• Korean Journal of Clinical Pharmacy
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• v.20 no.1
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• pp.78-84
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• 2010

Background: Clostridium difficile is the primary reason of the nosocomial diarrhea. The antimicrobial therapy plays a central role in the pathogenesis of Clostridium difficile associated diarrhea (CDAD). Although nearly all classes of antimicrobial agents have been associated with CDAD, clindamycin and the third-generation cephalosporins have traditionally been considered to the greatest risk factor. Recent studies have also implicated fluoroquinolones as high-risk agents due to increasing use of the agents. This study was to determine the incidence and the risk factors of CDAD related to the administered antibiotics and to assess the therapeutic regimen of metronidazole or vancomycin based on the C. difficile toxin assay Methods: A retrospective study was performed in patients with Clostridium difficile toxin assay at I Hospital (Incheon, South Korea) during the period from January 2007 through December 2007. Administrative, laboratory, and pharmacy data were collected from Electronic Medical Databases. Results: The analysis included 129 reported C.difficile toxin assay results, with 42 positive cases and 87 negative cases. Significant antibiotic risk factors for CDAD included the use of the fourth-generation cephalosporinse (OR=5.97, 95% CI 1.37-25.98, P=0.017). Administration of metronidazole was protective against CDAD (OR=0.30, 95% CI 0.12-0.74, P=0.009). Prolonged antimicrobial therapy has been associated with an increased risk of CDAD. The third-generation cephalosporins (OR=3.81, 95% CI 1.08-13.41, P=0.037) and aminoglycoside (OR=5.50, 95% CI 1.43-21.10, P=0.013) demonstrated greater risk for CDAD over 15 days than 8days or less days of treatment duration. Conclusions: The fourth and third generation cephalosporin, aminglycoside were the significant risk factors compared with other antibiotics, whereas metronidazole appears to be protective. The longer duration of antiobiotic use increased CDAD.

• Journal of Family Resource Management and Policy Review
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• v.27 no.1
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• pp.1-12
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• 2023

This study forecasts the outlook 10 years from now regarding domestic labor and caregiving by the Baby Boomer generation and the preparations needed in the context of the Fourth Industrial Revolution. The scenario-planning method was used to explore changing trends in domestic labor and caregiving, the rationale for which has been questioned by both seniors and family welfare experts. Based on the results of the survey and our researchers' opinions, it was concluded that the changing trends were caused by two factors: the probability of alterations in domestic labor and the strength of family relationships. On the basis of these conclusions, four scenarios regarding baby boomers' domestic labor and caregiving in 10 years were proposed using two axes: the "high and low probability of alterations" and the "strengthening and weakening of family relationships." The first scenario is a "preference for the self-caring form of family," which has a high probability of domestic labor alterations and weak family relationships. The second scenario is a "preference for the flexible form of family," which has a high probability of domestic labor alterations and strong family relationships. The third scenario is a "preference for the traditional form of family," which has a low probability of domestic labor alterations and strong family relationships. The fourth scenario is a "preference for the public caregiving form of family," which has a low probability of domestic labor alterations and weak family relationships. These results provide basic information about the various aspects of baby boomers' lives-including the development of various goods and services, the establishment of policies regarding seniors, and programs for successful aging-and can help equip our society to take the actions needed for a super-aged population.

• Journal of Families and Better Life
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• v.20 no.3
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• pp.125-138
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• 2002

The first purpose of this study is to inquire into the effect of new generation housewives'etiquette awareness on their etiquette implementation. For this purpose, this study will search the levels of new generation housewives'etiquette awareness and etiquette implementation, how the etiquette awareness and etiquette implementation vary according to their background variables, and the effect of new generation housewives'etiquette awareness as well as the background variables on their etiquette implementation. The major findings are as follows . First, the level of etiquette awareness was somewhat higher than that of etiquette implementation. Second, generally, their etiquette awareness didn't show a significant difference by the socio-demographic variables, but showed a significant difference by the psychological variables including communication level and humanism/materialism value orientation. Third, new generation housewives'etiquette implementation showed a significant difference only by monthly income like etiquette awareness. Meanwhile, as the psychological variables, etiquette implementation showed a significant difference by all Psychological variables except sex-role attitude. fourth, according to result of looking into relative influence of socio-demographic variables, psychological variables, and etiquette awareness about etiquette implementation, etiquette awareness was a significant variable which affects etiquette implementation.

• Journal of the Korean Society of Costume
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• v.53 no.3
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• pp.31-49
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• 2003

The Purpose of this research is to examine and contrast the cultural characteristics of the street fashion in new generations of Korea and Japan. We also intended to help clothing companies understand the current trend in this new generation. As the method for street fashion analysis. various literature, internet information and new media materials were utilized. Key observations obtained are as following First, they pursue a complex image. New generations seem to admix images from different areas to create a synthetic image, rather than adopting a single image; Second, practicality is an important factor. They Pursue a sense of their own unique trend: Third, distinction. The difference in society values between Koreans and Japanese is incorporated. The Korean new generation considers the traditional moral principles as important social values. In contrast the Japanese new generation is greatly influenced by the open sexuality culture ; Fourth. public ownership and sharing of the culture. There is a gradual deviation from a dominating unidirectional influence from one country on another. Now the two countries are influencing each other ; Fifth, sense. There are numerous fashion items and generalized total coordination. New generations express more active and creative fashion sense in those fashion items.

• Journal of Korea Multimedia Society
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• v.20 no.2
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• pp.420-428
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• 2017

In recent trends, the first age of digital device usage has been significantly getting low and the using frequencies for younger generation have been gradually increasing. Also, while there were more negative opinions of this trend in the past, the new idea is changing to more needs of training and approaches for children's sound using guidelines for digital device. In fact, people believe the new generation will face more advanced future, called the Fourth Industrial Revolution. The purpose of the paper is first to explain about the Jacques Lacan's concept of desire theory in order to understand the human's unconscious level through His desire theory. Second, the paper identifies how this unconscious level is affected to ethical aspects of new generations whose unconscious level are frequently and early exposed to digital media. Lastly, the paper will present the necessity of digital literacy education as well as future direction. Furthermore, the paper review for what is the ethics and positive guidelines of digital media for children who will become the future citizens in the era of the Fourth Industrial Revolution.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.23 no.11
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• pp.1478-1481
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• 2019

As core technologies(IoT, 5G, Cloud, Bigdata, AI etc) leading the Fourth Industrial Revolution promote smart convergence across the national socio-economic infrastructure, the threat of new forms of cyber attacks is increasing and the possibility of massive damage is also increasing. Reflecting this trend, cyber security is expanding from simple information protection to CPS(Cyber Physical System) protection that combines safety and security that implements hyper-connectivity and ultra-reliability. This study introduces the recent evolution of cyber attacks and looks at the next generation cyber security technologies based on the conceptual changes of cyber security technologies such as SOAR(Security Orchestration, Automation and Response) and Zero Trust.

• Journal of the Korean Physical Society
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• v.73 no.9
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• pp.1303-1309
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• 2018

In the present paper, we study the entropy analysis of boundary layer flow over a slender stretching sheet under the action of a non uniform magnetic field that is acting perpendicular to the flow direction. The effects of viscous dissipation and Joule heating are included in the energy equation. Using similarity transformation technique the momentum and thermal boundary layer equations to a system of nonlinear differential equations. Numerical solutions are obtained using the shooting and fourth-order Runge-Kutta method. The expressions for the entropy generation number and Bejan number are also obtained using a suggested similarity transformation. The main objective of this article is to investigate the effects of different governing parameters such as the magnetic parameter ($M^2$), Prandtl number (Pr), Eckert number (Ec), velocity index parameter (m), wall thickness parameter (${\alpha}$), temperature difference parameter (${\Omega}$), entropy generation number (Ns) and Bejan number (Be). All these effects are portrayed graphically and discussed in detail. The analysis reveals that entropy generation reduces with decreasing wall thickness parameter and increasing temperature difference between the stretching sheet and the fluid outside the boundary layer. The viscous and magnetic irreversibilities are dominant in the vicinity of the stretching surface.

• Fashion & Textile Research Journal
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• v.24 no.1
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• pp.81-94
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• 2022

The purpose of this study is to analyze the trends of MZ generation's lifestyle-related research from 2010 to 2020. As a result of searching keywords such as MZ generation's and lifestyle using academic database search sites, a total of 218 cases were used as analysis data to conduct frequency and content analysis. First, research type was 74 dissertations(34.6%), 144 journals(65.4%). The study of MZ generation was relatively active in journals. Second, the current status of academic field was 85(39.7%) in the social field, followed by 66(30.8%) in the arts/physical education, 21(9.8%) in the complex studies, 16(7.5%) in education, 15(7.0%) in nature, 6(2.8%) in engineering, 4(1.9%) in humanities, 1(0.5%) in agriculture/marine. Third, the current status of MZ generation research topics is 54 social participations(25.3%), 35 fashion/beauty(16.3%), 31 social/organizational adaptations(14.5%), 25 cultural/leisure activities(11.7%), 24 design/development projects(11.2%), 21 economic/employment/job projects(9.8%), 11 educational/career/experiences(5.1%), 9 self-concepts(4.2%), 4 welfare services(1.9%). Fourth, the current status of MZ generation research methods was quantitative research(survey/experiment) 125(58.4%), qualitative research(depth interview/participant observation) 42(19.6%), theory/literature research 35(16.4%) and mixed research 12(5.6%). Fifth, the study on the lifestyle of the MZ generation was conducted in four cases, one in 2016, one in 2019, two in 2020. This study is meaningful in that it grasped the overall flow of data of information exchange that can share the research trends of the MZ generation and suggested the basic data on the direction of future research, the individual tendency, behavior, and lifestyle characteristics of the MZ generation.

• Journal of Animal Science and Technology
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• v.52 no.6
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• pp.451-457
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• 2010

The porcine MHC (Major Histocompatibility Complex), encoding the SLA (Swine Leukocyte Antigen) genes, is one of the most significant regions associated with immune rejection in relation to transplantation. In this study, three SLA class I (SLA-1, SLA-3, SLA-2) loci and three SLA class II (DRB1, DQB1, DQA) loci were investigated in the previously unidentified Korean native pig (KNP) population that was closely inbred in the Livestock Technology Research Station in Cheongyang, Korea. Total thirteen KNPs from four generations were genotyped for the SLA alleles and haplotypes were investigated using PCR-SSP (Sequence-Specific Primer) method. The results showed that all of these KNPs had Lr-56.30/56.30 homozygous haplotype, indicating high level of inbreeding in the SLA genes. The inbreeding status of these animals was also investigated using microsatellite (MS) markers. From the 50 MS markers investigated, 17 MS markers were fixed in all generations and the fixed alleles are increased as 26 loci for the fourth generation. Two MS markers, S0069 and SW173, were heterozygous for all the animals tested. Observed and expected heterozygosities were calculated and the average inbreeding coefficients for each generation were also calculated. In the fourth generation, the average inbreeding coefficients was 0.732 and this may increase with further inbreeding process. Analysis of the SLA haplotypes and MS alleles can give important information for breeding the pigs for xenotransplantation studies.

• BMB Reports
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• v.40 no.5
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• pp.636-643
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• 2007

This study was designed to identify and characterize the mechanism of macrophage activation by AAP, an acidic polysaccharide fraction isolated from the roots of Angelica sinensis (Oliv.) Diels. As a result, AAP significantly enhanced nitric oxide (NO) production and cellular lysosomal enzyme activity in murine peritoneal macrophages in vitro and in vivo. Furthermore, L-NAME, a specific inhibitor of inducible nitric oxide synthase (iNOS), effectively suppressed AAP-induced NO generation in macrophages, indicating that AAP stimulated macrophages to produce NO through the induction of iNOS gene expression and the result was further confirmed by the experiment of the increase of AAP-induced iNOS transcription in a dose-dependent manner. To further investigate, AAP was shown to strongly augment toll-like receptor 4 (TLR4) mRNA expression and the pretreatment of macrophages with anti-TLR4 antibody significantly blocked AAP-induced NO release and the increase of iNOS activity, and tumor necrosis factor-$\alpha$ (TNF-$\alpha$) secretion.