• International Journal of Stem Cells
• /
• v.16 no.2
• /
• pp.156-167
• /
• 2023

Background and Objectives: Cellular reprogramming in regenerative medicine holds great promise for treating patients with neurological disorders. In this regard, small molecule-mediated cellular conversion has attracted special attention because of its ease of reproducibility, applicability, and fewer safety concerns. However, currently available protocols for the direct conversion of somatic cells to neurons are limited in clinical application due of their complex nature, lengthy process, and low conversion efficiency. Methods and Results: Here, we report a new protocol involving chemical-based direct conversion of human fibroblasts (HF) to matured neuron-like cells with a short duration and high conversion efficiency using temporal and strategic dual epigenetic regulation. In this protocol, epigenetic modulation by inhibition of histone deacetylase and bromodomain enabled to overcome "recalcitrant" nature of adult fibroblasts and shorten the duration of neuronal reprogramming. We further observed that an extended epigenetic regulation is necessary to maintain the induced neuronal program to generate a homogenous population of neuron-like cells. Conclusions: Therefore, our study provides a new protocol to produce neurons-like cells and highlights the need of proper epigenetic resetting to establish and maintain neuronal program in HF.

• Agribusiness and Information Management
• /
• v.9 no.1
• /
• pp.23-36
• /
• 2017

The incidents of garbage dumplings in 2004 and the report on giant castella are the examples that shows how big the influence of broadcasting on the industry is. There were discussions on the importance of securing the objectivity of broadcasting, however, the existing related researches have lacked the analysis of actual proof for the influence of broadcasting contents, and as that of the law and system was confined to theoretical arguments, there were not enough suggestions for realistic alternatives. In this paper, we will examine the influence of broadcasting contents on the food industry through an analysis of actual proof, and propose alternatives in terms of the law and policy for securing the objectivity and fairness of broadcasting, to solve this problem.

• Annual Conference on Human and Language Technology
• /
• 2023.10a
• /
• pp.190-195
• /
• 2023

의사소통 기술에서 유머는 사람을 웃게 만들며 분위기를 환기시키고, 관계를 돈독하게 만드는 효과를 지닌다. 이를 자연어처리에서 유머 분류, 인식, 탐지로 적용하여 유머를 기계에 학습시키려 하는 다양한 시도가 진행되고 있지만 유머의 주관성과 윤리적 문제로 탁월한 성능을 기록하기 어렵고, 특히 한국어 유머에 대한 자연어처리 분야의 논의는 미비한 상태이다. 이에 본 연구는 유머 평가 체계를 만들어 ChatGPT에 적용하여 유머 인식의 주관성을 극복할 수 있는 자동화 실험을 진행한다. 이때, 유머의 윤리적 문제를 보완하기 위해 한국 법률을 적용한 윤리 기준을 도입하여 유머 데이터셋을 마련하였으며, 데이터셋을 ChatGPT에 fine-tuning 하여 재미있는 생성 모델의 개발 가능성을 실험하였다.

• Journal of Korean Society of Rural Planning
• /
• v.14 no.4
• /
• pp.57-67
• /
• 2008

The Direct Payment Program for Rural Landscape Conservation (DPPRLC), introduced by the Korean government, currently offers subsidies to rural villages to encourage the growing of flower crops or wild flowers instead of common grain. However, in many of these villages, major landscape elements like walls and roofs of houses are built with cheap, urban materials, and kept in poor condition. This is a poor reflection of the DPPRLC goal to improve the aesthetic of korean rural landscape. This study surveyed and analyzed traditional style walls and roofs in ten selected villages taking part in the DPPRLC program. Villagers were interviewed for a proposed direct payment program for building and maintaining traditional walls and roofs. Major findings are: First, more than 86% of residents are willing to build and maintain traditional walls if subsidies are given. They would like to be reimbursed 75% to 100% of construction and maintenance costs. Second, about 64% of residents would be willing to build and maintain traditional roofs with the subsidies. They also would like to receive 75% to 100% of construction and maintenance costs. The policy implication of this study is that extending the DPPRLC program to include walls and roofs in rural villages will make rural landscape more attractive.

• Journal of the Korean Society of Physical Medicine
• /
• v.12 no.4
• /
• pp.83-92
• /
• 2017

PURPOSE: The purpose of this study was to investigate the effect of the elastic band and stretching exercise program on ankle joint maximal voluntary isometric contraction (MVIC) and plantar pressure in high-heel wearing women in their 20s. METHODS: Twenty women in their twenties were randomly assigned to the experimental group (n=10) and the control group (n=10). The experimental group (n=10) performed the elastic band exercise program, while the control group (n=10) performed the stretching exercise program. Both exercise programs were performed three times a week for a total of four weeks. The BTE Primus RS was used in order to measure the ankle joint MVIC during dorsiflexion, plantar flexion, inversion, and eversion. Maximum pressure ($N/cm^2$), average pressure ($N/cm^2$) were measured using the Pedoscan. SPSS v. 21.0 software was used for all statistical analyses in this study. RESULTS: The measurement of the ankle joint's MVIC revealed that in inversion, a significant change in both feet was seen in both the experimental and control groups. In eversion, there was a significant change in both feet only in the experimental group. In terms of the rest of the results, no significant changes were visible. With regard to the plantar pressure, no significant results were seen for either foot in the comparison between or within the groups. CONCLUSION: Exercise program using elastic band and exercise program using stretching were effective on MVIC of ankle joint muscles, although it had no effect on changes of plantar pressure.

• Journal of Nutrition and Health
• /
• v.41 no.4
• /
• pp.365-373
• /
• 2008

This study examined the needs and practice willingness for the health promotion program of restaurant industry among Seoul residents. Using structured self-administered questionnaires, data on subjects' general characteristics, health status, and eating out behavior characteristics, the needs and practice willingness of the health promotion program for restaurant industry were collected from 765 adults above the age of 19. The needs for nutrition labeling such as fat, calorie, sodium, fiber, and the practice willingness for consuming nutrition labeled food were high. Results showed that gender, restaurant's management status, and food quality status were significant indicators for needs for health promotion program. Education duration, food quality status, and the frequency of eating out were significant variables for practice willingness. The results imply that health promotion program for the restaurant industry should be based on the consumer's characteristics. Also, the results imply the necessity of several activities such as social marketing to inform the benefit of participation in the health promotion program for consumers, guidance to maintain the food quality and improve the ambiance of restaurant for suppliers, and the new establishment of research centers to validate the labeled information on meals and analyze the nutrients of the meals for agencies.

• Physical Therapy Rehabilitation Science
• /
• v.11 no.4
• /
• pp.488-492
• /
• 2022

Objective: The purpose of this study is to find out the reliability and validity of the newly updated Balancia 2.5 program using Wii balance board through equipment that can measure center of pressure data with the precision. Design: Cross-sectional study Methods: Twenty-seven healthy adults participated in the study. The subjects were assessed for static balance ability by Accusway, and were assessed for static balance ability on Wii balance board connected to theBalancia 2.5 program.To limit postural fluctuations due to stare, the subjects were asked to look at a 15 cm dot drawn 3 m in front of them for 30 seconds with their eyes open. Static balance ability data such as path length and sway velocity were extracted from all measurement tools.Intra-rater and inter-rater reliability and validity were extracted through intraclass correlation coefficient (ICC) and 95% confidence interval (CI). Results: The intra-rater reliability that the same rater shows consistent results through test-retest was a high level at ICC=0.968 (0.926~0.986), and inter-rater reliability that the requires consistent results even when measured by different raters was a high level at ICC=0.943 (0.870~0.975). The validity was a high level at ICC=0.948 (0.881~0.977), which shows whether the measurement tool is properly measuring what it is intended to measure. Conclusions: The Balancia 2.5 program, newly updated through this study, proved to be a program with high reliability and validity in evaluating static balance ability like the existingBalancia 2.0 program.

• Korean Journal of Health Education and Promotion
• /
• v.27 no.3
• /
• pp.1-12
• /
• 2010

Objectives: This study was to understand the essence and the meanings of smoking experience in female undergraduate students. Methods: Colaizzi's phenomenological method was used. Data were collected by in-depth interviews with six undergraduate female students. Field notes, recording under the subjects' agreement, and telephone interview were also used. Results: In the analysis, 131 significant statements, 15 themes, 7 categories emerged. The seven categories were as follows; 'the first smoking for change and adaptation', 'becoming a part of self', 'good friend without any reason', 'a bond with friends', 'gazing with bad eyes', 'unexpected guest without realizing it', 'willingness to smoke more'. Conclusion: The results of this study will help professionals to understand the smoking behavior of female undergraduate students. We should consider positive experience toward smoking in young women for considering to plan smoking cessation program.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
• /
• v.7 no.1
• /
• pp.125-134
• /
• 2012

The concerns for entrepreneurship education has increased significantly in decades. Government asking to university to teach the entrepreneurship on the undergraduate and graduate level. Existing graduate-level entrepreneurship program is not enough for the reciprocal relationship among the subjects. This study review the university's entrepreneurship program in the domestic and abroad. We suggest the process and algorithm based education program which is The Technology Entrepreneurship and Commercialization.

• Journal of the Korean Society of Food Culture
• /
• v.30 no.5
• /
• pp.491-501
• /
• 2015

This study examined the satisfaction level and effects of after-school program cooking activities in children of multicultural families. A total of 135 children of general and multicultural families from 3th to 6th grades and their 11 teachers were surveyed, and 75 multicultural family children underwent a cooking activity program. Children of multicultural families showed higher participation in cooking activities than other Korean children. Children of multicultural families wanted to be involved in cooking activity programs after school more than other Korean children. These children also showed a higher rate of wanting to cook Korean foods compared to children of general families. Regarding reasons for participating in cooking activities, 'I think I'm glad to be served delicious food' response was the most common. Children of multicultural families showed higher participation in cooking activities than children of general families. Regarding school life changes, children of multicultural families were found to be less picky of foods in general as well as kimchi and vegetables. In conclusion, cooking activity programs for children of multicultural family showed beneficial effects on diet and understanding of Korean culture.