• Journal of the Korean Society of Food Science and Nutrition
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• v.44 no.6
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• pp.800-808
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• 2015

In this study, gastritis inhibitory substance was ethanol-extracted from Saururus chinensis in order to examine the effect as a part of natural bioactive substance research. In an oral administration experiment, S. chinensis was administered at doses of 0.25 g/kg B.W. to 2 g/kg B.W., resulting in stabilization at 1.5 g/kg B.W. and an $LD_{50}$ of 1.81 g/kg B.W. In a chronic toxicity experiment, 0.5 g/kg B.W. of S. chinensis was administered for 13 weeks, but toxicity was not observed. S. chinensis ethanol-extracts were administered at a concentration of 250 or 500 mg/kg B.W. before induction of gastritis. Gastrorrhagia, stomach edema, cytokine production, and cell damage were reduced in a concentration-dependent manner. Therefore, S. chinensis ethanol extracts inhibit cell damage by stress-induced hemorrhagic gastritis in a concentration-dependent manner via inhibition of cytokine expression.

• Herbal Formula Science
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• v.27 no.3
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• pp.213-221
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• 2019

Objectives : The purpose of this study is to confirm the efficacy and safety of the treatment of gastritis with 'Hwangryunhaedok-tang'. Methods : Total 20 people, between 19 and 65 years old, will be recruited to participate in a comparative clinical trial. All subjects will take 2 capsules of Hwangryunhaedok-tang (Redoxin Cap.), 3 times a day, 30 minutes after meals, for 8 weeks. Outcomes will be measured at the baseline, 4th week, and 8th week. Primary outcomes is the improvement rates of gastritis symptoms, such as heartburn, nausea/vomiting, abdominal bloating, anorexia, heartburn, and trim. Results : This trial was approved by institutional review board of Pusan National University Korean Medicine Hospital (registry number: 2018011), and registered in Clinical Research information Service, one of WHO. Recruitment opened in April 2019 and is supposed to be completed by December 2019. Conclusions : This trial will provide clinical information to determine the efficacy and safety of treatment of gastritis with 'Hwangryunhaedok-tang'.

• The Journal of Internal Korean Medicine
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• v.43 no.5
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• pp.854-863
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• 2022

Objectives: The purpose of this study is to report the efficacy of applying Korean medical treatment to chronic gastritis. Methods: We treated a chronic gastritis patient with Korean medical treatments (herbal medicines, acupuncture, and herbal acupuncture therapy). To evaluate the results of this treatment, we took measurements using the Gastrointestinal Symptom Rating Scale and Visual Analogue Scale for abdominal pain, heartburn, nausea, and abdominal distension. The patient's generic health status was evaluated using the European Quality of Life 5 Dimensions Scale. Results: Improvements in gastrointestinal symptom ratings and the European Quality of Life 5 Dimensions Scale were observed after the treatments. Relief of symptoms was observed in abdominal pain, heartburn, nausea, vomiting, and abdominal distension using the Visual Analogue Scale. Conclusions: This study suggests that Korean medicine may be effective in the treatment of chronic gastritis.

• The Journal of Dong Guk Oriental Medicine
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• v.2 no.1
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• pp.127-137
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• 1993

In order to investigate the clinical efficiency based on Oriental Medical References of Hyang-Sa-Yuk-Gun-Ja-Tang and Oh-Pe-San, histological studies have been done by using the experimental animal. The following results were obtained. 1. The Hyang-Sa-Yuk-Gun-Ja-Tang showed a significant promoting effect of repair on the epithelial layer from the basement membrane of duodenal ulcer in rats. 2. The Oh-Pe-San showed efficiencies about repair of the necrosis in epithelial layer on the acute gastritis in rats. According to above results, it is concluded that Oh-Pe-San and Hyang-Sa-Yuk-Gun-Ja-Tang were recognized to be effective on the acute gastritis and the duodenal ulcer in rats, and this study may suggest a clinical guidance to the prescriptions for the treatment of gastritis end gastric ulcer.

• Journal of Veterinary Clinics
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• v.19 no.3
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• pp.375-378
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• 2002

A 3-year-old intact female korean pungsan dog showing chronic intermittent vomiting and anorexia was admitted to The Veterinary Medical leaching Hospital of Seoul National University. The patient had been received antiemetics, antacids or proton pump inhibitor for these symptoms but had not been recovered yet. All results of physical examination, complete blood count, serum chemical analysis, fecal test and radiography were normal. Gastric endoscopic examination was also performed and gastritis with hemorrhage on near antrum region was detected. In PCR assay of bioptic gastric tissues for detecting Helicobacter species infection, Helicobacter heilmannii infection was confirmed. After receiving triple therapy with amoxicillin, metronidazole and omeprazole for 21 days, all symptoms were recovered and had not been occurred again. Helicobacter heilmannii also were not detected.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.265.2-265.2
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• 2002

It is well known that flavonoids are the inhibitory effects on inflammations. This study was designed to determine the anti-inflammatory effects of luteolin-7-O-${\beta}$D-glucuronopyranoside (LGC). newly synthesized flavonoids. which was extracted from Salix gilgiana leaves. We investigated the protective action of LGC on reflux esophagitis and gastritis in rats. Esophagitis and gastritis were induced by surgical procedures and the exposure to indomethacin (50 mg/kg), respectively. LGC was injected intraduodenally immediately after the surgical procedures and the exposure to indomethacin (omitted)

• Journal of Food Hygiene and Safety
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• v.32 no.6
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• pp.536-541
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• 2017

The object of this study was to investigate the inhibitory effects of Litsea japonica fruit flesh extract (LJF-HE) on gastritis of an stress-induced SD rat model. Rats were randomly divided into six groups: Normal (normal group), Control (stress-induced gastritis), Ranitidine (stress-induced gastritis and ranitidine 50 mg/kg), LJF-HE-L (stress-induced gastritis pretreated with L. japonica fruit flesh extract at 30 mg/kg), LJF-HE-M (stress-induced gastritis pretreated with L. japonica fruit flesh extract at 60 mg/kg), LJF-HE-H (stress-induced gastritis pretreated with L. japonica fruit flesh extract at 120 mg/kg). In groups treated with LJF-HE, gastric mucosal damage and pepsin activity were reduced. Additionally, there were decreases in the expression of cholecystokinin 2 receptor (CCK-2r) in the gastric lesions. The plasma levels of IL-$1{\beta}$ slightly but significantly decreased in LJF-HE treated groups compared to control. The plasma level of PGE2 was also significantly increased in LJF-HE treated groups. These results suggest that LJF-HE has the ability to reduce of the severity stress-induced gastritis.

• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.1
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• pp.185-194
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• 2014

One in every 10 persons suffer from chronic gastritis in Korea. Endoscopy is most commonly used to diagnose the chronic gastritis. Endoscopic diagnosis is precise but it is accompanied with pain and high cost. According to pulse diagnosis in Traditional East Asian Medicine, health problems in stomach can be diagnosed with radial pulse signals in 'Guan' location in the right wrist, which are non-invasive and cost-effective. In this study, we developed a classification model of chronic gastritis using pulse signals in right 'Guan' location. We used both linear discrimination method and logistic regression model with respect to pulse features obtained with a peak-valley detection algorithm and a Gaussian model. As a result, we obtained sensitivity ranged between 77%~89% and specificity ranged between 72%~83% depending on classification models and feature extraction methods, and the average classification rates were approximately 80%, irrespective of the models. Specifically, the Gaussian model were featured by superior sensitivities (89.1% and 87.5%) while the peak-valley detection method showed superior specificities (82.8% and 81.3%), and the average classification rate (sensitivity + specificity) of the Gaussian model was 80.9% which was 1.2% ahead of the peak-valley method. In conclusion, we obtained a reliable classification model for the chronic gastritis based on the radial pulse feature extraction algorithms, where the Gaussian model was featured by outperformed sensitivity and the peak-valley method was featured by outperformed specificity.

• The Korean Journal of Physiology and Pharmacology
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• v.17 no.5
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• pp.469-477
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• 2013

This study investigated effect of extract containing quercetin-3-O-${\beta}$-D-glucuronopyranoside from Rumex Aquaticus Herba (ECQ) against chronic gastritis in rats. To produce chronic gastritis, the animals received a daily intra-gastric administration of 0.1 ml of 0.15% iodoacetamide (IA) solution for 7 days. Daily exposure of the gastric mucosa to IA induced both gastric lesions and significant reductions of body weight and food and water intake. These reductions recovered with treatment with ECQ for 7 days. ECQ significantly inhibited the elevation of the malondialdehyde levels and myeloperoxidase activity, which were used as indices of lipid peroxidation and neutrophil infiltration. ECQ recovered the level of glutathione, activity of superoxide dismutase (SOD), and expression of SOD-2. The increased levels of total NO concentration and iNOS expression in the IA-induced chronic gastritis were significantly reduced by treatment with ECQ. These results suggest that the ECQ has a therapeutic effect on chronic gastritis in rats by inhibitory actions on neutrophil infiltration, lipid peroxidation and various steps of reactive oxygen species (ROS) generation.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.4
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• pp.1769-1776
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• 2012

The purpose of this study is to evaluate the gastric mucosal damage effect by Hericium erinaceus cultibated with Artemisia capillaris (HEAC) with 0.15 M HCl in ethanol in rats. Among them, 80% ethanol extract showed potent inhibitory effect (67.7%) on gastritis. Using solvent fractionation, 80% ethanol extract of HEAC was separated into five fractions with $n$-hexane, methylene chloride, ethyl acetate, $n$-butanol and water. As a result, fractions obtained with methylene chloride exhibited strong inhibitory effects on gastritis. With this result, the methylene chloride extract was analyzed by GC/MS, HPLC, IR and NMR($^1H$, $^{13}C$) to identify primary active components and the main component in the extract was identified as ethyl linoleate. The effective does ($ED_{50}$) values of 80% ethanol extract of HEAC and ethyl linoleate showed 22.6 and 6.4 mg/kg, respectively and these values were higher than those of stillen (44.2 mg/kg) and selbex (46.5 mg/kg). Therefore, the administration of 80% ethanol extract of HEAC and ethyl linoleate have a strong protective effect agasint the gastritis induced by HCl-ethanol and may be promising new drug for treating gastritis and gastric ulcer.