Toxicological Evaluation of Oriental Herbal Medicine Kamijadowhan Preparations

  • Park, Young-Jin (Toxicology Lab., Korea Institute of Science and Technology, Seoul 136-791) ;
  • Ryu, Jae-Chun (Toxicology Lab., Korea Institute of Science and Technology, Seoul 136-791) ;
  • Choi, Seung-Hun (Department of Pathology, College of Oriental Medicine, Kyung Hee Universit, seoul, 130-701) ;
  • Kwon, Oh-Seung (Toxicology Lab., Korea Institute of Science and Technology, Seoul 136-791)
  • Published : 2002.10.01

Abstract

Choi group reported that Kamijadowhan (KMD). an oriental herbal medicine, has anti-angiogenic effects and it may be a potential agent for clinical chemoprevention since it inhibits angiogenesis. Objectives of this experiment are to investigate acute, genetic and reproductive/developmental toxicities of KMD preparations. Acute toxicity was performed after single administration of KMO (200-500 mg/kg) to mice. Supravital staining micronucleus assay was conducted using peripheral reticulocytes in mice. (omitted)

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