• The Plant Pathology Journal
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• 제25권3호
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• pp.263-269
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• 2009

Bacterial wilt, Fusarium wilt and Foot rot caused by Ralstonia solanacearum, Fusarium oxysporum, and Phytophthora capsici respectively, continue to be severe problems to tomato, potato and black pepper growers in Vietnam. Three bio-products, Bacillus vallismortis EXTN-1 (EXTN-1), Bacillus sp. and Paenibacillus sp. (ESSC) and Bacillus substilis (MFMF) were examined in greenhouse bioassay for the ability to reduce bacterial wilt, fusarium wilt and foot rot disease severity. While these bio-products significantly reduced disease severities, EXTN-1 was the most effective, providing a mean level of disease reduction 80.0 to 90.0% against bacterial wilt, fusarium wilt and foot rot diseases under greenhouse conditions. ESSC and MFMF also significantly reduced fusarium wilt, bacterial wilt and foot rot severity under greenhouse conditions. Bio-product, EXTN-1 with the greatest efficacy under greenhouse condition was tested for the ability to reduce bacterial wilt, fusarium wilt and foot rot under field condition at Song Phuong and Thuong Tin locations in Ha Tay province, Vietnam. Under field condition, EXTN-1 provided a mean level of disease reduction more than 45.0% against all three diseases compared to water treated control. Besides, EXTN-1 treatment increased the yield in tomato fruits 17.3% than water treated control plants.

• 미생물학회지
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• 제53권4호
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• pp.304-308
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• 2017

구제역 바이러스 연구가 BSL-3 시설에 제한되기 때문에 여러 가지 소독제나 항바이러스 제제에 대한 효력 및 효능 평가가 쉽게 이루어질 수 없다. 따라서 구제역 바이러스와 계통학적으로 유사한 bovine rhinovirus (BRV)와 human rhinovirus (HRV)의 특성을 열, pH 그리고 여러가지 소독제를 이용하여 평가하였다. 그 결과 구제역 바이러스의 성상과 매우 흡사한 것을 확인할 수 있었다. 이러한 결과로 BRV와 HRV는 구제역 바이러스를 대체할 수 있는 모델 바이러스로 이용이 가능하다.

• Journal of Platform Technology
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• 제9권3호
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• pp.36-43
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• 2021

뇌졸중 질환은 전세계적으로 가장 중요한 사망원인 중 하나이며, 특히 고령자에게 장애의 원인이 되는 가장 중요한 질환이다. 뇌졸중 질환이 발생하면 사망 또는 심각한 장애를 유발하기 때문에, 적극적인 일차 예방과 전조증상의 빠른 발견이 매우 중요하다. 특히, 일상생활에서의 뇌졸중 전조증상 발병을 감지 및 정확히 예측하여 전문가의 신속한 진단을 유도할 수 있어야 한다. 최근까지의 연구에서는 뇌졸중 환자의 전조증상을 예측하는 방법론으로 CT(Computed Tomography)나 MRI(Magnetic Resonance Imaging)와 같은 영상 분석이 대부분이었으나, 이러한 접근에는 오랜 검사 시간과 높은 검사 비용 등에 대한 한계점을 가지고 있다. 본 논문에서는 고령자의 뇌졸중 질환 발병이 보행 시 족압(Foot Pressure)에 어떤 영향을 미치는지 임상 데이터를 이용해 실험하였다. 실험 결과, 보행 중에 뇌졸중 고령자와 일반 고령자 간에 12개의 셀에서 * p < .05 인 유의미한 차가 있음을 분석 및 검증하였다. 결과적으로 고령의 뇌졸중 환자와 일반 고령자의 일상생활의 보행 패턴에 유의미한 차이를 발견했다는 것에 그 의미가 크다고 할 수 있다.

• 성인간호학회지
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• 제18권1호
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• pp.81-91
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• 2006

Purpose: The purpose of this study was to investigate foot ulcer risk factors, foot care knowledge, and foot care practice in patients with type 2 diabetes. Method: One hundred fifty type 2 diabetic patients were in and out-patients in a large urban hospital. The data were collected using a self-report questionnaire, chart review and foot examination. The questionnaires were developed by the researchers through the experts consultation and literature review. High risk for foot ulcer was evaluated by peripheral neuropathy(PN), peripheral vascular disease(PVD), and prior foot ulcer. Foot risk scores(FRS) means numbers of present risk factors. Results: 31.3% of subjects show 1 FRS, and 13.3% showed 2 FRS. Mean foot care frequency was 3.5 times per week. There were significant differences in foot care knowledge according to DM education (t=2.96, p=.004) and foot care education (t=3.65, p=.001). There were significant differences in the foot care practice activities according to duration of DM (t=3.48, p=.010) and educational levels. Conclusion: There were high proportion of foot ulcer risk among the patients. It is necessary to screen high risk foot ulcer patients and provide practical education for foot care practice of diabetic patients.

• 대한족부족관절학회지
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• 제19권3호
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• pp.107-113
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• 2015

Purpose: The question of surgical versus non-surgical treatment for diabetic foot osteomyelitis remains subject to debate. The aims of this study were to analyse the outcome of conservative treatment (antibiotic treatment and conservative surgery) for diabetic foot osteomyelitis and identify the predictive factors of remission in conservative treatment of diabetic foot osteomyelitis. Materials and Methods: Seventy-seven patients with diabetic foot osteomyelitis who initially received conservative treatment from January 2004 to July 2013 were identified, and their medical records were reviewed. Diabetic foot osteomyelitis was defined by imaging studies or histological evidence. Remission was defined as the absence of any sign of infection at the initial or contiguous site assessed at least 12 months after the end of treatment. The demographic, clinical, and therapeutic factors were analysed. Results: The mean age of the patients was $62.7{\pm}12.2$ years, and 47 patients (61.0%) were male. The median diabetes duration was $15.7{\pm}11.2$ years and mean HbA1c was $8.7%{\pm}2.4%$. Forty-eight patients (62.3%) healed with conservative treatment (antibiotic treatment and conservative surgery). Twenty-five patients (32.5%) underwent amputation. In the multivariate analysis, concomitant peripheral artery disease and inadequate antibiotic therapy were associated with failure of conservative treatment. Conclusion: Antibiotics alone, or with conservative surgery, were successful in treatment of diabetic foot osteomyelitis in 62.3% of the patients. Concomitant peripheral artery disease and inadequate antimicrobial therapy were risk factors for remission in conservatively treated diabetic foot osteomyelitis.

• 대한족부족관절학회지
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• 제20권2호
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• pp.78-83
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• 2016

Purpose: This study examined the factors affecting the treatment of diabetes mellitus foot patients who had undergone a Syme amputation. Materials and Methods: This study included 17 patients diagnosed with a diabetes mellitus foot and who had undergone a Syme amputation from January 2010 to January 2014. Some of the risk factors (age, body mass index [BMI], disease duration, smoking, ankle brachial index [ABI], HbA1c, serum albumin, total lymphocyte, C-reactive protein [CRP], and serum creatine) that affect the successful Syme amputation were analyzed. Results: The healing rate of a Syme amputation was significantly higher when the lymphocyte count was above $1,500mm^3$ (p=0.029). The factors affecting the surgical outcome according to multivariate analysis were HbA1c and the BMI (p=0.014, p=0.013). Regarding reamputation, there was a significant difference with HbA1c, lymphocyte, and BMI (p=0.01, p=0.03, and p=0.01). No significant differences were observed with age, disease duration of diabetes mellitus, smoking, ABI, serum albumin, CRP, and serum creatine. Conclusion: The HbA1c level, BMI and total lymphocyte count are risk factors that must be considered for successful Syme amputation in patients with diabetic foot disease.

• 대한족부족관절학회지
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• 제20권2호
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• pp.55-61
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• 2016

The cavus foot is a deformity characterized by an elevated medial longitudinal arch and a hindfoot varus with plantarflexed 1st ray. The etiology of cavus foot is usually related to neuromuscular disease or idiopathic cause. Thorough clinical and radiographic evaluation is required for differentiating etiology of the cavus. Most cases of cavus foot are stable and slowly progressive deformities which can initially be managed with conservative treatment including orthoses and physical therapies. Determining whether the deformity is flexible or rigid, the apex of the deformity and any muscle imbalances in foot and ankle is important for achievement of an adequately balanced plantigrade foot. Treatment should include systematic preoperative planning for selection of appropriate procedures for maintaining a functional and flexible foot with combinations of soft-tissue release, osteotomy, tendon transfer, and arthrodesis.

• 한국임상수의학회지
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• 제21권2호
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• pp.172-176
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• 2004

We described the clinical signs, gross lesions, histopathological lesions, and electronmicroscopy of pig Foot-and-Mouth Disease cases which had occurred in 2002, Korea. Grossly affected pigs showed vesicles on snout, tongue, coronary band, and udder. Histoapthologically, severe intercellular edema and necrosis of prickle cells, and separation between epidermis and dermis were found on the mucosa of tongue and coronary band. And myocardial necrosis and mononuclear cells infiltration in myocardium were found. Electronmicroscopically numerous picornavirus particles(18∼22 nm in diameter) were found in the cytoplasm of prickle cells. By those results, we confirm that those cases were typical FMD cases.

• 대한족부족관절학회지
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• 제5권2호
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• pp.165-169
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• 2001

Cavovarus deformities of both feet in 28 years old female patient with Charcot-Marie-Tooth disease were treated by one-staged pantalar arthrodesis. Excellent results were achieved at 6 years after surgery. She could walk without brace or stick and she was satisfied with the result of one-staged pantalar arthrodesis. One-stage pantalar arthrodesis is an effective method of treatment for cavovarus deformity of foot in Charcot-Marie-Tooth disease.

• 한국자기공명학회논문지
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• 제7권2호
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• pp.89-97
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• 2003

Foot-and-mouth disease virus (FMDV) belongs to the aphthovirus genus within the picornavirus which has a single copy of a positive sense RNA. The translation initiation process of FMDV occurs by a cap-independent mechanism directed by a highly structured element (∼435 nt) termed an internal ribosome entry site (IRES). We have designed and prepared FMDV 4-2 RNA (28nt) by in vitro transcription. The 2D NMR data revealed that FMDV 4-2 IRES domain RNA has a flexible loop and bulge conformation. In further study, we need to make an isotope labeled RNA sample and conduct 3D NMR experiments to completely determine the 3D structure. This study may establish a new drug design strategy to treat foot-and mouth disease.