• Korean Circulation Journal
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• v.54 no.5
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• pp.233-252
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• 2024

Background and Objectives: Myocardial ischemia-reperfusion injury (MIRI) refers to the damage of cardiac function caused by restoration of blood flow perfusion in ischemic myocardium. However, long non-coding RNA prostate androgen regulated transcript 1 (PART1)'s role in MIRI remain unclear. Methods: Immunofluorescence detected LC3 expression. Intermolecular relationships were verified by dual luciferase reporter assay. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, flow cytometry and transferase-mediated dUTP nick-end labeling (TUNEL) assays analyzed cell viability and apoptosis. The release of lactate dehydrogenase was tested via enzyme-linked immunosorbent assay (ELISA). Left anterior descending coronary artery surgery induced a MIRI mouse model. Infarct area was detected by 2,3,5-triphenyltetrazolium chloride staining. Hematoxylin and eosin staining examined myocardial injury. ELISA evaluated myocardial marker (creatine kinase MB) level. Results: PART1 was decreased in hypoxia/reoxygenation (H/R) induced AC16 cells and MIRI mice. PART1 upregulation attenuated the increased levels of Bax, beclin-1 and the ratio of LC3II/I, and enhanced the decrease of Bcl-2 and p62 expression in H/R-treated cells. PART1 upregulation alleviated H/R-triggered autophagy and apoptosis via miR-302a-3p. Mechanically, PART1 targeted miR-302a-3p to upregulate transcription factor activating enhancer-binding protein 2C (TFAP2C). TFAP2C silencing reversed the protected effects of miR-302a-3p inhibitor on H/R treated AC16 cells. We further established TFAP2C combined to dual-specificity phosphatase 5 (DUSP5) promoter and activated DUSP5. TFAP2C upregulation suppressed H/R-stimulated autophagy and apoptosis through upregulating DUSP5. Overexpressed PART1 reduced myocardial infarction area and attenuated MIRI in mice. Conclusion: PART1 improved the autophagy and apoptosis in H/R-exposed AC16 cells through miR-302a-3p/TFAP2C/DUSP5 axis, which might provide novel targets for MIRI treatment.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.160.2-160.2
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• 2003

When ginsenoside $R_{b1}$ and $R_{b2}$ were anaerobically incubated with human fecal microflora, these ginsenosides were metabolized to compound K. When ginsenoside $R_{g3}$ was anaerobically incubated with human fecal microflora, the ginsenoside $R_{g3}$ was metabolized it to ginsenoside $R_{h2}$. Among ginsenosides, compound K and 20(S)-ginsenoside $R_h2$ exhibited the most potent cyotoxicity against tumor cells: 50% cytotoxic concentrations of compound K in the media with and without fetal bovine serum (FBS) were 27.1 - 31.6 mM and0.1 - 0.6 mM, and those of 20(S)-ginsenoside $R_h2$ were 37.5 $\rightarrow$ 50 and 0.7 - 7.1 mM mM, respectively. (omitted)

• Korean Journal of Fisheries and Aquatic Sciences
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• v.33 no.6
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• pp.559-564
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• 2000

We studied to find out the effect of water temperature on the egg development of pearl oyster, Pincata fucata martensii and Pacific oyster, Crassostrea gigas. The optimum water temperatures for egg development were $20{\~}25^{\circ}C$ in P. fucata martensii and $15{\~}25^{\circ}C$ in C. gigas. The required time from fertilization to D-shaped lana was $41.7\;hours\;at\;20^{\circ}C$ and 27.5 hours at $25^{\circ}C$ in P. fucata martensii, and 35.3 hours at $15^{\circ}C$, 26.3 hours at $20^{\circ}C$ and 17.6 hours at$ 25^{\circ}C$ in C. gigas, respectively. The relationships between the water temperature ($WT:^{\circ}C$) and the required time (h: hour) from fertilization to each developmental stage were given as follows; P. fucata martensii Up to 8-cell $$1/h=0.0463WT-0.6945 (r^2=0.9702)$$ Up to morula $$1/h=0.0196WT-0.2184 (r^2=0.8118)$$ Up to trochophore $$1/h=0.0076WT-0.0802 (r^2=0.8756)$$ Up to D-shaped larva $$1/h=0.0031WT-0.0380 (r^2=0.9075)$$ C. gigas Up to 8-cell $$1/h=0.0210WT-0.1123 (r^2=0.9862)$$ Up to morula $$1/h=0.0143WT-0.1077 (r^2=0.9833)$$ Up to trochophore $$1/h=0.0052WT-0.0218 (r^2=0.9857)$$ Up to D-shaped lawn $$1/h=0.0029WT-0.0170 (r^2=0.9689)$$ Biological minimum temperature for egg development of P. fucata martensii and C. gigas was calculated as $$12.3^{\circ}C and 5.7{\circ}C$$, respectively.

• Kyungpook Mathematical Journal
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• v.53 no.3
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• pp.435-457
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• 2013

Using the Lukasiewicz 3-valued implication operator, the notion of an (${\alpha},{\beta}$)-intuitionistic fuzzy left (right) $h$-ideal of a hemiring is introduced, where ${\alpha},{\beta}{\in}\{{\in},q,{\in}{\wedge}q,{\in}{\vee}q\}$. We define intuitionistic fuzzy left (right) $h$-ideal with thresholds ($s,t$) of a hemiring R and investigate their various properties. We characterize intuitionistic fuzzy left (right) $h$-ideal with thresholds ($s,t$) and (${\alpha},{\beta}$)-intuitionistic fuzzy left (right) $h$-ideal of a hemiring R by its level sets. We establish that an intuitionistic fuzzy set A of a hemiring R is a (${\in},{\in}$) (or (${\in},{\in}{\vee}q$) or (${\in}{\wedge}q,{\in}$)-intuitionistic fuzzy left (right) $h$-ideal of R if and only if A is an intuitionistic fuzzy left (right) $h$-ideal with thresholds (0, 1) (or (0, 0.5) or (0.5, 1)) of R respectively. It is also shown that A is a (${\in},{\in}$) (or (${\in},{\in}{\vee}q$) or (${\in}{\wedge}q,{\in}$))-intuitionistic fuzzy left (right) $h$-ideal if and only if for any $p{\in}$ (0, 1] (or $p{\in}$ (0, 0.5] or $p{\in}$ (0.5, 1] ), $A_p$ is a fuzzy left (right) $h$-ideal. Finally, we prove that an intuitionistic fuzzy set A of a hemiring R is an intuitionistic fuzzy left (right) $h$-ideal with thresholds ($s,t$) of R if and only if for any $p{\in}(s,t]$, the cut set $A_p$ is a fuzzy left (right) $h$-ideal of R.

• Bulletin of the Korean Mathematical Society
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• v.47 no.5
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• pp.1067-1076
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• 2010

In this paper we investigate complete spacelike (r - 1)-maximal (i.e., $H_r\;{\equiv}\;0$) hypersurfaces with two distinct principal curvatures in the anti-de Sitter space $\mathbb{H}_1^{n+1}$(-1). We give a characterization of the hyperbolic cylinder.

• Bulletin of the Korean Chemical Society
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• v.18 no.2
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• pp.193-197
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• 1997

Theoretical studies on the base-catalyzed deprotonation of 4-phenacylpyridinium cations, R1-CO-CH2-C5H4N-R2, I (R1=YC6H4 -and R2=CH3), and II (R1=C6H5 and R2=CH2C6H4Y) have been carried out with bases, NH3 and XC6H4NH2 using AM1 MO method. The Brψnsted α values are 0.20 and 0.22 and the βB values are 0.62 and 0.61, respectively for cations I and II. The negative Ⅰ (=α-βB) values obtained are in accord with the experimental results in aqueous solution, although the theoretical gas-phase α values for I are somewhat smaller than the experimental values in water due to neglect of solvation effect. It has been stressed that the Brψnsted α is distorted not only by the lag in the resonance and solvation development in the carbanion, but also by the difference in the distance between the anionic center and substituents in the TS and in the product anion.

• Fashion & Textile Research Journal
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• v.7 no.2
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• pp.247-251
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• 2005

In this the study, the effects of the manufacturing process conditions on the properties Thick and Thin Diameter yarns(TTD yarns) prepared with hot plate device in the draw winder were determined. Physical properties including wet shrinkage, tenacity and elongation of the samples were measured and thick and thin effect was analysed with the evenness tester. The results were as the follows: There was little change the wet shrinkage of the TTD yarns in the range of $70^{\circ}C{\sim}80^{\circ}C$ of $R_1$ temperature(lower hot cylinder) with the same Hot Plate(H/P) temperature, but the wet shrinkage of the TTD yarns decreased 5-10% when $R_1$ temperature was $90^{\circ}C$. The wet shrinkage of the TTD yarns decreased with the H/P temperature at the same temperature of $R_1$. There was little effect of $R_1$ and H/P temperature on the tenacity of TTD yarns. The elongation of TTD yarns increased with $R_1$ temperature at the same H/P temperature. The elongation of TTD yarns increased little bit for the first time and then decreased above that temperature with increasing H/P temperature at the same $R_1$ temperature. The thick and thin effect on the TTD yarns was obvious in $110^{\circ}C$ of H/P temperature regardless of $R_1$ temperature, while there was no thick and thin effect on the TTD yarns in $140^{\circ}C$ of H/P temperature.

• Journal of the Korean Chemical Society
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• v.35 no.5
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• pp.493-499
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• 1991

The circular dichroism (CD) spectrum of trans-[Co(R,R-chxn)$_2Cl_2]^+$ complex with different counter-ions have been measured in several organic solvents, where R,R-chxn is (1R,2R)-1,2-diaminocyclohexane. The observed variations in the CD spectrum of the complex exhibited remarkable solvent dependences. And it has been observed that the degree of the change of CD spectrum in the first absorption band region $(^1A_{2g})$ depends on the donor number (DN) of the solvents. From $^1H$ NMR spectrum, it is interpreted that these variations in the CD spectrum of trans-[Co(R,R-chxn)$_2Cl_2]^+$ complex are due to the favorable interaction between solvent molecules and the equatorial N-H protons of R,R-chxn ligands.

• Bulletin of the Korean Chemical Society
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• v.18 no.3
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• pp.311-316
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• 1997

The synthesis and characterization of the mononuclear group 13 heterocyclic carboxaldehyde methyldithiocarbazate complexes Me2M[NC5H4CRNNC(S)SCH3] (M=Al, R=H(1); M=Ga, R=H(2); M=Al, R=CH3(3); M-Ga, R=CH3(4); M=In, R=CH3(5)) are described. Compounds 1-5 were prepared by the reaction of MMe3 (M=Al, Ga, In) with 2-formy or 2-acetylpyridine-S-methyldithiocarbazate in toluene. These compounds 1-5 have been characterized by microanalysis, NMR (1H, 13C) spectroscopy, mass spectra, and single-crystal X-ray diffraction. X-ray single-crystal diffraction analyses reveal that 4-5 are mononuclear metal compounds with coordination number of 5 and N,N,S coordination mode.

• Journal of the Korean School Mathematics Society
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• v.10 no.4
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• pp.519-533
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• 2007

In this paper we study a equality $\frac{1}{h_a}+\frac{1}{h_b}+\frac{1}{h_c}=\frac{1}{r}$ which contains altitudes and radius of inscribed circle of triangle. We search some paths for proving the equality, and find out 9 proof method of the equality which is related with descriptive geometry, coordinate geometry, and vector geometry.