• 한국경영과학회:학술대회논문집
• /
• 한국경영과학회 2008년도 추계학술대회 및 정기총회
• /
• pp.191-196
• /
• 2008

This paper presents an evolutionary algorithm for goal programming with preemptive priority. To do this, an evolutionary strategy is suggested which search for the solution satisfying the goals in the order of the priority. Two-sided assembly line balancing problems with multiple goals are used to validate the applicability of the algorithm. In the problems, three goals are considered in the following priority order: minimizing the number of mated-stations, achieving the goal level of workload smoothness, and maximizing the work relatedness. The proper evolutionary components such as encoding and decoding method, evaluation scheme, and genetic operators, which are specific to the problem being solved, are designed in order to improve the algorithm's performance. The computational result is reported.

• 대한약학회:학술대회논문집
• /
• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
• /
• pp.289.2-290
• /
• 2002

Choi group reported that Kamijadowhan (KMD). an oriental herbal medicine, has anti-angiogenic effects and it may be a potential agent for clinical chemoprevention since it inhibits angiogenesis. Objectives of this experiment are to investigate acute, genetic and reproductive/developmental toxicities of KMD preparations. Acute toxicity was performed after single administration of KMO (200-500 mg/kg) to mice. Supravital staining micronucleus assay was conducted using peripheral reticulocytes in mice. (omitted)

• 대한화장품학회:학술대회논문집
• /
• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
• /
• pp.630-644
• /
• 2003

A human Cu, Zn-superoxide dismutase (Cu, Zn-SOD) was fused with a Tat PTD of HIV-1 to produce a novel anti-aging ingredient, Tat-SOD for cosmeceuticals. Test of stability and evaluation of transduction efficacy and enzymatic activity suggest Tat-SOD is an effective active ingredient for anti-aging treatment.

• 한국지진공학회논문집
• /
• 제22권7호
• /
• pp.361-367
• /
• 2018

This study investigates the seismic performance of a hybrid seismic energy dissipation device composed of a viscoelastic damper and a steel slit damper connected in parallel. A moment-framed structure is designed without seismic load and is retrofitted with the hybrid dampers. The model structure is transformed into an equivalent simplified system to find out optimum story-wise damper distribution pattern using genetic algorithm. The effectiveness of the hybrid damper is investigated by fragility analysis of the structure with and without the dampers. The analysis results show that after seismic retrofit the probability of reaching damage states, especially the complete damage state, of the structure turn out to be significantly reduced.

• 대한지리학회지
• /
• 제41권5호
• /
• pp.623-629
• /
• 2006

현재 동해의 해저지형 가운데 한국대지, 쓰시마분지, 순요퇴 3개의 지 명 이 해저지명목록집(Gazetteer)에 등재되어 있다. 이들 지명은 지명등재의 근거가 전혀 기록되어 있지 않으며, 단지 국제해도(INT 511)에 표기되어 있는 명칭이 해저지명목록집에 기록된 것으로 추정된다. 그러나 이 중 쓰시마분지와 순요퇴는 수로학적 지질학적 근거나 지리적인 관련성이 부족하므로 지리적 성인적 측면에서 관계가 깊은 울릉분지와 이사부해산으로 명칭이 대체되어야 한다.

• 한국양식학회지
• /
• 제14권1호
• /
• pp.9-16
• /
• 2001

Characterization of a single pass of cDNA sequence, an expressed sequence tag (EST) has been a fast growing activity in fish genomics. Despite its relatively short history, fish EST databases (dbESTs) have already begun to play a significant role in bridging the gaps in our knowledge on the gene expression in fish genome. This review provides a brief description of the technology for establishing fish dbESTs, its current status, and implication of the ESTs to aquaculture and fisheries science with particular emphasis on the discovery of novel genes for transgenic application, the use of polymorphic EST markers in genetic linkage mapping and the evaluation of signal-responsive gene expression.

• Clinical and Experimental Pediatrics
• /
• 제51권9호
• /
• pp.935-943
• /
• 2008

Attention deficit hyperactivity disorder (ADHD) is a neurobehavioral developmental disorder characterized by a persistent pattern of inattention and/or hyperactivity, as well as forgetfulness, poor impulse control or impulsivity, and distractibility. The recommended evaluation includes documenting the type and severity of ADHD symptoms, verifying the presence of normal vision and hearing, screening for comorbid psychological conditions, reviewing the child's developmental history and school performance, and applying objective measures of cognitive function. Prevailing opinion characterizes ADHD as a disorder of executive function attributable to abnormal dopamine transmission in the frontal lobes and frontostriatal circuitry. A clearly defined etiology remains unknown, but studies suggest a strong genetic link. The aim of treatment is to decrease symptoms, enhance functionality, and improve well-being for the child and his or her close contacts. Stimulants remain the pharmacological agents of first choice for the management of ADHD, and psychosocial, behavioral and educational strategies that enhance specific behaviors may improve educational and social functioning in children with ADHD.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• 제11권sup1호
• /
• pp.44-54
• /
• 2008

Chronic functional constipation is a common problem in childhood, with soiling a significant issue. It presents a management problem for pediatrician, and parental concern is high. About 5% of pediatric patients is known to have constipation and/or encopresis which is the second most referred disease in pediatric gastroenterology clinic, accounting for up to 25% of all visits. The etiology of constipation was based on initiation factors including vicious cycle concept, genetic factors, psychological factors, dietary influences and histologic abnormalities of colon. Emphasis is placed on the evaluation and management options that are available to the treating pediatrician. Careful history taking is most important to diagnose functional constipation. In addition, diagnostic tests such as plain abdominal radiograph, colonic transit study, anorectal manometry, barium enema were helpful to diagnose the constipation. Childhood constipation can be very delicate to treat. It often requires prolonged supports by physicians and parents, demystification, medical treatment and especially with the child and parent's cooperation.

• Nuclear Medicine and Molecular Imaging
• /
• 제43권3호
• /
• pp.229-239
• /
• 2009

Molecular imaging strives to visualize processes in living subjects at the molecular level. Monitoring biochemical processes at this level will allow us to directly track biological processes and signaling events that lead to pathophysiological abnormalities, and help make personalized medicine a reality by allowing evaluation of therapeutic efficacies on an individual basis. Although most molecular imaging techniques emerged from the field of oncology, they have now gradually gained acceptance by the cardiovascular community. Hence, the availability of dedicated high-resolution small animal imaging systems and specific targeting imaging probes is now enhancing our understanding of cardiovascular diseases and expediting the development of newer therapies. Examples include imaging approaches to evaluate and track the progress of recent genetic and cellular therapies for treatment of myocardial ischemia. Other areas include in vivo monitoring of such key molecular processes as angiogenesis and apoptosis, Cardiovascular molecular imaging is already an important research tool in preclinical experiments. The challenge that lies ahead is to implement these techniques into the clinics so that they may help fulfill the promise of molecular therapies and personalized medicine, as well as to resolve disappointments and controversies surrounding the field.

• Advances in Computational Design
• /
• 제5권3호
• /
• pp.209-231
• /
• 2020

In order to evaluate the performance of three heuristic optimization algorithms, namely, simulated annealing (SA), genetic algorithm (GA) and particle swarm optimization (PSO) for optimal stacking sequence of laminated composite plates with respect to critical buckling load and non-dimensional natural frequencies, a multi-objective optimization procedure is developed using the weighted summation method. Classical lamination theory and first order shear deformation theory are employed for critical buckling load and natural frequency computations respectively. The analytical critical buckling load and finite element calculation schemes for natural frequencies are validated through the results obtained from literature. The comparative study takes into consideration solution and computational time parameters of the three algorithms in the statistical evaluation scheme. The results indicate that particle swarm optimization (PSO) considerably outperforms the remaining two methods for the special problem considered in the study.