Background: We reviewed the clinical outcomes of patients with oligometastatic (OM) non-small cell lung cancer (NSCLC) who received multimodal therapy including lung surgery. Methods: We retrospectively analyzed 117 patients with OM NSCLC who underwent complete resection of the primary tumor from 2014 to 2017. Results: The median follow-up duration was 2.91 years (95% confidence interval, 1.48-5.84 years). The patients included 73 men (62.4%), and 76 patients (64.9%) were under the age of 65 years. Based on histology, 97 adenocarcinomas and 14 squamous cell carcinomas were included. Biomarker analysis revealed that 53 patients tested positive for epidermal growth factor receptor, anaplastic lymphoma kinase, or ROS1 mutations, while 36 patients tested negative. Metastases were detected in the brain in 74 patients, the adrenal glands in 12 patients, bone in 5 patients, vertebrae in 4 patients, and other locations in 12 patients. Radiation therapy for organ metastasis was performed in 81 patients and surgical resection in 27 patients. The 1-year overall survival (OS) rate in these patients was 82.8%, and the 3- and 5-year OS rates were 52.6% and 37.2%, respectively. Patients with positive biomarker test results had 1-, 3-, and 5-year OS rates of 98%, 64%, and 42.7%, respectively. These patients had better OS than those with negative biomarker test results (p=0.031). Patients aged ≤65 years and those with pT1-2 cancers also showed better survival (both p=0.008). Conclusion: Surgical resection of primary lung cancer is a viable treatment option for selected patients with OM NSCLC in the context of multimodal therapy.
This study was conducted in a long-term experimental forest in the central hardwoods region of southwestern Michigan to retrospectively examine the role of past forest management practices and climate on red oak (Quercus rubra L.) productivity. Initially, in 1971, plots within the experimental forest were treated separately with a clearcut and shelterwood regeneration harvest in an attempt to increase red oak regeneration. From 1987-1989, a new study was initiated within a portion of the clearcut and shelterwood plots to evaluate the effectiveness of additional oak crop tree release using mechanical and chemical applications. Cumulative diameter and mortality rates of 719 red oaks were monitored across the four silvicultural treatments: Clearcut-A (clearcut without additional release treatment), Clearcut-B (clearcut with additional release treatment), Shelterwood-A (shelterwood without additional release), and Shelterwood-B (shelterwood with additional release) plus an untreated control. Increment cores were obtained from red oak trees and neighboring competitor species. Tree-ring analyses (dendrochronology) were applied to examine the effect of these silvicultural treatments and climatic factors (temperature and precipitation) on red oak productivity. The results indicated that crop tree release following a clearcut or shelterwood harvest reduced mortality rates and thus increased survival of red oak. Red oak in control plots or plots only receiving the initial regeneration harvesting treatment and no additional competition release were negatively affected by climatic stress, which included summer moisture stress. In contrast, red oak in plots that received the competition release treatment from shade tolerant tree species not only had higher tree level productivity (i.e., tree basal area) and lower mortality rates, but were also relatively more resilient to climatic stress by showing limited or no associations between climate and growth.
The objective of this study was to determine the effect of genotype (slower-growing vs. fast-growing) and production system (access to outdoors vs. indoor) on the growth performance, carcass yield and meat quality (chemical composition, physicochemical and sensory properties) of chickens. The experiment was performed on 1,040 day-old hybrid male chickens of two genotypes. Slower-growing chickens (Hubbard JA957, certified) and fast-growing chickens (Hubbard F15) were fed identical diets until 65 days of age. Both genotypes (each represented by 520 birds) were divided into two subgroups and were raised in pens on litter with outdoor access or in indoor confinement without outdoor access (four replications per subgroup, each of 65 birds). Until day 21, the birds stayed in the indoor facility, in deep-litter pens. The birds could forage on pasture 12 h daily, commencing at three weeks of age. Stocking density was 0.13 $m^2$ floor space per bird in pens on litter, and 0.8 $m^2$ per bird in grassy yards. Compared with fast-growing, slower-growing chickens were significantly lighter (by 17%), had a lower breast and thigh muscle yield and a higher abdominal fat content, but they were characterized by higher survival rates at 65 days, a higher protein content and a lower fat content of breast meat. Outdoor access had no negative effects on the growth performance, muscle yield, the fatty acid profile and oxidative status of meat lipids. The meat of free-range chickens was darker in color, it had a higher protein content and a better water-holding capacity, but it was less juicy than the meat of birds raised indoors.
A 15-wk feeding trial was conducted to examine the supplemental effects of Barodon on growth performance, gastrointestinal histology, feed digestibility and innate immunity in olive founder. A basal commercial diet was used as a control and two other diets were prepared by spraying 0.1% or 0.2% of Barodon. Triplicate groups of fish (BW, 145 g) were fed one of the test diets to apparent satiation twice daily. At the end of the feeding trial, fish growth performance was not significantly affected by dietary treatments; however, feed utilization was significantly improved (linear and quadratic, p<0.05) by Barodon supplementation. Significantly higher (p<0.05) survival rates were obtained in fish fed Barodon containing diets. Hepatosomatic index increased significantly in Barodon treated groups. Also, the use of Barodon resulted in significant increase (linear and quadratic, p<0.05) of intestine length and number of goblet cells. Significantly higher (Quadratic, p<0.05) apparent digestibility coefficient of DM was obtained by supplementation of Barodon. Lysozyme and myeloperoxidase activities increased quadratically and linearly, respectively, in Barodon treated fish. Also, significantly higher (linear and quadratic, p<0.05) superoxide dismutase activity was found in Barodon fed fish. The findings in this study show that inclusion of Barodon in diets for olive flounder improves feed utilization and digestibility, and positively affects digestive tract histology and innate immunity.
Park, Jun-Suk;Ju, Jin-Hee;Kim, Won-Tae;Yoon, Young-Han
Journal of the Korean Society of Environmental Restoration Technology
/
v.13
no.4
/
pp.10-17
/
2010
The objectives of this study were to compare the growth of Vitex rotundifolia as affected by the difference of soil depth and mixture ratio in a shallow-extensive green roof module system, and to identify the level of soil thickness and mixture ratio as suitable growing condition to achieve the desired plant growth in green roof. Different soil thickness levels were achieved under 7cm, 15cm and 25cm of shallow-extensive green roof module systems made by woody frame of $500{\times}500{\times}300mm$. Soil mixture ratio were eight types for perlite : peatmoss : leafmold = 7 : 1 : 2 (v/v/v, $P_7P_1L_2$), perlite : peatmoss : leafmold = 6 : 2 : 2 (v/v/v, $P_6P_2L_2$), perlite : peatmoss : leafmold = 5 : 3 : 2 (v/v/v, $P_5P_3L_2$), perlite : peatmoss : leafmold = 4 : 4 : 2 (v/v/v, $P_4P_4L_2$), only sand ($S_{10}$), sand : leafmold = 7 : 3 (v/v, $S_7L_3$), sand : leafmold = 5 : 5 (v/v, $S_5L_5$) and only leafmold ($L_{10}$). The growth response of Vitex rotundifolia had fine and sustain condition in $P_6P_2L_2$, $P_5P_3L_2$ and $P_4P_4L_2$., Especially, in case of $P_6P_2L_2$, growth response appeared to be good even in soil thickness 7cm, which showed low survival rates of Vitex rotundifolia in other soil mixtures. Tree height, root diameter, photosynthesis and chlorophyll contents tended to increase with increased soil thickness.
Rhodiola sachalinensis has been used as a traditional medicine in Asia. We were germination in vitro seedling of grow naturally in Chang bai Moutain. And callus induction from leaf segments, treatmented plant regeneration in plant growth regulators (Auxins and cytokinins). We investigated optimal conditions for efficient plant regeneration through callus induction and shoots formation on medium with various kinds of growth regulators. Callus induction and adventitious shoots formation was achieved when cytokinin and auxin combinated to this experiment. Especially, there was the highest callus induction rates when we were used to 1 mg/L kinetin and 2 mg/L NAA $(98\%)$, Adventitious shoots formation wear obtained difference rate when cytokinin alone 1 mg/L BA $(96.6\%)$. And regenerated plantlet was acclimatized and transplanted to the soil, showed $100\%$ survival.
Kim, Kyoung-Duck;Kim, Kang-Woong;Lee, Bong-Joo;Han, Hyon-Sob;Bae, Ki-Min
Korean Journal of Fisheries and Aquatic Sciences
/
v.51
no.2
/
pp.142-147
/
2018
This study was conducted to investigate the effects of practical diets containing different seaweed powders on the growth and body composition of juvenile sea cucumber Apostichopus japonicus. Six experimental diets were formulated to contain 40% of the following seaweed powders: Sargassum thunbergii (ST), Undaria pinnatifida (UP), Ascophyllum nodosum (AN), Hizikia fusiformis (HF), fermented Laminaria japonica (FLJ), and fermented Hizikia fusiformis (FHF). Sea cucumbers (30 per tank; initial mean weight $0.4{\pm}0.01g$) in three replicates of six groups were fed one of the six experimental diets for 15 weeks. Survival in all groups was 83-93%, with no significant differences among the experimental groups. The specific growth rates of the sea cucumbers fed the ST and UP diets were significantly higher than those of sea cucumbers fed the HF, FLJ, and FHF diets, but did not significantly differ from those of sea cucumbers fed the AN diet. The results of this study suggest that S. thunbergii, U. pinnatifida, and A. nodosum could be useful sources of seaweed powder for practical diets of juvenile sea cucumber.
This study was conducted to investigate the effects of chemical application and amout of soil moisture on low temperature stress of cucumber seedling under the greenhouse conditions. When chilling treatments ($2^{\circ}C$) were begun at 07:00AM, survival rates of seedlings of two conditions; -0.3 bar and -5.5 bar were 28.3% and 83.3% respectively. But when chilling treatments were begun at 6:00PM - even the soil moisture condition was -0.3 bar - the survival rate was above the 87%. When reducing the soil moisture from -0.3 bar to -9.0 bar, ABA content in leaf was inc.eased by 6.5fo1d. Spraying of abscisc acid (ABA) before or after the chilling significantly increased the survival rates of seedlings, decreased the amounts of leaking electrolytes and prevented the yield reductions. ABA application on the soil before the chilling appeared to be more effective than the application after the chilling with foliar spray. Spraying of ABA ($10^{-5}M$), urea (0.2%) or $KH_2PO_4$ was effective in counteracting the low temperature, which causes growth deterioration and yield reduction in cucumbers.
Elena N. Ponomareva;Marina N. Sorokina;Vadim A. Grigoriev;Mariya Mazanko;Vladimir A. Chistyakov;Dmitry V. Rudoy
Food Science of Animal Resources
/
v.44
no.4
/
pp.805-816
/
2024
The aim of this study was to evaluate a new Bacillus amyloliquefaciens B-1895 probiotic as a feed additive for farmed trout. Final weight, absolute and average daily gain of fish, and average daily growth rate were higher in the group that received the probiotic than in the control group (p<0.05). Moreover, the probiotic-fed trout had more intense growth rates than the control group (higher by 15.7%; p<0.05). A decrease in feed ratio was also observed in the group that received probiotic (25% decrease; p<0.05), indicating more efficient digestion and assimilation of feed. In general, the introduction of probiotic in the feed did not adversely affect the functional status of the fish. In young trout of the control group, when assessing the general chemical composition of the organism in the muscle tissue revealed significantly (p≤0.001) higher level of moisture content by 5.1% and lower by 11.0% dry matter content. In muscle, the protein content was higher by 1.33% (p≤0.001) and fat content by 2.1% (p≤0.001) in experimental fish. Generally, Lactobacilli, Enterococcus, Vibrio, Bacillus, and coliform bacteria were found in the intestinal samples of rainbow trout. Significant reliable difference (p≤0.05) between the samples of experimental and control groups was noted in the content of Bacillus bacteria. In the control group, 5.0±0.4×103 CFU/g was detected, while in the experimental group 8.4±0.8×104 CFU/g. Overall, the data indicate that probiotic bacteria B. amyloliquefaciens B-1895 has no adverse effect on selected microorganisms in the study fish.
Kim, Kae-Hwan;Seo, Byung-Soo;Yoon, Se-Eok;Park, Chong-Min
Korean Journal of Environment and Ecology
/
v.21
no.6
/
pp.544-553
/
2007
This study is focused on the cultivation of seedlings and cuttings of roundleaf chastetree(Vitex rotundifolia L. f.) according to the sorts of soil and fertilization methods. The results are summarized as follows: When roundleaf chastetree seedlings(aged 1-0) and cuttings(aged 1-0) were cultivated in three different kinds of soil- sand, granite soil, and yellow silt- without any fertilization, 70% of the seedlings survived in sand and granite soil, and 35% did in yellow silt; 90% of the cuttings survived in granite soil and 80% did in sand and yellow silt. The general growth of both seedlings and cuttings was good in granite soil, and sand but relatively inferior in yellow silt. Seedlings showed good stem growth while cuttings had fine root growth. In case of cultivation of seedlings with different kinds and quantities of fertilizer adjusted and with granite soil as basic soil, seedlings and cuttings survived in the experimental section where only the organic fertilizer was used as basic fertilization; in contrast, seedlings grown in the experimental section were all dead where both inorganic and liquefied fertilizer were used. Cuttings showed considerably higher survival rates than seedlings at the experimental fertilization section; particularly, the survival rate of cuttings was twice as much as that of seedlings at the experimental section with low fertilization. This study results revealed that cuttings are desirable than seedlings in general rootage, growth, adaptability to soil, and cuttings have lower demand for soil fertility in time of growing roundleaf chastetree saplings.
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