• Animal Systematics, Evolution and Diversity
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• v.27 no.1
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• pp.1-17
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• 2011

Thais Roding, 1798, commonly known as rock-shell, is among the most frequently found gastropod genera worldwide on intertidal rocky shores including those of Japan, China, Taiwan and Korea. This group contains important species in many marine environmental studies but species-level taxonomy of the group is quite complicated due to the morphological variations in shell characters. This study examined the genetic variations and relationships among three Korean Thais species based on the partial nucleotide sequences of mitochondrial cox1 gene fragments. Phylogenetic trees from different analytic methods (maximum parsimony, neighbor-joining, and maximum likelihood) showed that T. bronni and T. luteostoma are closely related, indicating the most recent common ancestry. The low sequence divergence found between T. luteostoma and T. bronni, ranging from 1.53% to 3.19%, also corroborates this idea. Further molecular survey using different molecular marker is required to fully understand a detailed picture of the origin for their low level of interspecific sequence divergence. Sequence comparisons among conspecific individuals revealed extensive sequence variations within the three species with maximum values of 2.43% in T. clavigera and 1.37% in both T. bronni and T. luteostoma. In addition, there is an unexpectedly high level of mitochondrial genotypic diversity within each of the three Korean Thais species. The high genetic diversity revealed in Korean Thais species is likely to reflect genetic diversity introduced from potential source populations with diverse geographic origins, such as Taiwan, Hong Kong, and a variety of different coastal regions in South China and Japan. Additional sequence analysis with comprehensive taxon sampling from unstudied potential source populations will be also needed to address the origin and key factors for the high level of genetic diversity discovered within the three Korean Thais species studied.

• Journal of Genetic Medicine
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• v.4 no.1
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• pp.1-5
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• 2007

Unprecedented amount of genetic information being generated from the result of Human Genome Project (HGP) and advances in genetic research is already forcing changes in the paradigm of health and disease. The ultimate goal of genetic medicine is to use genetic information and technology to develop new ways of treatment or even prevention of the disease on an individual level for 'personalized medicine'. Genetics is play ing an increasingly important role in the diagnosis, monitoring and management of common multifactorial diseases in addition to rare single-gene disorders. While wide range of genetic testing have provided benefits to patients and family, uncertainties surrounding test interpretation, the current lack of available medical options for the diseases, and risks for discrimination and social stigmatization may remain to be resolved. However an increasing number of genetic tests are becoming commercially available, including direct to consumer genetic testing, yet public is often unaw are of their clinical and social implications. The personal nature of information generated by a genetic test, its power to affect major life decisions and family members, and its potential misuse raise important ethical considerations. Therefore appropriate genetic counseling is needed for patient to be informed with the benefits, limitations and risks of genetic tests, prior to informed consent for the tests. Physician also should be familiar with the legal and ethical issues involved in genetic testing to tell patients how w ell a particular genetic risk factor relates with likelihood of disease, and be able to provide appropriate genetic counseling. Genetic counseling become a mandatory requirement as global standard for many genetic testing such as prenatal diagnosis, presymtomatic DNA diagnostic tests and cancer susceptibility gene test for familial cancer syndrome. In oder to meet the challenge of genetic medicine of 21 century in korean health care system, professional education program and certification board for medical genetics specialist including non-MD genetic counselors should be addressed by medical society and regulatory policy of national health insurance reimbursement for genetic counseling to be in place to promote the implementation of clinical genetic service including genetic counseling for proper genetic testing.

• Journal of Korean Institute of Industrial Engineers
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• v.35 no.1
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• pp.92-100
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• 2009

Today international trade through maritime transportation is significantly increasing. Due to this increase, shipping companies are faced with problems concerning the repositioning of empty containers from import dominant ports. The liner shipping service network has been provided to transport containers which load customers' freights. Container ships are moved on the liner shipping service network by observing the predetermined route and transportation time. This research deals with the empty containers distribution problem considering the container ship route. A mathematical model based on the mixed integer program has been introduced in this study. The objective is to minimize the total relevant costs of empty containers such as handling, leasing, and inventory holding, etc. Due to the complexity of the problem, a genetic algorithm has been suggested to solve large sized problems within a reasonable time. Numerical experiments have been conducted to show the efficiency of the genetic algorithm.

• Journal of Information Technology Services
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• v.10 no.3
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• pp.167-177
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• 2011

Code obfuscation is a technique that protects the abstract data contained in a program from malicious reverse engineering and various obfuscation methods have been proposed for obfuscating intention. As the abstract data of control flow about programs is important to clearly understand whole program, many control flow obfuscation transformations have been introduced. Generally, inlining is a compiler optimization which improves the performance of programs by reducing the overhead of calling invocation. In code obfuscation, inlining is used to protect the abstract data of control flow. In this paper, we define new control flow complexity metric based on entropy theory and N-Scope metric, and then apply genetic algorithm to obtain optimal inlining results, based on the defined metric.

• Journal of Sericultural and Entomological Science
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• v.43 no.1
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• pp.29-32
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• 2001

At present, more than 300 races of the Silkworm are conserved and used as valuable genetic resources. But because of the uneffectiveness of manual data management, faster and systematic data base construction is needed. So, development of silkworm genetic resources management program has been begun and the result can be practically used. When developing the program, Visual basic was used for data input system construction, and MS Access for database. IIS(Internet Information System) and ASP(Active Server Page) was also used for searching data and information with Internet Web Server and Web Browser which is comfortable for constructing database and providing information. Data input item consists of 46 practical characteristics such as race name, moltinism, larval period and pupation percentage etc.. And these characteristics are classified with qualitative and quantitative character. Photographs of silkworm, cocoon and other related items were scanned and the image data was recorded on the database.

• Proceedings of the IEEK Conference
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• 2002.07b
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• pp.1176-1179
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• 2002

This paper presents the use of a Genetic Algorithm to find the optimal layout for the placement of garment patterns on a fabric of fixed width to minimize fabric waste. We developed a program to simulate garment pieces and their layout on a fixed-width fabric. Each piece in the order book is placed with 2 possible orientations: 0 degrees and 180 degrees. The efficiency is measured by the length of fabric used after all the patterns in the order book have been laid out. A comparison is made between the placement using our proposed genetic algorithm to that made by an expert human using our simulation program. The results from our experiments on various pattern designs indicate that our genetic algorithm can effectively be used to obtain highly efficient solutions, comparable to that done by an expert while using a reasonable amount of time. The algorithm can also be adapted for use in other areas related to optimal consumption of sheet material such as metal, paper, and leather.

• Journal of Genetic Medicine
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• v.20 no.2
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• pp.39-45
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• 2023

As advanced sequencing technologies continue to uncover an increasing number of variants in genes associated with human genetic diseases, there is a growing demand for systematic approaches to assess the impact of these variants on human development, health, and disease. While in silico analyses have provided valuable insights, it is essential to complement these findings with model organism studies to determine the functional consequences of genetic variants in vivo. Drosophila melanogaster is an excellent genetic model for such functional studies due to its efficient genetic technologies, high gene conservation with humans, accessibility to mutant fly resources, short life cycles, and cost-effectiveness. The traditional GAL4-UAS system, allowing precise control of gene expression through binary regulation, is frequently employed to assess the effects of monoallelic variants. Recombinase medicated cassette exchange or CRISPR-Cas9-mediated GAL4 insertion within coding introns or substitution of gene body with Kozak-Gal4 result in the loss-of-function of the target gene. This GAL4 insertion strategy also enables the expression of reference complementary DNA (cDNA) or cDNA carrying genetic variants under the control of endogenous regulatory cis elements. Furthermore, the CRISPR-Cas9-directed tissue-specific knockout and cDNA rescue system provides the flexibility to investigate candidate variants in a tissue-specific and/or developmental-timing dependent manner. In this review, we will delve into the diverse genetic techniques available in Drosophila and their applications in diagnosing and studying numerous undiagnosed diseases over the past decade.

• Mycobiology
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• v.48 no.3
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• pp.240-244
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• 2020

Alternaria alternata JS-1623 is an endophytic fungus isolated from a stem tissue of Korean fir, Abies koreana. Ethyl acetate extracts of culture filtrates exhibited anti-inflammatory activity in LPS induced microglia BV-2 cell without cytotoxicity. Here we report a 33.67 Mb sized genome assembly of JS-1623 comprised of 13 scaffolds with N50 of 4.96 Mb, and 92.41% of BUSCO completeness. GC contents were 50.97%. Of the 11,197 genes annotated, gene families related to the biosynthesis of secondary metabolites or transcription factors were identified.

• Journal of Environmental Impact Assessment
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• v.15 no.6
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• pp.435-441
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• 2006

For the calibration of rainfall-runoff model, automatic calibration methods are used instead of manual calibration to obtain the reliable modeling results. When mathematical programming techniques such as linear programming and nonlinear programming are applied, there is a possibility to arrive at the local optimum. To solve this problem, genetic algorithm is introduced in this study. It is very simple and easy to understand but also applicable to any complicated mathematical problem, and it can find out the global optimum solution effectively. The objective of this study is to develope a parameter optimization program that integrate a genetic algorithm and a rainfall-runoff model. The program can calibrate the various parameters related to the runoff process automatically. As a rainfall-runoff model, SWMM is applied. The automatic calibration program developed in this study is applied to the Jangcheon watershed flowing into the Youngrang Lake that is in the eutrophic state. Runoff surveys were carried out for two storm events on the Jangcheon watershed. The peak flow and runoff volume estimated by the calibrated model with the survey data shows good agreement with the observed values.

• Journal of the Korean Society of Hazard Mitigation
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• v.9 no.6
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• pp.153-159
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• 2009

In order to estimate release water from reservoirs located on ungaged watersheds, an algorithm was suggested based on hydrologic reservoir routing and real time calibrating watershed parameters. A prototype - simple computer program was developed to implement the algorithm with Genetic Algorithm technic. The program was applied to a mid-size reservoir and its ungauged watershed area using observed rainfall data, spillway gates operation data and reservoir water stage time series data under a existing storm event. The result shows that the algorithm and the prototype would be useful to simulate released water from reservoirs.