• Korean Journal of Head & Neck Oncology
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• v.21 no.1
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• pp.48-52
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• 2005

Objectives: Castleman's disease(CD) is a lymphoproliferative disorder of unknown etiology. To elucidate the clinicopathologic characteristics of CD, we retrospectively reviewed our experience. Methods: Fifteen patients with CD of the neck and mediastinum were identified. Patients were divided into two groups: group I had an unicentric CD and group II had multicentric CD. The histology of CD was divided into 3 subtypes: hyaline-vascular(HV), plasma cell(PC), and mixed. Results: The study included 12 cases of group I, 3 cases of group II in the clinical aspect and 10 cases with HV, 3 cases with PC, 2 cases with mixed type in the histologic aspect. Of group I patients who underwent complete surgical excision, all are currently free of disease. The clinical course of group II patients was variable. Of two patients with multicentric plasma cell CD who were treated, one remain free from disease and the other had a local recurrence in the neck. One patient with multicentric mixed CD died of disease after 30 months of presentation. Conclusion: Surgical resection is recommend for patients with the unicentric CD, regardless of histologic subtype. Patients with multicentric disease do not benefit from surgical resection and should be candidates for multimodality therapy.

• Parasites, Hosts and Diseases
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• v.61 no.4
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• pp.449-454
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• 2023

Free-living amoebae (FLA) rarely cause human infections but can invoke fatal infections in the central nervous system (CNS). No consensus treatment has been established for FLA infections of the CNS, emphasizing the urgent need to discover or develop safe and effective drugs. Flavonoids, natural compounds from plants and plant-derived products, are known to have antiprotozoan activities against several pathogenic protozoa parasites. The anti-FLA activity of flavonoids has also been proposed, while their antiamoebic activity for FLA needs to be emperically determined. We herein evaluated the antiamoebic activities of 18 flavonoids against Naegleria fowleri and Acanthamoeba species which included A. castellanii and A. polyphaga. These flavonoids showed different profiles of antiamoebic activity against N. fowleri and Acanthamoeba species. Demethoxycurcumin, kaempferol, resveratrol, and silybin (A+B) showed in vitro antiamoebic activity against both N. fowleri and Acanthamoeba species. Apigenin, costunolide, (-)-epicatechin, (-)-epigallocatechin, rosmarinic acid, and (-)-trans-caryophyllene showed selective antiamoebic activity for Acanthamoeba species. Luteolin was more effective for N. fowleri. However, afzelin, berberine, (±)-catechin, chelerythrine, genistein, (+)-pinostrobin, and quercetin did not exhibit antiamoebic activity against the amoeba species. They neither showed selective antiamoebic activity with significant cytotoxicity to C6 glial cells. Our results provide a basis for the anti-FLA activity of flavonoids, which can be applied to develope alternative or supplemental therapeutic agents for FLA infections of the CNS.

• Journal of the Society of Naval Architects of Korea
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• v.32 no.1
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• pp.42-57
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• 1995

An efficient and accurate scheme has been constructed by taking advantages of the hi-quadratic spline scheme and the higher-order boundary element method selectively depending on computation domains. Boundary surfaces are represented by 8-node boundary elements to describe curved surfaces of a ship and its neighboring free surface more accurately. The variation of the velocity potential complies with the characteristics of the 8-node element on the body surface. But on the free surface, it is assumed to follow that of the hi-quadratic spline scheme. By which, the free surface solution is free from numerical damping and has better numerical dispersion property. As numerical examples, steady and unsteady Neumann-Kelvin problems are considered. Numerical results for a submerged spheroid, Series 60($C_B=0.6$) and a modified support the proposed method. Finally, a new upstream radiation condition is derived using a wave equation operator in order to deal with problems for subcritical reduced frequency. The relevance of this operator has been confirmed in the case of unsteady Kelvin source potential.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.31 no.5
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• pp.409-416
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• 2005

Purpose of study: The temporomandibular joint (TMJ) occupies a key functional role in mastication and contributes to normal deglutition, speech as well as cosmesis. When a large amount of mandible including the condyle head is resected, it is very difficult to reconstruct it as a functional unit. In this retrospective study, we present the functional, radiographic and cosmetic results of reconstructed temporomandibular joint using free fibular flap. Patients and Methods: Total 12 patients (M:F = 6:6) who underwent condylar reconstruction with the fibular flap were interviewed and examined by radiographs and Bio-PAK$^{(R)}$. Mean follow up periods was $47.7{\pm}20.0$ months and the average age was $38.7{\pm}15.3$ years. Remodeling of condyle and function of TMJ were evaluated and facial contour was judged subjectively. Results: All flaps were viable and no immediate postoperative complication had happened. One patient showed decreased mouth opening, so interpositional gap arthroplasty was performed. The resorption rates of reconstructed fibular were minimal and the condyle heads were changed into domeshaped neocondyle after 2 years. All patients had normal diet and no speech difficulty was reported. Nine patients were satisfied with their facial contour but three patients complained about the depression of cheek. Conclusion: The reconstruction of TMJ with free fibular flap was reliable methods and very effective means of restoring mandibular function. The functional and morphologic results were excellent and showed little complications.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.36 no.6
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• pp.303-307
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• 2014

Undifferentiated pleomorphic sarcoma (UPS), previously known as malignant fibrous histiocytoma, occurs commonly in the soft tissues in adult, but is rare in the maxillofacial region. It consists of undifferentiated mesenchymal tumor cells resembling histiocytes and fibroblasts. The purpose of this article is to report a case of UPS in the mandible. A 44-year-old patient presented with a painful growing mass in the mandible of two months' duration. Computed tomography and positron emission tomography-computed tomography revealed an ill-defined heterogenous, hypermetabolic mass about 4 cm in size in the left mandible invading adjacent soft tissues. A left mandiblulectomy and reconstruction with a fibular free flap were performed. Immunohistochemical study gave a diagnosis of UPS. The patient was referred for adjuvant chemotherapy after surgical removal of the tumor.

• Journal of Korea Society of Industrial Information Systems
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• v.22 no.2
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• pp.35-41
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• 2017

In This Paper, We Propose the Development of a Medical Questionnaire Recognition System using Vision Technology. The Proposed System is Able to Accurately Recognize and Effectively Process a Large Number of Questionnaires used in Community Health Surveys in the Medical and Health Fields. The System Consists of Questionnaire Scanning, Answer Recognition and Error Data Processing, Result Data Verification, Image Storage and DB Construction, and Analysis of Questionnaire Results. Unlike Existing Systems, This System is Free from the Form of Questionnaires used, and Enables Accurate Recognition by Processing Various Markings and Erroneous Markings. Experimental Results Show that the Proposed System has 98.9% Recognition rate.

• Journal of Microbiology and Biotechnology
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• v.7 no.4
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• pp.272-277
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• 1997

In the purification of elaiophylin from a culture of Streptomyces hygroscopicus MCY -846, mono- and di-methyl-elaiophylin were obtained through a O-methylation of the hemiketal hydroxy group of elaiophylin. All the three elaiophylins showed cytotoxicity against several human tumor cell lines and murine cell lines. Elaiophylin and monomethyl-elaiophylin also showed antimicrobial activities against gram-positive bacteria and potent inhibitory effects on the activation of B cells by lipopolysaccharide as well as on the proliferation of mouse splenic lymphocytes stimulated by mitogens but dimethyl-elaiophylin did not. This result indicates that elaiophylin and monomethyl-elaiophylin would be strong immunosuppressants. Furthermore this result revealed an interesting structure-activity relationship suggesting that the lack of symmetry and/or the free OH group at C-11 of elaiophylin might be important in conferring biological activities.

• Journal of Microbiology and Biotechnology
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• v.13 no.3
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• pp.360-365
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• 2003

The ability of 19 lactic acid bacteria to produce hydroxy fatty acids (HFAs) from unsaturated food fatty acids (USFAs) was tested. HFAs are related to human ailments, including steatorrhea. All the cultures produced HFAs from USFAs, unless their growth was inhibited by free USFAs. Lactococcus lactis subsp. lactis KFRI 131 converted oleic, linoleic, and linolenic acid into 10-hydroxyoctadecanoic acid (10-HODA), 10-hydroxyoctadecaenoic acid (10-HODEA), and 10-hydroxyoctadecadienoic acid (10-HODDEA), respectively. Both a USFA and a surfactant were needed for the bacterium to convert the fatty acid into the corresponding HFA. It was apparent that the production of 10-HODA was growth-related, while that of 10-HODDEA was not. It was unclear whether the production of 10-HODEA was growth-related.

• Journal of the Society of Naval Architects of Korea
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• v.50 no.6
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• pp.429-435
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• 2013

Recently, to improve the safety and maneuverability at fairway around harbor the POD system has been equipped on a ship. And the interest about maneuvering characteristics of a cruise ship has been increasing. In this paper the mathematical model of maneuvering motion of a cruise ship with twin POD system in general speed and slow speed are presented. And the maneuvering coefficients of mathematical model are obtained from the captive model tests using CPMC(Computerized Planar Motion Carriage). Computer simulation using mathematical model in general speed and slow speed are carried out and compared with the results of free running model test with the same model ship. The differences between the mathematical models are compared and discussed. In this paper the mathematical models, the results of captive model test and simulation results are presented.

• Korean Journal of Microbiology
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• v.41 no.2
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• pp.135-139
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• 2005

Antioxidant activity of monascus pigment of Monascus purpureus P-57 mutant was studied. Methanol extract from monascus pigment was separated into five organic solvent fractions; hexane, chloroform, ethyl acetate, butanol and water fractions. Hexane fraction showed the highest free radical scavenging effect on 1,l-diphenyl-2-picryl hydrazyl(DPPH), and the strongest inhibitory effect against xanthine oxidase, followed by chloroform fraction. But butanol and water fraction did not show inhibitory effect against the enzyme. Lineweaver-Burk plot showed that hexane fraction inhibited xanthine oxidase by non-competitive mode.