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Antioxidant Activity of Monascus Pigment of Monascus purpureus P-57 Mutant  

Park Chi Duck (Department of Microbiology, Keimyung University)
Jung Hyuck Jun (Department of Microbiology, Keimyung University)
Lee Hang Woo (Traditional Microorganism Resources Center, Keimyung University)
Kim Hyun Soo (Department of Microbiology, Keimyung University)
Yu Tae Shick (Department of Microbiology, Keimyung University)
Publication Information
Korean Journal of Microbiology / v.41, no.2, 2005 , pp. 135-139 More about this Journal
Abstract
Antioxidant activity of monascus pigment of Monascus purpureus P-57 mutant was studied. Methanol extract from monascus pigment was separated into five organic solvent fractions; hexane, chloroform, ethyl acetate, butanol and water fractions. Hexane fraction showed the highest free radical scavenging effect on 1,l-diphenyl-2-picryl hydrazyl(DPPH), and the strongest inhibitory effect against xanthine oxidase, followed by chloroform fraction. But butanol and water fraction did not show inhibitory effect against the enzyme. Lineweaver-Burk plot showed that hexane fraction inhibited xanthine oxidase by non-competitive mode.
Keywords
antioxidant activity; microbial pigment; monascus pigment; Monascus purpureus; xanthine oxidase inhibition;
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