• ETRI Journal
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• 제40권6호
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• pp.794-801
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• 2018

This paper proposes a novel graphene-based optical microelectromechanical systems MEMS accelerometer that is dependent on the intensity modulation and optical properties of graphene. The designed sensing system includes a multilayer graphene finger, a laser diode (LD) light source, a photodiode, and integrated optical waveguides. The proposed accelerometer provides several advantages, such as negligible cross-axis sensitivity, appropriate linearity behavior in the operation range, a relatively broad measurement range, and a significantly wider bandwidth when compared with other important contributions in the literature. Furthermore, the functional characteristics of the proposed device are designed analytically, and are then confirmed using numerical methods. Based on the simulation results, the functional characteristics are as follows: a mechanical sensitivity of 1,019 nm/g, an optical sensitivity of 145.7 %/g, a resonance frequency of 15,553 Hz, a bandwidth of 7 kHz, and a measurement range of ${\pm}10g$. Owing to the obtained functional characteristics, the proposed device is suitable for several applications in which high sensitivity and wide bandwidth are required simultaneously.

• Journal of Photoscience
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• 제7권2호
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• pp.45-46
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• 2000

The polyoxyethylene compounds were added into the photographic emulsion during the physical ripening of photo sensitive silver halide crystal in this emulsion. The polyoxyethylene compounds improved the photographic properties of the film to a great extent increasing the photo sensitivity and decreasing the fog density.

• Genomics & Informatics
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• 제8권4호
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• pp.177-184
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• 2010

The target of rapamycin (TOR) signaling pathway is a conserved pathway that regulates eukaryotic cell growth in response to environmental cues. Chemical genomic approaches that profile rapamycin sensitivity of yeast deletion strains have given insights into the function of TOR signaling pathway. In the present study, we analyzed the rapamycin sensitivity of yeast deletion library strains on synthetic medium. As a result, we identified 130 strains that are hypersensitive or resistant to rapamycin compared with wild-type cells. Among them, 36 genes are newly identified to be related to rapamycin sensitivity. Moreover, we found 16 strains that show alteration in rapamycin sensitivity between complex and synthetic media. We suggest that these genes may be involved in part of TOR signaling activities that is differentially regulated by media composition.

• 한국안광학회지
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• 제15권4호
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• pp.381-388
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• 2010

목적: 단초점렌즈를 착용했던 노안 이전의 젊은 사람에게 낮은 가입도로 설계된 기능성 누진가입도렌즈를 2개월동안 교체 착용하게 하여 기존의 단초점렌즈와 기능성 누진가입도렌즈와의 근거리 시각적 능력을 평가하는 대비감도 검사를 비교 분석하여 임상적인 성능 차이를 알아보고자 하였다. 방법: 안질환이 없는 평균연령 24.03${\pm}$1.87세의 대학생 32명(남자 23명, 여자 9명)을 대상으로 하여 단초점렌즈와 기능성 누진가입도렌즈(EYE-T, $Chemilens^{(R)}$ Co., Korea, 가입도 0.75D)를 2개월 동안 착용하게 하였다. 이때 기능성 누진가입도렌즈 착용 직후(1차)와 착용 2개월 후 (2차)에 원, 근거리 교정시력 측정, 근거리 대비감도 검사를 실시하여 결과를 비교하였다. 결과: 기능성 누진가입도 렌즈 착용 전과 착용 2개월 후에 측정하여 비교한 근거리 대비감도는 모든 공간주파수 영역에서 우안, 좌안, 양안 모두 단초점렌즈보다 기능성 누진가입도렌즈를 착용하였을 때 근거리 대비감도가 높게 측정되었다. 결론: 근거리에 관련된 시각적 능력과 질을 평가하는데 대비감도 검사가 유용하고 다양하게 응용될 수 있다고 사료된다.

• 핵의학기술
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• 제19권2호
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• pp.102-107
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• 2015

Purpose Serum Thyroglobulin measurement is a major tool for the follow-up of differentiated thyroid cancer (DTC) patients. Thyroglobulin is Normal thyroid tissue, or thyroid cancer tissue produced only. Thyroid hormone to a halt without Tg differentiation of thyroid cancer recurrence just by measuring how to decide whether there was increasing expectations if I can do it instead. Therefore, in excellent sensitivity Tg new inspection of the functional sensitivity by measuring the looked to evaluate the usefulness of reagents. Thyroidectomy is measuring the numbers Tg (total thyroidectomy) remaining thyroid ablation and radioactive iodine (radioactive iodine remnant ablation, RRA) DTC in patients being diagnosed with or help predict the remaining early detection of thyroid cancer recurrence. Materials and Methods Agent that I'm currently using Tg of the measurements of low clinical specimen for a second drainage of the three (0.08 0.17, 0.98, ng/mL) within the scope of the dilute magnification (2, 4, 8, 16, 32 times) by dilute Intraassy (n=10) and Interassay (n=10) out in no time. Concentration value according to the coefficient of variation and the mean and standard deviation of each measurement (Coefficient of variation, CV) the absolute value of the measured values that corresponds to 20 percent target a coefficient of variation of CV Find the value of the concentration of the functional sensitivity measurement did. Also, analytical sensitivity with recovery rates, Dilution test inspections, and interrelationship, compared. Results Sensitivity is an excellent analytical sensitivity within the prosecutor kit Tg 0.006 ng/mL, and core analytical sensitivity, conducted by the 0.006 ng/mL to same conclusion. Be rather high to 142 percent recovery rate was 60 to measurement and functional sensitivity, 0.01766 ng/mL(Intraassay n=10) was measured at. CBC is relatively good correlation as ($R^2=0.949$) the correlation. Conclusion Recently ultrasensitive thyroglobulin this clinically important indicators of the previous kit and demands are lower than sensitivity to the measurement results. Therefore, ultrasensitive thyroglobulin test is correlated that there would be useful in value in nuclear medicine the thyroid gland.

• BMB Reports
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• 제34권5호
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• pp.428-433
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• 2001

A defect in uvsC of Aspergillus nidulans caused high methyl methansulfonate (MMS)-sensitivity, hyporecombination, and a lack of UV induced mutation. The uvsC gene of Aspergillus nidulans shares a sequence similarity with the RAD51 gene of Saccharomyces cerevisiae. In this study, in vitro and in vivo tests were conducted in order to determine whether or not the UVSC protein had functional similarities to RAD51, the recombination enzyme in yeast. The purified recombinant UVSC protein, following expression in Escherichia coli, showed binding activity to single-stranded DNA (ssDNA), when both ATP and magnesium are present. In addition, ATPase activity was also demonstrated and its activity was stimulated in the presence of ssDNA. The UVSC protein that was expressed under the ADH promoter in S. cerevisiae suppressed in part the sensitivity to MMS of the rad51 null mutant. Similarly, when the uvsC cDNA was expressed from the nmt promoter, the MMS sensitivity of the rhp51 null mutant of Schizosaccharomyces pombe was partially complemented. These results indicate that the A. nidulans UVSC protein is a functional homologue of the RAD51 protein.

• Korean Journal of Radiology
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• 제19권6호
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• pp.1110-1118
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• 2018

Objective: To perform a meta-analysis to quantitatively assess functional magnetic resonance imaging (MRI) in the diagnosis of locally recurrent prostate cancer. Materials and Methods: A comprehensive search of the PubMed, Embase, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews was conducted from January 1, 1995 to December 31, 2016. Diagnostic accuracy was quantitatively pooled for all studies by using hierarchical logistic regression modeling, including bivariate modeling and hierarchical summary receiver operating characteristic (HSROC) curves (AUCs). The Z test was used to determine whether adding functional MRI to T2-weighted imaging (T2WI) results in significantly increased diagnostic sensitivity and specificity. Results: Meta-analysis of 13 studies involving 826 patients who underwent radical prostatectomy showed a pooled sensitivity and specificity of 91%, and the AUC was 0.96. Meta-analysis of 7 studies involving 329 patients who underwent radiotherapy showed a pooled sensitivity of 80% and specificity of 81%, and the AUC was 0.88. Meta-analysis of 11 studies reporting 1669 sextant biopsies from patients who underwent radiotherapy showed a pooled sensitivity of 54% and specificity of 91%, and the AUC was 0.85. Sensitivity after radiotherapy was significantly higher when diffusion-weighted MRI data were combined with T2WI than when only T2WI results were used. This was true when meta-analysis was performed on a per-patient basis (p = 0.027) or per sextant biopsy (p = 0.046). A similar result was found when $^1H$-magnetic resonance spectroscopy ($^1H$-MRS) data were combined with T2WI and sextant biopsy was the unit of analysis (p = 0.036). Conclusion: Functional MRI data may not strengthen the ability of T2WI to detect locally recurrent prostate cancer in patients who have undergone radical prostatectomy. By contrast, diffusion-weight MRI and $^1H$-MRS data may improve the sensitivity of T2WI for patients who have undergone radiotherapy.

• Korean Journal of Mathematics
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• 제25권3호
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• pp.405-435
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• 2017

We deal with a sensitivity analysis of an optimal shape control problem for the stationary Navier-Stokes system. A two-dimensional channel flow of an incompressible, viscous fluid is examined to determine the shape of a bump on a part of the boundary that minimizes the viscous drag. By using the material derivative method and adjoint variables for a shape sensitivity analysis, we derive the shape gradient of the design functional for the model problem.

• Macromolecular Research
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• 제17권12호
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• pp.1025-1031
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• 2009

Several kinds of biodegradable hydrogels were prepared via in situ photopolymerization of Pluronic F127/poly($\varepsilon$-caprolactone) macromer and acrylic acid (AA) comonomer in aqueous medium. The swelling kinetics measurements showed that the resultant hydrogels exhibited both thermo- and pH-sensitive behaviors, and that this stimuli-responsiveness underwent a fast reversible process. With increasing pH of the local buffer solutions, the pH sensitivity of the hydrogels was increased, while the temperature sensitivity was decreased. In vitro hydrolytic degradation in the buffer solution (pH 7.4, $37^{\circ}C$), the degradation rate of the hydrogels was greatly improved due to the introduction of the AA comonomer. The in vitro release profiles of bovine serum albumin (BSA) in-situ embedded into the hydrogels were also investigated: the release mechanism of BSA based on the Peppas equation was followed Case II diffusion. Such biodegradable dual-sensitive hydrogel materials may have more advantages as a potentially interesting platform for smart drug delivery carriers and tissue engineering scaffolds.

• 한국안광학회지
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• 제12권4호
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• pp.119-125
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• 2007

본 연구는 콘택트렌즈 착용자와 안경 장용자 그리고 정시안의 대비감도를 비교하기 위해 시행되었다. 조사 대상은 만 19-26세로 근시 70안과 정시 30안을 대상으로 시행하였다, 근시안 그룹은 안경장용자 48안과 콘택트렌즈 착용자 22안으로 모두 교정시력이 1.0 이상인 안구를 대상으로 시행하였다. 공간 대비감도는 EyeView$^{(R)}$ Functional Vision Analysis software가 포함된 Optec 6500 Vision Tester$^{(R)}$ (Stereo Optical. USA)을 이용하여 Photopic (85cd)과 mesopic (3cd) 상태에서 대비 감도를 조사하여 비교하였다. 안경장용자는 정시안과 비교하여 모든 조건에서 대비감도에서 의의 있는 차이가 없었다. 소프트 콘택트렌즈 착용자는 정시안에 비해 1.5와 12cpd에서 통계적으로 낮은 대비감도를 보였다. 본 연구의 콘택트렌즈 착용자에서 대비감도가 낮게 나온 것은 콘택트렌즈 착용자의 각막 병리로 진행하기 전단계에서 나타나는 각막 문제의 증거로 해석될 수도 있다. 이러한 대비감도 검사는 소프트렌즈 콘택트렌즈 평가하는데 유용한 방법이 될 수 있는 것으로 사료된다.