• 한국실내디자인학회논문집
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• 제20권5호
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• pp.68-77
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• 2011

In this research it is concentrated first of all on the attempts to reconstruct the historical context of the idea for the space design based on the natural construction and to re-appropriate il critically to the present context. Sequentially in the areas of philosophy, biology, neuroscience, and architecture it has been variously discussed on the problems about the synthesis of biology and techniques. In the context of the consilience of biology and technique Werner Nachtigall, who has intended to shed light on the morphological principles in the natural construction, founded the 'Bionik', which is different from the bionics or the biomechanics that are oriented to the imitation of natural forms. The space design that is on the basis of the Bionik treats organisms as a functional whole. Therefore the Bionik space design follows two kinds of principle such as the principle of analogy and the principle of optimization. After all the understanding of the consilience of nature and technique for Nachtigall and Bionik designers tends toward the explication of the complex process in which the human perceptions, the environment, and the phenomenal techniques are united together, and this complex process is associated with the space design based on the Bionik.

• Preventive Nutrition and Food Science
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• 제13권4호
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• pp.340-347
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• 2008

This study was conducted to develop a recipe for a nutritional cookie with lotus root powder that had the optimal composition of ingredients and texture resulting in high preference by all age groups. Wheat flour was partially substituted with lotus root powder to reduce its content. Response Surface Methodology was used to analyze the measured results, which showed 16 experimental points including 2 replicates for lotus root powder, sugar and butter. The compositional and functional properties were measured, and these values were applied to a mathematical model. A canonical form and perturbation plot showed the influence of each ingredient on the final mixture product. The sensory evaluation results showed significant values in color (p<0.01), texture (p<0.05) and overall quality (p<0.05). As a result, the optimal sensory ratio was determined to be 22.59 g of lotus root powder, and 53.08 g of sugar for every 120 g of butter.

• 상하수도학회지
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• 제23권4호
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• pp.417-430
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• 2009

A BNR comprehensive performance evaluation (BNR CPE) system was established employing system-oriented evaluation methodology for biological nutrient removal (BNR) processes based on the CPE techniques developed by U.S. EPA for evaluation of conventional biological processes. The BNR CPE system applied to five domestic BNR plants adopting $A^2/O$ process confirmed that all target plants except the smallest one had not any serious defective performance and process stability was enhanced with increasing plant size. The system also clearly verified relatively poor performances in anoxic reactors without exception mainly due to influent carbon limit rather than functional defect. Consistent good performances were confirmed even during both winter season and wet weather generally known to be difficult to achieve satisfactory removals. Presentation of evaluation results by modified radar chart system simplified and clarified the evaluation and analysis procedures. The BNR CPE system could not only discover readily the causes of present and prospective poor performances but also facilitate the suggestion of their optimization options. Mutual effect and cause-and-effect among operation parameters and unit processes were also found easily using the evaluation system. The system justified that the adverse effect of defective operating parameters could be compensated by other favorable parameters, especially in anaerobic and anoxic reactors as well as during the winter season.

• Bulletin of the Korean Chemical Society
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• 제34권4호
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• pp.1043-1046
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• 2013

Prediction of physicochemical properties of organic molecules is an important process in chemistry and chemical engineering. The MSEP approach developed in our lab calculates the molecular surface electrostatic potential (ESP) on van der Waals (vdW) surfaces of molecules. This approach includes geometry optimization and frequency calculation using hybrid density functional theory, B3LYP, at the 6-31G(d) basis set to find minima on the potential energy surface, and is known to give satisfactory QSPR results for various properties of organic molecules. However, this MSEP method is not applicable to screen large database because geometry optimization and frequency calculation require considerable computing time. To develop a fast but yet reliable approach, we have re-examined our previous work on organic molecules using two semi-empirical methods, AM1 and PM3. This new approach can be an efficient protocol in designing new molecules with improved properties.

• International Journal of Control, Automation, and Systems
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• 제4권3호
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• pp.382-393
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• 2006

Mechanical system dynamics plays an important role in the area of computational structural biology. Elastic network models (ENMs) for macromolecules (e.g., polymers, proteins, and nucleic acids such as DNA and RNA) have been developed to understand the relationship between their structure and biological function. For example. a protein, which is basically a folded polypeptide chain, can be simply modeled as a mass-spring system from the mechanical viewpoint. Since the conformational flexibility of a protein is dominantly subject to its chemical bond interactions (e.g., covalent bonds, salt bridges, and hydrogen bonds), these constraints can be modeled as linear spring connections between spatially proximal representatives in a variety of coarse-grained ENMs. Coarse-graining approaches enable one to simulate harmonic and anharmonic motions of large macromolecules in a PC, while all-atom based molecular dynamics (MD) simulation has been conventionally performed with an aid of supercomputer. A harmonic analysis of a macroscopic mechanical system, called normal mode analysis, has been adopted to analyze thermal fluctuations of a microscopic biological system around its equilibrium state. Furthermore, a structure-based system optimization, called elastic network interpolation, has been developed to predict nonlinear transition (or folding) pathways between two different functional states of a same macromolecule. The good agreement of simulation and experiment allows the employment of coarse-grained ENMs as a versatile tool for the study of macromolecular dynamics.

• 한국전산구조공학회논문집
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• 제18권3호
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• pp.255-263
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• 2005

본 논문에서는 다양한 문제들의 형상 설계 민감도 해석에 대한 효율적인 경계기반 기법을 제시하였다 우선 문제에서 정의된 일반적인 함수들에 대한 연속체 형태의 식에 근거하여, 경계 적분 형태의 해석적 민감도 식을 유도하였다. 이 식은 다양한 형상 설계 문제들의 경사를 계산하는데 편리하게 사용할 수 있다. 그리고 경계법은 형상 변분 벡터가 전체 도메인이 아닌 경계에서만 요구된다는 장점이 있는데, 여기서 경계 형상 변분은 형상 함수의 복잡한 해석적 미분 대신 형상을 미소 증분시킴으로써 편리하게 계산할 수 있다. 제시한 방법의 효율성을 보이기 위해 포텐셜 유동 문제와 필렛(fillet)에서의 응력 집중 문제에 이를 적용하였다.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2004년도 춘계학술대회
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• pp.1047-1052
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• 2004

An efficient boundary-based technique is developed for addressing shape design sensitivity analysis in supercavitating flow problem. An analytical sensitivity formula in the form of a boundary integral is derived based on the continuum formulation for a general functional defined in potential flow problems. The formula, which is expressed in terms of the boundary solutions and shape variation vectors, can be conveniently used for gradient computation in a variety of shape design in potential flow problems. While the sensitivity can be calculated independent of the analysis means, such as the finite element method (FEM) or the boundary element method (BEM), the FEM is used for the analysis in this study because of its popularity and easy-touse features. The advantage of using a boundary-based method is that the shape variation vectors are needed only on the boundary, not over the whole domain. The boundary shape variation vectors are conveniently computed by using finite perturbations of the shape geometry instead of complex analytical differentiation of the geometry functions. The supercavitating flow problem is chosen to illustrate the efficiency of the proposed methodology. Implementation issues for and optimization procedure are addressed in this flow problem.

• 한국정보처리학회논문지
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• 제6권3호
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• pp.781-791
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• 1999

DD(Decision Diagrams) is an efficient operational data structure for an optimal expression of boolean functions. In a graph-based synthesis using DD, the goal of optimization decreases representation space for boolean functions. This paper represents boolean functions using OPKFDD(Ordered Pseudo-Kronecker Functional Decision Diagrams) for a graph-based synthesis and is based on the number of nodes as the criterion of DD size. For a property of OPKFDD that is able to select one of different decomposition types for each node, OPKFDD is variable in its size by the decomposition types selection of each node and input variable order. This paper proposes a method for generating OPKFDD efficiently from the current BDD(Binary Decision Diagram) Data structure and an algorithm for minimizing one. In the multiple output functions, the relations of each function affect the number of nodes of OPKFDD. Therefore this paper proposes a method to decide the input variable order considering the above cases. Experimental results of comparing with the current representation methods and the reordering methods for deciding input variable order are shown.

• 한국전기전자재료학회논문지
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• 제21권11호
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• pp.987-994
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• 2008

The optimal structure of the Tonpilz transducer was designed. First, the FE model of the transducer was constructed, that included all the details of the transducer which used practical environment. The validity of the FE model was verified through the impedance analysis of the transducer. Second, the resonance frequency, the sound pressure, the bandwidth, and the impulsive shock pressure of the transducer in relation to its structural variables were analyzed. Third, the design method of $2^n$ experiments was employed to reduce the number of analysis cases, and through statistical multiple regression analysis of the results, the functional forms of the transducer performances that could consider the cross-coupled effects of the structural variables were derived. Based on the all results, the optimal geometry of the Tonpilz transducer that had the highest sound pressure level at the desired working environment was determined through the optimization with the SQP-PD method of a target function composed of the transducer performance. Furthermore, for the convenience of a user, the automatic process program making the optimal structure of the acoustic transducer automatically at a given target and a desired working environment was made. The developed method can reflect all the cross-coupled effects of multiple structural variables, and can be extended to the design of general acoustic transducers.

• Current Optics and Photonics
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• 제5권4호
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• pp.351-361
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• 2021

Speckle imaging is capable of dynamic data acquisition at high spatiotemporal resolution, and has played a vital role in the functional study of biological specimens. The presence of various optical scatterers within the tissue causes alteration of speckle contrast. Thus structures like blood vessels can be delineated and quantified. Although laser speckle imaging is frequently used, an optimization process to ensure the maximum speckle contrast has not been available. In this respect, we here report an experimental procedure to optimize speckle contrast via applying different combinations of varying polarization of the illuminating laser light and multiple analyzer angles. Specifically, samples were illuminated by the p-polarization, 45°-polarization, and s-polarization of the incident laser, and speckle images were recorded without and with the analyzer rotated from 0° to 180° (Δ = 30°). Following the baseline imaging of a solid diffuser and a fixed brain sample, laser speckle contrast imaging (LSCI) was successfully performed to visualize in vivo mouse-brain blood flow. For oblique laser illumination, the maximum contrast achieved with p-polarized and s-polarized light was perpendicular to the analyzer's axis. This study demonstrates the optimization process for maximizing the speckle contrast, which can improve blood-flow estimation in vivo.