• Genomics & Informatics
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• v.12 no.4
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• pp.289-292
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• 2014

Next-generation sequencing (NGS) is widely used to identify the causative mutations underlying diverse human diseases, including cancers, which can be useful for discovering the diagnostic and therapeutic targets. Currently, a number of single-nucleotide variant (SNV)-calling algorithms are available; however, there is no tool for visualizing the recurrent and phenotype-specific mutations for general researchers. In this study, in order to support defining the recurrent mutations or phenotype-specific mutations from NGS data of a group of cancers with diverse phenotypes, we aimed to develop a user-friendly tool, named mutation arranger for defining phenotype-related SNV (MAP). MAP is a user-friendly program with multiple functions that supports the determination of recurrent or phenotype-specific mutations and provides graphic illustration images to the users. Its operation environment, the Microsoft Windows environment, enables more researchers who cannot operate Linux to define clinically meaningful mutations with NGS data from cancer cohorts.

• KIEAE Journal
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• v.15 no.4
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• pp.85-90
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• 2015

Purpose: In design and planning Building Integrated Photovoltaic(BIPV) system can reduce cost by replacing building facade as construction material such as roofs, outer walls and windows as well as generating electricity. BIPV system should be applied at the early stage of architectural design. However, it is hard to decide whether using BIPV system or not for architects and builders who are not professional at BIPV system because performance of system is considerably influenced by types of module, installation position, installation methods and so on. It is also hard for experts because commercialized analytical program of photovoltaic systems is too complicated to use and domestic meteorological data is limited to partial areas. Therefore, we need evaluation program of BIPV system which can easily but accurately interpret generating performance and evaluate validity of BIPV system at the early stage of architectural design even for inexpert. Method: In this study, we collected meteorological data of domestic major region and analyzed generation characteristic of BIPV system by using PVsyst(commercialized software) in accordance with regions, types of solar module, place and methods of installation and so on. Based on this data, we developed performance evaluation program of BIPV system named BIPV-Pro, through multiple regression analysis and evaluated its validity. Result: When comparing predictive value of annual average PR and annual electricity production of BIPV-Pro an that of PVsyst, each of root mean square error was 0.01897 and 123.9.

• Journal of Institute of Control, Robotics and Systems
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• v.7 no.4
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• pp.334-343
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• 2001

Polishing a die that has free-form surfaces is a time-consuming and tedious job, and requires a considerable amount of high-precision skill. Some workers tend to gradually avoid the polishing work because of the poor environment caused by dust and noise. In order to reduce the polishing time and cope with the shortage of skilled workers, a user-friendly automatic polishing system was developed in this research. The polishing system with five degrees of freedom is able to keep the polishing tool normal to the die surface. The polishing system is controlled by a PC-NC controller. To easily operate the developed polishing robot system, this study developed an integrated program in the Windows environment. This program consists of four modules: the polishing module, the graphic simulator, the polishing data generation module, and the teaching module. Also, the automatic teaching system was developed to easily obtain teaching data and it consists of a three dimensional joystick and a proximity sensor. The joystick is used to simultaneously drive the polishing system to an arbitrary orientation and the proximity sensor is used to obtain teaching points precisely. Also, to evaluate the stability of the driving program and the teaching system, polishing experiments of a die of saddle shape were carried out.

• ETRI Journal
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• v.35 no.3
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• pp.431-438
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• 2013

This paper presents a new realization of the implicit root-mean-square (RMS) detector, employing three second-generation current conveyors and MOS transistors. The proposed circuit can be applied in measuring the RMS value of complex, periodic signals, represented in the form of the Fourier series. To verify the theoretical analysis, circuit Simulation Program with Integrated Circuit Emphasis simulations and experiment results are included, showing agreement with the theory.

• Journal of computational fluids engineering
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• v.20 no.2
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• pp.23-36
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• 2015

The $2^{nd}$ generation ice accretion analysis program has been developed and validated for various icing conditions. The essential feature of the $2^{nd}$ generation code lies in its capability of handling general 3-D geometry and improved accuracy. The entire velocity fields are obtained based on Navier-Stokes equations in order to take the massively separated flow field into account. Unlike $1^{st}$ generation code, the droplet trajectories are calculated using Eulerian approach, which is adopted to yield appropriate collection efficiency even in the shadow region. For improved thermodynamic analysis on the surfaces, water film model and modified Messinger model are newly included in the present analysis. The ice shape for a given time step is obtained by considering the exact amount of ice accreted on the surface. Each module of the icing analysis code has been seamlessly integrated on the OpenFOAM platform. The developed code was validated against available experimental data for 2D airfoils and 3D DLR-F4. Due to the lack of experimental data, the computed results of DLR-F4 were compared with those obtained from FENSAP-ICE, which is state-of-the-art 3D icing analysis code. It was clearly shown that the present code produces comparable results to those of FENSAP-ICE, in terms of prediction accuracy and the capability of handling general 3-D geometries.

• Bulletin of the Korean Chemical Society
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• v.26 no.5
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• pp.740-746
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• 2005

In this article, we report the tandem mass spectrometry investigations for the electron capture efficiencies of the protons belonging to the different locations (generations) in a poly(propylene imine) dendrimer with three layers of a repeat unit (named as the third generation dendrimer). The employed tandem mass spectrometry methods include SORI-CAD (sustained off-resonance irradiation collisional activation dissociation) and ECD(electron capture dissociation) mass spectrometry. We obtained SORI-CAD spectra for the dendrimer ions in the different charge states, ranging from 2+ to 4+. The analysis of fragmentation sites provides the information as to where the protons are distributed among various generations of the dendrimer. Based upon this, a new strategy to study the electron capture efficiencies of the protons is utilized to examine a new type of triplycharged ions by SORI-CAD, i.e., the 3+ ions generated from the charge reduction of the native 4+ ions by ECD: (M+4H)$^{4+}\;+\;e^-\;{\rightarrow}$ (M+4H)$^{3+\bullet}$ ${\rightarrow}\;({H^{\bullet}}_{ejected}$) + (M+3H)$^{3+}\;\rightarrow$ CAD. Interestingly, comparison of these four SORICAD spectra indicates that the proton distribution in the charge-reduced 3+ ions is very close to that in the native 4+ ions. It further suggests that in this synthetic polymer ($\sim$1.7 kDa) with an artificial architecture, the electron capture efficiencies of the protons are actually insensitive to where they are located in the molecule. This is somewhat contradictory to common expectations that the protons in the inner generations may not be well exposed to the incoming electron irradiation as much as the outer ones are, thus may be less efficient for electron capture. This finding may carry some implications for the case of medium sized peptide ions with similar masses, which are known to show no obvious site-specific fragmentations in ECD MS.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.28 no.12
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• pp.753-764
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• 2015

Among several types of energy saving smart window technologies, the leader, the dynamic EC (electrochromic) window one needs integrated PV (photovoltaics), to minimize expensive electrical wiring as well as to obviate the need for external energy. Self-powered smart windows were reviewed according to PV types used. DSSCs (dye sensitized solar cells) were found to be compatible with EC cells, to have several categories of next generation smart windows such as PECCs (photoelectrochromic cells), PVCCs (photovoltachromic cells), EC polymer PECCs. In addition silicon solar cells and third generation solar cells were investigated. They are summarized in a table showing their advantages and disadvantages respectively for a fast comparison. The strategy to expedite the commercialization of these next generation smart windows includes developing retrofit smart window coverings for use on flexible polymer substrates adhered to the inside surface of a window and easily replaced after use for upto 10 years.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2014.10a
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• pp.818-819
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• 2014

Recently there are many works conducted on utilizing the DIBR (Depth-Image-Based Rendering) based intermediate images for the three-dimensional displays that do not require the use of stereoscopic glasses. However the prior works have used expensive depth cameras to obtain high-resolution depth images since DIBR-based intermediate image generation method requires the accuracy for depth information. In this study, we have developed the simulation to generate multi-view intermediate images based on the depth and color images using Microsoft Kinect. This simulation aims to support the acquisition of multi-view intermediate images utilizing the low-resolution depth and color image from Kinect, and provides the integrated service for the quality evaluation of the intermediate images. This paper describes the architecture and the system implementation of this simulation program.

• KIEE International Transactions on Power Engineering
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• v.3A no.3
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• pp.139-147
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• 2003

The paper presents a novel approach of constructing the state matrix of the multi-machine power system for SSR (subsynchronous resonance) analysis using the linearized equations of individual devices including electrical transmission network dynamics. The machine models in the local d-q reference frame are integrated with the network models in the common R-I reference frame by simply transforming their output equations into the R-I frame where the transformed output is used as the input to the network dynamics or vice versa. The salient feature of the formulation is that it allows for modular construction of various component models without rearranging the overall state space formulation. This universal SSR small signal stability program provides a flexible tool for systematic analyses of SSR small-signal stability impacts of both conventional devices such as generation systems and novel devices such as power electronic apparatus and their controllers. The paper also presents its application results to IEEE benchmark models.

• KIEE International Transactions on Power Engineering
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• v.5A no.4
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• pp.416-424
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• 2005

At present, the Korean electricity industry is undergoing restructuring and the Cost Based-generation Pool (CBP) market is being operated in preparation of a Two Way Bidding Pool (TWBP) market. In deregulated electricity industries, an integrated power market simulator is one of the tools that can be used by market participants and market operators analyzing market behaviors and studying market structures and market codes. In this regard, it is very important to develop an electricity market simulator that reflects market code providing a market operation mechanism. This paper presents the development of an integrated market simulator, called the Power Exchange Simulator (PEXSIM), which is designed to imitate the Korean electricity market considering the various features of the market operating mechanism such as uniform price and constrained on/off payment. The PEXSIM is developed in VB.NET and composed of five modules whose titles are M-SIM, P-SIM, O-SIM, T-SIM and G-SIM interfacing the Access database program. To verify the features and the performance of the PEXSIM, a small Two Way bidding market with a 12-bus system and a One Way bidding market for generator competition will be presented for the electricity market simulations using PEXSIM.