• Title/Summary/Keyword: Gamma Index

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Anti-encephalomyocarditis Virus Activity of Water Soluble Substance from Elfvingia applanata Alone and in Combinations with Interferons (Elfvingia applanata 수용성 물질의 항엔세파로미오카디티스 바이러스작용과 인터페론과의 병용효과)

  • 김준희;어성국;김영소;한성순
    • YAKHAK HOEJI
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    • v.43 no.4
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    • pp.464-468
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    • 1999
  • In order to find less toxic antiviral agents from basidiomycetes, EA, the water soluble substance, was isolated from the carpophores of Elfvingia applanata (Pers.) Karst. Anti-encephalomyocarditis (EMC) virus activity of EA was examined in Vero cells by plaque reduction assay in vitro. And the combined antiviral effects of EA with interferon (IFN) alpha and gamma were examined on the multiplication of EMC virus. EA exhibited a concentration-dependent reduction in the plaque formation of EMC virus with 50% effective concentration ($EC_{50}$) of 2.12 mg/ml. The results of combination assay were evaluated by the combination index (CI) that was analysed by the multiple drug effect analysis. The combination of EA with IFN alpha showed potent synergism with CI values of 0.40~0.60 for 50%, 70% and 90% effective levels, but that with IFN gamma showed antagonism with CI values of 2.16~2.83.

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Anti-influenza Virus Activity of Water Soluble Substance from Elfvingia applanata Alone and in Combinations with Interferons (잔나비걸상버섯 수용성물질의 항인플루엔자바이러스 작용과 인터페론과의 병용효과)

  • 정선식;어성국;김영소;한성순
    • YAKHAK HOEJI
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    • v.43 no.4
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    • pp.469-473
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    • 1999
  • EA, the water soluble substance, was prepared from the carpophores of Elfvingia applanata (Pers). Karst. Anti-influenza A virus (anti-Flu A) activity of EA was examined of Vero cells by plaque reduction assay in vitro. And the combined antiviral effects fo EA with interferon (IFN) alpha and gamma were examined on the multiplication of Flu A with 50% effective concentration ($EC_50$) of 1.50 mg/ml. The results of combination assay were evaluated by the combination index (CI) that was analysed by the multiple drug effect analysis. The combination of EA with IFN alpha on Flu A showed more potent synergism with CI values of 0.50~0.52 of 50%, 70%, 90% effective levels than that with IFN gamma with CI values of 0.82~0.99.

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Application of Quantitative Indices for Urban Environment Analysis in the Consideration of Remote Sensed Imagery: Accessibility and Connectivity

  • Lee, Ki-Won;Oh, Se-Kyung
    • Proceedings of the KSRS Conference
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    • 2003.11a
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    • pp.228-230
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    • 2003
  • In this study, uses of remote sensed imagery in urban environment analysis are represented with the actual processed results with newly implemented programs running under ESRI ArcView-GIS to extract secondary information about mainly urban transportation environment. Implemented programs are about Accessibility index and Connectivity index. Accessibility index and Connectivity index are composed of four types of different algorithms and three types of algorithms such as alpha, gamma, and shimmel index. As show applied examples, tried to find out how remotely sensed imageries can be effectively utilized at actual processing in the direct or indirect ways in these algorithms.

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The Effect of MLC Leaf Motion Constraints on Plan Quality and Delivery Accuracy in VMAT (체적조절호형방사선치료 시 갠트리 회전과 다엽콜리메이터의 이동 속도에 따른 선량분포 평가)

  • Kim, Yon-Lae;Chung, Jin-Beom;Lee, Jeong-woo;Shin, Young-Joo;Kang, Dong-Jin;Jung, Jae-Yong
    • Journal of radiological science and technology
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    • v.42 no.3
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    • pp.217-222
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    • 2019
  • The purpose of this study is to evaluate the dose distribution by gantry rotation and MLC moving speed on treatment planning system(TPS) and linear accelerator. The dose analyzer phantom(Delta 4) was scanned by CT simulator for treatment planning. The planning target volumes(PTVs) of prostate and pancreas was prescribed 6,500 cGy, 5,000 cGy on VMAT(Volumetric Modulated Arc Therapy) by TPS while MLC speed changed. The analyzer phantom was irradiated linear accelerator using by planned parameters. Dose distribution of PTVs were evaluated by the homogeneity index, conformity index, dose volume histogram of organ at risk(rectum, bladder, spinal cord, kidney). And irradiated dose analysis were evaluated dose distribution and conformity by gamma index. The PTV dose of pancreas was 4,993 cGy during 0.1 cm/deg leaf and gantry that was the most closest prescribed dose(5,000 cGy). The dose of spinal cord, left kidney, and right kidney were accessed the lowest during 0.1 cm/deg, 1.5 cm/deg, 0.3 cm/deg. The PTV dose of prostate was 6,466 cGy during 0.1 cm/deg leaf and gantry that was the most closest prescribed dose(6,500 cGy). The dose of bladder and rectum were accessed the lowest during 0.3 cm/deg, 2.0 cm/deg. For gamma index, pancreas and prostate were analyzed the lowest error 100% at 0.8, 1.0 cm/deg and 99.6% at 0.3, 0.5 cm/deg. We should used the optimal leaf speed according to the gantry rotation if the treatment cases are performed VMAT.

Bayesian reliability estimation in a stress-strength system

  • Chang, In-Hong;Oh, Soo-Jin
    • Journal of Applied Reliability
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    • v.11 no.2
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    • pp.151-165
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    • 2011
  • We consider the problem of estimating the system reliability using noninformative priors when both stress and strength follow generalized gamma distributions with index, scale, and shape parameters. We first derive group-ordering reference priors using the reparametrization. We next provide the sufficient condition for propriety of posterior distributions and provide marginal posterior distributions under those noninformative priors. Finally, we provide and compare estimated values of the system reliability based on the simulated values of parameter of interest in some special cases.

Reliability Calculation of Power Generation Systems Using Generalized Expansion

  • Kim, Jin-O
    • Journal of Electrical Engineering and information Science
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    • v.2 no.6
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    • pp.123-130
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    • 1997
  • This paper presents a generalized expansion method for calculating reliability index in power generation systems. This generalized expansion with a gamma distribution is a very useful tool for the approximation of capacity outage probability distribution of generation system. The well-known Gram-Charlier expansion and Legendre series are also studied in this paper to be compared with this generalized expansion using a sample system IEEE-RTS(Reliability Test System). The results show that the generalized expansion with a composite of gamma distributions is more accurate and stable than Gram-Charlier expansion and Legendre series as addition of the terms to be expanded.

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Clinical Analysis of Inverse Planning for Radiosurgery ; Gamma Knife Treatment Plan Study (방사선 수술 역방향 치료계획 유용성 평가)

  • Jin, Seong Jin;Je, Jae Yong;Park, Cheol Woo
    • Journal of the Korean Society of Radiology
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    • v.9 no.6
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    • pp.343-348
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    • 2015
  • The purpose of this study is a comparison of forward planning(FP) and inverse planning(IP) of a radiosurgery procedure. 10 patients of acoustic schwannoma MR image were used for treatment plan. FP-1,2 and IP were established under the same condition. FP and IP were compared by number of shot, conformity index(CI), paddic conformity index(PCI), gradiant index(GI) and treatment time. On average the treatment plan produced by IP tool provided an improved or similar CI, PCI, GI and reduced treatment time as compared to the FP (CI;FP-1:0.85, FP-2:0.86, IP:0.94, PCI;FP-1:0.79, FP-2:0.81, IP:0.78, GI;FP-1:2.94, FP-2:2.94, IP:3.01). The inverse planning system provides a clinically useful plan while reducing the planning time and treatment time.

Small Target Detection Method under Complex FLIR Imagery (복잡한 FLIR 영상에서의 소형 표적 탐지 기법)

  • Lee, Seung-Ik;Kim, Ju-Young;Kim, Ki-Hong;Koo, Bon-Ho
    • Journal of Korea Multimedia Society
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    • v.10 no.4
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    • pp.432-440
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    • 2007
  • In this paper, we propose a small target detection algorithm for FLIR image with complex background. First, we compute the motion information of target from the difference between the current frame and the created background image. However, the slow speed of target cause that it has the very low gray level value in the difference image. To improve the gray level value, we perform the local gamma correction for difference image. So, the detection index is computed by using statistical characteristics in the improved image and then we chose the lowest detection index a true target. Experimental results show that the proposed method has significantly the good detection performance.

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Studies on the Stability of Catapol Components, and Genotoxic Safety of ${\gamma}-Irradiated$ Rehmanniae Radix crude (감마선 조사(照射) 생지황(生地黃)의 Catapol 성분에 대한 안전성 및 유전독성학적 연구)

  • Choi, Ho-Young;Cho, Jung-Hee;Ahn, Duk-Kyun;Yook, Chang-Soo;Byun, Myung-Woo;Lee, Ju-Woon;Im, Moo-Hyeog;Kim, Do-Hoon;Kim, Jong-Wook
    • Korean Journal of Pharmacognosy
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    • v.36 no.2 s.141
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    • pp.75-80
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    • 2005
  • This study is concerning to identify the hygienic problems occurring in processing, storage, and distribution of Rehmanniae radix crude, and to investigate the possibility of application of safe and hygienic ${\gamma}-irradiation$ techniques. The results are as follows. To compare the contents of catapol, index compound of Rehmanniae Radix crude, between before and after ${\gamma}-irradiated$,0,2.5,5,7.5,10,12.5,15,20, and 30 kGy of ${\gamma}-irradiation$ was applied to standard catapol and Rehmanniae radix crude. The contents of catapol in standard material and Rehmanniae radix crude were decreased with the increase of ${\gamma}-irradiation$ level. However, active components of Rehmanniae Radix crude were not changed with ${\gamma}-irradiation$. These results indicate that active components of Rehmanniae Radix crude were preserved after ${\gamma}-irradiation$ and those of Rehmanniae Radix crude did not showed significant change after irradiation of ${\gamma}-ray$ up to 20 kGy.

A Method to Calculate a Pass Rate of the ${\gamma}$-index Analysis in Tomotherapy Delivery Quality Assurance (DQA) (단층치료기를 이용한 방사선 치료의 환자별 정도관리 평가를 위한 감마인덱스의 정량화 방법)

  • Park, Dahl;Kim, Yong-Ho;Kim, Won-Taek;Kim, Dong-Won;Kim, Dong-Hyun;Jeon, Ho-Sang;Nam, Ji-Ho;Lim, Sang-Wook
    • Progress in Medical Physics
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    • v.21 no.4
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    • pp.340-347
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    • 2010
  • DQA, a patient specific quality assurance in tomotherapy, is usually performed using an ion chamber and a film. The result of DQA is analysed with the treatment planning system called Tomo Planning Station (TomoPS). The two-dimensional dose distribution of film measurement is compared with the dose distribution calculated by TomoPS using the ${\gamma}$-index analysis. In ${\gamma}$-index analysis, the criteria such as 3%/3 mm is used and we verify that whether the rate of number of points which pass the criteria (pass rate) is within tolerance. TomoPS does not provide any quantitative information regarding the pass rate. In this work, a method to get the pass rate of the ${\gamma}$-index analysis was suggested and a software PassRT which calculates the pass rate was developed. The results of patient specific QA of the intensity modulated radiation therapy measured with I'mRT MatriXX (IBA Dosimetry, Germany) and DQA of tomotherapy measured with film were used to verify the proposed method. The pass rate was calculated using PassRT and compared with the pass rate calculated by OmniPro I'mRT (IBA Dosimetry, Germany). The average difference between the two pass rates was 0.00% for the MatriXX measurement. The standard deviation and the maximum difference were 0.02% and 0.02%, respectively. For the film measurement, average difference, standard deviation and maximum difference were 0.00%, 0.02% and 0.02%, respectively. For regions of interest smaller than $24.3{\times}16.6cm^2$ the proposed method can be used to calculate the pass rate of the gamma index analysis to one decimal place and will be helpful for the more accurate DQA in tomotherapy.