The Journal of Korean Medicine (대한한의학회지)

  • 제44권3호
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  • Pages.201-224
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  • 2023
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  • 1010-0695(pISSN)
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  • 2288-3339(eISSN)
The Society of Korean Medicine (대한한의학회)
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Gwibi-tang for Renal Anemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

귀비탕이 신성빈혈에 미치는 효과에 대한 체계적 문헌 고찰 및 메타분석

  • Mikyung Kim (Department of Internal Medicine, Dongguk University Ilsan Oriental Medicine Hospital ) ;
  • Chang-ho Han (Department of Internal Medicine, College of Korean Medicine, Dongguk University)
  • 김미경 (동국대학교 일산한방병원 한방내과) ;
  • 한창호 (동국대학교 한의과대학 내과학교실)
  • 투고 : 2023.07.22
  • 심사 : 2023.08.17
  • 발행 : 2023.09.01
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초록

Objectives: The purpose of this study was to evaluate the effect of Gwibi-tang (GBT) on renal anemia. Methods: A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to investigate changes in anemia levels before and after oral administration of GBT in patients with renal anemia. Relevant literature published up to May 25, 2023, was searched in 10 academic electronic databases. Results: Data from 489 patients from 7 RCTs were obtained and analyzed. All participants were receiving erythropoietin-stimulating agent treatment, and most of them were under hemodialysis. Additional administration of GBT to the participants significantly increased the hemoglobin concentration (10.55 g/L, 95% CI 6.99 to 14.11) compared to the control group. Hematocrit, red blood cell count, serum ferritin concentration, transferrin saturation, and the total effective rate for anemia was also significantly higher in the GBT-treated group than in the control group. Conclusions: This study suggests that GBT may be considered to be a promising option for the effective management of patients with renal anemia under conventional treatment. However, the limitations of this study, including the quantitative and qualitative weakness of the RCTs, the lack of safety-related evidence, and the absence of long-term follow-up data, should be taken into account when interpreting the results of this study.

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참고문헌

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