• IMMUNE NETWORK
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• 제22권1호
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• pp.4.1-4.22
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• 2022

In the era of immunotherapeutic control of cancers, many advances in biotechnology, especially in Ab engineering, have provided multiple new candidates as therapeutic immuno-oncology modalities. Bispecific Abs (BsAbs) that recognize 2 different antigens in one molecule are promising drug candidates and have inspired an upsurge in research in both academia and the pharmaceutical industry. Among several BsAbs, T cell engaging BsAb (TCEB), a new class of therapeutic agents designed to simultaneously bind to T cells and tumor cells via tumor cell specific antigens in immunotherapy, is the most promising BsAb. Herein, we are providing an overview of the current status of the development of TCEBs. The diverse formats and characteristics of TCEBs, in addition to the functional mechanisms of BsAbs are discussed. Several aspects of a new TCEB-Blinatumomab-are reviewed, including the current clinical data, challenges of patient treatment, drawbacks regarding toxicities, and resistance of TCEB therapy. Development of the next generation of TCEBs is also discussed in addition to the comparison of TCEB with current chimeric antigen receptor-T therapy.

• 한국자기학회지
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• 제18권3호
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• pp.103-108
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• 2008

비휘발성 메모리 분야에서 MRAM이 큰 주목을 받지 못하는 이유는 일반적인 비휘발성 메모리에 비해 기록용량이 작다는 문제를 안고 있기 때문이다. 이러한 문제는 MRAM의 일반적인 구조가 자기 효율이 떨어지는 구조를 가지고 있기 때문이다. MRAM이 고용량화 되기 위해선 한 셀의 구조가 작아져야 하는데 두 전류라인만을 이용하는 일반적인 구조에선 큰 기록 필드를 발생시킬 수 없기에 셀의 구조를 작게하는 것은 불가능하다. 본 논문에서는 MRAM의 기록층 양단에 큰 투자율을 가진 Pole을 추가한 형태의 새로운 MRAM을 제안하고 있다. 새로이 고안된 MRAM은 일반적인 MRAM에 비해 자기효율이 크게 향상 되기 때문에 큰 기록 필드를 발생시킬 수 있기 때문에 보자력이 큰 기록 층을 사용할 수 있고 이로 인해 한 셀의 사이즈를 줄일 수 있게 된다. 본 연구는 3차원 유한요소법을 사용하여 진행 되었다.

• 한국유기농업학회지
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• 제19권3호
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• pp.385-396
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• 2011

본 연구는 구기자 유기재배 시 발생하는 주요 병해충에 대해 친환경적인 방제방법을 개발하기 위해서 수행하였다. 관내 주요 유기재배 농가의 병해충의 발생을 조사한 결과 18종의 병해충이 조사되었는데 그 중 발생의 정도에 따라 병해로 흰가루병과 뒷면곰팡이병 해충으로 복숭아혹진딧물과 꽃노랑총채벌레 및 나방류가 친환경적인 방제연구가 필요하였다. 이에 방제 시험한 결과 초여름 발생하는 흰가루병에는 Bacilus subtilis QST 713 수화제와 Sulfur 수화제가 효과가 좋았고 초가을에 발생하는 흰가루병에는 Sulfur 수화제와 Copper hydroxide 수화제, Paraffinic oil 유제의 효과가 좋았다. 또한 뒷면곰팡이병 방제시험 결과 Paraffinic oil 유제와 Bacilus subtilis GB-0365 액상수화제의 방제효과가 70% 이상으로 좋았다. 해충 친환경 방제시험에서 총채벌레의 방제에 천적인 유럽애꽃노린재(Orius laevigatus)를 방사하여 80%이상 방제가능 하였다. 왕담배나방은 미생물농약인 Bacillus thuringiensis subsp. aizawai GB413 액상수화제와 Bacillus thuringiensis aizawa 0423 수화제로 70%이상의 방제가로 방제할 수 있었으며, 구기자 뿔나방(Hedma lycia sp.)은 B.T. servar aizawai 수화제가 70% 이상의 방제가로 효과가 우수하였다. 마지막으로 복숭아혹진딧물을 친환경제제로 방제 시험한 결과 Bacillus subtilis(Seoncho)와 Bacillus subtilis(Jinsami)가 80%이상의 방제가로 약효가 우수하였으며 Ginkgo nut extract로도 70%이상 방제할 수 있었다. 이상의 방제시험으로 구기자 유기재배시 우선 문제되는 5종의 병해충에 대해서 방제방법을 제시할 수 있었다.

• 한국정보전자통신기술학회논문지
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• 제12권3호
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• pp.257-264
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• 2019

최근 이더넷 신호를 융통성 있게 구성하도록 하는 FlexE는 OTN을 통해 투명하게 전달하기 위하여 OTN으로 수용하는 것을 ITU-T에서 권고하고 있다. FlexE신호를 OTN 페이로드로 맵핑할 때 발생할 수 있는 비트율 차이를 보상하기 위하여 유휴 코드워드를 제거하거나 삽입하는 방법을 사용한다. 그러나 이와 같은 방법을 구현하기 위해 필요한 세부적인 기능 블록은 아직 공개되고 있지 않다. 본 논문에서는 최근 ITU-T 요구사항을 기초로 하여 400G급을 기준으로 FlexE 신호의 OTN 맵핑을 위한 세부적인 기능 블록을 살펴보았다. 또한 세부 기능 블록을 바탕으로 유휴 코드워드의 제거 및 삽입되는 발생 특성을 얻기 위하여 수학적인 분석을 하였고, 이를 이용한 시뮬레이션을 결과를 보였다.

• 한방안이비인후피부과학회지
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• 제19권2호
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• pp.202-211
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• 2006

Objectives : This study is designed to evaluate correlation between the data of D.I.T,I examination in Bell's palsy and the improving period. Methods : This study researched into the clinical statistics for 50 patients who are in Bell's palsy and they are treated with oriental medical care of Dongshin university during 18months from January 1, 2005 to June 1, 2006. The data which examinated by D.I.T.I, are the thermal difference of normal and abnormal site of acupuncture int Gl4 BL2 GB3 S3 S4 S6 TE17 in Bell's palsy. Result : There was statistic significance between thermal difference of normal, abnormal site and the improving period. The period was shorter in normal thermal pattern than hypothermal pattern, hyperthermal pattern. Conclusion : According to the result, there was a statistic significance that more thermal difference and more difficult to recover in Bell's palsy.

• 대한약침학회지
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• 제11권1호
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• pp.55-69
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• 2008

Objective : We investigated the effects of distilled Wild Ginseng Herbal Acupuncture on autonomic nervous system with the Heart Rate Variability(HRV) in adult man. as well as we tried to observe how distilled Wild Ginseng Herbal Acupuncture on the balance of the autonomic nervous system. Method : We investigated the effects of distilled Wild Ginseng Herbal Acupuncture on autonomic nervous system with the Heart Rate Variability(HRV) in adult man. as well as we tried to observe how distilled Wild Ginseng Herbal Acupuncture on the balance of the autonomic nervous system. 1 healthy volunteers consisted of 31 subjects in experiment(distilled Wild Ginseng Herbal Acupuncture) group and 30 subjects in control(Normal Saline) group. Study form was a randomized, placebo-controlled, double-blind clinical trial. 31 subjects in experiment group were injected distilled Wild Ginseng Herbal Acupuncture at $GB_{21}$(Kyonjong) and 30 subjects in control group were injected Normal Saline at $GB_{21}$(Kyonjong). except of 2 subjects(in control group) who can't be measured and 11 subjects(7 in experiment group and 4 in control group) who move or make unforceable error during measuring. Finally 24 subject in experiment group and 24 subject in control group are studied. We measured HRV by PolyG-I on 7 times : before and after injection per 5 minutes during 30 minutes. The SPSS 10.0 for windows was used to analyze the data and the paired t-test(in group) and Student t-test(between two groups) were used to verify the result. Result : 1. After distilled Wild Ginseng Herbal Acupuncture injection, Mean HRV is significantly low only for first 5 minute, SDNN is significantly high after 5 minute, Complexity is significantly low after 5 minute, HRV index is significantly high after 10 minute and pNN50 is significantly low after 5 minute. 2. SDNN of distilled Wild Ginseng Herbal Acupuncture Group significantly increased from 20minute to 25minute, and pNN50 of distilled Wild Ginseng Herbal Acupuncture Group significantly decreased from 10minute to 15minute and 20 minute to 30 minute compared with those of Normal Saline group. 3. After distilled Wild Ginseng Herbal Acupuncture injection, Ln(TP), Ln(VLF) and Ln(LF) are significantly high after 5 minute, normalized LF is significantly high after 5 minute and normalized HF is significantly low after 5 minute. 4. Ln(TP) and Ln(VLF) of distilled Wild Ginseng Herbal Acupuncture Group significantly increased from 20minute to 25 minute compared with those of Normal Saline group. Conclusion : The results suggest that distilled Wild Ginseng Herbal Acupuncture in healthy adult man tend to activate the autonomic nervous system and sympathetic nervous system compared to Normal Saline within normal range.

• Journal of Acupuncture Research
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• 제24권5호
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• pp.207-217
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• 2007

Objectives: We investigated the safty of distilled Astragali Radix Herbal Acupuncture, Wild Ginseng Herbal Acupuncture and Rehmannia glutinosa Herbal Acupuncture on vital sign -BP, pulse, resperation-in adult man. Methods : We investigated on 106 healthy volunteers consisted of each 30 subjects in experiment (distilled Astragali Radix Herbal Acupuncture, Wild Ginseng Herbal Acupuncture and Rehmannia glutinosa Herbal Acupuncture) group and 30 subjects in control(Normal Saline) group. Study form was a randomized, placebo-controlled, double-blind clinical trial. 30 subjects in each experiment group were injected distilled Astragali Radix Herbal Acupuncture, Wild Ginseng Herbal Acupuncture, Rehmannia glutinosa Herbal Acupuncture at $GB_{21}$(Kyonjong) and 30 subjects in control group were injected Normal Saline at $GB_{21}$ (Kyonjong). except of 2 subjects(in control group) who can't be measured and 10 subjects(6 in experiment group and 4 in control group) who move or make unforceable error during measuring. Finally each 25. subject, subject, subject in experiment group and 24 subject in control group are studied. We measured resperation by PolyG-I and BP & pulse by electric manometer on 5 times : before injection per 5 minutes during and after injection per 10 minutes during 35 minutes. The SPSS 13.0 for windows was used to analyze the data and the Student t test(between two groups) were used to verify the result. Results : 1. After distilled Astragali Radix Herbal Acupuncture injection, Wild Ginseng Herbal Acupuncture and Rehmannia glutinosa Herbal Acupuncture , systolic BP is not significantly change in all experiment time. 2. After distilled Astragali Radix Herbal Acupuncture injection, Wild Ginseng Herbal Acupuncture and Rehmannia glutinosa Herbal Acupuncture , diastolic BP is not significantly change in all experiment time. 3. After distilled Astragali Radix Herbal Acupuncture injection, Wild Ginseng Herbal Acupuncture and Rehmannia glutinosa Herbal Acupuncture , pulse is not significantly change in all experiment time. 4. After distilled Astragali Radix Herbal Acupuncture injection, Wild Ginseng Herbal Acupuncture and Rehmannia glutinosa Herbal Acupuncture , resperation is not significantly change in all experiment time. Conclusions : The results suggest that distilled Astragali Radix Herbal Acupuncture, Wild Ginseng Herbal Acupuncture and Rehmannia glutinosa Herbal Acupuncture in healthy adult man don't influence vital sign within normal range. This result is derived from that distilled Astragali Radix Herbal Acupuncture, Wild Ginseng Herbal Acupuncture and Rehmannia glutinosa Herbal Acupuncture in healthy adult man are safety.

• 동의신경정신과학회지
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• 제19권1호
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• pp.107-124
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• 2008

We investigated the effects of distilled Astragali Radix Herbal Acupuncture on autonomic nervous system with the Heart Rate Variability(HRV) in adult man. as well as we tried to observe how distilled Astragali Radix Herbal Acupuncture on the balance of the autonomic nervous system. Methods : We investigated on 61 healthy volunteers consisted of 31 subjects in experiment(distilled Astragali Radix Herbal Acupuncture) group and 30 subjects in control(Normal Saline) group. Study form was a randomized, placebo-controlled, double-blind clinical trial. 31 subjects in experiment group were injected distilled Astragali Radix Herbal Acupuncture at GB21(Kyonjong) and 30 subjects in control group were injected Normal Saline at GB21(Kyonjong). except of 2 subjects(in control group) who can't be measured and 10 subjects(6 in experiment group and 4 in control group) who move or make unforceable error during measuring. Finally 25 subject in experiment group and 24 subject in control group are studied. We measured HRV by PolyG-I on 7 times : before and after injection per 5 minutes during 30 minutes. The SPSS 10.0 for windows was used to analyze the data and the paired t test(in group) and Student t test(between two groups) were used to verify the result. Results : I. After distilled Astragali Radix Herbal Acupuncture injection, SDNN is significantly high from 5 minute to 10 minute and from 15 minute to 30 minute, Complexity is significantly low from 20 minute to 30minute. HRV index is significantly mgb for first 20 minute and from 25 minute to 30 minute, RMSSD is significantly high only from 15 minute to 20 minute. 2. HRV index of distilled Astragali Radix Herbal Acupuncture Group significantly increased from 25 minute to 30 minute, pNN50 of distilled Astragali Radix Herbal Acupuncture Group significantly decreased from 25 minute to 30 minute and RMSSD of distilled Astragali Radix Herbal Acupuncture Group significantly increased from 25 minute to 30 minute compared with those of Normal Saline group. 3. After distilled Astragali Radix Herbal Acupuncture injection, Ln(TP) is significantly high from 5 minute to 10 minute and from 15 minute to 30 minute. Ln(VLF) is significantly high after 5 minute, Ln(LF) is significantly high after 15 minute and Ln(HF) is significantly high from 5 minute to 10 minute and 25 minute to 30 minute, but significantly low for first 5 minute and from 10 minute to 20 minute. Normalized LF is significantly high after 20 minute and Normalized LF is significantly low after 20 minute. Conclusions : The results suggest that distilled Astragali Radix Herbal Acupuncture in healthy adult man tend to activate the autonomic nervous system within normal range. This result is derived from that parasympathetic nervous system was continuously activated and sympathetic nervous system was activated a little later.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제24권1호
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• pp.7-14
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• 2018

Purpose: This study analyzes mental healthcare delivery services and types of facilities, the status of installation and operation, and planning standard. The purpose of the study is to propose a basic data for the performance of related research and work tasks, along with an understanding of the Chinese mental healthcare facility type and support system. Furthermore, it will show a lack of current function management as the changes of mental health concept and demand for services increases, and it is intended to provide implications for the construction of mental health facilities. Methods: This study was conducted by a research on law and regulation of China's mental healthcare delivery service system and mental healthcare facility. The analyzed data are the national standard GB, the optional national standard GB/T, the building construction standard JGJ, and the report issued by the Health Planning and Development Committee. Results: At present mental healthcare facility construction in China is in the period of rapid development and it exposes the layout of medical facilities, which is not currently reasonable and the service does not reach the designated position and so on. Overall, it requires more detailed guidelines to enhance the quality of mental healthcare service. Implications: It is expected that the research of this paper will provide effective reference for future research on Chinese Mental healthcare system and facilities, and can promote construction of Chinese mental healthcare facility theory in perfect condition.

• Asian-Australasian Journal of Animal Sciences
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• 제17권6호
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• pp.743-749
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• 2004

The gene encoding human serum albumin (HSA) was cloned from human liver cDNA library by PCR. The HSA cDNA in size of 2,176 bp, including 1,830 bp of open reading frame, was cloned into the plasmid carried with the 5'flanking sequence of goat $\beta$-casein gene (-4,044 to +2,025 bp) to get a tissue specific expression vector in mammary gland named pGB562/HSA (12.5 kb). A 9.6 kb DNA fragment in which the sequence is in order of goat $\beta$-casein gene regulatory sequence, HSA cDNA and SV40 polyadenylation signals was isolated from the pGB562/HSA by SacI and DraIII cutting, and used to microinject into the pronuclei of mouse fertilized eggs to produce transgenic mice. Three transgenic mice (2 female and 1 male) were identified by PCR and dot Southern blot analysis. The copy numbers of integrated transgene were more than 10 copies in line #21 and #26 as well as over 50 copies in line #31 of transgenic mice. HSA protein collected from the milk of lactating transgenic mice was confirmed by immuno-detection of Western and slot blot. The concentrations of HSA in the milk were from 0.05 to 0.4 mg/ml. An obvious antigen and antibody conjugate could be observed in immunohistochemical stain of mammary gland tissue from lactating day 11 of HSA transgenic mice. The transmission of transgene and its expression was recognized according to the results of RT-PCR and sequences analyses of their progeny.