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Studies on the Stability of Catapol Components, and Genotoxic Safety of ${\gamma}-Irradiated$ Rehmanniae Radix crude  

Choi, Ho-Young (Kyung Hee University)
Cho, Jung-Hee (Korea Food & Drug Administration)
Ahn, Duk-Kyun (Jaseng Research Institute of Bioscience)
Yook, Chang-Soo (Kyung Hee University)
Byun, Myung-Woo (Korea Atimic Energy Research Institute)
Lee, Ju-Woon (Korea Atimic Energy Research Institute)
Im, Moo-Hyeog (Korea Food & Drug Administration)
Kim, Do-Hoon (Korea Food & Drug Administration)
Kim, Jong-Wook (Korea Food & Drug Administration)
Publication Information
Korean Journal of Pharmacognosy / v.36, no.2, 2005 , pp. 75-80 More about this Journal
Abstract
This study is concerning to identify the hygienic problems occurring in processing, storage, and distribution of Rehmanniae radix crude, and to investigate the possibility of application of safe and hygienic ${\gamma}-irradiation$ techniques. The results are as follows. To compare the contents of catapol, index compound of Rehmanniae Radix crude, between before and after ${\gamma}-irradiated$,0,2.5,5,7.5,10,12.5,15,20, and 30 kGy of ${\gamma}-irradiation$ was applied to standard catapol and Rehmanniae radix crude. The contents of catapol in standard material and Rehmanniae radix crude were decreased with the increase of ${\gamma}-irradiation$ level. However, active components of Rehmanniae Radix crude were not changed with ${\gamma}-irradiation$. These results indicate that active components of Rehmanniae Radix crude were preserved after ${\gamma}-irradiation$ and those of Rehmanniae Radix crude did not showed significant change after irradiation of ${\gamma}-ray$ up to 20 kGy.
Keywords
Rehmanniae Radix crude; ${\gamma}-irradiation$; catapol; kGy;
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