• Journal of the Korean Society of Physical Medicine
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• v.15 no.2
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• pp.109-120
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• 2020

PURPOSE: This study was conducted to verify the effects of a functional correction of the pain of patients with chronic low back pain(CLBP), and to examine the effect of dysfunctional factors on health-related quality of life. METHODS: A preliminary survey was first conducted on 90 patients with CLBP after functional orthodontic treatment. Some revised questionnaires were also prepared. The survey was distributed for approximately eight weeks, and 215 copies were used as the final analysis data, except for questionnaires that were inadequate, error or non-response. RESULTS: Path analysis using the structural equation model of CLBP patients showed a positive correlation between all the path coefficients and the potential factors. The multidimensional relationship between pain and dysfunction after orthognathic treatment was confirmed using three subdivisions of the pain variables as independent variables and the dysfunctional variables as the dependent variables. Multiple regression analysis was performed to examine the effects of pain on the dysfunction. To identify the multidimensional relationship between dysfunction and the health-related quality of life, eight sub-factors of dysfunctional variables were set as the independent variables, and multiple regression was analyses were performed with the dependent variables of the health-related quality of life. CONCLUSION: This study examined the structural and influence relationships of the functional correction with pain, dysfunction, and health-related quality of life. The results, suggest that a functional orthodontic treatment can be used as a positive program for the health-related quality of life. In addition, this study is meaningful in that it provieds useful information for intervention such as psychosocial change of patients.

• BMB Reports
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• v.38 no.5
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• pp.619-623
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• 2005

The efficacy of chemotherapeutic agents on tumor cells has been shown to be modulated by tumor suppressor gene p53 and its target genes such as Bcl-2 family members (Bax, Noxa, and PUMA). However, various chemotherapeutic agents can induce cell death in tumor cells that do not express the functional p53, suggesting that some chemotherapeutic agents may induce cell death in a p53-independent pathway. Here we showed that etoposide can induce the similar degree of cell death in p53-deficient HCT 116 cells, whereas 5'-FU-mediated cell death is strongly dependent on the existence of functional p53 in HCT 116 cells. Further, we provide the evidence that etoposide can induce the cytochrome c release from isolated mitochondria, and etoposide-induced cytochrome c release is not accompanied with the large amplitude swelling of mitochondria. These data suggest that etoposide can directly induce the mitochondrial dysfunction irrespective of p53 status, and it may, at least in part, account for the p53-independent pathway in cell death induced by chemotherapeutic agents.

• BMB Reports
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• v.48 no.2
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• pp.81-90
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• 2015

p73 is a structural and functional homologue of the p53 tumor suppressor protein. Like p53, p73 induces apoptosis and cell cycle arrest and transactivates p53-responsive genes, conferring its tumor suppressive activity. In addition, p73 has unique roles in neuronal development and differentiation. The importance of p73-induced apoptosis lies in its capability to substitute the pro-apoptotic activity of p53 in various human cancer cells in which p53 is mutated or inactive. Despite the great importance of p73-induced apoptosis in cancer therapy, little is known about the molecular basis of p73-induced apoptosis. In this review, we discuss the p73 structures reported to date, detailed structural comparisons between p73 and p53, and current understanding of the transcription-dependent and -independent mechanisms of p73-induced apoptosis.

• Journal of the Korean housing association
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• v.14 no.5
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• pp.117-128
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• 2003

The purpose of this study is to investigate the effect of functional ability on relocation among the elderly. Longitudinal data from the Asset and Health Dynamics among the Oldest Old (1993, 1995) were analyzed for 6,225 respondents aged 70 or older. Among functional ability measures, difficulties in advanced activities of daily living (i. e., making telephone calls, taking medications, and managing money), lower body activities (i. e., walking several blocks, climbing one flight of stairs, pulling or pushing large objects, and carrying over 10 pounds), and household activities of daily living (i. e., preparing hot meals and shopping for groceries) were the predictors of increased residential move. Difficulties in basic activities of daily living (i. e., bathing, dressing, getting in and out, and using the toilet) were strongly related to increased entrance into an institutional care facility. Efforts to enhance the independent living of the elderly in the community setting should target the compensation of these functional difficulties.

• IE interfaces
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• v.19 no.1
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• pp.53-61
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• 2006

We propose a new supply chain planning methodology for both a manufacturer and a distributor in order to find a global supply chain plan for functional product markets. Functional products as opposed to innovative products include the staples that people buy regularly from their nearby places to satisfy basic needs. In the functional product market, the distributor has an initiative of supply chain control and planning with a freedom to request any profit maximizing order quantities until the manufacturer refuses, whereas the manufacturer may not provide more than requested. In this paper, two independent agents on behalf of the manufacturer and the distributor are introduced, and supply chain planning can be conducted by collaboration between them. In addition, mathematical models and a numerical example are presented to show the possibility of the proposed methodology.

• Journal of Power Electronics
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• v.15 no.4
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• pp.1054-1065
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• 2015

Multi-functional voltage source inverters (VSIs) have attracted increasing attention in recent years for their advantageous auxiliary services for power quality enhancement in autonomous microgrids. These types of VSIs can not only achieve a proper control scheme in autonomous mode but also cope with the prescribed power quality and stability requirements. These functionalities are integrated within the same device, thereby significantly improving the cost-effectiveness of microgrids while decreasing the investment and bulk compared with those of multiple devices with independent functionalities. Control strategies for power quality enhancement in autonomous microgrids using multi-functional VSIs are comprehensively reviewed in this paper. In addition, such VSIs are discussed in detail, and comparisons of which are also provided. Lastly, a number of future research directions for multi-functional VSIs are recommended.

• East Asian mathematical journal
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• v.34 no.1
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• pp.69-84
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• 2018

In this paper, we study the viscoelastic Kirchhoff type equation with a nonlinear source for each independent kernels h and g with respect to Volterra terms. Under the smallness condition with respect to Kirchhoff coefficient and the relaxation function and other assumptions, we prove the uniform decay rate of the Kirchhoff type energy.

• Journal of Korean Society for Quality Management
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• v.21 no.1
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• pp.152-160
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• 1993

In developing a quadratic regression relationship, independent variable is frequently measured with error. In this paper the integrated mean square error of prediction is developed for a quadratic functional relationship model as a measure of the effect of measurement error of the independent variable on the predicted values. The amount of the effect of error is presented and illustrated with an example.

• Fashion & Textile Research Journal
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• v.4 no.4
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• pp.383-393
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• 2002

The purpose of this study was to evaluate wearing evaluation method in order to propose well fitted bodice pattern. For this study, the subjects were drawn from obese boys at the ages 9 to 11. Wearing evaluation had use of 3 bodice type and 3 evaluative method. The appearance evaluation was to evaluate subjects by professional group. The functional evaluation was to valued subjects by self-evaluation. The quantitative evaluation was to estimate subjects through Electomyograph. Wearing evaluation was done through questionnaire of 32 item in objectivity, 36 item in subjectivity, and 36 item in quantity. The data were analyzed by using ANOVA. From wearing evaluation, appearance and functional evaluation had significant most of them but quantitative evaluation had not significant. It was known that the human sense was more sensitive the quantitative mechanism. And its obtained by both functional evaluation and quantitative evaluation, respectively was found to be significantly correlated, Independent relation was observed in the results from both appearance evaluation and functional evaluation as well as from both functional evaluation and quantitative evaluation. Therefore, we propose that it is proper to evaluate the propriety of bodice pattern for obese boys of school year, mutually compromising both appearance evaluation and functional evaluation or both functional evaluation and quantitative evaluation.

• Journal of Korean Academy of Nursing
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• v.32 no.5
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• pp.643-653
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• 2002

The purpose of this study was to identify factors that influence the functional status of chronic lung disease patients. Method: A descriptive, correlational study design was used. The study was conducted at the outpatient respiratory clinic of the large university hospital in Korea. A convenience sample of 128 chronic lung patients (age = 64.2 yrs; 106 COPD, 17 bronchiectasis, 5 DILD) with mean FEV1 64.4 % predicted. Functional status was measured with SIP. Physical variables (FEV1% predicted, dyspnea, fatigue, pulmonary symptom distress), psychological variables (mood, stress), and situational variable (sleep quality) were examined. Dyspnea was measured by the BDI, fatigue was measured with the MFI. Mood was measured with the modified Korean version of POMS. Sleep quality was measured with the Pittsburgh Sleep Quality Index. Potential independent variables for the regression were age, gender, years since diagnosis, FEV1% predicted, dyspnea, fatigue, pulmonary symptom distress, stress, and sleep quality. Result: In general, functional status was relatively good. In regression analysis, functional status were significantly influenced by dyspnea, mood, age and fatigue. These variables explained 70 % of the variances in functional status. Conclusion: The results suggest that psychophysiologic symptom management should be a focus to enhance the functional status in this group.