• Journal of Physiology & Pathology in Korean Medicine
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• v.25 no.5
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• pp.759-764
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• 2011

Through analyzing the frequencies of medicinal herb combinations in the prescriptions of "wenrejingwei(溫熱經緯)", we could understand the characteristics of prescription composition and author's medical thoughts. So we conducted this study that analyze combination of 187 medicinal herbs in 113 prescriptions, and found meaningful combinations of 273. Among these, the most meaningful combinations are the one of 7 herbs, Glycyrrhiza uralensis Fischer, Zingiber Rhizoma, Ziziphus jujube Mille, Pinellia ternata Breitenbach, Panax ginseng C.A.Meyer, Cyprinus carpio, Coptis chineis Franch. These are the same medicinal herbs which consist of Banhasasim-tang(banxiaxiexin-tang). It means these combinations are effective in stuffiness caused by stomach deficiency. In conclusion, prescriptions of "wenrejingwei(溫熱經緯)" involve herbs mostly used to treat stuffiness caused by stomach deficiency, and this is the author's important one of medical view points.

• The Korea Journal of Herbology
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• v.25 no.3
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• pp.53-60
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• 2010

Objectives : This study was conducted to evaluate the antioxidative and fibrinolytic activity of the water and ethanol extracts from medicinal plants. Methods : Five kinds of medicinal plants(Carthami Flos, Glycyrrhizae Radix, Schisandrae Fructus, Atractylodes Rhizoma, Shiitake mushiroom) were extracted with distilled water and 70% ethanol, and the extracts were tested for their antioxidative and fibrilytic activities. Results : The highest polyphenol contents of the water and ethanol extracts from medicinal plants were 812.52 mg and 685.44 mg per 100 g of Carthamus tinctorius and Schizandra chinensis, respectively. The electron donating abilities (EDA) of the water extracts from all medicinal plants except Lentinus edodes were about 90% at 1,000 ppm and ethanol extracts were higher than those of water extracts. The highest SOD-like activity and nitrite scavenging abilities (NSA) were both of water and ethanol extracts from Schizandra chinensis. Five kinds of medicinal plants had fibrinolytoc activity and the highest activities were water and ethanol extracts from Glycyrrhiza uralensis. Conclusion : These results suggest that the medicinal plants can be used as natural antioxidant to prevent oxidative damage in normal cells probably because of their antioxidative and fibrinolytic activities.

• Proceedings of the Botanical Society of Korea Conference
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• 1995.06a
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• pp.40-56
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• 1995

During the past two decades, China has seen her great progress in plant biotechnology. Since the Chinese market of herb medicine is huge, while the plant resources are shrinking, particular emphasis has been placed in plant tissue and cell cultures of medicinal plants, this includes fast propagation, protoplast isolation and regeneration, cell suspension cultures and large scale fermentation. To optimize culture conditions for producing secondary compounds in vitro, various media, additives and elicitors have been tested. Successful examples of large scale culture for the secondary metabolite biosynthesis are quite limited : Lithospermum ery throrhizon and Arnebia euchroma for shikonin derivatives, Panax ginseng, P. notoginseng, P. quinquefolium for saponins, and a few other medicinal plants. Recent development of genetic transformation systems of plant cells offered a new approach to in vitro production of secondary compounds. Hairy root induction and cultures, by using Ri-plasmid, have been reported from a number of medicinal plant species, such as Artemisia annua that produces little artemisinin in normal cultured cells, and from Glycyrrhiza uralensis. In the coming five years, Chinese scientists will continue their work on large scale cell cultures of a few of selected plant species, including Taxus spp. and A. annua, for the production of secondary metabolites with medicinal interests, one or two groups of scientists will be engaged in molecular cloning of the key enzymes in plant secondary metabolism.

• Journal of Oriental Neuropsychiatry
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• v.24 no.1
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• pp.1-12
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• 2013

Objectives : The purpose of this study was to take around herbal medicine for Attention Deficit Hyperactivity Disorder in China. Methods : A journal search was performed using China National Knowledge Infrastructure (CNKI) from 2007 to 2012. Key words searched were 'ADHD'. Results : 25 studies were selected. Case control studies showed that herbal medicine treatment reported better results than the western medicine treatment group. 12 case reports reported a significant improvement in herbal medicine treatment for patients with ADHD. Frequently used herbal materials were Rhizome of Polygalae Radix and Rhizome of Acori Gramineri Rhizoma (16 times), Root of Glycyrrhiza uralensis Fisch (14 times), Root of Rehmanniae Radix et Rhizoma Preparata and Sclerotium of Poria cocos Wolf (12 times). Conclusions : There have been many studies regarding herbal medicine for Attention Deficit Hyperactivity Disorder in China, and these studies can be applied to the clinical practices in Korea.

• Journal of Food Hygiene and Safety
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• v.8 no.3
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• pp.141-145
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• 1993

Thirty nine kinds of Korean herb drugs have screened for antimicrobial activity of some pathogenic microorganisms. It was revealed that some of hot water extracts from herb drugs showed antimicrobial activity in one or more strain of pathogenic microorganisms. Phellodendron amurense and Coptis chinensis inhibited growth of Staphylococcus aureus. Rubus coreanus showed antibacterial activity in Staphylococcus aureus and Pseudomonas aeruginosa. Citrus unshill inhibited growth of Escherichia coli and Cornus officinalis showed antibacterial activity in E. coli and Pseudomonas aeruginosa. Dioscorea battltas and Cinnamomum cassia showed antibacterial activity in Pseodomonas aeruginosa. And also, ScutelJa baicaJerrsis inhibited growth of Candida albicanus. Achyranthes japonica and Glycyrrhiza uralensis showed antifungal activity in Aspergillus niger. It was noteworthy that Glycrrhiza uranensis inhibited growth of Staphylococcus aureus, E. coli, Pseudomonas aeruginosa and Aspergillus niger.

• Herbal Formula Science
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• v.25 no.2
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• pp.209-222
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• 2017

Objectives : The purpose of this study was to investigate the interpretation of the Soyo-san(SYS) prescription in order to obtain the evidence for clinical applications. Methods and Result : We interpreted on the SYS-related contents based on 25 classic books, analyzed it according to followed categories ; meaning of name, alteration of herbal composition according to age, usage, origin, physiological and pathological situation of SYS, description of each herbal drug Conclusion : 1. So(逍) mean diminish(消), 遙 mean roll(搖). It reflected feature of SYS, that alleviate depression without impairing vital energy(正氣). 2. SYS was first mentioned in the prescription of peaceful benevolent dispensary(太平惠民和劑局方), its essential application was harminizing liver depression and spleen deficiency(肝鬱脾虛) 3. SYS originated from Sayuk-san. Sayuk-san was appropriate for soothe the liver and regulate the spleen(疏肝理脾), while SYS was suitable for depressed liver and blood deficiency(肝鬱血虛) 4. Most medical literature insisted that application situation of SYS is blood deficiency(血虛), depressed liver(肝鬱), spleen deficiency(脾虛). And there is strong correlation between three factors. 5. Bupleurum falcatum L.(柴胡), Mentha arvensis L.(薄荷) alleviates liver depression as "pungent dissipate-qi uprais (辛散氣升)" nature. Angelica gigas Nakai(當歸), Paeonia lactiflora Pall.(白芍藥) emoliates the liver by nourishing the blood. Atractylodes japonica Koidz. ex Kitam.(白朮), Poria cocos(茯苓), Glycyrrhiza uralensis Fisch.(甘草), Zingiber officinale Roscoe(生薑) cultivate the basis as tonifying earth(補土).

• The Journal of Pediatrics of Korean Medicine
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• v.34 no.2
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• pp.1-39
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• 2020

Objectives The purpose of this study is to compare prescriptions of gastrointestinal diseases from Soauibang and Donguibogam, by analyzing the prescription formula of the herbal medicines that were added or removed in Soauibang. This process will also help to analyze the view of disease states of the authors from Soauibang and Donguibogam, based on the results. Methods 122 prescriptions for gastrointestinal diseases from Soauibang were selected and analyzed based on indications. The difference between the contents of the prescriptions from Soauibang and Donguibogam were analyzed. Results According to the Soauibang prescriptions, the herb that rectifies Qi, which releases the exterior and transform dampness were frequently added in the prescription. Conclusions The author of the Soauibang frequently used herbs that rectifies Qi and a root of Zingiber officinale Roscoe to improve digestive function, and use less of the Zizyphus jujube and Glycyrrhiza uralensis, which can cause digestive disorders when used excessively. in the prescription formula for the gastrointestinal diseases.

• Journal of the Korean Applied Science and Technology
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• v.37 no.2
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• pp.279-286
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• 2020

Natural extracts were isolated from 20 kinds of medicinal plants that have been traditionally widely used in Korea to develop treatments for dental caries. Medicinal plants showing antibacterial activity against a cariogenic bacterium, Streptococcus sobrinus KCOM 1157 were investigated. The natural extracts of Glycyrrhiza uralensis, Sophora flavescens, Coptis Chinensis, Mentha arvensis, Pinus densiflora, Spirodela polyrhiza showed antimicrobial activities against S. sobrinus KCOM 1157. The extracts of Pinus densiflora, Sophora flavescens, Coptis Chinensis among these medical herbs showed significant antimicrobial activity. These results suggested that the natural products of Pinus densiflora, Sophora flavescens, Coptis Chinensis could be the potential source of anticariogenic agent against dental pathogens including S. sobrinus.

• Nutrition Research and Practice
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• v.6 no.6
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• pp.491-498
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• 2012

Glycyrrhiza uralensis (or licorice) is a widely used Oriental herbal medicine from which the phenylflavonoids dehydroglyasperin C (DGC), dehydroglyasperin D (DGD), and isoangustone A (IsoA) are derived. The purpose of the present study was to evaluate the antioxidant properties of DGC, DGD, and IsoA. The three compounds showed strong ferric reducing activities and effectively scavenged DPPH, $ABTS^+$, and singlet oxygen radicals. Among the three compounds tested, DGC showed the highest free radical scavenging capacity in human hepatoma HepG2 cells as assessed by oxidant-sensitive fluorescent dyes dichlorofluorescein diacetate and dihydroethidium bromide. In addition, all three compounds effectively suppressed lipid peroxidation in rat tissues as well as $H_2O_2$-induced ROS production in hepatoma cells. This study demonstrates that among the three phenylflavonoids isolated from licorice, DGC possesses the most potent antioxidant activity, suggesting it has protective effects against chronic diseases caused by reactive oxygen species as well as potential as an antioxidant food additive.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.18 no.1
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• pp.135-153
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• 2005

Herbal mixture water extract of (Phellodendron amurense, Scuellaria baiklensis, Spphora flavescens, Lithospermum erythrorhizon, Mellaphis chinesis, Alumite, Zanthoxylum schinifolium, Glycyrrhiza uralensis), which exhibit several beneficial effects including acne and skin diseases, was tested for anti-microbial activity and anti-inflammation effects. The herbal mixture extract showed antimicrobial activity against Stapylococcus epidermis, Propionibacterium acne, and Malassezia furfur. The growth of Stapylococcus epidermis, Propionibacterium acne, and Malassezia furfur was inhibited allergy and LPS induced cyclooxygenase-2(COX-2)gene expression in RAW24.7macrophage. The results indicated th ear swelling and histamine release induced by compound 48/80 were dose-dependently reduced, ranging 11-38% and 11-56%, respectively. Furthermore the extract inhibited the expression of LPS-induced COX-2 proteins and mRNAs without an appreciable cytotoxic effects on RAW264.7 cells. The cytotoxicity of the extract using M7T assay showed the cytotoxicity of 7 and 18% against L929 cell line. Based on these results, it is concluded that the herbal mixture water extract can be applied to the acne and skin diseases therapy.