• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
• /
• v.9 no.2
• /
• pp.142-146
• /
• 1998

Background : It has been established that the fundamental frequency(Fo) of the vowels varies systemically as a function of vowel height. Specifically, high vowels have a higher Fo than low vowels. Two major explanations or hypotheses dominate contemporary accounts of fired to explain the mechanisms underlying intrinsic variation in vowel Fo, source-tract coupling hypothesis and tongue-pull hypothesis. Objectives : Total laryngectomy surgery necessiates removal of all structures between the hyoid bone and the tracheal rings. Therefore, the assumption that no direct interconnection exists between the tongue and pharyngoesophageal segment that would mediate systematic variation in vowel Fo appears quite reasonable. If tongue-pull hypothesis is correct, systemic differences in Fo between high versus low vowels produced by esophageal speakers would not Or expected. We analyzed the Fo in the vowels of esophageal voice. Materials and method : The subjects were 11 cases of laryngectomee patients with fluent esophageal voice. The five essential vowels were recorded and analyzed with computer speech analysis system(Computerized Speech Lab). The Fo was measured using acoustic waveform, automatically and manually, and narrow band spectral analysis. Results : The results of this study reveal that intrinsic variation in vowel Fo is clearly evident in esophageal speech. By analysis using acoustic waveform automatically, the signals were too irregular to measure the Fo precisely. So the data from automatic analysis of acoustic waveform is not logical. But the Fo by measuring with manually calculated acoustic waveform or narrowband spectral analysis resulted in acceptable results. These results were interpreted to support neither the source-tract coupling nor the tongue-pull hypotheses and led us to offer an alternative explanation to account for intrinsic variation of Fo.

• The Journal of Korean Medicine
• /
• v.36 no.3
• /
• pp.23-34
• /
• 2015

Objectives: This study is aimed at assessing the reliability of a standard instrument of diagnosis and assessment for Spleen Qi deficiency pattern questionnaire (SQDQ) and examining the validity of the SQDQ by comparing the pattern identification scores of different groups. Methods: We conducted a survey of 72 participants (60 patients with chronic dyspepsia and 12 healthy subjects) using self-reported questionnaire. Participants were given written consent and this study was performed under the permission of institutional review board of Kyung-Hee university Korean medicine hospital. Results: The reliability and the validity of the questionnaire were inspected. Internal consistency of the SQDQ was excellent. Construct validity analyzed by exploratory factor analysis produced 4 factors, which were selected from eigenvalues that are greater than 1.0. The factor 1, 2, 3 and 4 showed 'fatigue', 'meal', 'diagnosis' and 'figure' respectively. For most of SQDQs' items, there were significant differences observed between the Spleen Qi and the non-Spleen Qi groups. However, the 'emaciation', 'tongue diagnosis' and 'pulse diagnosis' showed no significant differences. Conclusions: The SQDQ restructured in this study may provide a fundamental questionnaire and a further study is required for a more advanced, standardized and statistically proven questionnaire.

• The Journal of Korean Medicine
• /
• v.38 no.3
• /
• pp.1-12
• /
• 2017

Objectives: To interpret the meanings of Ryodoraku data and to use it as diagnosis tool, study on relationship between Ryodoraku and autonomic nervous reaction (ANR) has to be preceded prior to disease studies. This study aims to observe the change of Ryodoraku characteristics with ANR caused by treadmill exercise via a feasibility study. Methods: The electric current at 24 Ryodoraku points(H1~H6 at left/right wrists and F1~F6 at left/right feet) and vital signs were measured at rest, immediately after the treadmill exercise test, and at later recovery times(10min, 20min, 30min, 60min, 120min after the exercise test). The calculated Ryodoraku scores (RSs) were analyzed using repeated ANOVA test. Results: The RSs in the wrist Ryodoraku points were significantly increased immediately after the exercise (p<.05) and at 10min recovery time (p<.01), and no significant differences were found during the rest of the experimental sets. To the contrary, the RSs in the feet Ryodoraku points showed less difference throughout all the measurement time. Conclusions: The Ryodoraku characteristics change more sensitively in the wrists than in the feet in accordance with the previously reported sweat gland responses of the treadmill exercise. This is the first feasibility study to observe the change of Ryodoraku characteristics caused by treadmill exercise, and it shows the Ryodoraku characteristics are in accordance with known ANS responses.

• The Korea Journal of Herbology
• /
• v.31 no.6
• /
• pp.29-35
• /
• 2016

Objectives : Blood stasis (BS) is related to be caused by blood circulation and stagnation which are cancer, atherosclerosis and hyperlipidemia in traditional medicine. We extracted 3 kinds of BS formula; Seogakjihwang-tang (SGT), Tonggyuhawlhyul-tang (THT), Hyulbuchukeo-tang (HCT). This study was conducted to investigate whether the 3 kinds of herbal formula extracts have inhibitory efficacy association with anti-adipogenesis. Methods : To investigate the anti-adipogenesis, we used the mouse fibroblast cell line, 3T3-L1 which differentiated into adipocytes in response to insulin, IBMX and dexamethasone (MDI). Cytotoxicity of herbal formula extracts were examined by CCK-8 kit. Intracellular lipid droplets were detected by Oil-Red-O staining. Triglyceride (TG) and leptin were measure using elisa kit. Results : The yield of water extracts was 14.62% (SGT), 21.27% (THT), 20.02% (HCT). Lipid accumulation was reduced significantly by 3 kinds of herbal formula compared to control. Especially, THT and HCT decreased lipid droplet, respectively at all concentration. The TG and leptin were also inhibited by 3 kinds of herbal formula. The IC50 of TG were $280.51{\mu}g/m{\ell}$ (SGT), $52.62{\mu}g/m{\ell}$ (THT), $313.99{\mu}g/m{\ell}$ (HCT). The IC50 of leptin were $348.76{\mu}g/m{\ell}$ (SGT), $164.02{\mu}g/m{\ell}$ (THT), $257.00{\mu}g/m{\ell}$ (HCT). THT was better than other herbal formula on anti-adipogenesis. Conclusion : kinds of herbal formula inhibited adipogenesis in MDI-induced 3T3-L1 adipocytes, as indicated by the significant reduction in TG and leptin concentration without cytotoxicity. Therefore, 3 kinds of herbal formula for BS might act as a therapeutic agent for preventing lipid diseases, such as obesity and atherosclerosis.

• The Korea Journal of Herbology
• /
• v.32 no.4
• /
• pp.61-68
• /
• 2017

Objectives : Jema-sunghyangjungkisan (JSGS, Jima Xingxiang Zhengqi san) and yeoldahanso-tang (YDHST, Reduo hanshao decoction) are traditional herbal formulas which commonly used to prevent and treat stroke in traditional korean medicine. However, JSGS and YDHST extracts have not been previously reported to have anti-inflammatory effects. Therefore, We measured the anti-inflammatory effects of JSGS and YDHST extracts on lipopolysaccharide (LPS)-stimulated murine macrophage cell line, RAW 264.7 cells. Methods : To investigate the anti-inflammatory activities of JSGS and YDHST extracts, tumor necrosis factor-alpha ($TNF-{\alpha}$), interleukin (IL)-6, nitric oxide (NO) and prostaglandin $E_2$ ($PGE_2$) were examined in RAW 264.7 cells with LPS of $1{\mu}g/m{\ell}$. Results : JSGS and YDHST extracts did not have any cytotoxicity in RAW 264.7 cells. $TNF-{\alpha}$ concentration decreased 49.67% at $500{\mu}g/m{\ell}$ by JSGS but, YDHST has no statistically significant effect at all concentration. IL-6 accumulation on JSGS and YDHST extracts in LPS-stimulated RAW 264.7 cells reduced 22.03% and 41.44% at $500{\mu}g/m{\ell}$ respectively. In addition, JSGS has no inhibitory effects on NO accumulation and YDHST reduced 10.08% at $500{\mu}g/m{\ell}$. Moreover, JSGS and YDHST treatment does-dependently reduced the $PGE_2$ production. In particular, YDHST ($500{\mu}g/m{\ell}$) extract was more effective compared with $10ng/m{\ell}$ of indomethacin which is the $PGE_2$ positive control. Conclusions : Our results suggest that treatment of JSGS and YDHST extracts decreased the LPS-stimulated inflammation. Therefore, in the present study, we demonstrated that JSGS and YDHS may be used as a potential anti-inflammatory therapeutic agent.

• Journal of Veterinary Science
• /
• v.21 no.3
• /
• pp.49.1-49.14
• /
• 2020

Background: Coinfection with avian leukosis virus subgroup J (ALV-J) and reticuloendotheliosis virus (REV) is common in chickens, and the molecular mechanism of the synergistic pathogenic effects of the coinfection is not clear. Exosomes have been identified as new players in the pathogenesis of retroviruses. The different functions of exosomes depend on their cargo components. Objectives: The aim of this study was to investigate the function of co-regulation differentially expressed proteins in exosomes on coinfection of ALV-J and REV. Methods: Here, viral replication in CEF cells infected with ALV-J, REV or both was detected by immunofluorescence microscopy. Then, we analyzed the exosomes isolated from supernatants of chicken embryo fibroblast (CEF) cells single infected and coinfected with ALV-J and REV by mass spectrometry. KEGG pathway enrichment analyzed the co-regulation differentially expressed proteins in exosomes. Next, we silenced and overexpressed tripartite motif containing 62 (TRIM62) to evaluate the effects of TRIM62 on viral replication and the expression levels of NCK-association proteins 1 (NCKAP1) and actin-related 2/3 complex subunit 5 (ARPC5) determined by quantitative reverse transcription polymerase chain reaction. Results: The results showed that coinfection of ALV-J and REV promoted the replication of each other. Thirty proteins, including TRIM62, NCK-association proteins 1 (NCKAP1, also known as Nap125), and Arp2/3-5, ARPC5, were identified. NCKAP1 and ARPC5 were involved in the actin cytoskeleton pathway. TRIM62 negatively regulated viral replication and that the inhibition of REV was more significant than that on ALV-J in CEF cells coinfected with TRIM62. In addition, TRIM62 decreased the expression of NCKAP1 and increased the expression of ARPC5 in coinfected CEF cells. Conclusions: Collectively, our results indicated that coinfection with ALV-J and REV competitively promoted each other's replication, the actin cytoskeleton played an important role in the coinfection mechanism, and TRIM62 regulated the actin cytoskeleton.

• The Journal of Korean Association of Computer Education
• /
• v.13 no.4
• /
• pp.13-26
• /
• 2010

The purpose of this study is to develop the enrichment curriculum connected to a Revised Version of 7th National Informatics Curriculum in Middle School for gifted students in IT education. This study uses a Delphi Method to develop a curriculum which is comprised of educational objectives, educational contents, teaching-learning method and educational evaluation. This study carried out a three-round delphi survey in 'The problem-solving method and its procedure' field from grade 1 to grade 3. In this study, first, the responses of the experts about educational objectives, educational contents, teaching-learning method and educational evaluation of each grade were analyzed. Second, organized items were designed. Finally, important items were selected by statistics.

• Journal of Engineering Education Research
• /
• v.12 no.2
• /
• pp.71-82
• /
• 2009

In spite of rather short history of about 10 years, Engineering Accreditation has been spreaded, drastically. Considerable number of faculties in diverse engineering majors keep pouring their efforts for better engineering education. Nevertheless, due to unfamiliarity to certain terminologies that can be easily found in other areas, major number of engineering faculties suffer from difficulties in fulfilling the requirements for Engineering Accreditation. This paper presents fundamental knowledge underlying Accreditation Standards and requirements of each Standard, in detail. This paper eventually provides engineering programs with concrete ways by which one can fulfill all the requirements for Engineering Accreditation.

• Hwankyungkyoyuk
• /
• v.20 no.2
• /
• pp.16-24
• /
• 2007

The purpose of this study is to understand how the unit objectives and contents associated with environment are reflected on the 6 kinds of chemistry- I textbooks in the 7th curriculum and to present how to deal with the environmental education in chemistry- I. The results of this study are as follows. First, units associated with environment account for an average of 43.7% on chemistry- I in 7th curriculum. Second, contents of units related to environmental education on chemistry- I in 7th curriculum are environmental pollution(17.8%), environmental preservation and environmental pollution prevention(15.9%), environmental hygiene(12.2%), and any other things, Environmental pollution takes up a considerable part of environmental education. Third, the results for analyzing the objectives of chemistry- I in 7th curriculum show that Information Knowledge Awareness(34.0%) and Skill (29.9%) take up most parts. Fourth, Orientation (I) as analysis standard for objective of the units related to environmental education accounts for 10.2% of the total. It is clear that environmental education is carried out from STS point of view. In conclusion, environmental education in Chemistry- I focuses on fostering students' ability to apply the fundamental notion of chemistry to real life associated with environments. Therefore, it is necessary that environmental education in Chemistry- I should include value, attitude and participation and that improve students' ability to approach the environmental problem comprehensively.

• ETRI Journal
• /
• v.44 no.5
• /
• pp.733-745
• /
• 2022

In software-defined wireless networking (SDWN), the optimal routing technique is one of the effective solutions to improve its performance. This routing technique is done by many different methods, with the most common using integer linear programming problem (ILP), building optimal routing metrics. These methods often only focus on one routing objective, such as minimizing the packet blocking probability, minimizing end-to-end delay (EED), and maximizing network throughput. It is difficult to consider multiple objectives concurrently in a routing algorithm. In this paper, we investigate the application of machine learning to control routing in the SDWN. An intelligent routing algorithm is then proposed based on the machine learning to improve the network performance. The proposed algorithm can optimize multiple routing objectives. Our idea is to combine supervised learning (SL) and reinforcement learning (RL) methods to discover new routes. The SL is used to predict the performance metrics of the links, including EED quality of transmission (QoT), and packet blocking probability (PBP). The routing is done by the RL method. We use the Q-value in the fundamental equation of the RL to store the PBP, which is used for the aim of route selection. Concurrently, the learning rate coefficient is flexibly changed to determine the constraints of routing during learning. These constraints include QoT and EED. Our performance evaluations based on OMNeT++ have shown that the proposed algorithm has significantly improved the network performance in terms of the QoT, EED, packet delivery ratio, and network throughput compared with other well-known routing algorithms.