• Title/Summary/Keyword: Functional Factor

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Transforming Growth Factor-$\alpha$ Increases the Yield of Functional Dopaminergic Neurons from in vitro Differentiated Human Embryonic Stem Cells Induced by Basic Fibroblast Growth Factor

  • Lee, Keum-Sil;Shin, Hyun-Ah;Cho, Hwang-Yoon;Kim, Eun-Young;Lee, Young-Jae;Wang, Kyu-Chang;Kim, Yong-Sik;Lee, Hoon-Taek;Chung, Kil-Saeng
    • Proceedings of the Korean Society of Developmental Biology Conference
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    • 2003.10a
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    • pp.102-102
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    • 2003
  • Embryonic stem (ES) cells proliferate extensively in the undifferentiated state and have the potential to differentiate into a variety of cell types in response to various environmental cues. The generation of functional dopaminergic neurons from ES cells is promising for cell replacement therapy to treat Parkinson's disease. We compared the in vitro differentiation potential of pluripotent human embryonic stem (hES, MB03) cells induced with basic fibroblast growth factor (bFGF) or retinoic acid (RA). Both types of treatment resulted in similar neural cell differentiation patterns at the terminal differentiation stage, specifically, 75% neurons and 11% glial cells. Additionally, treatment of hES cells with brain derived neurotrophic factor (BDNF) or transforming growth factor (TGF)- $\alpha$ during the terminal differentiation stage led to significantly increased tyrosine hydroxylase (TH) expression, compared to control (P<0.05). In contrast, no effect was observed on the rate of mature or glutamic acid decarboxylase-positive neurons. Immunostaining and HPLC analyses revealed the higher levels of TH (20.3%) and dopamine in bFGF and TGF-$\alpha$ treated hES cells than in RA or BDNF treated hES cells. The results indicate that TGF-$\alpha$ may be successfully used in the bFGF induction protocol to yield higher numbers of functional dopaminergic neurons from hES cells.

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A Study on Development and Analysis of Accident Influence Factor Verification Tools for the Elderly People in the Welfare Facilities for the Aged (노인주거 복지시설 거주 노인의 안전사고 영향변수 검증도구 개발 및 분석에 관한 연구)

  • You, Jong-Ok;Park, Jae-Seung
    • Korean Institute of Interior Design Journal
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    • v.20 no.3
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    • pp.242-248
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    • 2011
  • According to a study on the accident patterns of older people in 2006 by Korea Consumer Agency (CISS), the number of accidents of the elderly at home reached 486, and the figure has increased every year. As Korea is about to enter into the aged society, it is important to investigate the factors that cause an accident in the welfare facilities for the aged and establish the barrier-free construction standards. The accident influence factors include facility environmental, physical functional, socio demographic and socio psychological factors. In terms of the verification tools, there are Facility Evaluation Index, FIM, MMSE-K and General Feature. In terms of analysis method, in addition, there are real number, percentage, t-test, ANOVA and logistic regression. In conclusion, this paper attempts to reveal correlations among the accident influence factors using the Facility Evaluation Standards (115 items in total) for facility environmental factor, FIM (3 items) for physical functional factor, MMSE-K (6 items) for socio psychological factor and questionnaire (5 items) for socio demographic factor.

Users' Satisfaction on the Dormitory of High School in Jeonju City (고등학교 기숙사 주거시설에 대한 사용자 만족도 - 개인공간 단위실을 중심으로 -)

  • An, Jin-Sook;Choi, Byung-Sook
    • Journal of the Korean housing association
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    • v.18 no.6
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    • pp.93-101
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    • 2007
  • This study was to find out users' satisfaction on the dormitory of high school in Jeonju City and to propose it's physical environmental improvement directions. This was performed by a questionnaire survey method, and the questionnaire was designed by researchers considering relative literatures. Data were collected from 200 students, who had been dwelling 4 high school dormitories in Jeonju City. By analyzing those data, findings were as follows: 1) Users of students were satisfied the whole of their dormitory; facilities, spaces, and living. 2) They were highly concerned about a library and a personal unit space in their dormitory. 3) They needed their personal unit space to be designed bedroom+bathroom type with 2 persons' sharing and be equipped one story bed and desk furniture. Also, they needed improvement on heating & cooling, small space and indoor air quality of unit space. 4) The users' satisfaction on unit space were 2.88, and their satisfaction of the technical factor was 2.71 that was the lowest score in them. And The functional factor was highly effected their satisfaction. 5) The space utility and the space size of functional factor, the soundproof, the heating/ventilation and the indoor quality of technical factor, and the privacy of behavior factor were highly correlative to their satisfaction of unit space.

A Study on Analysis Indicators on the Servicescapes of Senior Welfare Facility (노인여가복지시설의 서비스스케이프 분석지표에 관한 연구)

  • Han, Ji-Eun;Nam, Kyoung-Sook
    • Korean Institute of Interior Design Journal
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    • v.24 no.2
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    • pp.11-20
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    • 2015
  • To make provision for the super-aged society, the senior welfare facility which is a kind of typical physical environment of the nursing service would be expected to perform a very important role in local community. This study was conducted to identify the constructs of the servicescapes of senior welfare facility and to draw analysis indicators of it. For this, we performed literature review based on domestic & foreign government guide, service marketing theory and interior architectural results concerning the physical environment of the senior welfare facility. The result of this study showed as follows: servicescapes of the senior welfare facility could be explained as "a whole set of physical environment to support a variety of services provided by the senior welfare facility for the elderly or services of the kind of tangible clues". Analysis indicators of the senior welfare facility's servicescape could be explained as five factors: safety factor, functional factor, aesthetic factor, ambient factor and social factor. In addition we developed 37 pieces of detailed factors referred to five factors. The evaluation and verification of analysis indicators was carried out through 8 experts in-depth interviews. We inspected importance factor using a 5-point Likert scale, therefore safety factor was 4.41, functional factor was 4.27, aesthetic factor was 3.66, ambient factor was 4.20 and social factor was 4.25. More than anything else, in this study, there is a sense that it has established the concept of servicescape adapted to the senior welfare facility and contained a social element between the employees and the physical environment. Theoretical and practical implications of findings are discussed, and future research directions are proposed. we expect to be a little or benefits to the senior welfare facility corresponding to the future of the super-aged society.

Healthy Functional Food Consumption for Overweight and Obese Koreans (과체중과 비만소비자의 건강기능성 식품 소비 행동 결정요인 연구)

  • You, So-Ye
    • The Korean Journal of Community Living Science
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    • v.20 no.4
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    • pp.503-514
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    • 2009
  • The purpose of this study was to explore the influencing factors of consumption behavior of healthy functional foods including vitamin/mineral products for overweight and obese Koreans. Overweight and obese Koreans were selected based on the body mass index(BMI) from the KNHANES that was collected in 2007. Probit estimation model was used to find the influencing factors such as age, gender, job, education, income, nutrition education, and cultural capital(parents' education) on consuming the healthy functional foods. Overweight consumers were found to consume vitamin/mineral products and healthy functional foods at 17.5% and 22.7%, respectively. Obese consumers were found to consume vitamin/mineral products and healthy functional foods at 18.2% and 22.8%, respectively. In addition, self decision was found to be a significant factor to consume both products in both groups. Nutritional education and job were significant factors to consume vitamin/mineral products in overweight consumers, while mother's education and job(service) were significant factors in obese consumers. Weight control for body shape, gender, age, and income were significant factors to consume healthy functional foods in overweight consumers, while nutrition label and perceived health status were significant for obese consumers. Therefore, providing consumer information on functional foods might be useful for consumers to consider the healthy functional foods as an available option to purchase. Various influencing factors between two groups might be concerned to develop different strategies for promoting the healthy functional foods consumption including vitamin/mineral products.

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A Study on Effect of Silver Consumer's Lifestyle on Purchase Satisfaction and Repurchase Intention of the Health Functional Foods (실버 소비자의 라이프스타일이 건강기능식품 구매 만족도 및 재 구매 의도에 미치는 영향에 관한 연구)

  • Choi, Soo-Il;Kwak, Jong-Hyung
    • The Korean Journal of Food And Nutrition
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    • v.20 no.3
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    • pp.334-340
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    • 2007
  • The purpose of this study is to analyze silver consumers' life style, and whether silver consumers ’ life style have an effect on purchase satisfaction and repurchase intention of the health functional foods. To this end, a survey was conducted from May 28 to June 20 in 2007, among silver consumer aged in over 50s, on their purchase experience of the health functional foods. The survey was conducted with 326 subjects, and the statistical analysis methods were frequency analysis, factor analysis, and multiple regression analysis. According to the result of this study, First, the silver consumers' life style factors were determined to be health and leisure pursuit, material pursuit, family pursuit, and outgoing challenge pursuit. And purchase satisfaction factors of the health functional foods were determined to be taking after dosage and service, function and purchase, appearance of health functional foods. Second, silver consumers' family pursuit life style and outgoing challenge life style had an effect on taking and service satisfaction, appearance and products satisfaction of the health functional foods. Third, purchase satisfaction had an effect on repurchase intention of the health functional foods. Therefore, this study is significant in that it clarifies the relation of silver consumers' life style and purchase satisfaction and repurchase intention of the health functional foods.

A Study on the Relation of Functional Limitation, Functional Disability and Back Pain during Pregnancy (임부의 요통, 기능제한 및 기능장애와의 상관관계 연구)

  • Shim, Mi-Jung
    • Women's Health Nursing
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    • v.8 no.1
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    • pp.96-105
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    • 2002
  • The purpose of this study is to identify the relation between functional limitation, functional disability and back pain during pregnancy. Data was collected by interview or self-report from 66 pregnant women between the gestational ages of 17 and 22 weeks who had experienced back pain from February 17 through July 28, 2001. The results of this study are as follows; 1. The prevalent mean week of back pain starting during pregnancy was 12.8. The mean pain intensity scores on the VAS during the past week and now were 5.6 and 3.7. The mean score on the functional limitations was 38.9. The mean score on the functional disability was 19.7. 2. The pain intensity on the past week was correlated with the pain intensity now (r=.339, p<0.01) and the functional limitations (r=.251, p<0.05). The pain intensity now was correlated with the functional limitations (r=.295, p<0.05) and the functional disability (r=.429, p<0.01). The functional limitations was correlated with the functional disability (r=.229, p<0.01). The higher pain intensity was the more functional limitation and functional disability occurred. 3. There was a statistically significant correlation between the pain intensity now and the type of housing (t=-2.051, p=.045), and back pain history before pregnancy (t=-2.429 p=.003). 4. There was a statistically significant correlation between the functional limitation and income (F=2.803, p=.047) and back pain history before pregnancy (t=-3.225, p=.002). There was a statistically significant correlation between the functional disability and back pain history before pregnancy (t=-3.058 p=.003). In conclusion, we found that a history of back pain was an important factor when predicting back pain and functional disability and limitation during pregnancy. The nurse and the prenatal educator should detect risk factors of back pain early in pregnancy and manage continuously though pregnancy.

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Analyzing the Functional Spaces of Military Dining Facilities Using Analytic Hierarchy Process (AHP를 이용한 군 취사식당 기능공간 분석)

  • Lee, Seung-Hoo;Lee, Hyun-Soo;Park, Moonseo;Ji, Sae-Hyun
    • Journal of the Architectural Institute of Korea Structure & Construction
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    • v.36 no.5
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    • pp.155-164
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    • 2020
  • This research used Analytic Hierarchy Process(AHP) to analyze the importance and priority of functional space and evaluation factors of each functional space of the military dining facility. Dining in the military is an important factor in restoring combat power and promoting morale. The military dining facility serves as a not only for meals, but also for watching TV, education and club activities. Workers working in dining facility spend most of their work hours in dining facility, perform tasks such as cooking, dishwashing, and leftover disposal, and take breaks. As such, the military dining facility is a space where various functions are performed, and space planning should take into account these various functions when planning the building of the dining facility. However, the criteria for defense and military facilities, which are the basis for planning the space of military dining facility, are calculated only by simply analyzing the standard floor plan to match the size of the person-to. Therefore, when there is space to be reduced in the total area, there are side effects such as leaving visible table space without consideration for priority or functional space, unseen office space, and adjusting the entire area through reduction of the lounge. Accordingly, based on the priority of the space that the staff of the military dining facility considers important, this research aims to analyze the characteristics of each functional space through classification according to its unique function. This can be an indicator that can be used as a basis for future revision of the building floor area standards of the defense and military facilities standards, and it can improve usability with an efficient space plan that takes into account the characteristics of the Korean military and the satisfaction of its workers. Furthermore, efficient use of the defense budget through rational building plans can contribute to budget reduction.

A Structural Equation Modelling of the Relationship between User Experience, Self-efficacy and Game Performance in Healthcare Serious Gam (체감형 헬스게임에서 사용자경험과 자기효능감이 게임 만족도와 성과에 미치는 영향)

  • Noh, Ghee-Young
    • Journal of Korea Game Society
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    • v.12 no.2
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    • pp.15-29
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    • 2012
  • In order to predict satisfaction and performance of sensible healthcare game using motion recognition sensor, this study analyzed the effects of flow, presence and social cognitive factor and then, it attempted to verify structural relationships thereof. Self-efficacy, being a social cognitive factor, was found to affect the level of functional satisfaction of health game but it showed no direct effect to intention of using game. Flow experience was also observed to be a meaningful predictor for the level of functional and entertainment satisfaction in the direction hypothesized. It is also shown that presence exerts a direct effect on functional satisfaction. Finally, it is discovered that functional satisfaction has meaningful influence on entertainment satisfaction as well as future intention to use. The results verifies that even in sensible healthcare game, user experience and social cognitive factor have significant effects on satisfaction and performance of a serious game.