• Title/Summary/Keyword: Food and drug

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Monitoring on the Bacterial Resistance to Antibiotics

  • Jeong, Hye-Yoon;Jang, Seung-Jae;Lee, Song-Deuk;Min, Chung-Shik;Lee, So-Yeon;Lee, Kyung-Hee;Lee, Jung-Eun;Lee, Min-Seok;Lee, Kyung-Won
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.227.2-227.2
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    • 2003
  • In the situation of high bacterial resistance to antibiotics in Korea, to assess diffusion of methicillin-resistant Staphylococcus aureus (MRSA) and levels of bacterial resistance to antibiotics in community, we monitored antibiotic resistance of S. aureus isolates from healthy volunteers of community. (omitted)

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Potential for Dependence on Lisdexamfetamine - In vivo and In vitro Aspects

  • Yun, Jaesuk;Lee, Kwang-Wook;Eom, Jang-Hyeon;Kim, Young-Hoon;Shin, Jisoon;Han, Kyoungmoon;Park, Hye-Kyung;Kim, Hyung Soo;Cha, Hye Jin
    • Biomolecules & Therapeutics
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    • v.25 no.6
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    • pp.659-664
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    • 2017
  • Although lisdexamfetamine is used as a recreational drug, little research exists regarding its potential for dependence or its precise mechanisms of action. This study aims to evaluate the psychoactivity and dependence profile of lisdexamfetamine using conditioned place preference and self-administration paradigms in rodents. Additionally, biochemical techniques are used to assess alterations in the dopamine levels in striatal synaptosomes following administration of lisdexamfetamine. Lisdexamfetamine increased both conditioned place preference and self-administration. Moreover, after administration of the lisdexamfetamine, dopamine levels in the striatal synaptosomes were significantly increased. Although some modifications should be made to the analytical methods, performing high performance liquid chromatography studies on synaptosomes can aid in predicting dependence liability when studying new psychoactive substances in the future. Collectively, lisdexamfetamine has potential for dependence possible via dopaminergic pathway.

Detection of CTX-M Type ESBL Producing Salmonella in Retail Meat in Korea

  • Kim, Yong Hoon;Joo, In Sun;Kim, Yoon Jeong;Oh, Mi Hyun;Cho, Joon Il;Han, Min Kyong;Kim, Soon Han;Moon, Tae Wha;Park, Kun Sang
    • Journal of Food Hygiene and Safety
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    • v.29 no.1
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    • pp.47-52
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    • 2014
  • This study was performed to evaluate antimicrobial resistance of food-borne pathogens isolated from retail meat in Korea. A total of 157 samples of beef, pork, and chicken were collected and analyzed for E. coli, Salmonella, Campylobacter. Resistances to tetracycline were declined in accord with reduced usage of tetracycline in live stock production. E. coli stains from chicken meat had higher multi-drug resistance ratio than strains from other meat. One extended spectrum beta lactamase (ESBL) producing E. coli and two ESBL producing Salmonella were identified in this study. ESBL producing Salmonella strains were confirmed to carry CTX-M-1 type genes.

Development of a Quantitative Analytical Method for Determining the Concentration of Human Urinary Paraben by LC-MS/MS

  • Lee, Seung-Youl;Son, Eunjung;Kang, Jin-Young;Lee, Hee-Seok;Shin, Min-Ki;Nam, Hye-Seon;Kim, Sang-Yub;Jang, Young-Mi;Rhee, Gyu-Seek
    • Bulletin of the Korean Chemical Society
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    • v.34 no.4
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    • pp.1131-1136
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    • 2013
  • Parabens, the esters of p-hydroxybenzoic acid, have been widely used as antimicrobial preservatives in cosmetic products, drugs, and processed foods and beverages. However, some parabens have been shown to have weak estrogenic effects through in vivo and in vitro studies. Because such widespread use has raised concerns about the potential human health risks associated with exposure to parabens, we developed a simultaneous analytical method to quantify 4 parabens (methyl, ethyl, propyl, and butyl) in human urine, by using solid-phase extraction and high-performance liquid chromatography coupled with triple quadrupole mass spectrometry. This method showed good specificity, linearity ($R^2$ > 0.999), accuracy (92.2-112.4%), precision (0.9-9.6%, CV), and recovery (95.7-102.0%). The LOQs for the 4 parabens were 1.0, 0.5, 0.2, and 0.5 ng/mL, respectively. This method could be used for quick and accurate analysis of a large number of human samples in epidemiological studies to assess the prevalence of human exposure to parabens.