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http://dx.doi.org/10.7853/kjvs.2020.43.3.129

Application of biodegradable metal based drug delivery carrier on Foot and Mouth Disease vaccination in pigs  

Cho, Ara (Division of Animal Diseases & Health, National Institute of Animal Science, RDA)
Oh, Sang-Ik (Division of Animal Diseases & Health, National Institute of Animal Science, RDA)
Choe, Changyong (Division of Animal Diseases & Health, National Institute of Animal Science, RDA)
Jung, Young-Hun (Division of Animal Diseases & Health, National Institute of Animal Science, RDA)
Do, Yoon Jung (Division of Animal Diseases & Health, National Institute of Animal Science, RDA)
Kim, Suhee (Division of Animal Diseases & Health, National Institute of Animal Science, RDA)
Choo, Hyun Wook (LABnPEOPLE Co. Ltd.)
Gu, Jong Su (LABnPEOPLE Co. Ltd.)
Chung, Woo-Jin (LABnPEOPLE Co. Ltd.)
Cho, Sung Youn (LABnPEOPLE Co. Ltd.)
Yoo, Jae Gyu (Division of Animal Diseases & Health, National Institute of Animal Science, RDA)
Publication Information
Korean Journal of Veterinary Service / v.43, no.3, 2020 , pp. 129-137 More about this Journal
Abstract
In this study, we applied biodegradable drug delivery carries (BDDC) for food-and-mouth (FMD) vaccination. After FMD vaccination using BDDC, we estimated the percentage inhibition (PI) of antibody, decomposed patterns, and histopathologic features of BDDC. PI of antibody was higher than 50 at two weeks after injection and sustained positive PI until 10 weeks after injection. BBDC injection group showed significantly an increased pattern of blood monocyte at two and three weeks after injection. According to the Micro CT, micro-cracks were observed at two weeks after injection and the morphology of BDDC was lost at four weeks after injection. For histopathological examination, acute inflammation with neutrophil infiltration and micro-metallic residues were observed around BDDC until four weeks after injection and inflammatory responses gradually decreased at 10 weeks. Based on our experiment, BDDC is considered as an alternative way to vaccine injection for veterinary applications. Our study can be used as basic data for the drug delivery system using biodegradable metals in the future.
Keywords
Biodegradable metal; Vaccine injection; Animal application;
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Times Cited By KSCI : 2  (Citation Analysis)
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1 Pandya M, Pacheco JM, Bishop E, Kenney M, Milward F, Doel T, Golde WT. 2012. An alternate delivery system improves vaccine performance against foot-and-mouth disease virus (FMDV). Vaccine 30: 3106-11.   DOI
2 Park YR, Lim DR, Kim HR, Park MJ, Kim B, Kim WI, Hong CH, Kim SN, Park CH. 2017. Evaluation of efficacy of a commercial vaccine stress-relieving agent to reduce the adverse effects of foot-and-mouth disease vaccination site in pig. Korean J Vet Serv 40: 177-18   DOI
3 Rahim M, Ullah S, Mueller P. 2018. Advances and Challenges of Biodegradable Implant Materials with a Focus on Magnesium-Alloys and Bacterial Infections. Metals 8: 532.   DOI
4 Schaller B, Saulacic N, Beck S, Imwinkelried T, Liu EWY, Nakahara K, Hofstetter W, Iizuka T. 2017. Osteosynthesis of partial rib osteotomy in a miniature pig model using human standard-sized magnesium plate/screw systems: Effect of cyclic deformation on implant integrity and bone healing. J Craniomaxillofac Surg 45: 862-71.   DOI
5 Singh M, O'Hagan DT. 2003. Recent advances in veterinary vaccine adjuvants. Int J Parasitol 33: 469-78.   DOI
6 Aucouturier J, Dupuis L, Ganne V. 2001. Adjuvants designed for veterinary and human vaccines. Vaccine 19: 2666-72.   DOI
7 Bose RJC, Kim MW, Chang JH, Paulmurugan R, Moon JJ, Koh WG, Lee SH, Park HS. 2019. Biodegradable polymers for modern vaccine development. Journal of Industrial and Engineering Chemistry 77: 12-24.   DOI
8 Cha CN, Park EK, Yoo CY, Kim S, Yun YW, Lee HJ. 2017. Blood parameter changes in Korean traditional calves and pigs after foot-and-mouth disease vaccination. Korean J Vet Res 57: 43-45.   DOI
9 van der Maaden K, Jiskoot W, Bouwstra J. 2012. Microneedle technologies for (trans)dermal drug and vaccine delivery. J Control Release 161: 645-55.   DOI
10 Cho SY, Chae SW, Choi KW, Hyun Seok HK, Han HS, Yang SJ, Kim YY, Kim JT, Jung JY, Assad M. 2012. Load-bearing capacity and biological allowable limit of biodegradable metal based on degradation rate in vivo. Journal of Biomedical Materials Research Part B: Applied Biomaterials 100: 1535-44.
11 Wiwanto S, Sulistyani LD, Latief FDE, Supriadi S, Priosoeryanto BP, Latief BS. 2018. The experiment of magnesium ECAP miniplate as alternative biodegradable material (on male white New Zealand rabbits). In AIP Conference Proceedings 020013 AIP Publishing.
12 Li XJ, Xie L, Pan FS, Wang Y, Liu H, Tang YR, Hutnik C. 2018. A feasibility study of using biodegradable magnesium alloy in glaucoma drainage device. International journal of ophthalmology 11: 135.   DOI
13 Eble PL, Weerdmeester K, Hemert-Kluitenberg F, Dekker A. 2009. Intradermal vaccination of pigs against FMD with 1/10 dose results in comparable vaccine efficacy as intramuscular vaccination with a full dose. Vaccine 27: 1272-78.   DOI
14 Faustini M, Munari E, Colombani C, Russo V, Maffeo G, Vigo D. 2000. Haematology and plasma biochemistry of Stamboek pre-pubertal gilts in Italy: reference values. J Vet Med A Physiol Pathol Clin Med 47: 525-32.   DOI
15 Gu X, Zheng Y, Cheng Y, Zhong S, Xi T. 2009. In vitro corrosion and biocompatibility of binary magnesium alloys. Biomaterials 30: 484-98.   DOI
16 Heublein, B, Rohde R, Kaese V, Niemeyer M, Hartung W, Haverich A. 2003. Biocorrosion of magnesium alloys: a new principle in cardiovascular implant technology? Heart 89: 651-6.   DOI
17 Lee JW, Han HS, Han KJ, Park J, Jeon H, Ok MR, Seok HK, Ahn JP, Lee KE, Lee DH, Yang SJ, Cho SY, Cha PR, Kwon H, Nam TH, Han JH, Rho HJ, Lee KS, Kim YC, Mantovani D. 2016. Long-term clinical study and multiscale analysis of in vivo biodegradation mechanism of Mg alloy. Proc Natl Acad Sci U S A 113: 716-21.   DOI
18 Lim HK, Byun SH, Woo JM, Kim SM, Lee SM, Kim BJ, Kim HE, Lee JW, Kim SM, Lee JH. 2017a. Biocompatibility and biocorrosion of hydroxyapatite-coated magnesium plate: animal experiment. Materials 10: 1149.   DOI
19 Lim KS, Park JK, Jeong MH, Nah JW, Bae IH, Park DS, Shim JW, Kim JH, Kim HK, Kim SS, Sim DS, Hong YJ, Kim JH, Ahn Y. 2017b. Long-term preclinical evaluation of bioabsorbable polymer-coated drug-eluting stent in a porcine model. Macromolecular Research 25: 730-38.   DOI
20 Mario CD, Griffiths H, Goktekin O, Peeters N, Verbist J, Bosiers M, Deloose K, Heublein B, Rohde R, Kasese V, Ilsley C, Erbel R. 2004. Drug-eluting bioabsorbable magnesium stent. J Interv Cardiol 17: 391-5.   DOI