• Title/Summary/Keyword: Foot-and-Mouth Disease

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Application of biodegradable metal based drug delivery carrier on Foot and Mouth Disease vaccination in pigs (돼지에서 생체 분해 금속성 전달체를 활용한 구제역 백신의 적용 연구)

  • Cho, Ara;Oh, Sang-Ik;Choe, Changyong;Jung, Young-Hun;Do, Yoon Jung;Kim, Suhee;Choo, Hyun Wook;Gu, Jong Su;Chung, Woo-Jin;Cho, Sung Youn;Yoo, Jae Gyu
    • Korean Journal of Veterinary Service
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    • v.43 no.3
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    • pp.129-137
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    • 2020
  • In this study, we applied biodegradable drug delivery carries (BDDC) for food-and-mouth (FMD) vaccination. After FMD vaccination using BDDC, we estimated the percentage inhibition (PI) of antibody, decomposed patterns, and histopathologic features of BDDC. PI of antibody was higher than 50 at two weeks after injection and sustained positive PI until 10 weeks after injection. BBDC injection group showed significantly an increased pattern of blood monocyte at two and three weeks after injection. According to the Micro CT, micro-cracks were observed at two weeks after injection and the morphology of BDDC was lost at four weeks after injection. For histopathological examination, acute inflammation with neutrophil infiltration and micro-metallic residues were observed around BDDC until four weeks after injection and inflammatory responses gradually decreased at 10 weeks. Based on our experiment, BDDC is considered as an alternative way to vaccine injection for veterinary applications. Our study can be used as basic data for the drug delivery system using biodegradable metals in the future.

The Effects of Dietary Probioties Fortified with Micro-minerals on Egg Production and the Improvement of Egg Quality in Old Layer (사료내 미량광물질 강화 복합미생물 첨가가 산란노계의 계란생산 및 난질개선에 마치는 영향)

  • Jeong, Soo-Jin;Joo, Eun-Jung;Lee, Woo-Sic;Yon, Byeng-Sun;Lee, Ju-Sam;Nam, Ki-Taek;Hwang, Seong-Gu
    • Korean Journal of Organic Agriculture
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    • v.12 no.2
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    • pp.219-230
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    • 2004
  • In recent years, the consumption of livestock products were markedly decreased by awareness of world-widely occurred diseases including mad cow disease, Foot and mouth disease, Hog cholera, and Poultry Influenza virus. the consumers ara also wanting to have highly safe food such as organic animal products because of concerning about residual of antibiotics in animal products. However, disease control and impairment of productivity are the major problem in organic animal production. On these points of view, the present study was undertaken to investigate the effects of 1% or 2% of dietary probiotics fortified with various minerals on improvement of egg production and egg quality in old lay6r feeding low quality feed mainly composed of food waste, sesame meal, and rice bran. After 4 weeks of experimental feeding, the diameter of spreading of egg white was clearly decreased from 11.2cm of control eggs to 10.5m and 10.1m in 1% and 2% treatment group eggs, respectively. The color of egg yolk was 9.3 in control eggs but remarkably increased in treatment groups showing 10.1~10.2. Egg production was 75.8% in control layers but significantly increased to 79.8% of 1% treatment group and 82.9% of 2% treatment group layers. Egg weights (C : 66.3g, 1% : 73.2g, and 2% : 76.7g) and egg shell thickness (C : 0.33mm, 1% : 0.35mm and 2% : 0.36mm) were also increased by the addition of 1% or 2% of probiotics when compared to those of control group eggs. All together, it has been suggested that dietary addition of probiotics fortified with various minerals can improve the egg quality and egg production in layer's productivities by the recycling of organic waste resources such as food waste and agricultural by-products.

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Assessment of Instrument Efficiency in Detecting Airborne Virus (공기 중 바이러스 포집 장비의 효율성 평가)

  • Ha, Tae-Hwan;Lee, In-Bok;Kwon, Kyeong-Seok;Lee, Sung-Bok;Song, Sang-Hyeon;Bitog, Jessie. P.;Yoon, Soon-Seek
    • Journal of The Korean Society of Agricultural Engineers
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    • v.54 no.1
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    • pp.63-72
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    • 2012
  • In livestock industry, damage caused by the epidemic diseases such as Foot-and-Mouth Disease (FMD), Highly-Pathogenic-Avian-Influenza (HPAI) and Porcine-Reproductive-and-Respiratory-Syndrome (PRRS) was very serious. The financial loss incurred from FMD alone which occurred on Nov. 2011 in Korea was estimated at 3 billion won, 23 % of annual livestock industry production. The livestock industry in Korea has greater risk of disease infection because of high density production, etc. Investigating the spread of livestock diseases should consider both direct and indirect contact as well as other various factors including airborne. Airborne infection of livestock disease was first hypothesised in the early 1900s, however, field experimental studies are still limited. Furthermore, no protocol is available in detecting airborne viruses in the field. In this study, effective virus samplers were investigated by comparative analysis of the type of samplers used detect to airborne virus. Laboratory experiments were conducted to compare virus samplers such as Bio-sampler, Dust-sampler, Compact-Cascade-Impactor (CCI) and Microflow in detecting PRRSV. Samples were analyzed by Reverse-Transcription PCR to assess the efficiency of the instrument in detecting the airborne virus. First, samples were classified into five levels according to light intensity of gel images and then the classified results were normalized. In every case, Bio-sampler and Dust-sampler were comparable with each other and have shown to be more effective than CCI and Microflow samplers.

Fast Detection of Disease in Livestock based on Deep Learning (축사에서 딥러닝을 이용한 질병개체 파악방안)

  • Lee, Woongsup;Kim, Seong Hwan;Ryu, Jongyeol;Ban, Tae-Won
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.21 no.5
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    • pp.1009-1015
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    • 2017
  • Recently, the wide spread of IoT (Internet of Things) based technology enables the accumulation of big biometric data on livestock. The availability of big data allows the application of diverse machine learning based algorithm in the field of agriculture, which significantly enhances the productivity of farms. In this paper, we propose an abnormal livestock detection algorithm based on deep learning, which is the one of the most prominent machine learning algorithm. In our proposed scheme, the livestock are divided into two clusters which are normal and abnormal (disease) whose biometric data has different characteristics. Then a deep neural network is used to classify these two clusters based on the biometric data. By using our proposed scheme, the normal and abnormal livestock can be identified based on big biometric data, even though the detailed stochastic characteristics of biometric data are unknown, which is beneficial to prevent epidemic such as mouth-and-foot disease.

Development of Predicting Model for Livestock Infectious Disease Spread Using Movement Data of Livestock Transport Vehicle (가축관련 운송차량 통행 데이터를 이용한 가축전염병 확산 예측모형 개발)

  • Kang, Woong;Hong, Jungyeol;Jeong, Heehyeon;Park, Dongjoo
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • v.21 no.4
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    • pp.78-95
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    • 2022
  • The result of previous studies and epidemiological invstigations for infectious diseases epidemic in livestock have shown that trips made by livestock-related vehicles are the main cause of the spread of these epidemics. In this study, the OD traffic volume of livestock freight vehicle during the week in each zone was calculated using livestock facility visit history data and digital tachograph data. Based on this, a model for predicting the spread of infectious diseases in livestock was developed. This model was trained using zonal records of foot-and-mouth disease in Gyeonggi-do for one week in January and February 2015 and in positive, it was succesful in predicting the outcome in all out of a total 13 actual infected samples for test.

Enterovirus 71 infection and neurological complications

  • Lee, Kyung Yeon
    • Clinical and Experimental Pediatrics
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    • v.59 no.10
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    • pp.395-401
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    • 2016
  • Since the outbreak of the enterovirus 71 (EV71) infection in Malaysia in 1997, large epidemics of EV71 have occurred in the Asia-Pacific region. Many children and infants have died from serious neurological complications during these epidemics, and EV71 infection has become a serious public health problem in these areas. EV71 infection causes hand, foot and mouth disease (HFMD) in children, and usually resolves spontaneously. However, EV71 occasionally involves the central nervous system (CNS), and induces diverse neurological complications such as brainstem encephalitis, aseptic meningitis, and acute flaccid paralysis. Among those complications, brainstem encephalitis is the most critical neurological manifestation because it can cause neurogenic pulmonary hemorrhage/edema leading to death. The characteristic clinical symptoms such as myoclonus and ataxia, cerebrospinal fluid (CSF) pleocytosis, and brainstem lesions on magnetic resonance imaging, in conjunction with the skin rash of HFMD and the isolation of EV71 from a stool, throat-swab, or CSF sample are typical findings indicating CNS involvement of EV71 infection. Treatment with intravenous immunoglobulin and milrinone are recommended in cases with severe neurological complications from EV71 infection, such as brainstem encephalitis. Despite the recent discovery of receptors for EV71 in human cells, such as the scavenger receptor B2 and P-selection glycoprotein ligand 1, it is not known why EV71 infection predominantly involves the brainstem. Recently, 3 companies in China have completed phase III clinical trials of EV71 vaccines. However, the promotion and approval of these vaccines in various countries are problems yet to be resolved.

Transcriptome analysis of a transgenic Arabidopsis plant overexpressing CsBCAT7 reveals the relationship between CsBCAT7 and branched-chain amino acid catabolism

  • Kim, Young-Cheon;Lee, Dong Sook;Jung, Youjin;Choi, Eun Bin;An, Jungeun;Lee, Sanghyeob;Lee, Jeong Hwan
    • Journal of Plant Biotechnology
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    • v.48 no.4
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    • pp.228-235
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    • 2021
  • The amino acids found in plants play important roles in protein biosynthesis, signaling processes, and stress responses, and as components in other biosynthesis pathways. Amino acid degradation helps maintain plant cells' energy states under certain carbon starvation conditions. Branched-chain amino acid transferases (BCATs) play an essential role in the metabolism of branched-chain amino acids (BCAAs) such as isoleucine, leucine and valine. In this paper, we performed genome-wide RNA-seq analysis using CsBCAT7-overexpressing Arabidopsis plants. We observed significant changes in genes related to flowering time and genes that are germination-responsive in transgenic plants. RNA-seq and RT-qPCR analyses revealed that the expression levels of some BCAA catabolic genes were upregulated in these same transgenic plants, and that this correlated with a delay in their senescence phenotype when the plants were placed in extended darkness conditions. These results suggest a connection between BCAT and the genes implicated in BCAA catabolism.

Pork Production in China, Japan and South Korea

  • Oh, S.H.;Whitley, N.C.
    • Asian-Australasian Journal of Animal Sciences
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    • v.24 no.11
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    • pp.1629-1636
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    • 2011
  • Global pork markets are becoming more competitive, riding the wind of the bilateral free trade agreement. China is the world's largest pork producer with nearly 50% of the world's total production. China's fast growing economy has provided its people with higher purchasing power, resulting in a rapid expansion of the Chinese swine industry over the past decades. Worldwide, China consumes the greatest amount of pork and it is believed that this trend will continue. Japan is the world's largest pork importing country, even though it also produces a lot of pork. The Japanese swine industry encounters weighty obstacles in production costs and environmental limitations which result in reduced domestic supply and creates the situation in which Japan has to import a significant amount of pork for their consumption. South Korea is also a large buyer of pork, with a status greatly influenced by the struggle that the country has faced with Foot and Mouth Disease (FMD) which occurred in 2000, 2002 and 2010. High production costs, low production efficiency, and forced culling following the FMD outbreak resulted in the loss of many hog farming households in the country, reducing supply of domestic pork in the face of continued demand. Overall, pork production in these economically important countries can greatly impact the industry globally. The goal of this review paper is to describe pork production in China, Japan, and South Korea and discuss these countries' role in global pork export markets.

A Possible Role of Trehalose as a Regulatory Molecule in Plant Drought Resistance

  • Hwang, Eul-Won;Cho, Soo-Muk;Kwon, Hawk-Bin
    • Korean Journal of Environmental Agriculture
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    • v.23 no.3
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    • pp.123-127
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    • 2004
  • In many organisms, trehalose has been Down as an energy source and a protectant against various environmental stresses such as desiccation, freezing, heat and osmotic pressure. Previously, we have isolated and characterized the genes encoding trehalose-6-phosphate synthase (ZrTPS1) and trehalose-6-phosphate phosphatase (ZrTPS2) from one of the most osmotolerant yeasts, Zygosaccharomyces rouxii. We have also generated transgenic plants by co-introduction of ZrTPS2 and ZrTPS2 into potato plant (ZrTPS2-2A-ZrTPS1 plant) in an attempt to metabolically engineer trehalose in the transgenic plant using the foot-and-mouth disease virus(FMDV) 2A system and to generate drought resistant crop plants. In this research, we assayed previously generated the ZrTPS2-2A-ZrTPS1 plant biofunctionally by drought treatment, and measured the amount of trehalose in the ZrTPS2-2A-ZrTPS1 transgenic plants. The ZrTPS2-2A-ZrTPS1 transgenic plant showed strong drought resistance in spite of little or no accumulation of transgenic in he transgenic plant compared with control plant.

ICT Fusion Type Plasma Waste Heat Ventilation System for Improvement of Indoor Air Quality (실내 공기질 개선을 위한 ICT 융복합형 플라즈마 폐열 환기 시스템)

  • Kim, Eung-Kon
    • The Journal of the Korea institute of electronic communication sciences
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    • v.14 no.6
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    • pp.1215-1220
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    • 2019
  • Currently, each farm bears both the outbreak of foot-and-mouth disease and the damage caused by AI. In addition, complaints about odors in the livestock industry are constantly being recovered and are expected to occur in the future. The purpose of this study is to improve the indoor air quality of enclosed facilities such as barns, houses, pigsty, and etc. This paper develops low-temperature plasma waste heat ventilation system to be installed in ventilation unit location and standardizes heat exchange element, low-temperature plasma lamp, and ballast for enhanced air cleaning function. In addition, this study intends to develop a new control system so that the farmers can connect with existing weather systems, flow fans, and other facility equipment by incorporating ICT.