• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.5361-5365
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• 2013

The objective of this study was to evaluate the influence of a genetic variant in the multidrug resistance 1 gene (MDR1) on hepatocellular carcinoma (HCC) risk. This case-control study was conducted in a Chinese population of 645 HCC cases and 658 cancer-free controls. The genotype of the c.3751G>A genetic variant in the MDR1 gene was investigated by created restriction site-polymerase chain reaction (CRS-PCR) and DNA sequencing methods. Our data demonstrated significantly differences detected in the allelic and genotypic frequencies between HCC cases and those of cancer-free controls. Association analyses indicated that there were statistically increased risk of HCC in the homozygote comparison (AA versus (vs.) GG: OR=2.22, 95% CI 1.51-3.27, ${\chi}^2$=16.90, P<0.001), dominant model (AA/GA vs. GG: OR=1.25, 95% CI 1.00-1.55, ${\chi}^2$=3.98, P=0.046), recessive model (AA vs. GA/GG: OR=2.14, 95% CI 1.47-3.09, ${\chi}^2$=16.68, P<0.001) and allele comparison (A vs. G: OR=1.33, 95% CI 1.13-1.57, ${\chi}^2$=11.66, P=0.001). The allele-A and genotype-AA may contribute to HCC susceptibility. These preliminary findings suggest that the c.3751G>A genetic variant in the MDR1 gene is potentially related to HCC susceptibility in a Chinese Han population, and might be used as a molecular marker for evaluating HCC susceptibility.

• 복식
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• 제66권1호
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• pp.108-121
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• 2016

The objective of the study is to propose diverse knitwear designs by expanding the scope of the use and application of knit fabric. The study looked into diversifying the knitwear designs by using different types of zippers and with the combination of the diversity given by the zipper used in attachable and detachable method and the traditional North European knit patterns. One way of contributing to the diversity of fashion design is to use the zipper, as it can be implemented as an attachable and detachable fastening system. Also, the combination of North European traditional knit patterns with knit fabric can create a new and unique knit styling. The content of the research focuses on the history and definition of North European traditional knitwear based on the analysis of theoretical background, types, and characteristics of the knit patterns. Case studies were observed to show the application of knit patterns. The methods of the study used are preceding research along with research, collection, analysis of data, information from Korean and foreign literature, and Internet websites. During knitwear production, the two types of zippers were used in combination with four traditional Northern European knitwear Aran, Fair Isle, Nordic, and Ropy. The knitting techniques applied in the process were cable fisherman (5GG, SES 124CS) and Tubular Jacquard (3GG, 7GG, SES 122CS) for knitting machinery, and the technique of whole garment for hand knitting.

• Asian Journal of Atmospheric Environment
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• 제5권1호
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• pp.41-46
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• 2011

The port of Busan is the fifth busiest container port in the world in terms of total mass of 20-foot equivalent units transported. Yet no attempts have been made to estimate the greenhouse gas (GHG) emissions from the port of Busan by accounting for all port-related activities of the various transportation modes. With these challenges in mind, this study estimates the first activity-based GHG emissions inventory in the port of Busan, which consists of four transportation modes: marine vessels, cargo-handling equipment, heavy-duty trucks, and railroad locomotives. The estimation results based on the most recent and complete port-related activity data are as follows. First, the average annual transportation GHG emission in the port of Busan during the analysis period from 2000 to 2007 was 802 Gg $CO_2$-eq, with a lower value of 773 Gg $CO_2$-eq and an upper value of 813 Gg $CO_2$-eq. Second, the increase in the transportation-related GHG emissions in the port of Busan during the analysis period can be systematically explained by the amount of cargo handled ($R^2$=0.98). Third, about 64% of total GHG emissions in the port of Busan were from marine vessels because more than 40% of all maritime containerized trade flows in the port were transshipment traffic. Fourth, approximately 22% of the total GHG emissions in the port of Busan were from on-road or railroad vehicles, which transport cargo to and from the port of Busan. Finally, the remaining 14% of total GHG emissions were from the cargo handling equipment, such as cranes, yard tractors, and reach stackers.

• 한국약용작물학회지
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• 제24권6호
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• pp.444-450
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• 2016

Background: The roots of Atractylodes macrocephala Koidzumi contain atractylone, which is used to suppress appetite and indigestion caused by gastrointestinal disturbance. The present study was conducted to investigate the effect of several organic compost on the growth and root yield of A. macrocephala with organic fertilizer. Methods and Results: When organic fertilizer was applied basally, the average yield of 10 a was 184.6 kg in the HA (Hwanggeumjidae, organic material mix), 171.3 kg in the GG (Gyunbaeyangchegreen, bacterial cuture filtrate) and 175.0 kg in the CF (Customary fertilization, control) each other in practice of CF had no statistical significance. Atractylenolide I was significantly greater in the HA (0.036%) than the GG (0.034%) or CF (0.023%). With regard to the amount of organic fertilzer, 10 a yield was the most common of 203.0 kg at 2.0 times of the organic 1 (HA), conventional fertilization of 134.0 kg and 173.0 kg of no application was a statistically significant. Organic fertilizer 1 was 1.5 to 2.0 times, organic fertilizer was 2 to 1.5 times that were most suitable. Conclusions: The results of the present study indicated that HA and GG are the most suitable for the organic cultivation of A. macrocephala. The content of atractylone I was highest under the HA treatment and lowest under the CU (Chamjoa, oil cake), TG (Totogreen, plant oil cake) and HG (Heuksalgreen, Castor oil cake) treatment.

• 생물정신의학
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• 제26권2호
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• pp.88-93
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• 2019

Objectives Psychological stress has been known to increase the risk of schizophrenia. Because stress responses are mainly mediated by cortisol, the action of the glucocorticoid receptors (Nuclear Receptor Subfamily 3 Group C Member 1, NR3C1) is possibly related to the pathogenesis of schizophrenia. In this study, we investigated the associations between polymorphisms of NR3C1 and schizophrenia. Methods Four single nucleotide polymorphisms (SNPs) (rs17100236, rs2963155, rs9324924, and rs7701443) of NR3C1 were genotyped in 208 patients with schizophrenia and 339 healthy individuals. A chi-square test was performed to test differences in allele distributions among groups. A multiple logistic regression model was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs), and multiple inheritance models to analyze the associations between schizophrenia and SNPs (the dominant, recessive and additive models). Results The minor allele frequencies of two SNPs were significantly higher in the schizophrenia group than in those of the control group (rs2963155 G > A : 0.25 vs. 0.18, p = 0.0066 ; rs7701443 A > G : 0.40 vs. 0.33, p = 0.012). The genotype frequencies of two SNPs were found to be significantly different between patients with schizophrenia and controls in the dominant model (rs2963155 : AG/GG vs. AA, OR = 1.66, 95% CI = 1.16-2.38, p = 0.0055, rs7701443 : AG/AA vs. GG, OR = 1.61, 95% CI = 1.11-2.34, p = 0.01) and the log-additive model (rs2963155 : AG vs. GG vs. AA, OR = 1.54, 95% CI = 1.13-2.10, p = 0.0067). Conclusions This study showed significant associations between NR3C1 polymorphisms and schizophrenia. It suggests that NR3C1 may play a role in the pathogenesis of schizophrenia.

• 전기전자학회논문지
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• 제17권1호
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• pp.77-82
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• 2013

본 논문에서는 인덕터의 흐르는 전류를 감지하여 출력 전압을 일정하게 유지시키는 Peak Current-mode 방식의 DC-DC Buck Converter를 제안하고, 소신호 모델링에 기초하여 Power Stage 설계 방법과 시스템의 안정도를 설계하는 방법을 제안한다. 또한, dc-dc 컨버터의 신뢰성과 성능을 향상시키기 위해 보호회로를 추가하였다. 그리고 정전기 방지를 위하여 ESD 보호회로를 제안하였다. 제안된 보호회로는 게이트-기판 바이어싱 기술을 이용하여 낮은 트리거 전압을 구현하였다. 시뮬레이션 결과는 일반적인 ggNMOS의 트리거 전압(8.2V) 에 비해 고안된 소자의 트리거 전압은 4.1V 으로 더 낮은 트리거 전압 특성을 나타냈다. 본 논문에서 제안하는 회로의 시뮬레이션은 0.35um BCB 공정 파라미터를 이용하였고, Mathworks 사의 Mathlab과 Synopsys 사의 HSPICE 프로그램을 사용하여 검증하였다.

• 대한한의정보학회지
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• 제14권1호
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• pp.1-18
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• 2008

The elementary idea of 'function-words' in Classical Chinese originates from Han dynasty. But because of the pictographic nature the methodology for 'content words' had been applied to the study on 'function words', ane the conditions had not changed until modern times. In grammar functions of the function-word syntactical, morphological in unit sentence were studied in this using the method of quantitative analysis for all the function-words appeared in ${\ll}$Hwang je nae gyung-Somun${\gg}$. In the previous studies about function word, many data were collected and analyzed diachronically. But those studies failed to examine function-words closed in connection with synchronic study. Besides, in the explain about relevant function-words also, the case which was made centering around exegetic explain was most. And in the case to explain the function-words have in unit sentence also, the explain only about some function-words is made, but the analysis about concrete function to have in syntactical system is being handled negligently. This study stands not only on the background df the traditional studies but also on the basis of the western grammar and linguistics, especially the descriptive grammar and linguistics, especially the descriptive grammar. ${\ll}$Hwang je nae gyung-Somun${\gg}$ is collect and recorded the mythology and special contents related to Daoism in the side of contents as what was written on the basis of the historical consciousness of individual in contents regardless of compilation system. The purpose of this study is to clarify how the role and function of fuction-words are being made in the composition of unit sentence which appeard in ${\ll}$Hwang je nae gyung-Somun${\gg}$ through synchronic grammar system.

• 한방비만학회지
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• 제6권2호
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• pp.59-73
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• 2006

Objectives: This study was conducted to investigate the effects of Uncoupling protein (UCP) polymorphisms on weight loss. We analyzed associations between polymorphisms of UCP-2, 3 and changes in percentage of obesity phenotypes (Body mass index and percent body fat) after treatment. Materials and Methods: A total of 207 Korean women (BMI over 25) were recruited from the obesity clinic in Kirin Oriental Medical Hospital (Seoul, Korea). All patients were treated with a very low calorie diet and oriental medical therapy for one month. The effect of UCP polymorphisms on changes in obesity-phenotypes were analyzed. For the genotyping of a single nucleotide polymorphism (SNPs), genomic DNA from each subject was extracted from whole blood and genotyped using the TaqMan Method. Associations between changes in percentage of obesity phenotypes (BMI and percent body fat) and UCP polymorphisms were analyzed using age-adjusted general linear model. Results and Conclusions: In this study, AG, GG type of UCP-2 -866A>G, CC, CT type of UCP-2 +4787C>T, CG, GG type of UCP-3 +2564C>G, AG, GG type of UCP-3 +3106A>G, and TC, CC type of UCP-3 +4589T>C played a role as a resistance gene to weight loss.

• 한국축산시설환경학회지
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• 제9권1호
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• pp.1-8
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• 2003

우리나라는 1998년도에 가축 사육두수가 감소되고 축산물 소비가 둔화되는 등 어려운 점이 많았으나 2012년까지 장기전망으로는 가축 사육두수가 축종에 관계없이 완만하게 상승될 전망이다. 분뇨분해에 의한 아산화질소 배출량은 고유의 분뇨처리시설 유형 점유형태에 대한 자료를 가지고 IPCC (2000)에서 제시하는 조건별 $N_2O$ emission factor 적용하여 산출하였으며 기준년도인 1990년도에 3.71 Gg이었으며 2005, 2010, 2015 및 2020년도에 5.84, 6.07, 6.23 및 6.53Gg으로 각각 추정되었고 기준년도에 비해 2005, 2010, 2015 및 2020년도에는 각각 57.4, 63.6, 67.9 및 76.0% 증가할 것으로 전망되었다. 아산화질소 배출을 줄이면 메탄배출이 오히려 증가하는 특성이 있어 아직까지는 아산화질소 배출저감을 위한 수단이 미약한 실정이며 추후 기술적인 검토가 필요하며 IPCC의 고정값을 사용한 것을 고유의 값으로 교체해야 하는 등 배출계수 (emission factor)의 정확도를 제고시켜나가야 한다는 과제를 안고 있다.

• Journal of Microbiology and Biotechnology
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• 제29권4호
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• pp.562-570
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• 2019

${\beta}$-Glucosylglycerol (${\beta}-GG$) and their derivatives have potential applications in food, cosmetics and the healthcare industry, including antitumor medications. In this study, ${\beta}-GG$ and its unnatural glycosides were synthesized through the transglycosylation of two enzymes, Sulfolobus shibatae ${\beta}$-glycosidase (SSG) and Deinococcus geothermalis amylosucrase (DGAS). SSG catalyzed a transglycosylation reaction with glycerol as an acceptor and cellobiose as a donor to produce 56% of ${\beta}-GGs$ [${\beta}$-$\text\tiny{D}$-glucopyranosyl-($1{\rightarrow}1/3$)-$\text\tiny{D}$-glycerol and ${\beta}$-$\text\tiny{D}$-glucopyranosyl-($1{\rightarrow}2$)-$\text\tiny{D}$-glycerol]. In the second transglycosylation reaction, ${\beta}$-$\text\tiny{D}$-glucopyranosyl-($1{\rightarrow}1/3$)-$\text\tiny{D}$-glycerol was used as acceptor molecules of the DGAS reaction. As a result, 61% of ${\alpha}$-$\text\tiny{D}$-glucopyranosyl-($1{\rightarrow}4$)-${\beta}$-$\text\tiny{D}$-glucopyranosyl-($1{\rightarrow}1/3$)-$\text\tiny{D}$-glycerol and 28% of ${\alpha}$-$\text\tiny{D}$-maltopyranosyl-($1{\rightarrow}4$)-${\beta}$-$\text\tiny{D}$-glucopyranosyl-($1{\rightarrow}1/3$)-$\text\tiny{D}$-glycerol were synthesized as unnatural glucosylglycerols. In conclusion, the combined enzymatic synthesis of the unnatural glycosides of ${\beta}-GG$ was established. The synthesis of these unnatural glycosides may provide an opportunity to discover new applications in the biotechnological industry.