• Proceedings of the KIEE Conference
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• 1997.07e
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• pp.1779-1781
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• 1997

The 2.0 GeV Pohang Light Source (PLS) is consisted of a full energy Linac and a storage ring. Four kicker magnets are installed in the storage ring tunnel to move the stored beam orbit in the storage ring closer to the injected beam from the beam transfer line. The injected beam then falls into the storage ring beam dynamic aperture. A kicker magnet modulator drives all four kicker magnets to maintain field balance and also synchronized kick of the beam. The kicker modulator can handle 2 GeV full energy beam. The kicker magnet modulator is installed in the storage ring tunnel and under stable operation. Specification of the kicker magnet modulator is ${\sim}6.0{\mu}s$ pulse-width, 200 ns flat-top width with ${\pm}0.2%$ regulation, ${\sim}24\;kA$ peak current, and 10 Hz repetition rate. Two thyratron switches (EEV CX-1536AX) are used in the system. In this article, design, and experimental results of the kicker magnet modulator are discussed.

• Korean Journal of Food Science and Technology
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• v.5 no.4
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• pp.240-248
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• 1973

Reduction of penta-O-acetyl-myo-inosose-2 by catalytic hydrogenation and with sodium-amalgam was carried out in alcohol solution of pH $3{\sim}4$. The former reduction product was axial-alcohol, and the latter equatorial-alcohol. On reduction of penta-O-acetyl-DL-epi-inosose-2 with sodium borohydride and sodium-amalgam in the previous condition, ax.-alcohol and eq.-alcrhol have been obtained. The synthesis of various inositol-p-hydroxybezoate are described. The esters have been characterized by paper chromatography and saponification, and their antimicrobial activities on some microbes were tested for the application of food industry. As the result, it was found that the antimicrobiol activity of epi-inositol ester was superior to its analogues.

• Genomics & Informatics
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• v.11 no.4
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• pp.245-253
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• 2013

A radioresistant cell line was established by fractionated ionizing radiation (IR) and assessed by a clonogenic assay, flow cytometry, and Western blot analysis, as well as zymography and a wound healing assay. Microarray was performed to profile global expression and to search for differentially expressed genes (DEGs) in response to IR. H460R cells demonstrated increased cell scattering and acidic vesicular organelles compared with parental cells. Concomitantly, H460R cells showed characteristics of increased migration and matrix metalloproteinase activity. In addition, H460R cells were resistant to IR, exhibiting reduced expression levels of ionizing responsive proteins (p-p53 and ${\gamma}$-H2AX); apoptosis-related molecules, such as cleaved poly(ADP ribose) polymerase; and endoplasmic reticulum stress-related molecules, such as glucose-regulated protein (GRP78) and C/EBP-homologous protein compared with parental cells, whereas the expression of anti-apoptotic X-linked inhibitor of apoptosis protein was increased. Among DEGs, syntrophin beta 2 (SNTB2) significantly increased in H460R cells in response to IR. Knockdown of SNTB2 by siRNA was more sensitive than the control after IR exposure in H460, H460R, and H1299 cells. Our study suggests that H460R cells have differential properties, including cell morphology, potential for metastasis, and resistance to IR, compared with parental cells. In addition, SNTB2 may play an important role in radioresistance. H460R cells could be helpful in in vitro systems for elucidating the molecular mechanisms of and discovering drugs to overcome radioresistance in lung cancer therapy.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2018.04a
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• pp.68-68
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• 2018

In this study, we investigated whether S. baicalensis rhizome ethanol extract (SBRE) has antioxidant capacities against oxidative stress induced cellular damage in the HaCaT keratinocytes. Our results revealed that treatment with SBRE prior to hydrogen peroxide ($H_2O_2$) exposure significantly increased the HaCaT cell viability. SBRE also effectively attenuated $H_2O_2$ induced comet tail formation, and inhibited the $H_2O_2$ induced phosphorylation levels of the histone ${\gamma}H2AX$, as well as the number of apoptotic bodies and Annexin V positive cells. In addition, SBRE exhibited scavenging activity against intracellular ROS generation and restored the mitochondria membrane potential loss induced by $H_2O_2$. Moreover, $H_2O_2$ enhanced the cleavage of caspase-3 and degradation of poly (ADP-ribose)-polymerase as well as DNA fragmentation; however, these events were almost totally reversed by pretreatment with SBRE. Furthermore, SBRE increased the levels of HO-1 associated with the induction of Nrf2. Therefore, we believed that SBRE may potentially serve as an agent for the treatment and prevention of neurodegenerative diseases caused by oxidative stress.

• The Journal of Internal Korean Medicine
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• v.42 no.6
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• pp.1269-1284
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• 2021

Objectives: Phragmitis Rhizoma is the fresh or dried rhizome of Phragmites communis Trin., which has been prescribed in traditional Korean medicine to relieve fever and vomiting and to nourish the body fluids. Recently, the protective effect of Phragmitis Rhizoma extract or its components on myelotoxicity and inflammatory responses have been reported, but no study has yet been conducted on oxidative stress. Methods: The present study investigated whether an ethanol extract of Phragmitis Rhizoma (PR) could protect against cellular damage induced by oxidative stress in Chang liver cells. Results: Pretreatment with PR significantly suppressed the hydrogen peroxide (H₂O₂)-induced reduction of Chang cell viability and generation of reactive oxygen species (ROS), thereby deferring apoptosis. PR also markedly inhibited H₂O₂-induced comet tail formation and phospho-γH2AX expression, suggesting that PR protected against oxidative stress-mediated DNA damage. PR also effectively prevented the inhibition of ATP synthesis in H₂O₂-treated Chang cells by inhibiting the loss of mitochondrial membrane potential, indicating that PR maintains energy metabolism through preservation of mitochondrial function while eliminating ROS generated by H₂O₂. Immunoblotting results indicated that PR attenuated the H₂O₂-induced downregulation of Bcl-2 and upregulation of Bax expression. Conclusions: PR protects against oxidative injury in Chang liver cells by regulating energy homeostasis via ROS generation blockade, which is at least partly mediated through inactivation of the mitochondria-mediated apoptosis pathway.

• Bulletin of the Korean Mathematical Society
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• v.39 no.1
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• pp.63-69
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• 2002

Given vectors x and y in a Hilbert space, an intepolating operator is a bounded operator T such that Tx=y. an interpolating operator for n vectors satisfies the equation Tx$_{i}$=y, for i=1, 2,…, n. In this article, we obtained the fellowing : Let x = (x$_{i}$) and y = (y$_{i}$) be two vectors in H such that x$_{i}$$\neq$0 for all i = 1, 2,…. Then the following statements are equivalent. (1) There exists an operator A in AlgＬ such that Ax = y, A is a trace-class operator and every E in Ｌ reduces A. (2) (equation omitted).mitted).

• Journal of Web Engineering
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• v.14 no.15
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• pp.3206-3218
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• 2022

Helicobacter pylori (H. pylori) is a Gram-negative bacterium that colonizes the gastric mucosa and triggers various stomach diseases. H. pylori induces reactive oxygen species (ROS) production and DNA damage. The heterodimeric Ku70/Ku80 protein plays an essential role in the repair of DNA double-strand breaks (DSB). Oxidative stress stimulate apoptosis and DNA damage that can be repaired by Ku70/80. However, excessive reactive oxygen species (ROS) can cause Ku protein degradation, resulting in DNA fragmentation and apoptosis. α-lipoic acid (α-LA), which is found in organ meats such as liver and heart, spinach, broccoli, and potatoes, quenches free radicals, chelates metal ions, and reduces intracellular DNA damage induced by oxidative stress. Here, we investigated whether H. pylori decreases Ku70/80 and induces apoptosis, and whether α-LA inhibits changes induced by H. pylori. We analyzed ROS, DNA damage markers (γ-H2AX, DNA fragmentation), levels of Ku70/80, Ku-DNA binding activity, Ku80 ubiquitination, apoptosis indices (Bcl-2, Bax, apoptosis-inducing factor (AIF), and caspase-3), and viability in a human gastric epithelial adenocarcinoma cell line (AGS). H. pylori increased ROS, DNA damage markers, Ku80 ubiquitination, and consequently induced apoptosis. It also decreased nuclear Ku70/80 levels and Ku-DNA-binding activity; increased Bax expression, caspase-3 cleavage, and truncated AIF; but decreased Bcl-2 expression. These H. pylori-induced alterations were inhibited by α-LA. The antioxidant N-acetylcysteine and proteasome inhibitor MG-132 suppressed H. pylori-induced cell death and decreased nuclear Ku70/80 levels. The results show that oxidative stress induced Ku70/80 degradation via the ubiquitin-proteasome system, leading to its nuclear loss and apoptosis in H. pylori-infected cells. In conclusion, α-LA inhibited apoptosis induced by H. pylori by reducing ROS levels and suppressing the loss of Ku70/80 proteins in AGS cells.

• Journal of applied mathematics & informatics
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• v.11 no.1_2
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• pp.431-436
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• 2003

Given vectors x and y in a Hilbert space, an interpolating operator is a bounded operator T such that Tx = y. An interpolating operator for n vectors satisfies the equation $Tx_i\;:\;y_i,\;for\;i\;=\;1,\;2,\;{\cdots},\;n$. In this article, we obtained the following : $Let\;x\;=\;\{x_i\}\;and\;y=\{y_\}$ be two vectors in a separable complex Hilbert space H such that $x_i\;\neq\;0$ for all $i\;=\;1,\;2;\cdots$. Let L be a commutative subspace lattice on H. Then the following statements are equivalent. (1) $sup\;\{\frac{\$\mid${\sum_{k=1}}^l\;\alpha_{\kappa}E_{\kappa}y\$\mid$}{\$\mid${\sum_{k=1}}^l\;\alpha_{\kappa}E_{\kappa}x\$\mid$}\;:\;l\;\in\;\mathbb{N},\;\alpha_{\kappa}\;\in\;\mathbb{C}\;and\;E_{\kappa}\;\in\;L\}\;<\;\infty\;and\;$\mid$y_n\$\mid$x_n$\mid$^{-1}\;=\;1\;for\;all\;n\;=\;1,\;2,\;\cdots$. (2) There exists an operator A in AlgL such that Ax = y, A is a unitary operator and every E in L reduces, A, where AlgL is a tridiagonal algebra.

• Honam Mathematical Journal
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• v.41 no.4
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• pp.683-695
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• 2019

In the present paper, we study curves in 𝔼³ with density $e^{ax^2+by^2}$, where a, b ∈ ℝ not all zero constants and give the parametric expressions of the curves with vanishing weighted curvature. Also, we create ruled surfaces whose base curves are the curve with vanishing weighted curvature and the ruling curves are Smarandache curves of this curve. Then, we give some characterizations about these ruled surfaces by obtaining the mean curvatures, Gaussian curvatures, distribution parameters and striction curves of them.

• Molecules and Cells
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• v.42 no.11
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• pp.794-803
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• 2019

Ultraviolet light (UV)-induced cellular response has been studied by numerous investigators for many years. Long noncoding RNAs (lncRNAs) are emerging as new regulators of diverse cellular process; however, little is known about the role of lncRNAs in the cellular response to UV treatment. Here, we demonstrate that levels of lncRNA-HOTTIP significantly increases after UV stimulation and regulates the UV-mediated cellular response to UV through the coordinate activation of its neighboring gene Hoxa13 in GC-1 cells (spermatogonia germ cell line). UV-induced, G2/M-phase arrest and early apoptosis can be regulated by lncRNA-HOTTIP and Hoxa13. Furthermore, lncRNA-HOTTIP can up-regulate ${\gamma}-H_2AX$ and p53 expression via Hoxa13 in UV-irradiated GC-1 cells. In addition, p53 has the ability to regulate the expression of both lncRNA-HOTTIP and Hoxa13 in vitro and in vivo. Our results provide new data regarding the role lncRNAs play in the UV response in spermatogenic cells.