• Biomolecules & Therapeutics
• /
• v.22 no.5
• /
• pp.406-413
• /
• 2014

to valproic acid (VPA) during pregnancy produces ASD-like core behavioral phenotypes as well as hyperactivity in offspring both in human and experimental animals, which makes it a plausible model to study ASD-related neurobiological processes. In this study, we examined the effects of two of currently available attention defecit hyperactivity disorder (ADHD) medications, methylphenidate (MPH) and atomoxetine (ATX) targeting dopamine and norepinephrine transporters (DAT and NET), respectively, on hyperactive behavior of prenatally VPA-exposed rat offspring. In the prefrontal cortex of VPA exposed rat offspring, both mRNA and protein expression of DAT was increased as compared with control. VPA function as a histone deacetylase inhibitor (HDACi) and chromatin immunoprecipitation experiments demonstrated that the acetylation of histone bound to DAT gene promoter was increased in VPA-exposed rat offspring suggesting epigenetic mechanism of DAT regulation. Similarly, the expression of NET was increased, possibly via increased histone acetylation in prefrontal cortex of VPA-exposed rat offspring. When we treated the VPA-exposed rat offspring with ATX, a NET selective inhibitor, hyperactivity was reversed to control level. In contrast, MPH that inhibits both DAT and NET, did not produce inhibitory effects against hyperactivity. The results suggest that NET abnormalities may underlie the hyperactive phenotype in VPA animal model of ASD. Profiling the pharmacological responsiveness as well as investigating underlying mechanism in multiple models of ASD and ADHD may provide more insights into the neurobiological correlates regulating the behavioral abnormalities.

• Korean Journal of Clinical Pharmacy
• /
• v.24 no.1
• /
• pp.33-38
• /
• 2014

Background: Diabetes is accompanied by complications. One of the chronic complications, diabetic retinopathy is the most common cause of the loss of eyesight and thus has enormous impacts on the quality of life to the patients. It has been reported that thorough glucose regulation can prevent or postpone the outset of diabetic retinopathy in diabetic patients and that the patients who received anti-diabetic manage & care education would be capable of more thorough glucose-level regulation than those who did not. Method: This study set out to investigate the current state of education on anti-diabetic manage & care in South Korea and connections between anti-diabetic manage & care education and occurrence of diabetic retinopathy in diabetic patients based on the Korea National Health and Nutrition Examination Survey of 2011. Results: Of the 410 diabetes patients, 74 received anti-diabetic manage & care education, which means that only 15% of diabetic patients benefited from the education in the nation. The occurrence rate of diabetic retinopathy was 28% in the education group and 24% in the non-education group with no significant differences between them. The anti-diabetic manage & care education group recorded a higher occurrence rate of diabetic retinopathy, one of the chronic diabetic complications, than the non-education group contrary to the hypothesis. One of the reasons was that the educated group had a significantly longer duration of diabetes and significantly higher HbA1c than the noneducated group, which indicates that anti-diabetic manage & care education is provided to those who have progressed farther along the course of diabetes instead of the early stage and cannot regulate their glucose-level well in the nation. Conclusion: Those findings raise a need for active educational policies in order to provide anti-diabetic manage & care education under the goals of preventing complications through anti-diabetic education for many patients in early stages of diabetes.

• Journal of the korean academy of Pediatric Dentistry
• /
• v.39 no.4
• /
• pp.348-356
• /
• 2012

The treatment pattern of pediatric dentistry has been changing recently, because of so many socioeconomic changes such as decrease of birth rates and prevalence of caries. The purpose of this study is to recognize the changing patterns in pediatric dental treatment and to help predict future direction for pediatric dentistry. Patients distribution and treatment pattern were examined in all new patients of the department of pediatric dentistry, Chosun University Dental Hospital and two pediatric local clinics in Gwang-ju, from 2005 to 2010. The number of new patients in recent 5 years has been increasing. There was a higher ratio of male patients. Age distribution has shown the percentage of 3~4 age group was highest. The hospital visit rate to Chosun University Dental Hospital was high, whereas the visit rate for local clinics was low. Dental caries showed the highest percentage in chief complaints, oral examinations have increased. The percentage of restoration treatment was highest, fluoride treatment had increased. In restorative treatment, the percentage of resin and GIC restoration was highest and amalgam restoration has decreased. The percentage of sedation treatment was decreased a little, Chosun University Dental Hospital showed a higher rate than local clinics.

• Journal of Radiation Protection and Research
• /
• v.43 no.3
• /
• pp.120-123
• /
• 2018

Background: Analysis of enrichment of $UO_2$ is important to verify the information declared by the license-holders. The redundancy methods are required to guarantee the analysis result. Korea Institute of Nuclear Nonproliferation and Control (KINAC) used to analyze it with alpha spectrometry and consign to Korea Basic Science Institute (KBSI) Thermal Ionization Mass Spectrometry (TIMS). This article evaluated the similarity of the results with two methods and derive correlation equation. It could be compared to the results measured by TIMS running by KBSI. Materials and Methods: There are not many certified materials for the uranium enrichment value. Therefore, 34 uranium pellets, which have the wide range of uranium enrichment from 0.21 to 4.69 wt%, were used for the experiments by the alpha spectrometry and the TIMS. Results and Discussion: The study shows there are the tendency of analyzed enrichment by each equipment. It shows uranium enrichment with alpha spectrometry evaluated 17% higher than that with TIMS on average. The regression equations were also derived in case the similarity between the two results with two methods is lower than predicted. Two experiments were designed to compare the effect of number of samples. The $R^2$ was 0.9977 with 34 pellets. It shows the equation is appropriate to predict the enrichment values by TIMS with that of alpha spectrometry. The $R^2$ was 0.9858 with four pellets for ten times. The $R^2$ decreased while the number of samples increased. The discrepancy between the lowest and highest enrichment seems to be one of the reason for it. Conclusion: KINAC expects the first equation with 34 samples is useful to predict the result with TIMS, the redundancy method, based on the alpha spectrometry. The extra samples are necessary to collect if the enrichment value analyzed by TIMS is lower than the value predicted with the equation. Further study would be followed related to the impact of the peak counts for each uranium isotopes, sample amount and number of experiments when TIMS established in KINAC by the end of 2018.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.46 no.9
• /
• pp.1143-1150
• /
• 2017

The aim of this study was to determine the chemical and intracellular antioxidant activities of ${\beta}$-carotene and lycopene and to compare their quantitative structure-activity relationship (QSAR). In our previous study, the second ionization energy of lycopene was higher than that of ${\beta}$-carotene, as calculated by QSAR. Chemical antioxidant activities of ${\beta}$-carotene, lycopene, and Trolox were examined by measuring ferric reducing antioxidant power (FRAP) and 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity. Intracellular antioxidant activities were evaluated by intracellular reactive oxygen species (ROS) and DNA fragmentation. The FRAP of lycopene was higher than that of ${\beta}$-carotene (P<0.05), and the two carotenoids had similar antioxidant activities in DPPH radical scavenging activity assay. Trolox had the greatest chemical antioxidant activities (P<0.05). When RAW264.7 cells were treated with lipopolysaccharide (LPS) (100 ng/mL) for 20 h, intracellular ROS and DNA fragmentation significantly increased (P<0.05). RAW 264.7 cells pretreated with ${\beta}$-carotene ($4{\mu}M$) and lycopene ($0.4{\sim}2{\mu}M$) for 4 h formed significantly less intracellular ROS than LPS-treated control cells (P<0.05), whereas cells with Trolox did not reduce production of intracellular ROS. In addition, cells pretreated with $2{\mu}M$ lycopene produced less intracellular ROS than those treated with ${\beta}$-carotene (P<0.05). DNA fragmentation of cells with ${\beta}$-carotene and lycopene was similar to that of LPS-treated control cells as measured by Hoechst staining. The antioxidant ability of lycopene was greater than that of ${\beta}$-carotene in the QSAR, FRAP, and intracellular ROS assays (P<0.05). ${\beta}$-Carotene and lycopene had lower antioxidant activities as measured by FRAP (P<0.05) but higher intracellular protective effects against LPS-induced oxidative stress in comparison with Trolox.

• The Journal of the Korea Contents Association
• /
• v.16 no.1
• /
• pp.708-719
• /
• 2016

This research is conducted to grasp emotional labor, job satisfaction, and related turnover intention of nurses at a regional general hospital; to lower level of emotional labor; to raise job satisfaction; to reduce turnover intention; to perform efficient personnel management; and then, to provide qualitative nursing care. Convenient sampling of 100 nurses at a general hospital in D city, who agreed to participation in the test, was made and an analysis method of t-test, ANOVA, Pearson's correlation was used from April 6 to April 12, 2015 by using questionnaires. According to the research, average score of emotional labor was $3.37{\pm}.85$; average score of job satisfaction was $2.86{\pm}.66$; and, average score of turnover intention $3.47{\pm}.87$. Emotional labor had negative correlation with job satisfaction (r=-.56, p<.001) but it showed positive correlation with turnover intention (r=.67, p<.001) while job satisfaction revealed negative correlation with turnover intention (r=-.64, p<.001). According to result of the research, it is required to prepare systematic measures in order to lower level of emotional labor of nurses who play important role of the hospital and to raise job satisfaction, and it is also required to make positive efforts to solve fundamental problems to provide high quality caring service through satisfying nurses' morale.

• Journal of Practical Engineering Education
• /
• v.12 no.1
• /
• pp.109-116
• /
• 2020

The effects of mentoring education bring positive effects such as mentees' capacity building, knowledge improvement and positive attitude. The major difficulties that nursing college students experience in clinical practice are low adaptability, lack of confidence, etc. Therefore, this study developed mentoring education program to improve the problem-solving ability, learning attitude, and confidence in nursing skill before clinical practice for nursing college students and evaluated their effectiveness. In order to develop the program, a group of experts consisting of professors and clinical nurses selected 11 topics after discussing nursing skills and knowledge, which were most required in clinical practice. The program involved 14 mentors who operated practice, counseling, video clips, and contextual discussions for two days to a group of 9 to 10 people. Nursing college students who received the mentoring education program showed a significant increase in learning attitude and confidence in performance of nursing skills, but there was no statistically significant difference in problem-solving ability. This study is meaningful in that it has improved the educational effect by using mentoring methods, away from formal in-school practice education. In the future, it will be necessary to evaluate whether the mentoring education program affect the problem-solving ability of nursing students by applying it before, during, and after clinical practice rather than in a short period.

• KIPS Transactions on Computer and Communication Systems
• /
• v.2 no.1
• /
• pp.15-26
• /
• 2013

IP-based Wireless Sensor Networks (IP-WSNs) are gaining importance for their broad range of applications in health-care, home automation, environmental monitoring, industrial control, vehicle telematics and agricultural monitoring. In all these applications, mobility in the sensor network with special attention to energy efficiency is a major issue to be addressed. Because of the energy inefficiency of networks-based mobility management protocols can be supported in IP-WSN. In this paper we propose a network based mobility supported IP-WSN protocol called Multicasting-based inter-Domain Mobility Management Scheme in Sensor-based Fast Proxy Mobile IPv6 Networks (mSFP). Based on [8,20], We present its network architecture and evaluate its performance by considering the signaling and mobility cost. Our analysis shows that the proposed scheme reduces the signaling cost, total cost, and mobility cost. With respect to the number of IP-WSN nodes, the proposed scheme reduces the signaling cost by 7% and the total cost by 3%. With respect to the number of hops, the proposed scheme reduces the signaling cost by 6.9%, the total cost by 2.5%, and the mobility cost by 1.5%. With respect to the number of IP-WSN nodes, the proposed scheme reduces the mobility cost by 1.6%.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.21 no.3
• /
• pp.230-236
• /
• 2020

A trash screen is installed in front of the inflow channel of a drainage pumping station, sewage treatment plant, and a power plant to block floating contaminants. The bottleneck phenomenon, which decreases the water inflow, causes damage to the damper as a result of clogging in between the screen if string type obstacles are not removed. In this paper, the apron was removed, and the screen was expanded, to prevent breakage of the bottleneck phenomenon and string type obstacles. This was designed using an extended rake by adding an inner rake in between the screen interspace to remove the bottleneck phenomenon and string type obstacles. To design the inner rake that satisfies the allowable stresses of the existing damper rake, the experiment points were determined according to the experimental design method using the inner rake vertical length and the thickness of the reinforced section as parameters. The use of the ANSYS static structural module and statistical analysis tool R software gives the optimized shape according to the response surface method. The relative error between the response surface analysis results and the simulation results was 1.63% of the determined optimal design-point rake length of 210.2 mm and the reinforcement section thickness of 2 mm. Through empirical experiments, a test rake was constructed to the actual size, and approximately 97% of the bottleneck phenomenon and string type obstacles could be removed.

• Korean Journal of Remote Sensing
• /
• v.33 no.5_3
• /
• pp.773-786
• /
• 2017

This study was to analyze data of climate change impacts on social infrastructure using text-mining methodology, and to visualize the spatial information by integrating those with regional data layers. First of all, the study identified that the following social infrastructure; power, oil and resource management, transport and urban, environment, and water supply infrastructures, were affected by five kinds of climate factors (heat wave, cold wave, heavy rain, heavy snow, strong wind). Climate change impacts on social infrastructure were then analyzed and visualized by regions. The analysis resulted that transport and urban infrastructures among all kinds of infrastructure were highly impacted by climate change, and the most severe factors of the climate impacts on social infrastructure were heavy rain and heavy snow. In addition, it found out that social infrastructure located in Seoul and Gangwon-do region were relatively largely affected by climate change. This study has significance that atypical data in media was used to analyze climate change impacts on social infrastructure and the results were translated into spatial information data to analyze and visualize the climate change impacts by regions.