• Korean Journal of Veterinary Service
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• v.42 no.1
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• pp.31-37
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• 2019

There have been a total tenth FMD outbreaks in Korea and for the first time, type O and A were detected simultaneously in 2017, which led to difficulties in FMD control. For the effective prevention of FMD, the importance of discrimination of serotypes became greater. Therefore, the most urgent requirement in case of FMD outbreak is differential diagnosis of serotypes. In this study, we developed a PNA probe-mediated multiplex real-time reverse transcription-polymerase chain reaction (rRT-PCR) assay using the peptide nucleic acid (PNA) probe, which is known to be stable to nucleotide mutation and that could specifically detect the all FMDV serotype A, FMDVA Yeoncheon strain which was occurred in Korea in 2017, and FMDV A viruses shown 96% similarity with FMDVA/Yeoncheon strain, at the same time. Therefore, It is believed that the newly introduced FMDVA will be effectively diagnosed using the PNA probe multiplex RT-PCR developed in this study, and ultimately contribute to the prevention of FMD.

• Korean System Dynamics Review
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• v.14 no.4
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• pp.37-62
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• 2013

The purpose of this paper is to find out some clues about effectiveness and implementing timing of the control measures against Foot-and-Mouth Disease (FMD) in Korea. To do that, the case of FMD, which broke out during November 2010 in Korea, is examined and constructed as a system dynamics simulation model. The implications of simulation result are as follows. First of all, it is most effective measure to prevent the movement of vehicle from infected farmhouse to other noninfected farmhouses, which are located far away, in the early stage of FMD diffusion. Secondly, earlier vaccination can be adopted as a reliable means to control the epidemic when FMD spreads widely. Finally, reducing the time to vaccinate the whole noninfected livestock is a little help to restrain the additional infections of FMD.

• Asian-Australasian Journal of Animal Sciences
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• v.28 no.2
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• pp.166-170
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• 2015

Foot-and-mouth disease (FMD) is a highly contagious disease affecting cloven-hoofed animals and causes severe economic loss and devastating effect on international trade of animal or animal products. Since FMD outbreaks have recently occurred in some Asian countries, it is important to understand the relationship between diverse immunogenomic structures of host animals and the immunity to foot-and-mouth disease virus (FMDV). We performed genome wide association study based on high-density bovine single nucleotide polymorphism (SNP) chip for identifying FMD resistant loci in Holstein cattle. Among 624532 SNP after quality control, we found that 11 SNPs on 3 chromosomes (chr17, 22, and 15) were significantly associated with the trait at the p.adjust <0.05 after PERMORY test. Most significantly associated SNPs were located on chromosome 17, around the genes Myosin XVIIIB and Seizure related 6 homolog (mouse)-like, which were associated with lung cancer. Based on the known function of the genes nearby the significant SNPs, the FMD resistant animals might have ability to improve their innate immune response to FMDV infection.

• Journal of Animal Science and Technology
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• v.57 no.4
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• pp.10.1-10.7
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• 2015

Control and prevention of foot and mouth disease (FMD) by vaccination remains unsatisfactory in endemic countries. Indeed, consistent and new FMD epidemics in previously disease-free countries have precipitated the need for a worldwide control strategy. Outbreaks in vaccinated animals require that a new and safe vaccine be developed against foot and mouth virus (FMDV). FMDV can be eradicated worldwide based on previous scientific information about its spread using existing and modern control strategies.

• Korean Journal of Veterinary Service
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• v.35 no.4
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• pp.255-261
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• 2012

Foot and mouth disease (FMD) is highly infectious disease of cloven-hoofed animals, particularly cattle, sheep, pigs and goats. Last outbreak reported in November, 2010 induced the enormous social and economical impacts. Culling of infected animals, movement control, and vaccination are the major control measures of FMD. The aim of this study was to detection foot-and-mouth disease virus (FMDV) in the soil and leachate from modeling burial for pig carcass as measured by real-time reverse transcriptase polymerase chain reaction (RT-PCR). FMDV and Coxsakievirus B1 (CVB1) were detected in soil by week 16 and Coxsakievirus B1 (CVB1) by weeks 12, respectively. FMDV and CVB1 also detected by weeks 8 in the leachate. Results from this study provides an evidence that FMDV could be inactivated for safe of pig carcasses infected with FMDV within 4 month in the carcass burial site.

• Korean Journal of Veterinary Service
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• v.45 no.2
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• pp.125-131
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• 2022

The purpose of this study was to examine antibody titers to structural protein (SP) of the foot-and-mouth disease (FMD) virus after vaccination in animals of the Seoul zoo. After the initial inoculation of FMD vaccine to the susceptible animals of the zoo, a total of 235 blood samples were collected from 42 species of zoo animals during treatment or necropsy. All samples were tested by using enzyme-linked immunosorbent assay (ELISA). The overall positive rate of SP antibodies against FMD virus was 94.0% (221/235). However, the positive rates varied according to animal species. The results of positive rates in 30 species were 100% but in 12 species were 50-94.7%. We showed that most animals that have received FMD vaccine in Seoul zoo have been reached to the level of herd immunity against FMD virus after the vaccination. To the best of our knowledge, this study would be the first report for monitoring the vaccine-induced SP antibody titers against FMD virus after vaccination in various zoo animal species in Korea.

• Korean Journal of Veterinary Service
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• v.41 no.1
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• pp.9-13
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• 2018

The best way to prevent foot-and-mouth disease (FMD) constantly occurring in Korea will be vaccination. In this study, FMD vaccines were given to Korean native cattle (Hanwoo), dairy cattle, and pigs to investigate the antibody positive rate of FMD vaccine by age in year and month. Hanwoo, dairy cattle, and pigs showed antibody positive rates of 99.5%, 97.7%, and 95.9%, respectively. High antibody positive rates more than 95% were found in Hanwoo and dairy cattle. In particular, high antibody positive rates were found in Hanwoo and dairy cattle regardless of age. Pigs showed a relatively low antibody positive rate of 57.6% at 3 months of age and then constantly maintained a high antibody positive rate of above 95.0% after 4 months of age. As a result of this study, high antibody positive rates were found when regular FMD vaccination was given to newborn calves and piglets after FMD vaccination twice to them. Therefore, it is considered the most important to receive vaccination thoroughly according to vaccination plan in order to prevent FMD.

• Journal of the Korean Professional Engineers Association
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• v.44 no.2
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• pp.34-38
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• 2011

Foot and mouth disease (FMD) is a highly contagions disease of cloven-hoofed animals and occurs in many non-European countries, in particular in huge parts of Asia including Turkey, in most countries of Africa and in parts of South America. The extreme contagiousness of the disease requires comprehensive to control an outbreak, causing high economic losses. The outbreak of FMD, which affects livestock including cattle, swine,sheep,goats,deer and other animals as a highly communicable disease that affects. The agency issued a statement noting that FMD disease does not spread to humans. The disease and meat from infected animals are news reports that more than 3.400.000 livestock have been ordered slaughtered so far across the country.

• Asian-Australasian Journal of Animal Sciences
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• v.9 no.3
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• pp.315-317
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• 1996

An investigation was carried out to find out the strains of foot-and-mouth disease (FMD) virus in 24 districts of Bangladesh. A total of 505 FMD virus samples were collected from June, 1989 to June, 1991 and tested by complement fixation test (CFT). Of these, 276 (54.7%) were found positive for different strains of FMD virus and the rest 45.3% were either negative or anticomplementary. Strains identified were O, C, Asia-1 and sub-strains $A_5$ and $A_{22}$. Strain O was found to be most prevalent(39.8%) followed by Asia-1 (5.7%), C (5.3%), $A_5$ (3.4%) and $A_{22}$ (0.4%). Prevalence of sub-strain $A_5$ was reported for the first time in Bangladesh. District-wise typing of FMD virus has been done which would be helpful for appropriate vaccination programme in different districts of Bangladesh for control of the malady.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.9
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• pp.292-301
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• 2016

Because damages arising from the occurrence of foot-and-mouth disease (FMD) are very great, it is essential to make a preemptive diagnosis to cope with it in order to minimize those damages. The main symptoms of foot-and-mouth disease are body temperature increase, loss of appetite, formation of blisters in the mouth, on hooves and breasts, etc. in a cow or a bull, among which the body temperature check is the easiest and quickest way to detect the disease. In this paper, an algorithm to detect FMD from the hooves of cattle was developed and implemented for preemptive coping with foot-and-mouth disease, and a hoof check test is conducted after the installation of a high-resolution camera module, a thermo-graphic camera, and a temperature/humidity module in the cattle shed. Through the algorithm and system developed in this study, it is possible to cope with an early-stage situation in which cattle are suspected as suffering from foot-and-mouth disease, creating an optimized growth environment for cattle. In particular, in this study, the system to cope with FMD does not use a portable thermo-graphic camera, but a fixed camera attached to the cattle shed. It does not need additional personnel, has a function to measure the temperature of cattle hooves automatically through an image algorithm, and includes an automated alarm for a smart phone. This system enables the prediction of a possible occurrence of foot-and-mouth disease on a real-time basis, and also enables initial-stage disinfection to be performed to cope with the disease without needing extra personnel.