• 생물정신의학
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• 제22권4호
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• pp.179-186
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• 2015

Objectives Adrenergic alpha 1 and 2 receptors work as pathways to control the serotonergic neuron moderation and mirtazapine acts as antagonist of these receptors. The adrenoreceptor alpha 1a (ADRA1A) gene, which encodes adrenergic alpha 1 receptor, has Arg-347Cys genetic polymorphism and the polymorphism has strong relationship with many neuro-psychiatric diseases. In this study, we explored the relationship between ADRA1A R347C polymorphism and mirtazapine treatment response in Koreans with major depression. Methods 352 patients enrolled in this study, and the symptoms were evaluated by 17-item Hamilton Depression Rating (HAMD-17) scale. After 1, 2, 4, 8, and 12 weeks of mirtazapine treatment, the association between ADRA1A R347C polymorphism and remission/response outcomes was evaluated. Results Treatment response to mirtazapine was significantly better in T allele carriers than C allele homozygotes after 12 weeks of mirtazapine monotherapy. The percentile decline of HAMD-17 score in T allele carriers was larger than that of C allele homozygotes. ADRA1A R347C genotypes were not significantly associated with remission. Conclusions The result showed that treatment response to mirtazapine was significantly associated with ADRA1A R347C genetic polymorphism. T allele carriers showed better treatment response than C allele homozygotes. It can be supposed that T allele carriers have a trend of better treatment response to mirtazapine monotherapy.

• Asian Pacific Journal of Cancer Prevention
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• 제15권20호
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• pp.8705-8708
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• 2014

Disrupted transforming growth factor-${\beta}$ (TGF-${\beta}$) signaling is involved in the development of various types of cancer and the TGF-${\beta}$ receptor II (TGFBR2) is a key mediator of TGF-${\beta}$ growth inhibitory signals. It is reported that the G-875A polymorphism in TGFBR2 is implicated in risk of various cancers. However, results for the association between this polymorphism and cancer remain conflicting. To derive a more precise estimation, a meta-analysis of 3,808 cases and 4,489 controls from nine published case-control studies was performed. Our analysis indicated that G-875A is associated with a trend of decreased cancer risk for allele A versus(vs.) allele G [odds ratio (OR) =0.64, 95% confidence intervals (CI): 0.55-0.74], as well as for both dominant model [(A/A+G/A) vs. G/G, OR=0.76, 95% CI: 0.64-0.90] and recessive model [A/A vs. (G/G+G/A), OR=0.74, 95% CI: 0.59-0.93). However, larger scale primary studies are required to further evaluate the interaction of TGFBR2 G-875A polymorphism and cancer risk in specific cancer subtypes.

• Asian Pacific Journal of Cancer Prevention
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• 제17권sup3호
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• pp.149-153
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• 2016

Breast cancer is the most common cancer in Iran. In the recent years an upward trend has been observed in the Iranian population. Early detection by molecular approaches may reduce breast cancer morbidity and mortality. We provided consultation to 3,782 women diagnosed with early onset breast cancer during the past 15 years (1999-2014). To establish a data set for BRCA gene alterations of the Iranian families at risk, two hundred and fifty four women who met our criteria were analyzed. A total number of 46 alterations including 18 variants with unknown clinical significance (39.1%), 18 missense mutations (39.1%), 7 Indels (15.2%) and 3 large rearrangement sequences (6%) were identified. Further scanning of affected families revealed that 49% of healthy relatives harbor identical causative mutations. This is the first report of comprehensive BRCA analysis in Iranian women with early onset breast cancer. Our findings provide valuable molecular data to support physicians as well as patients for the best decision making on disease management.

• Current Research on Agriculture and Life Sciences
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• 제2권
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• pp.42-55
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• 1984

The direction of scientific researches on tree improvement and forest management in several universities and research institutes in Japan can be summarized as follows: They put a great emphasis on sugi, Cryptomeria japonica and cypress, Chamaecyparus oblusa which are two major conifer species largerly planted in the Japanese forestry. In the research of sugi, a great concern has been made in evaluating inheritance of forest tree, quantitative characters and genetic parameter of growth, and in breeding for resistance to diseases and insects and to all the natural calamities. Interaction between environmental conditions and genetic nature of tree can be concerned factors in relation with forest damage, together with silvicultural conditions and pest infestation. Selfing hybrids of $F_1$ made from crossing twisted-leaf sugi, defomity leaf type and midori sugi, normal leaf type segregated the normal needle, twisted needle, green leaf and albino leaf type. It seemed that separation of many defomity individuals can be governed by two dominant complementary genes and from the near loci of which it was detected lethal genes. 52% of Japanese forestry is occupied by the small forest landowners like Korean forestry. This made difficulty for forest improvement such as progressive afforestation and for capital accumulation form forestry. The Forest Corporation was established at first in 1959 to aming at productive forestry structure and forest management, and afforestation. For these purpose, 35 Forest Corporations are at moment operating throughout Japan. However, investment in forestry business becomes less attractive since the wage in forest production duction increased in higher trend. than timber price. Therefore, an artifical afforestation becomes yearly decreased. At present. the self-sufficient rate of timber production in Japan is about 35%, and so a great effort is being made to increase self-sufficient rate of timber production.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2022년도 추계학술대회
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• pp.272-272
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• 2022

Water and phosphorus (P) fertilizer are two of the most critical inputs in rice cultivation. Under climate change scenarios and urbanization, irrigation and fertilizer are becoming limiting factors often leading to significant decrease in yield whenever supplied scarcely. It has been shown that the Pup1 QTL confers tolerance to P starvation and improved early-stage root vigor in indica rice grown in the tropics. However, whether the QTL works in japonica rice genetic background grown in temperate regions remains to be elucidated. Here, we have introgressed the Pup1 QTL into three temperate rice varieties MS11, TR22183, and Dasan using marker-assisted backcrossing and next generation sequencing. The selected lines all harbored the full Pup1 QTL with recurrent parent genome recovery rates ranging from 66.5% to 99.8%. Evaluation of the introgression rice lines grown in South Korea under low inputs of P and water revealed early vegetative growth advantage relative to that of the recurrent parents. Under rainfed condition, Pup1 introgression lines had yield advantage ranging from 7.2 to 19.9% and 24 to 26% in P non-supplied soil and P-supplied soil, respectively compared to that of the recurrent parents suggesting that Pup1 confers enhanced yield under low P and water inputs in temperate rice genetic background grown in temperate climate. In terms of early vegetative growth, temperate Pup1 introgression lines showed a similar trend on the extent to which Pup1 promotes yield advantage in temperate rice in comparison with indica control Pup1 introgression line IR64-Pup1.

• 한국작물학회지
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• 제68권3호
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• pp.216-223
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• 2023

This study aimed to identify and compare the characteristics of Elymus humidus on common wheat (Triticum aestivum L. cv. Chinse Spring, CS). The seed length, width, height, and weight of E. humidus were smaller than those of the CS. In particular, the germination rate of E. humidus was substantially lower than that of CS. In the anatomical dissection of the leaf, E. humidus showed a considerably different xylem diameter of the main vascular bundle in the main vein; however, there was no difference in the phloem of the main vascular bundle compared with the xylem and phloem of the main vascular bundle in the main vein of CS, although E. humidus showed a leaf structure similar to that of CS. In addition, E. humidus had a thinner epidermis than that of CS. Regarding stomatal traits, E. humidus showed a graminoid stomata type similar to that of CS. On the adaxial and abaxial sides, the density, length, and width of the stomata in E. humidus were smaller than those in CS, whereas the distance between stomata in E. humidus was greater than that in CS. The chromosomes of E. humidus were classified as long and short based on their respective lengths. Long chromosomes were classified based on the ratio of the long arm to the short arm e.g., 1:1 or 2:1. Short chromosomes showed the same trend and some short chromosomes were microsatellites. To evaluate genetic diversity, 38 barley EST markers with polymorphisms between E. humidus and CS were selected from 236 barley EST markers.

• Asian-Australasian Journal of Animal Sciences
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• 제19권5호
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• pp.627-631
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• 2006

The objective of this study was to evaluate the association of genetic differences in the bovine leptin gene and milk yield, reproduction, body condition score (BCS), and plasma glucose level in Iranian Holstein cows. In total, two hundred and thirty eight cows were used and genotyped for a restricted fragment length polymorphism at the leptin gene locus. Two genotypes, AA and AB, have been distinguished which have the frequencies of 0.89 and 0.11, respectively. The genotypes were distributed according to the Hardy - Weinberg equilibrium ($x^2$ = 0.733). During the first 12 wk of lactation, milk yield and composition, live weight, BCS and plasma glucose were measured in 50 cows. Data were analyzed based on a repeated measures ANOVA. During this period, milk yield and composition, live weight, BCS and plasma glucose level were similar among the genotypes. The first cumulative 60-d milk yield, 305-d milk yield, days to first breeding, days open and days from first breeding to conception using previous lactation records were also analyzed using Standard Least Square within mixed models. Fixed effects were year, season, parity and age at calving, and sire. For the reproductive traits the cumulative first 60-d milk yield was also added to the model. Animal was fitted as a random effect. A significant association was detected between the RFLP-AB genotype and 305-d milk yield (p<0.05). The first 60-d cumulative milk yield was similar for the two genotypes (p = 0.21) and tended to be higher in the heterozygous cows. The heterozygous genotypes at the above mentioned locus had a trend to better reproductive performance than the homozygous. The results demonstrate that the RFLP B-allele can yield a higher 305-d milk production with a trend to better reproductive performance.

• Environmental Engineering Research
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• 제22권4호
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• pp.407-416
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• 2017

$CO_2$ emission is increasingly focused by public. Beijing and Tianjin are conceived to be a new economic point of growth in China. However, both of them are suffering serious environmental stress. In order to seek for the effect of socioeconomic factors on the $CO_2$ emission of this region, a novel methodology -symbolic regression- is adopted to investigate the relationship between $CO_2$ emission and influential factors of Beijing and Tianjin. Based on this method, $CO_2$ emission models of Beijing and Tianjin are built respectively. The models results manifested that Beijing and Tianjin own different $CO_2$ emission indicators. The RMSE of models in Beijing and Tianjin are 255.39 and 603.99, respectively. Further analysis on indicators and forecast trend shows that $CO_2$ emission of Beijing expresses an inverted-U shaped curve, whilst Tianjin owns a monotonically increasing trend. From analytical results, it could be argued that the diversity rooted in different development orientation and the mixture of different natural and industrial environment. This research further expands the investigation on $CO_2$ emission of Beijing and Tianjin region, and can be used for reference in the study of carbon emissions in similar regions. Based on the investigation, several policy suggestions are presented.

• 한방안이비인후피부과학회지
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• 제34권2호
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• pp.21-37
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• 2021

Objectives : Allergic rhinitis(AR) is a common chronic disease that accounts for 10-40% of the world's population. This study aims to analyze the status of claims, prevalence, and medical utilization of allergic rhinitis patients using representative patients sample data. Methods : This study used the National Patients Sample(HIRA-NPS) of the Health Insurance Review and Assessment Service for 7 years(2010-2016). And we defined AR patients as all statements including J30 or a subcategory of J30 as the main disease, using the Korean Standard Classification of Diseases(KCD-7). The trend of AR patients by year was divided into Western medicine(WM) and Korean medicine(KM), and analyzed by subgroup analysis such as inpatient/outpatient, gender, age, insurance type, and care institution. Results : Patients with AR were mainly claimed for first sub diagnosis in WM and major diagnosis in KM, and the number of claims increased about 1.3 times and 1.4 times compared to 2010 in WM and KM, respectively. In addition, the total annual medical expenses in 2016 increased 1.3 times and 1.7 times compared to 2010, respectively. Conclusions : Both WM and KM are showing a steadily increasing trend in medical use due to allergic rhinitis. Further research is needed by considering genetic and environmental factors and individual characteristics, and linking with additional data.

• Journal of Gastric Cancer
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• 제9권4호
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• pp.186-192
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• 2009

목적: 위암 분야 전문 학술지인 대한위암학회지와 외과 대표 학술지인 대한외과학회지에 게재된 위암 외과 관련 논문들을 대상으로 이들의 연구 경향을 분석함으로써, 그간의 국내 외과 영역에서의 위암 연구들의 흐름을 살펴보고, 향후 방향점을 논의하고 미흡한 연구 부분에 대한 연구를 유도할 수 있는 효과와 창간 이후 대한위암학회지의 질적 양적인 향상이 있었는지에 대하여 간접적으로 평가해 보고 개선 방향을 제시하고자 하였다. 대상 및 방법: 분석 대상은 2001년도부터 2008년도까지 8년간 위암 분야 전문 학술지인 대한위암학회지와 외과 대표 학술지인 대한외과학회지에 투고된 위암 연구에 관한 논문들로 하였다. 결과: 대한위암학회지와 대한외과학회지의 투고 논문의 경향을 보면, 전자의 경우에는 종설은 많았다가 점차 감소하는 추세를 보이다가 최근에 증가하였다. 후자는 8년간 총 6편만 발표되었고 전반적으로 종설에 대한 발표 편수가 적었다. 증례는 대한위암학회지에서는 점차 증가하다가 감소하는 추세를 보였고, 대한외과학회지에서는 매년 1~3편 전후로 전반적으로 낮은 추세로 비슷한 경향을 보였다. 독특하게도 보고서는 대한위암학회지에서만 2004~2005년도에 활발하였다. 후향적 연구는 대한위암학회지에서 초기에 많았다가 감소하다가 다시 증가하는 U자 형태를 보였고, 대한외과학회지에서는 초기에 잠시 증가하다가 감소하는 추세를 보였다. 전향적 연구는 대한위암학회지에서 점차 증가하다가 최근에 감소하는 추세를 보였고 대한외과학회지에서는 계속 감소 추세를 보였다. 위암의 생물학적 연구, 암표지자 연구, 유전자 연구는 두 학회지 모두 게재 비율이 낮았다. 결론: 앞으로의 연구의 방향은 후향적 연구에서 전향적 연구로 이행되어 가고, 임상적 연구보다는 기초에서 임상으로 이어지는 이행성 연구가 중시될 것이며, 단일 기관 또는 연구자 단독 연구보다는 다기관 또는 다학제간의 협력 연구가 더 높이 평가되고 지원되고 장려될 것으로 보인다.