• 한방재활의학과학회지
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• 제25권3호
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• pp.81-90
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• 2015

Objectives This study was designed to compare the effects Gwibi-tang herbal-medication with Danggwisusan herbal-medication for patients with acute cervical and lumbar sprains due to a traffic accident. Methods This study was carried out on 119 acute cervical & lumbar sprain patients by traffic accident. We divided these patients into 2 groups. Group A was treated with Gwibi-tang and Group B was treated with Danggwisusan three times a day for three days. Each patient was treated with acupuncture, physical therapy and two types of herbal-medication. We measured the numerical rating scale (NRS) at two time points : pre-treatment (Tx). and post-Tx. Results 1. The NRS scores significantly decreased after treatment in all patients. 2. The changed NRS scores of nuchal pain showed a borderline significant difference between Group A and Group B (p=0.067). 3. In sub-group analysis, Gwibi-tang showed a greater effect on NRS scores of lumbago pain in female patients (p=0.068) and patients under 30s (p=0.054) compared to Danggwisusan. Conclusions In this study, both types of herbal-medication; Gwibi-tang and Danggwisusan were highly effective on acute cervical and lumbar sprain patients. Especially Gwibi-tang (Group A) was more effective than Danggwisusan (Group B) in reducing the initial nuchal pain. Also Gwibi-tang was more effective for lumbago pain in female and patients under 30s.

• 대한한방부인과학회지
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• 제23권4호
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• pp.47-56
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• 2010

Purpose: This study was performed to evaluate the single dose oral toxicity of Gwibi-tang extract in ICR mice. Methods: 0(control group), 1250, 2500 and 5000 mg/kg of Gwibi-tang extracts were orally administered to 20 male and 20 female ICR mice. After single oral administration of Gwibi-tang extract to ICR mice, we observed number of the death, clinical signs, changes of body weights for 14 days. After 14 day of Gwibitang extract administration, all mice were sacrificed and major organs were observed. Results: Compared with the control group, we could not find any toxic signs in the mortalities, clinical signs, body weight changes, necropsy findings and hematological values in all treated groups(1250, 2500 and 5000 mg/kg). Conclusions: $LD_{50}$ value of Gwibi-tang extracts may be over 5000 mg/kg and it may have no side toxic effect to ICR mice.

• 대한한방내과학회지
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• 제37권4호
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• pp.678-684
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• 2016

Objectives: This clinical study describes the effect of Korean medicine on a patient with alcohol-related dementia.Methods: A patient with cognitive disorder and memory impairment due to alcohol abuse was treated with the herbal medicine “Gami Gwibi-tang”, acupuncture, and moxibustion, together with basic Western medicine. The patient’s cognitive function was evaluated by the Mini-Mental State Examination-Korean (MMSE-K) and Clinical Dementia Rating (CDR). Brain Magnetic Resonance Imaging (MRI) was used to estimate the severity of structural brain damage.Results: Following treatment with Gami Gwibi-tang, patent’s MMSE-K score and CDR improved.Conclusion: This clinical case study provides evidence of the effect of Korean medicine, including Gwibi-tang-gami, on alcohol-related dementia.

• 대한한의학방제학회지
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• 제24권4호
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• pp.367-376
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• 2016

Objectives : The purpose of this study was to investigate the interpretation of the Gwibi-tang(歸脾湯, GBT) prescription in order to obtain the traditional significance. Methods : We have analyzed the interpretation on the GBT prescription through translations and comparisons based on classic books about the oriental medical prescriptions. Results : 1. The source of GBT in Dongeuibogam(東醫寶鑑) is Guchiryuyo(口齒類要), Jeongcheryuyo(正體類要) and Gyojubuinyangbang(校註婦人良方) etc. 2. Meaning of "GwiBi(歸脾)" in the GBT name is returning to the Bi(脾) which is origin of generating Gi(氣) and Blood(血). 3. GBT is composed of Sagunja-tang(四君子湯), Hwanggi-tang(黃芪湯) and Danggwibohyeol-tang(當歸補血湯) etc. 4. According to wide range of symptom, GBT can be varied by adding or subtracting herbs. Conclusions : In this study, we have demonstrated various methodologies. This paper will be useful to the future researchers and clinicians to conduct a study on herbal medicines such as the GBT.

• 대한한의학회지
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• 제44권3호
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• pp.201-224
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• 2023

Objectives: The purpose of this study was to evaluate the effect of Gwibi-tang (GBT) on renal anemia. Methods: A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to investigate changes in anemia levels before and after oral administration of GBT in patients with renal anemia. Relevant literature published up to May 25, 2023, was searched in 10 academic electronic databases. Results: Data from 489 patients from 7 RCTs were obtained and analyzed. All participants were receiving erythropoietin-stimulating agent treatment, and most of them were under hemodialysis. Additional administration of GBT to the participants significantly increased the hemoglobin concentration (10.55 g/L, 95% CI 6.99 to 14.11) compared to the control group. Hematocrit, red blood cell count, serum ferritin concentration, transferrin saturation, and the total effective rate for anemia was also significantly higher in the GBT-treated group than in the control group. Conclusions: This study suggests that GBT may be considered to be a promising option for the effective management of patients with renal anemia under conventional treatment. However, the limitations of this study, including the quantitative and qualitative weakness of the RCTs, the lack of safety-related evidence, and the absence of long-term follow-up data, should be taken into account when interpreting the results of this study.

• 대한한방부인과학회지
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• 제24권3호
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• pp.222-232
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• 2011

Objectives: The purpose of this study is to report the effect of oriental medicine on 2 patients with secondary amenorrhea. Methods: The patients who had secondary amenorrhea were treated by oriental medical treatments such as herbal medication(Gami-joukyung-tang, Gwibi-tanggagam-bang), acupuncture and moxibustion therapy. Results: After oriental medical treatments, the patients could have their periods again and their menstrual condition was improved. Conclusion: This case report shows that the oriental medical therapy is effective for treating secondary amenorrhea.

• 한방안이비인후피부과학회지
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• 제18권3호
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• pp.127-134
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• 2005

The Henoch-Schnlein Purpura (HSP) is a systemic small vasculitis, characterized by palpable purpura, abdominal pain, hematuria or proteinuria, and arthritis. The etiology is unknown but it is manifested by allergic reaction, so it is called Anaphylactoid Purpura. The prognosis of disease is usually good, but about 50% of patients have experienced recurrences. Oral corticosteroid is treatment of choice, but it cannot prevent recurrence of Disease. We experienced two case of young patients who suffered from the Henoch-Schnlein purpura. We prescripted Mokyangbinrang-hwan, Insamyang-witang, Gwibi-tang. For both two patient, symptoms were much relieved.

• 대한한방부인과학회지
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• 제21권3호
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• pp.60-74
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• 2008

Purpose: This study was designed to investigate the effects of Gwibi-Tang(GBT) on the polycystic ovary(PCO) induced by estradiol valerate(EV) in rats. Methods: PCO was induced by single intramuscular injection with EV(4mg) in female rats. Normal group(n=8) were injected with sesame oil and orally administrated distilled water for eight weeks. PCO control group(n=8) were injected with EV and orally administrated distilled water for eight weeks. GBT treated group(n=8) were injected with EV and orally administrated GBT for eight weeks. Then we measured weight of body, ovaries, adrenal glands, and uterus of rats. The histopathology changes of ovaries were also evaluated. The expression of nerve growth factor(NGF) was analyzed in the central nervous system, adrenal glands and ovaries by immunohistochemistry. And also CRF expression in median eminance of Rats were analyzed. Results: 1. The weight(g) of rats in GBT treated group($275{\pm}14$) was significantly increased(p<0.01) compared with control group($253{\pm}8$), 2. The weight(mg) of ovaries in GBT treated group($75.8{\pm}16.7$) was significantly increased(p<0.001) compared with control group($37.4{\pm}6.7$). 3. The number of mature follicles in GBT treated group($3.6{\pm}1.2$) was significantly increased(p<0.01) compared with control group($1.5{\pm}1.5$. 4. The number of atretic follicles in GBT treated group($8.0{\pm}3.1$) was significantly decreased(p<0.01) compared with control group($18.6{\pm}6.0$). 5. The number of cystic follicles in GBT treated group($0.5{\pm}0.5$) was significantly increased(p<0.01) compared with control group($2.3{\pm}1.3$). 6. The number of corpora lutea in GBT treated group($6.1{\pm}3.9$) was significantly increased(p<0.01) compared with control group($1.6{\pm}2.3$). 7. The expression of NGF-immunoreactive cells in the ovarian granulosa cells in GBT treated group was lesser observed than control group. Conclusion: From the above results, we concluded that Gwibi-Tang has inhibitory effect on the development of EV-induced polycystic ovary. And it's effect may be related with decreased NGF activities in the ovary.

• 대한예방한의학회지
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• 제21권3호
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• pp.43-50
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• 2017

Objectives : This study was conducted to survey on uncovered services in National Health Insurance(NHI) of Traditional Korean Medicine(TKM) Institution. Methods : For TKM doctors working in hospital, it was surveyed to professors working in university-affiliated hospital. A total of 40 professors were participated online survey and all of them was included. For TKM doctors working in clinic, an e-mail survey was conducted for members of the association of Korean medicine. A total of 436 TKM doctors, 279 TKM doctors were included study and 157 were excluded because of duplication clinic or not working in clinic. It was conducted general status and uncovered services in NHI status. Results : The proportion of uncovered services in NHI was 54.7% for hospitals, 39.0% for clinics and there was a significant difference between hospital and clinic. Decoction and herbal(bee venom) acupuncture were most commonly used in both institutions. For decoction treated patients, It was commonly treated Sibjeondaebo-tang, Bojungykki-tang, Gwibi-Tang and patients chief complaints was thoraco-lumbar pain, functional dyspepsia, fatigue. Conclusions : It is necessary to expansion of benefits range of the NHI on TKM services.

• 대한한방부인과학회지
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• 제33권3호
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• pp.136-148
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• 2020

Objectives: Hot flush and sweating is the most of common symptoms and the main cause of treatment in Menopause. This study aims to report the therapeutic effect of Korean medicine for menopausal sweating by analysis for the patients hospitalized in a Korean Medicine Hospital. Methods: To analyze treatment of menopausal sweating, we studied 21 patients complaining of menopausal sweating hospitalized in Kyung Hee University Hospital at Gangdong from 1^st January 2015 to 31^th May 2020 with retrospective chart review. Results: All 21 subjects are treated by acupuncture, moxibustion and cupping therapy during hospitalization for an average of 11.3±9.14 days. The most common used korean herbal medicine was Gwibi-tang-gagambang, Soyo-san-gagambang, and Dangwiyukhwang-tang-gagambang, every 6 case (20%), followed by Ojeok-san with 2 cases (6.7%). The improvement rate averaged 56.4% for daytime sweating and 53.6% for night sweating. Conclusions: The results suggest that menopausal sweating could improve by treatment of korean medicine, confirming significant treatment effects.