• The Journal of Korean Physical Therapy
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• v.15 no.3
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• pp.388-411
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• 2003

The purpose of this study has been conducted to reduce the lower limbs' spasticity of the patients with hemiplegia caused by cerebral stroke of apoplexy and find differences about spasticity effects among each group. The objects of this study covered 24 patients with hemiplgia who are either in the oo hospital in Daegu or under treatment from home to hospital. The objects fall into three groups which are a group of neurological development treatment, a group of functional stimulus treatment and a group of neurological development treatment and functional stimulus treatment. The result of this study were as follows : 1) The neurological development treatment has been found to reduce the lower limbs' spasticity of patients with hemiplegia caused by cerebral stroke of apoplexy and compared to before-treatment, the MAS value of spasticity has been shown to be statistically meaningful ,and gradually over the period of between 4 weeks and 8 weeks(P <.05). 2) The functional electric stimulus treatment has been shown to reduce the lower limb's spasticity of patients with hemiplegia caused by cerebral stroke of apoplexy and compared to before-treatment, the MAS value of spasticity was statistically meaningful and compared to 4 weeks, even at the time of 8 weeks, the MAS value of spasticity have shown statistical meaningness. (P <.05) 3) When neurological development treatment and functional electric stimulus treatment was applied at the same time, the lower limbs' spasticity of patients with hemiplegia was reduced meaningfully(P <.05). Compared to before-treatment at the time of 4 weeks, the MAS value of spasticity was statistically meaningful and compared to 4 weeks at the time of 8 weeks the MAS value of spasticity was also statistically meaningful(P <.05) 4) In the case of time-based MAS value of each group, functional electric stimulus treatment reduced the spasticity more meaningfully than neurological development treatment, and the group of same application of functional electric stimulus treatment and neurological development treatment showed better statistical meaningness than functional electric stimulus treatment alone(P <.05) and finally the group of same application of neurological development treatment and functional electric stimulus treatment showed more meaningful difference than neurological development treatment alone(P <.05)

• Journal of the Korean Professional Engineers Association
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• v.41 no.4
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• pp.38-42
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• 2008

Current urban development paradigm is aiming from plane, single-functional. and public-driven to multi-dimensional, multi-functional, and private-driven development. However, existing laws and regulations relating urban development are not in accordance with the current paradigm. This paper is intended to focus on the necessity and urgency to reorganize the current legislative system.

• Journal of the Korean Society of Food Science and Nutrition
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• v.41 no.9
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• pp.1253-1258
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• 2012

In the present study, we investigated the effects of Rubus coreanus Miquel (RCM) on memory ability of senescence-accelerated mice (SAM). Prone 8 strains of SAM mice (SAMP8), which is a useful animal for investigating the mechanism of brain aging and senile dementia, were fed a diet containing 100 mg/kg body weight/day of RCM for 8 weeks. Memory ability of mice was examined by using passive avoidance test and Morris water maze test. SAMP8 mice showed remarkable memory impairment compared with senescence-resistant 1 strains of SAM (SAMR1). RCM significantly improved memory ability of SAMP8 mice. In addition, acetylcholineasterase activities decreased in the brain of SAMP8 mice treated with RCM. Taken together, these results suggest that RCM may act as an acetylcholineasterase inhibitor, thereby improving senescence-related memory impairment.

• Journal of Life Science
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• v.23 no.1
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• pp.1-7
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• 2013

Understanding salt tolerance mechanisms is important for the increase of crop yields, and so, several screening approaches were developed to identify plant genes which are involved in salt tolerance of plants. Here, we transformed the Arabidopsis cDNA library into a salt-sensitive calcineurin (CaN)-deficient ($cnb{\Delta}$) yeast mutant and isolated the colonies which can suppress salt-sensitive phenotype of $cnb{\Delta}$ mutant. Through this functional complementation screen, a total of 34 colonies functionally suppressed the salt-sensitive phenotype of $cnb{\Delta}$ yeast cells, and sequencing analysis revealed that these are 9 genes, including CaS, AtSUMO1 and AtHB-12. Among these genes, the ectopic expression of CaS gene increased salt tolerance in yeast, and CaS transcript was up-regulated under high salinity conditions. CaS-antisense transgenic plants showed reduced root elongation under 100 mM NaCl treatment compared to the wild type plant, which survived under 150 mM NaCl treatment, whereas CaS-antisense transgenic plant leaves turned yellow under 150 mM NaCl treatment. These results indicate that the expression of CaS gene is important for stress tolerance in yeast and plants.

• Journal of Information Technology Services
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• v.11 no.2
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• pp.259-274
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• 2012

A well organized system requirements provide a solid basis of achiving a successful project and are effective methods of communication among stakeholders. We illustrate and propose a 'System Requirement Development Framework' to develop correct requirements as a methodical approach. We first organize a 'Requirement Development Process' and then establish a 'Non-Functional Requirements Principle'. On these basis, we next propose a 'Requirement Development Guideline' from a perspective of 'Functional Requirement', 'Non-Functional Requirement' and 'Triage' in advanced stages. We also verify and evaluate the suitability of our proposed 'System Requirement Development Framework' by applying it to several projects.

• Animal cells and systems
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• v.10 no.1
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• pp.41-47
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• 2006

Development of the mammalian pre-implantation embryos has unique features, such as a slow and unsynchronized cell division, compaction, and eventual formation of blastocysts with inner cell mass and trophectoderm. In order to have a clue on molecular mechanisms that reside in mouse early development, we suppressed expression of early embryo-specific genes with RNAi and observed their development in vitro. We observed developmental defects in embryos microinjected with dsRNAs for Oct4 or Nanog among the tested genes. Careful examinations revealed that development of the most of the Oct4- or Nanog-suppressed embryos were arrested at the morula stage. These results suggest that the Oct4 and Nanog activities are also required for embryogenesis earlier than the blastocyst stage.

• International Journal of Internet, Broadcasting and Communication
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• v.15 no.3
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• pp.219-230
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• 2023

With the development of autonomous driving technology, as the use of software in vehicles increases, the complexity of the system increases and the difficulty of development increases. Developments that meet ISO 26262 must be carried out to reduce the malfunctions that may occur in vehicles where the system is becoming more complex. ISO 26262 for the functional safety of the vehicle industry proposes to consider functional safety from the design stage to all stages of development. Specifically at the software level, the requirements to be complied with during development and the requirements to be complied with during verification are defined. However, it is not clearly expressed about specific design methods or development methods, and it is necessary to supplement development guidelines. The importance of analysis and verification of requirements is increasing due to the development of technology and the increase of system complexity. The vehicle industry must carry out developments that meet functional safety requirements while carrying out various development activities. We propose a process that reflects the perspective of system engineering to meet the smooth application and developmentrequirements of ISO 26262. In addition, the safety analysis/verification FMEA processforthe safety of the proposed ISO 26262 function was conducted based on the FCAS (Forward Collision Avoidance Assist System) function applied to autonomous vehicles and the results were confirmed. In addition, the safety analysis/verification FMEA process for the safety of the proposed ISO 26262 function was conducted based on the FCAS (Forward Collision Avoidance Assist System) function applied to the advanced driver assistance system and the results were confirmed.

• The Research Journal of the Costume Culture
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• v.17 no.1
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• pp.149-161
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• 2009

The purposes of this study are to examine older consumers' seeking benefits and purchase intentions for functional materials and their attitudes towards such materials and investigate the differences between purchasers and non-purchasers of functional materials in their seeking benefits for functional materials and their emphasis on self development and pursuit of fashion. In doing so, this study samples the older adult population living in Seoul, Busan, and Gyeonggi Province and analyzes 267 questionnaire responses obtained from the sampled older consumers. The main findings from the analysis are as follows: First, the older consumers' seeking benefits for functional materials were represented by three different dimensions: reliability, brands/fashion, and others-oriented pursuit. Second, the influence on the dimension of reliability was more significant in the order of knowledge on functional materials, pursuit of fashion, and emphasis on self-development the interest in garments and the pursuit of fashion were found to have significant influence on the dimensions of brands/fashion and others-oriented pursuit. Third, the respondents' attitudes towards functional materials showed significant correlations with the dimensions of reliability and others-oriented pursuit, while their purchase intentions for functional materials were significantly influenced by the dimensions of reliability and brands/fashion. Finally, when the differences in the respondents' seeking benefits for functional materials and their pursuit of fashion and emphasis on self-development were investigated according to whether or not they had ever purchased clothes made from any functional material, the group of purchasers showed a higher mean value than the non-purchaser group.

• The Korean Journal of Food And Nutrition
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• v.27 no.6
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• pp.1090-1095
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• 2014

Anthocyanins, a class of flavonoids, are natural water-soluble pigments, which are mainly found in vegetables and fruits. Anthocyanins have attractive pharmacological activities, such as anti-oxidant, anti-inflammatory, anti-cancer, and anti-diabetic. The purpose of this study was to investigate the protective effects of anthocyanins-rich fraction (ANF) from Korean purple sweet potato variety, "Shinjami", against hydrogen peroxide ($H_2O_2$)-induced oxidative stress. In our results, pre-treatment of HepG2 cells with ANF ($10{\mu}g/mL$) significantly prevented cell death and maintained cell integrity, following exposure to 0.9 mM hydrogen peroxide. The $H_2O_2$-dependent production of intracellular ROS was also significantly decreased by pre-treatment with ANF (6 h, $10{\mu}g/mL$). In addition, ANF increased the mRNA levels of antioxidant enzymes, catalase and glutathione level in $H_2O_2$-treated HepG2 cells. These results indicated that ANF protected HepG2 cells against $H_2O_2$-induced oxidative stress by inducing protective system.

• Nutrition Research and Practice
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• v.5 no.3
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• pp.192-197
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• 2011

The dietary intake of whole grains is known to reduce the incidence of chronic diseases such as obesity, diabetes, cardiovascular disease, and cancer. To investigate whether there are anti-adipogenic activities in various Korean cereals, we assessed water extracts of nine cereals. The results showed that treatment of 3T3-L1 adipocytes with Sorghum bicolor L. Moench, Setaria italica Beauvois, or Panicum miliaceum L. extract significantly inhibited adipocyte differentiation, as determined by measuring oil red-O staining, triglyceride accumulation, and glycerol 3-phosphate dehydrogenase activity. Among the nine cereals, P. miliaceum L. showed the highest anti-adipogenic activity. The effects of P. miliaceum L. on mRNA expression of peroxisome proliferator-activated receptor-${\gamma}$, sterol regulatory element-binding protein 1, and the CCAAT/enhancer binding protein-${\alpha}$ were evaluated revealing that the extract significantly decreased the expression of these genes in a dose-dependent manner. Moreover, P. miliaceum L. extract changed the ratio of monounsaturated fatty acids to saturated fatty acids in adipocytes, which is related to biological activity and cell characteristics. These results suggest that some cereals efficiently suppress adipogenesis in 3T3-L1 adipocytes. In particular, the effect of P. miliaceum L. on adipocyte differentiation is associated with the downregulation of adipogenic genes and fatty acid accumulation in adipocytes.