• 대한한방부인과학회지
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• 제26권2호
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• pp.104-119
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• 2013

Purpose: The purpose of this study is to recognize menstrual pattern, stress, digestive disorder of female college students who have oligomenorrhea and effects of Gamiguibi-tang. Methods: We researched 30 female students who responded to have menstrual irregulation at ${\bigcirc}{\bigcirc}$ college by questionnaires investigating their menstruation, stress, digestive disorder, and changes of symptoms before and after taking Gamiguibi-tang. Results: 1. There was statistical correlation between menstrual pattern and Qi-Stasis Questionnaire symptoms. 2. There was statistical correlation between menstrual pattern and digestive disorder symptoms. 3. There was statistical correlation between improvement of Qi-Stasis Questionnaire symptoms and usage of Gamiguibi-tang. 4. There was statistical correlation between improvement of digestive disorder symptoms and usage of Gamiguibi-tang. Conclusions: This study showed the stress and digestive disorder symptoms are effectively relieved by Gamiguibi-tang. By this result we expect that Gamiguibi-tang can be used for oligomenorrhea caused by stress or digestive disorder.

• 대한한방내과학회지
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• 제37권5호
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• pp.822-830
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• 2016

Objective: To report the effect of Gamiguibi-tang (加味歸脾湯) as a treatment for insomnia. Methods: An insomnia patient who scored 27 points for her insomnia severity index was enrolled in this study. She received oriental treatment with herbal medication (Gamiguibi-tang), acupuncture, and moxibustion for 1 month. Results: After treatment, sleep duration and sleep quality were improved. After the patient had taken Gamiguibi-tang, her score for the Pittsburgh Sleep Quality Index (PSQI) decreased from 21 to 9, and associated symptoms were also improved without taking sleeping pills. Conclusions: Gamiguibi-tang is effective for the treatment of insomnia. More clinical data and studies are required in patients suffering from insomnia.

• 동의신경정신과학회지
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• 제20권4호
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• pp.1-13
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• 2009

Objectives : As depression falls into the category of Wuljeung, Gamiguibi-Tang(Jiaweiguipitang) is the standard prescription to cure Wuljeung. This study develops a questionnaire for building the guidelines to administer Gamiguibi-Tang to depression and evaluates reliability and validity of questionnaire. Methods : With extracting the text related to depression and Gamiguibi-Tang through total 9 Korean medicine books and consulting the experts, the study selected 80 items and converted them into a questionnaire. It surveyed the neuropsychiatry professors and the medical specialists three times by Delphi method, and lastly selected 21 final items of a questionnaire. On the basis of the questionnaire, it collected total 216 samples and tested their reliability and validity. Results : 21 items all didn't reduce total Cronbach alpha coefficient and satisfied test-retest reliability. As a result of factor analysis, totally 5 factors were extracted such as mental state, sleep, accompaniment, fatigue and weakness. Finally, in comparing a depression group with a normal control group, two groups all showed meaningful difference in each 21 items' point, the sum of factor 1 to 5 items' points, and the sum of 21 items' points. Conclusions : The questionnaire on the updated depression prescription guideline of Gamiguibi-Tang satisfied both of reliability and validity. Later it can help objectifying to apply Gamiguibi-Tang to depression cure.

• 대한한방내과학회지
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• 제38권5호
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• pp.698-708
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• 2017

Objectives: The aim of this study was to report the clinical effects of a combination of Gamiguibi-tang and sweet bee venom on a patient with Raynaud's disease. Methods: The patient with Raynaud's disease was treated with Gamiguibi-tang three times a day for 43 days and with sweet bee venom daily. The effects on Raynaud's disease were measured on both hands using a cold stress test and an infrared thermometer and by digital infrared thermographic imaging and a NRS (Numeric Rating Scale). We conducted the cold stress test at 6-8 day intervals from 2016.04.27 to 2016.06.08. Results: After treatment, the symptoms of pain were decreased in both hands and digital infrared thermographic imaging (DITI) confirmed a rise in the temperature of the fingers. The fingertip temperature increased from 29.6 to 30.4 degrees and the cooling/rewarming ratio (CRR) increased steadily. No adverse events were found at discharge. Conclusions: Gamiguibi-tang combined sweet bee venom may improve symptoms in patients with Raynaud's disease.

• 동의신경정신과학회지
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• 제21권1호
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• pp.1-11
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• 2010

Objectives: This study was perfomed to investigate the antioxidant activity and serotonin activity of Gami-guibi-tang on P815 Mast Cell. Methods: The effects of Gami-guibi-tang on activation of TPH-1 mRNA and AAADC mRNA in P815 mast cell were investigated. The effect of Gami-guibi-tang on content of serotonin in P815 mast cell was investigated. The effects of Gami-guibi-tang on activation of DPPH radical scavenging and SOD in P815 mast cell were investigated. Results: 1. The Gami-guibi-tang increased SOD activity and DPPH radical scavenging activity. 2. The Gami-guibi-tang increased the intracellular concentration of serotoninin 60 ${\mu}g/ml$, 80 ${\mu}g/ml$ experiment group. 3. The Gami-guibi-tang increased menaingful the manifestation TPH mRNA. 4. The manifestation of AAADC and MAO mRNA have not made menaingful changes on Gami-guibi-tang. Conclusions: This experiment shows that Gami-guibi-tang had significant anti-oxidative effect. And Gami-guibi-tang increased the intracellular concentration of serotonin. Therefore, Gami-guibi-tang can be used by the medication of major depression disorder. But Study on mechanism of increased serotonin and clinical research of Gami-guibi-tang is suggested for future research.

• 동의생리병리학회지
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• 제32권5호
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• pp.333-340
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• 2018

Gamiguibi-tang (GGBT) is a traditional herbal medicine generally used to treat anemia, insomnia, anxiety, and nervousness. GGBT is being commercially produced in the form of extract granule and the quality control methods are specified in the Korean Herbal Pharmacopeia (KHP). However, there is no method to simultaneously analyze compound preparations. In this study, a HPLC method was developed and validated for the simultaneous determination of marker compounds in GGBT. And the contents of marker components and biological activities of the commercial GGBT extract granules (GGBT-2 and GGBT-3) were compared with those of the GGBT decoction (GGBT-1). We confirmed the robustness of simultaneous analytical method by monitoring the contents of the commercial GGBT products and carrying out validation. The marker components of GGBT were geniposide ($8.03{\sim}12.70{\mu}g/mL$), paeoniflorin ($2.79{\sim}4.25{\mu}g/mL$) and glycyrrhizic acid ($5.06{\sim}6.30{\mu}g/mL$). DPPH and ABTS radical scavenging activities were 47.34~63.17% and 21.52~33.61% in the GGBT products concentration of $1,000{\mu}g/mL$, respectively. The GGBT products significantly decreased NO, iNOS and COX-2 production in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages in a concentration-dependent manner. The GGBT-2 had higher contents of marker components and biological activities than GGBT-1 and GGBT-3. The research suggest that be used in developing quality control methods for enhancing the quality of herbal medicines.

• 대한한방내과학회지
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• 제39권5호
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• pp.886-894
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• 2018

Objective: Despite being the most common cause of cranial dystonia, Meige syndrome remains a rare clinical entity. It is characterized by blepharospasm and orofacial dystonia. This case study reports on the use of traditional Korean medicine for a patient who suffered from blepharospasm and oromandibular dystonia suspected to be the result of Meige syndrome. Methods: A patient was given a series of Korean medicine therapy treatments, including administration of the herbal medicine Gamiguibi-tang-gamibang, acupuncture, and cupping, over a 19 day hospitalization period. We measured the state and progress of this case using the numeric rating scale and dystonia frequency. Results: A decrease in subjective symptoms and reduction in the frequency of oromandibular dystonia was observed after Korean medicine therapy treatments. Conclusion: This case is useful for describing herbal medicine treatment for Meige syndrome, and further case reports and studies will be needed in the future.

• 동의신경정신과학회지
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• 제32권2호
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• pp.95-109
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• 2021

Objectives: The coronavirus disease 2019 (COVID-19) has become a global pandemic. Mental sequelae occurring in patients with COVID-19 and the general population are important concerns. In Korea, herbal medicine is used nationwide to respond to this pandemic. It can be prescribed by COVID-19 telemedicine center of Korean medicine (KM). Among some herbal medicines, Gamiguibi-tang is the only herbal medicine prescribed for individuals with mental health, especially for those with insomnia. In this mini-review, the objective of this study was to summarize the evidence of some promising herbal medicines available for treating primary insomnia based on existing clinical and preclinical studies. Methods: A research team was formed for KM clinical practice guidelines for insomnia (version 1.0). Team members were provided with a list of references of relevant herbal medicines for insomnia. To gather evidence from clinical studies with appropriate sample sizes, among the list of references, randomized controlled trials for primary insomnia that included 50 subjects or more per arm and used herbal medicine were included in the final analysis. Moreover, pre-clinical studies examining the mechanism of action of each herbal medicine and studies on herb-drug interactions, were searched and summarized. Results: Four herbal medicines (Ondam-tang, Sanjoin-tang, Guibi-tang, and Hyeolbuchugeo-tang) were reviewed based on existing clinical and preclinical studies. Based on findings of existing studies, some suggestions of herbal medicines for insomnia in the COVID-19 era in Korea were suggested. Conclusions: Data of this study could be used to prepare a future revision of the manual of COVID-19 telemedicine center of KM.