13% 산소호흡; HH)에서 최대산소섭취량의 약 40% 운동강도로 15분간 싸이클링을 실시하였다. 심박수는 SH그룹이 SN그룹보다 높았고(p<0.05), HH그룹이 SH그룹보다 높게 나타났다(p<0.05). 혈중산소포화도는 SH그룹이 SN그룹보다 유의한 감소를 나타내었다(p<0.05). 이완기혈압(p<0.05) 및 평균동맥압(p<0.05)은 안정시 앉은 자세에서보다 HDT 자세에서 유의하게 낮아졌다. 체액변인인 Hb, Hct과 전해질 변인인 나트륨, 칼륨, 염소는 모든 그룹에서 차이가 나타나지 않았다(p>0.05). 대사적 변인 중 Lactate는 SH그룹이 SN그룹보다 유의한 증가를 나타내었다(p<0.05). 결론적으로, 저산소호흡과 자세의 이중자극은 심혈관계반응에 영향을 주지 않았다.

• 한국위성정보통신학회논문지
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• 제9권2호
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• pp.23-27
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• 2014

본 논문에서는 DVB-S3 시스템에 정의되어 있는 64-APSK 변조 방식에 대한 연판정 비트 검출 기법을 제안한다. 본 논문에서 제안한 방식은 심볼을 구성하고 있는 각 비트에 대하여 경판정 경계(hard decision threshold; HDT) 선을 이용한 방법으로써, 수신단에서 검출된 심볼과 HDT 선과의 거리를 연판정 값으로 계산하는 것이다. HDT가 간단하게 결정될 경우 복잡도는 기존의 지수적 복잡도를 요구하는 최우(maximum likelihood; ML) 검출 기법에 비하여 매우 급격히 감소될 수 있다. 이러한 점을 고려하여, 본 논문에서는 먼저 64-APSK에 대한 각 구성 비트별 HDT 선을 유도하고, 이를 이용하여 연판정 비트 값을 계산할 수 있는 방법을 제안한다. 연판정 입출력을 필요로 하는 터보부호를 이용하여 ML 기법과 성능을 비교한 결과, 본 논문에서 제시한 방법은 ML 기법보다 적은 복잡도를 가지고 거의 유사한 성능을 도출할 수 있음을 보였다.

• 생명과학회지
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• 제21권7호
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• pp.985-991
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• 2011

본 연구는 고지방식이로 인한 비만으로 불균형된 지질구성과 산화적 손상이 신경세포형성과 초기발현단백질에 미치는 생물학적 영향을 알아보고, 규칙적인 운동의 효과를 알아보기 위하여 실시하였다. 실험동물은 4주령 SD rat 수컷 30마리를 1주간의 적응기간을 둔 뒤, 15주간 고지방식이를 통해 비만으로 유도하였으며, high fat diet sedentary (HDS, n=15)와 high fat diet and training (HDT, n=15)으로 분류하여 연구하였다. 운동강도는 1~4주는 저강도, 5~8주는 중강도로 주5회 실시하였다. 8주 트레이닝 후 혈청지질, 8-OHdG, MDA, neurotrophic factor, 그리고 IEG를 분석하였다. 그 결과 TC와 TG에서 HDS와 HDT 사이 유의한 차이가 나타났다(p<0.05). 8-OHdG에서 HDT는 트레드밀 트레이닝 후에 HDS보다 낮게 나타났다(p<0.05). 해마에서 c-jun, BDNF 그리고 간에서 MDA의 단백질 발현은 HDT가 트레드밀 트레이닝 후 HDS보다 높게 나타났다(p<0.05). 결론적으로 8주간 트레드밀 훈련은 고지방식이 비만 유도 쥐의 혈청지질 성분의 불균형을 개선시키고, 조직과 혈청의 산화적 손상과 DNA 손상을 완화시켜 주어, 비만으로 인한 합병증 예방에 도움을 줄 수 있을 것으로 사료된다. 또한 NT의 발현을 증가시킴으로써 손상된 뇌기능과 신경세포의 생성 기전 활동에 긍정적 영향을 나타냄으로써 공간적 학습기능의 향상을 가져온 것으로 판단된다.

• Fibers and Polymers
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• 제7권4호
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• pp.358-366
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• 2006

Thermotropic liquid crystal polymer (TLCP)-reinforced poly(butylene terephthalate) (PBT) composites were prepared by melt processing. The improvement in the mechanical properties and the processability of the PBT/TLCP composites was attributed to the reinforcing effect by TLCP phase and its well distribution in the PBT matrix. X-ray diffraction results demonstrated that a slow cooling process leads to the thicker lamellar structures and the formation of more regular crystallites in the composites. The incorporation of TLCP improves not only the tensile strength and flexural modulus but also the heat distortion temperature (HDT) of the PBT/TLCP composites. The HDT values of the composites were dependent on TLCP content. The improvement in the HDT values of the PBT/TLCP composites may be explained in terms with the increased flexural modulus, the development of more regular crystalline structures, and the enhancement of the ability of the composites to sustain the storage modulus by TLCP phase. In addition, the simple additivity rule makes it possible to predict the HDT values of the PBT/TLCP composites.

• Elastomers and Composites
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• 제55권1호
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• pp.6-12
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• 2020

Poly(ethylene-co-vinyl acetate) compounds and vulcanizates containing dicumyl peroxide (DCP) (HD) were prepared, and the curing agent and reaction products were analyzed using gas chromatography/mass spectrometry (GC/MS). Samples containing trially cyanurate (TAC) and DCP (HDT) were also prepared and analyzed. Some raw DCP were decomposed in the injector region of GC to produce acetophenone. DCP was detected in the HD compound but was not observed in the HD vulcanizate, and instead acetophenone and 2-phenyl-2-propanol were detected. Both DCP and TAC were observed in the HDT compound but not in the HDT vulcanizate, where acetophenone and 2-phenyl-2-propanol were detected. Thus, some of the DCP decomposed during the compounding process. The formation mechanism for acetophenone and 2-phenyl-2-propanol during the crosslinking reaction was identified, and differences in the crosslinking reactions of HD and HDT compounds were discussed.