• 한국강구조학회 논문집
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• 제16권2호통권69호
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• pp.201-213
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• 2004

본 논문에서는 유전자 알고리즘과 보-기둥 접합부, 부재, 그리고 구조물 전체의 재료 및 기하학적 비선형 거동을 고려할 수 있는 개선소성힌지해석 방법을 접목시킨 평면 반강접 강골조 구조물의 최적설계법을 제안하였다. 개선소성힌지해석에서는 강골조 구조물의 기하학적 비선형성을 고려하기 위해 보-기둥 요소의 안정함수를 사용하였으며, 재료적 비선형성을 고려하기 위해 잔류응력, 소성힌지, 반강접 접합부 그리고 기하학적 불완전성 등에 의한 점진적인 강성감소모델을 사용하였다. 최적설계시 마이크로 유전자 알고리즘과 재생산을 위한 개체 선택 도구로 토너먼트 선택방법을 사용하였으며, 적합도 함수는 목적함수 및 벌칙함수로 나타낸 무제약 함수값의 조합으로 구성하였다. 목적함수로는 구조물의 중량을, 제약조건으로는 하중-저항능력, 사용성, 연성도, 그리고 시공성에 관한 기준을 사용하였다. 강접 및 반강접 접합부를 갖는 강골조 구조물의 최적설계결과의 비교를 통해 본 연구에서 제시한 방법의 적합성을 검증하였다.

• Asian-Australasian Journal of Animal Sciences
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• 제31권6호
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• pp.798-803
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• 2018

Objective: The objective of this study was to estimate the genetic parameters for milk ${\beta}$-hydroxybutyrate (BHBA), acetone (Ac), fat protein ratio (FPR), and energy balance (EB) using milk test day records and investigate the effect of early lactation FPR and EB on milk ketone body concentrations. Methods: Total 262,940 test-day records collected from Korea Animal Improvement Association during the period of 2012 to 2016 were used in this study. BHBA and Ac concentrations in milk were measured by Fourier transform infrared spectroscopy (FTIR). FPR values were obtained using test day records of fat and protein percentage. EB was calculated using previously developed equation based on parity, lactation week, and milk composition data. Genetic parameters were estimated by restricted maximum likelihood procedure based on repeatability model using Wombat program. Results: Elevated milk BHBA and Ac concentrations were observed during the early lactation under the negative energy balance. Milk FPR tends to decrease with the decreasing ketone body concentrations. Heritability estimates for milk BHBA, Ac, EB, and FPR ranged from 0.09 to 0.14, 0.23 to 0.31, 0.19 to 0.52, and 0.16 to 0.42 respectively at parity 1, 2, 3, and 4. The overall heritability for BHBA, Ac, EB and FPR were 0.29, 0.32, 0.58, and 0.38 respectively. A common pattern was observed in heritability of EB and FPR along with parities. Conclusion: FPR and EB can be suggested as potential predictors for risk of hyperketonemia. The heritability estimates of milk BHBA, Ac, EB, and FPR indicate that the selective breeding may contribute to maintaining the milk ketone bodies at optimum level during early lactation.

• 대한조선학회논문집
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• 제46권5호
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• pp.479-487
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• 2009

This paper describes the design of a full-spade twisted rudder section by using the genetic algorithm based on VLM(Vortex Lattice Method) and panel method. The developed propeller- rudder analysis program has been validated by comparing with experimental data. The developed code has been used for the design of a twisted full-spade rudder especially for finding out optimum section. The optimization has been firstly carried out by the genetic algorithm. The more detail variation of a rudder section has been also conducted by changing section profile in more detail to confirm the most optimum section profile. The developed new twisted rudder has been compared with existing twisted rudder by cavitation testing in the cavitation tunnel at MOERI. It is concluded that the developed twisted rudder has a lower cavity in comparison with existing twisted rudder. The verification of efficiency gain is expected to be carried out through self-propulsion tests in the near future.

• The Plant Pathology Journal
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• 제27권4호
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• pp.378-384
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• 2011

Tomato yellow leaf curl virus (TYLCV), a member of genus Begomovirus, was isolated in Korea in 2008. We sequenced and analyzed the DNA-A of 51 TYLCV isolates from Korea, and 13 of the TYLCV isolates were selected as type representatives of TYLCV from six Korean provinces. The 13 TYLCV isolates were classified into Korea Group 1 (KG1, nine isolates) and Korea Group 2 (KG2, four isolates) based on the results of phylogenetic analysis and genome size (2774 and 2781 nucleotides, respectively). A recombination detection program 3 (RDP3) revealed two recombinations between the TYLCV Korea isolates and other TYLCV isolates [Thailand (AF206674), Iran (AJ132711), and Israel (X76319)]. TYLCV Jeju isolate was characterized by two recombination events (E1 and E2) caused by the presence of E1 in ORF V1 and C3, which may seem to be the mutations of the high nucleotide transversion and transition rate. Collectively, our results suggest that the occurrence of nucleotide transversions and transitions in TYLCV DNA-A might have induced novel recombination events within the TYLCV Korea isolates.

• Biomolecules & Therapeutics
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• 제24권3호
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• pp.207-243
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• 2016

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social and communication impairments, as well as repetitive and restrictive behaviors. The phenotypic heterogeneity of ASD has made it overwhelmingly difficult to determine the exact etiology and pathophysiology underlying the core symptoms, which are often accompanied by comorbidities such as hyperactivity, seizures, and sensorimotor abnormalities. To our benefit, the advent of animal models has allowed us to assess and test diverse risk factors of ASD, both genetic and environmental, and measure their contribution to the manifestation of autistic symptoms. At a broader scale, rodent models have helped consolidate molecular pathways and unify the neurophysiological mechanisms underlying each one of the various etiologies. This approach will potentially enable the stratification of ASD into clinical, molecular, and neurophenotypic subgroups, further proving their translational utility. It is henceforth paramount to establish a common ground of mechanistic theories from complementing results in preclinical research. In this review, we cluster the ASD animal models into lesion and genetic models and further classify them based on the corresponding environmental, epigenetic and genetic factors. Finally, we summarize the symptoms and neuropathological highlights for each model and make critical comparisons that elucidate their clinical and neurobiological relevance.

• 한국산학기술학회논문지
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• 제9권1호
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• pp.221-227
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• 2008

시간제한을 가지는 차량경로문제는 배송 및 물류에서 가장 중요한 문제 중의 하나이다. 현실적으로 고객의 서비스를 위하여 정해진 시간 안에 출발해서 배송을 끝마쳐야 한다. 그러므로 본 연구는 개선된 유전자 알고리즘을 이용하여 차량의 용량 및 운행시간을 초과하지 않으면서 고객의 서비스를 제공해주며 비용을 최소화하는 목적이 있다. 그리고 본 연구에서 제안한 개선된 유전자 알고리즘을 이용하면 다른 휴리스틱 기법보다 더욱 효율적인 시간제한을 가지는 차량경로문제에서 훌륭한 해를 도출할 수 있다. 따라서 차량경로문제의 해를 도출할 수 있는 개선된 유전자 알고리즘을 이용한 GUI 방식의 컴퓨터 프로그램을 개발하고 표준문제를 통하여 비교한 결과 본 연구에서 개발된 프로그램이 매우 유용한 결과를 보였다.

• 한국정보과학회논문지:시스템및이론
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• 제27권2호
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• pp.135-148
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• 2000

본 논문에서는 유전 알고리즘을 이용하여 다중프로세서 시스템을 위한 선형 스케쥴링 알고리즘을 제안하였다. 일반적으로 유전 알고리즘은 초기세대를 임의로 생성하기 때문에, 문제에 적합하지 않은 개체들의 영향으로 긴 천이시간과 느린 수렴속도를 갖는다. 제안된 알고리즘은 프로세서간의 통신비용을 고려하며, 초기세대를 생성할 때 현재 노드를 기준으로 직접 후임노드만을 동일 프로세서에 할당함으로써 선형 스케쥴링을 하게 되고, 교배연산과 변이연산에서도 기준 노드의 직접 전임노드나 직접 후임노드의 결합을 변화시킴으로써 선형성을 유지하게 된다. 선형 스케쥴링은 비선형에 비해 프로그램의 병렬성을 최대한 활용할 수 있을 뿐 아니라, 코오스 그레인(coarse grain) 방향성 비순환 그래프(directed acyclic graph: DAG)에서 항상 우수한 스케쥴ㄹㅇ 결과를 생성한다. 본 논문의 목적은 유전 알고리즘의 실시간 사용 가능성에 중점을 두었으며, 시뮬레이션 결과 제안된 알고리즘은 대부분의 DAG에서 50세대 내의 빠른 수렴속도를 나타내었다.

• 한국작물학회지
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• 제51권2호
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• pp.163-168
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• 2006

Improvement of crop yield can be achieved through understanding genetic variation in reproductive characters and its impact on yield components. The present study was performed to evaluate genetic diversity for reproductive growth characters in exotic germplasm resources and to determine the relationships between developmental and growth periods with yield and yield components in soybean cultivar groups. For phenotypic evaluation such as reproductive and agronomic traits, a total of 80 indigenous and exotic soybean cultivars collected from four different geographical regions (China, Japan, Korea, and Vietnam) were grown from May to November of 2003 at the Seoul National University Farm, Suwon, Korea ($127^{\circ}02'E$ longitude, $37^{\circ}26'N$ latitude). Most of all the characters exhibited wide range of phenotypic variation, of which pod number, seed number, and plant yield showed greater range as compared to other characters. Korean cultivar groups showed greater diversity than the other cultivar groups in seven characters. Correlation analysis showed that days to flowering (DTF) and days to maturity (DTM) had close association with agronomic traits as well as yield and yield components. Both DTF and DTM had positive correlation with the other characters except one hundred seed weight. Stepwise multiple linear regression revealed that seed and pod number were identified as being significant for plant yield. The results in this study indicated wide variation in agronomic traits including DTF and DTM, suggesting the valuable genetic resources in a soybean breeding program.

• 한국어류학회지
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• 제20권3호
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• pp.156-162
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• 2008

넙치의 자원조성을 위해 인위적으로 생산된 넙치종묘를 방류함에 따라 이들 방류에 의해 그 지역에 서식하고 있는 자연집단에 미치는 영향을 파악하기 위하여 4개 지역 (YD, SC, GJ, WD)에서 어획된 넙치집단의 유전학적 구조와 다양성을 5개의 microsatellite DNA marker를 이용하여 조사하였다. 조사된 지역에서 방류넙치의 혼획율은 20.0~95.8%였다. 넙치집단의 평균 이형접합체(Ho)의 범위는 0.833~0.876이었으며, 지역집단별 평균대립유전자수는 YD 집단 15.0개, SC 집단 17.8개, GJ 집단 14.6개, WD 집단 12.4개였으며, 방류어의 혼획율이 20.0%이었던 SC 집단에서 높게 나타났고 방류어의 혼획율이 95.8%이었던 WD 집단에서 낮게 나타나 방류어의 혼획율이 높을수록 지역집단의 대립유전자의 수가 낮은 경향을 보였다. 집단간 유전학적 거리의 범위는 0.026~0.232로서 WD 집단과 GJ 집단간에서 가장 낮았고, SC-R 집단과 YD-W 집단간에서 가장 멀게 나타났다.

• Asian-Australasian Journal of Animal Sciences
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• 제28권1호
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• pp.25-36
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• 2015

The complex analysis of the pedigree records of Czech Landrace (CLA), Czech Large White-dam line (CLWd), Czech Large White-sire line (CLWs), Duroc (DC), and Pietrain (PN) was performed to determine trends of genetic diversity (GD), and to find the main sources of the GD loss. The total size of the pedigree was 132,365, 391,151, 32,913, 13,299, and 7,160 animals in CLA, CLWd, CLWs, DC, and PN, respectively. Animals born in the years 2011 through 2013 were assumed as the reference population. The average pedigree completeness index for one generation back was 95.9%, 97.4%, 91.2%, 89.8%, and 94.2% for appropriate breeds. Number of ancestors explaining 100% of gene pool was 186, 373, 125, 157, and 37 in CLA, CLWd, CLWs, DC, and PN, respectively. The relative proportion of inbred animals (58%, 58%, 54%, 47%, and 25%), the average inbreeding (2.7%, 1.4%, 2.5%, 3.6%, and 1.3%) and the average co-ancestry (3.1%, 1.6%, 3.3%, 4.2%, and 3.3%) were found over the past decade in analysed breeds. The expected inbreeding under random mating increased during the last 10 years in CLWs and PN and varied from 1.27% to 3.2%. The effective population size computed on the basis of inbreeding was 76, 74, 50, 35, and 83 in 2012 in CLA, CLWd, CLWs, DC, and PN, respectively. The shortest generation interval (1.45) was observed for CLWd in sire to son selection pathway. The longest generation interval obtained PN (1.95) in sire to daughter pathway. The average relative GD loss within last generation interval was 7.05%, 4.70%, 9.81%, 7.47%, and 10.46%, respectively. The relative proportion of GD loss due to genetic drift on total GD loss was 85.04%, 84.51%, 89.46%, 86.19%, and 83.68% in CLA, CLWd, CLWs, DC, and PN, respectively. All breeds were characterized by a high proportion of inbred animals, but the average inbreeding was low. The most vulnerable breeds to loss of GD are DC and PN. Therefore, a breeding program should be more oriented to prevent the increase of GD loss in these breeds.