• Journal of Navigation and Port Research
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• v.26 no.1
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• pp.35-42
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• 2002

The roles and importance of the application of simulator in harbor and waterway design are emphasized. On this paper Different methods of simulation and their application are described. A large-scale simulation concept, group simulation, is proposed. Requirements of the simulation for accomplishing the tasks properly and effectively are suggested. Some points on modeling of ship hydrodynamics and environmental factors. which are critical especially in waterway desing simulation, are discussed and algorisms presented.

• Proceedings of the Korean Institute of Interior Design Conference
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• 2008.05a
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• pp.247-250
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• 2008

As society and culture becomes complicated and diverse, so do the ensuing problems. The symptoms from the stress there was mainly focused on the adult group, however, now, they are shown in children. So the play therapy attracts attention as a way to cure stress. This study is intend to analysis an environment of play therapy space which would play an active role during treatment through the understanding of children's playing behavior. Disable children's playing therapy and pattern should be considered in the playing environmental design, and their feelings also need to be considered. The cozy and relaxed environment is important to children, so that they can have a natural interaction with the environment during the therapies. Output the factor of environment for play therapy and suggest the space of play therapy which fit on it.

• Molecules and Cells
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• v.27 no.6
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• pp.667-671
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• 2009

Visfatin (Nampt/PBEF) plays a pivotal role in the salvage pathway for $NAD^+$ biosynthesis. Its potent inhibitor, FK866, causes cellular $NAD^+$ levels to decline, thereby inducing apoptosis in tumor cells. In an effort to improve the solubility and binding interactions of FK866, we designed and synthesized IS001, in which a ribose group is attached to the FK866 pyridyl ring. Here, we report the crystal structure of rat visfatin in complex with IS001. Like FK866, IS001 is positioned at the dimer interface, and all of the residues that interact with IS001 are involved in hydrophobic or ${\pi}-{\pi}$-stacking interactions. However, we were unable to detect any strong interactions between the added ribose ring of IS001 and visfatin, which implies that a bulkier modifying group is necessary for a tight interaction. This study provides additional structure-based information needed to optimize the design of visfatin inhibitors.

• Journal of Nutrition and Health
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• v.33 no.5
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• pp.491-496
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• 2000

Food intake is regulated by both central and peripheral mechanisms. In the central nervous, the hypothalamus acts for autonomic and endocrine homeostasis. The paraventricular nucleus(PVN) of hypothalamus is an imprtant site of interaction in central feeding pathways. Neuroepetide Y(NPY)is one of the most powerful neurochemical stimulants of food intake known. Also brain nitric oxide(NO), known as neurotransmitter, is involved in the mechanisms that regulate food intake. In this experiment, 24h fasting mice and anorexia mutant mice have been to examine the expression of NPY, which is the major neuropeptide increasing food intake. Double staining with NPY and nicotinamide-adenine-dinucleotide-phosphate diaphorase(NADPH-d), followed by immunohistochemical method and image analysis, have been used to observe coexisting neurons and the level of expression of each neurons. The results were as follows. 1) NPY-immunoreactivitys reduced immune response of the hypothalamus, particularly paraventricular nucleus(PVN), in anorexia mutant mice. Decreased level of NPY is assumed to be a major pathological factor in anorexia mutant mice. On the other hand, PVN in hypothalamus of fasting mice showed increased immunoreactivity which is in agreement of other researchers. 2) NPY and NADPH-d double staining revealed coexisting neurons in the cerebral cortex. Fasting mice had a tendency to have increased level of coexisting neurons compared to the control group. Compared to the control group, fasting mice express is not increase level of NPY-immunoreactivity, while anorexia mutant mice tended to have a decreased level.

• 재활복지
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• v.18 no.4
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• pp.279-293
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• 2014

The purpose of the study was to investigate the effects of task presentation methods (animation vs. picture) on verb naming abilities as a function of verb argument structures for normal elderly adults. Participants were categorized into the two groups: animation group(n=21) vs. picture group(n=21). Data for the animation group were from obtained from Sung and Choi (2012). Percent of accuracy for the verb naming task served as a dependent measure for statistical analyses. After the years of education was controlled as a covariate, a two-way mixed ANOVA was performed with the group as a between-subject factor and the argument structure(1-, 2-, and 3-place) as a within-subject factor. Results revealed that there was a significant interaction between the group and argument structure, whereas there were no main effects for either of the factors. The animation group performed better than the picture group for one-place verb, whereas the opposite pattern was observed for the three-place verbs. The results suggested that the presentation methods are one of the critical factors that influenced verb naming abilities in elderly adults.

• The Journal of Advanced Prosthodontics
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• v.3 no.4
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• pp.221-228
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• 2011

PURPOSE. Veneering porcelain might be delaminated from underlying zirconia-based ceramics. The aim of this study was the evaluation of the effect of different surface treatments and type of zirconia (white or colored) on shear bond strength (SBS) of zirconia core and its veneering porcelain. MATERIALS AND METHODS. Eighty zirconia disks (40 white and 40 colored; 10 mm in diameter and 4 mm thick) were treated with three different mechanical surface conditioning methods (Sandblasting with $110{\mu}m$ $Al_2O_3$ particle, grinding, sandblasting and liner application). One group had received no treatment. These disks were veneered with 3 mm thick and 5 mm diameter Cercon Ceram Kiss porcelain and SBS test was conducted (cross-head speed = 1 mm/min). Two and one way ANOVA, Tukey's HSD Past hoc, and T- test were selected to analyzed the data (${\alpha}=0.05$). RESULTS. In this study, the factor of different types of zirconia ceramics (P=.462) had no significant effect on SBS, but the factors of different surface modification techniques (P=.005) and interaction effect (P=.018) had a significant effect on SBS. Within colored zirconia group, there were no significant differences in mean SBS among the four surface treatment subgroups (P=0.183). Within white zirconia group, "Ground group" exhibited a significantly lower SBS value than "as milled" or control (P=0.001) and liner (P=.05) groups. CONCLUSION. Type of zirconia did not have any effect on bond strength between zirconia core and veneer ceramic. Surface treatment had different effects on the SBS of the different zirconia types and grinding dramatically decreased the SBS of white zirconia- porcelain.

• Human Ecology Research
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• v.53 no.5
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• pp.475-488
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• 2015

Economic activity and social participation by women has recently increased; however, working mothers raising young children are under new stress due to the simultaneous combination of job and parenting responsibilities. This stress has resulted in social problems of career break and low fertility. This study investigates the effect of clinical art therapy on occupational stress and parenting stress of working mothers. We analyzed 34 working mothers in full-time employment (over 8 hours a day) who have preschool children (0-6 years old). They were divided into 17 subjects in the experimental group and 17 subjects in the control group. For the experimental group, 10 hours and a half sessions of group art therapy were participated in once a week from April to August in 2014. We perform Dan Occupational Stress Index by Ivancevich and Matteson, Parenting Stress Index/Short Form and salivary cortisol test before and after the group art therapy. For qualitative analysis, Kinetic House-Tree-Person (KHTP) drawing test was used. Using SPSS ver. 19.0, paired t -test or Wilcoxon signed rank test compared the pre and post analysis results. The results of this study are as follows. First, scores of 'occupational stress factor' subpart showed significant improvement in the Occupational Stress Index after the clinical art therapy. Second, scores of 'parental distress,' 'parent-child dysfunctional interaction,' and 'difficult child' subpart in Parenting Stress Index also showed a significant improvement. Third, a positive change was observed after the clinical art therapy in the KHTP drawing test. In conclusion, this study suggests that the clinical art therapy can be effective for occupational stress factors and the parenting stress of working mothers.

• Journal of Society of Preventive Korean Medicine
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• v.7 no.1
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• pp.1-15
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• 2003

This study tried to evaluate the difference of stress degree by Sasang constitution and lifestyle for workplace labors, and suggested the preventive oriental medicine approaches in occupational health area. 479 data for research were collected through the process of oriental health examination with questionnaire in workplace, and collected data were analyzed with frequency, crosstab, and Two-Way ANOVA. The results were as follows: 1) All subjects, total 479 were men, and constitutional distributions were 39.2% of Taeumin, 32.4% of Soumin, and 28.4% of Soyangin. The distributions of stress score were 13.2% of normal group, 13.4% of high risk group, and 73.5% of potential risk group. 2) There were no statistically significant differences for stress by constitution(p=0.085). By the results of optimal scaling and homogeneity analysis, Soyangin was close to potential risk group compared to other constitution, and Soumin and Taeumin were close to high risk and normal group, respectively. 3) For the difference of stress score by Sasang constitution and lifestyle, Soumin who exercised nearly everyday had the highest stress score with interaction in Factor 4 area(p<0.05), and there was no interaction in other area. 4) For the difference of PWI score by lifestyle, there were statistically significant differences for drinking(p<0.01), smoking(p<0.01), and obesity index(p<0.01)

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.2
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• pp.743-746
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• 2013

Background: Some studies have indicated an inverse relationship between cancer risk and sunlight exposure. Others have reported that the prognosis of some cancers such as prostate, colon, ovarian and non melanoma skin cancer, were affected by the season in which the cancer was diagnosed. In our study, we evaluated whether season is prognostic in Turkish patients with breast cancer. Materials and Methods: A total of 517 patients from Kayseri Training and Research Hospital were analysed retrospectively. Patients were divided into 4 groups according to season of cancer diagnosis: winter, spring, summer and autumn. The prognostic factors for disease free survival and overall survival were investigated. Results: No significant differences were found among groups regarding prognostic factors overall. Only estrogen receptor status and lymphovascular invasion were independent prognostic factors (p=0.001 and p=0.001 respectively). We found significantly differences for mean disease free survival among groups (p=0.019). Winter group had better mean DFS while summer group had worse DFS. Mean overall survival was similar in the four groups (p=0.637). Conclusions: The season is not an independent predictive factor. However, due to interaction with other factors, we think that the season of cancer diagnosis is important for cancer prognosis.

• Journal of Korean Academy of Nursing
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• v.4 no.2
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• pp.131-143
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• 1974

Antenatal care is zoomed toward3 assisting the Individual to achieve safe and wholesome state of health during pregnancy. Nature of fear is assumed to be rooted to complex interaction between past experiences, human relationship and present state of health, however. specific relationship between fear and the variables have not yet been ascertained. This study is designed to investigate the nature of fear of pregnancy, and the correlation between fear and the personal and environmental variables such as personal characteristics past experiences. and psycho-social factors. During the period from October 23 to November 5, 215 pregnant and 104 non-pregnant women of similar chronological are group residing in Seoul were interviewed according to check-list by random General anxiety test, general personality test and test for fear of pregnancy, family according to specific variables such as past experiences of Pregnancy and childbirth, structure of family, family relationship and month of pregnancy was done to the group of pregnant women. To non-pregnant group, general anxiety test was performed to compare with pregnant group. Results of the study are as follows; 1. Hypothesis 1; Degree of general anxiety will be higher e pregnant women compared to that of non-pregnant women. There is no significant difference between the general anxiety of pregnant women and that of non-pregnant women. Therefore, hypothesis I is rejected. 2. Hypothesis 2: Fear of pregnancy and general anxiety will be correlated with personality factors. Through test for fear of pregnancy and general anxiety, a meager contra-correlation between fear and only two personal factors (R and E factor) is revealed but there is no significant correlation between fear and other personal factors (A.S. and T factor). Degree of fear of pregnancy tends to b: higher in the group with low personality factors; responsibility and emotional stability expect the correlation between ascendancy, sociability, and confidence-inferiority. non-significant. Through general anxiety test, level of general anxiety tends to be higher in the group. with low personality factors; responsibility. emotional stability, and confidence except ascendency and sociability, non-significant. Hypothesis 2 is partially supported. 3. Hypothesis 3; General anxiety and fear of pregnancy will be correlated with the past experience-ol pregnancy, and child-birth experience. Though general anxiety test and test for fear of pregnancy, non-significant difference is revealed by P〉.05 level Hypothesis 3 is rejected. 4. Hypothesis 4: General anxiety and fear of pregnancy will be correlated with the month at pregnancy will be correlated with the month of pregnancy. Through tests of general anxiety and fear, significant correlation is revealed degree of fear by-P〈.05 level (CR=1.98) and level of general anxiety by P〈.005 level (CR=3. 11) is higher in the earlier stage of pregnancy. Hypothesis 4 is supported. 5. Hypothesis 5, 6, 7; General anxiety and fear of pregnancy will be correlated with socio-economic status, family structure, and family relationship. Through general anxiety test and tear of pregnancy test, non-significant is revealed by P〉.05 level. Hypothesis 3.6.7 are rejected. Conclusion and recommendation Level of general: anxiety and degree of fear of pregnancy is shown not to be correlated with variables of past experiencers of pregnancy and child-birth. and family factors except the month of - pregnancy. Personal characteristics are shown to be partially contra-correlated meagerly with genera anxiety and fear of pregnancy. This study revealed contrasted results, in regard to presence of correlation between general anxiety and fear of pregnancy to other thesis. In this context. further studies under controlled environment is recommended.