• Journal of Advanced Navigation Technology
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• v.18 no.4
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• pp.288-295
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• 2014

Current ILS is difficult for the many aircraft to access to the system at the same time because of it's system. And the equipments should be installed at the direction of every runway. Also, There is limitation that landing procedures must be have of only ILS single course when the aircraft land on the ground. hereupon, The more air traffic exist, the longer delay time of flight be. GBAS using the GNSS has been developed to overcome those limitations. Before flight test in Teean airport, this paper compares the taean approach procedure and curved approach procedure by using the simulator. Comparison study shows that curved approach procedure takes less flight time, low fuel consumpsion and make it possible to avoid noise airspace more than original procedure.

• Journal of Advanced Navigation Technology
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• v.12 no.6
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• pp.567-573
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• 2008

According to the ICAO's Global Air Navigation Plan for CNS/ATM - Communications, Navigation, and Surveillance - systems, employing digital technologies, including satellite systems together with various levels of automation, are to be applied in support of a seamless global air traffic management system. For the future navigation, the focus of future implementation efforts can be placed entirely on an expected gradual migration toward GNSS-based navigation, Korea has been considered various options for airspace GNSS augmentation system: GBAS, SBAS and GRAS. This paper discusses current status and future trend of GNSS airspace navigation systems, and presents the results of possible augmentation options and scenarios to analyze system availabilities which could lead to the conclusion of the best program for Korea. The results showed that Korea could have sufficient availabilities from en-route to CAT-I approach with ABAS and GBAS. The study was in cooperated with MITRE, an American research company.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.42 no.6
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• pp.453-460
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• 2014

We analyze fault detection algorithm of ephemeris included in navigation message, which is one of the GNSS risk factors. This algorithm uses carrier-phase measurement and baseline vector of two reference stations and is alternative method for uncertainty condition of previous ephemeris. Even though same ephemeris fault is occurred, the geometry condition, between baseline vector of reference stations and satellites, effects on performance of algorithm. Also, we introduce the suitable geometry of reference stations, threshold and performance index (MDE : Minimum Detectable Error) in jeju international airport.

• Journal of Animal Science and Technology
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• v.62 no.3
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• pp.293-305
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• 2020

The difference in the breeding programs and population history may have diversely shaped the genomes of Korean native cattle breeds. In the absence of phenotypic data, comparisons of breeds that have been subjected to different selective pressures can aid to identify genomic regions and genes controlling qualitative and complex traits. In this study to decipher genetic variation and identify evidence of divergent selection, 3 Korean cattle breeds were genotyped using the recently developed high-density GeneSeek Genomic Profiler F250 (GGP-F250) array. The three Korean cattle breeds clustered according to their coat color phenotypes and breeding programs. The Heugu breed reliably showed smaller effective population size at all generations considered. Across the autosomal chromosomes, 113 and 83 annotated genes were identified from Hanwoo-Chikso and Hanwoo-Heugu comparisons, respectively of which 16 genes were shared between the two pairwise comparisons. The most important signals of selection were detected on bovine chromosomes 14 (24.39-25.13 Mb) and 18 (13.34-15.07 Mb), containing genes related to body size, and coat color (XKR4, LYN, PLAG1, SDR16C5, TMEM68, CDH15, MC1R, and GALNS). Some of the candidate genes are also associated with meat quality traits (ACSF3, EIF2B1, BANP, APCDD1, and GALM) and harbor quantitative trait locus (QTL) for beef production traits. Further functional analysis revealed that the candidate genes (DBI, ACSF3, HINT2, GBA2, AGPAT5, SCAP, ELP6, APOB, and RBL1) were involved in gene ontology (GO) terms relevant to meat quality including fatty acid oxidation, biosynthesis, and lipid storage. Candidate genes previously known to affect beef production and quality traits could be used in the beef cattle selection strategies.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.43 no.1
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• pp.49-61
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• 2015

Ground Based Augmentation System(GBAS) is a system that offers an aircraft within 23 NM radius from the airport precision positioning service and precision approach service using the concept of Differential Global Positioning System(DGPS). After GBAS ground equipment installing at the airport, functionalities and performances of GBAS should be verified through the GBAS ground and flight testing. This paper describes the methods and results for GBAS flight test using the flight inspection aircraft at Gimpo International Airport. From the test results, we confirmed that the VDB data was received without misleading within the VDB coverage of Gimpo International Airport, and VDB field strength, protection level, and course alignment accuracy met the evaluation's criteria.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.17 no.6
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• pp.57-64
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• 2007

As a ubiquitous environment approaches and the use of the wireless Internet using the mobile terminals is on the increase. Therefore, the users have to undergo the inconvenience of repeatedly input the same information for the user registration and the ID certification. The information the users have to put in to register in on-line services range from the basic personal information to the more other private information such as financial information. Accordingly the user can be in control of users personal information and safely manage the information by conveniently selecting from the Digital ID Wallet the Ticket that holds various information including the basic, financial or payment certification-related information. Consequently, we propose a digital identity management mechanism to control one's personal information in a mobile environment.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.17 no.2
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• pp.55-62
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• 2017

Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by beta-glucosidase deficiency. An 18 month-old male with hepatosplenomegaly, anemia, thrombocytopenia, and growth retardation referred to our hospital. The patient showed neurological symptoms, such as supranuclear gaze palsy and developmental delay. Bone marrow biopsy performed to rule out malignancy and the results revealed no malignant cell; however, abnormal histiocytes suggesting storage disease was noted. Based on hepatosplenomegaly, bicytopenia and unexplained neurologic manifestations, enzyme activity and genetic analysis were conducted emergently with a strong suspicion of GD. Beta-glucosidase activity in leukocyte was decreased. GBA sequencing to confirm the diagnosis revealed compound heterozygous pathogenic variants (i.e., c.754T>A, c.887G>A), both previously reported as the cause of neuronopathic GD. Under the diagnosis of type 3 GD, the patient immediately received enzyme replacement therapy (ERT). After 17 months of ERT, the size of spleen decreased, and hemoglobin and platelet count returned to normal. In addition, the activity of chitotriosidase and angiotensin converting enzyme decreased. However, myoclonic movement and generalized seizure occurred at the age of 19 months and antiepileptic drug was started. Other neurological deterioration including supranuclear gaze palsy and developmental delay also persisted. A new therapy to overcome neurologic problems should be developed for patients with type 3 GD.

• Journal of Biomedical Engineering Research
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• v.39 no.3
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• pp.124-133
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• 2018

We tried to investigate the changes in cortical activities according to emotional valence states during watching video clips. We examined the neural basis of two emotional states (positive and negative) using spectral power analysis and brain functional connectivity analysis of cortical current density time-series reconstructed from high-density electroencephalograms (EEGs). Fifteen healthy participants viewed a series of thirty-two 2 min emotional video clips. Sixty-four channel EEGs were recorded. Distributed cortical sources were reconstructed using weighted minimum norm estimation. The temporal and spatial characteristics of spectral source powers showing significant differences between positive and negative emotion were examined. Also, correlations between gamma-band activities and affective valence ratings were determined. We observed the changes of cortical current density time-series according to emotional states modulated by video clip. Gamma-band activities showed significant difference between emotional states for thirty seconds at the middle and the latter half of the video clip, mainly in prefrontal area. It was also significantly anti-correlated with the self-ratings of emotional valence. In addition, the gamma-band activities in frontal and temporal areas were strongly phase-synchronized, more strongly for negative emotional states. Cortical activities in frontal and temporal areas showed high spectral power and inter-regional phase synchronization in gamma-band during negative emotional states. It is inferred that the higher amygdala activation induced by negative stimuli resulted in strong emotional effects and caused strong local and global synchronization of neural activities in gamma-band in frontal and temporal areas.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.13 no.1
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• pp.37-42
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• 2013

Gaucher disease is a lysosomal storage disease caused by deficiency of glucocerebrosidase (GBA). This condition is characterized by accumulation of glucocerebrosidase in liver, spleen, lung, skeletal system, and central nervous system. Gaucher disease is the prototype of disease in which efficacy of enzyme replacement therapy has been established. However, because recombinant enzyme is not able to enter the central nervous system, its efficacy is limited to the non-neurological manifestations of Gaucher disease. Importantly, approximately a half of Korean patients with Gaucher disease suffer from neurological manifestations. In addition, Korean Gaucher disease patients exhibit distinct mutation spectrum from those in other populations. Common mutations in Korean patients with Gaucher disease are also associated with neurological phenotype. Therefore, therapeutic strategies tailored to Korean patients were necessary. Interestingly, a chemical chaperone, ambroxol, has been known to increase residual enzymatic activities of the select mutant GBAs encoded by mutations prevalent in Korean patients. One promising aspect of this drug is that it can cross blood-brain barrier, and enhance the enzyme activity in the brain. In vitro study suggested this chemical chaperone as one of new therapeutic agents in Gaucher disease, and a well-designed human trial is required to confirm its efficacy.