• Biomolecules & Therapeutics
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• v.27 no.6
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• pp.522-529
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• 2019

M1/M2 polarization of immune cells including microglia has been well characterized. It mediates detrimental or beneficial roles in neuroinflammatory disorders including cerebral ischemia. We have previously found that sphingosine 1-phospate receptor subtype 1 ($S1P_1$) in post-ischemic brain following transient middle cerebral artery occlusion (tMCAO) can trigger microglial activation, leading to brain damage. Although the link between $S1P_1$ and microglial activation as a pathogenesis in cerebral ischemia had been clearly demonstrated, whether the pathogenic role of $S1P_1$ is associated with its regulation of M1/M2 polarization remains unclear. Thus, this study aimed to determine whether $S1P_1$ was associated with regulation of M1/M2 polarization in post-ischemic brain. Suppressing $S1P_1$ activity with its functional antagonist, AUY954 (5 mg/kg, p.o.), attenuated mRNA upregulation of M1 polarization markers in post-ischemic brain at 1 day and 3 days after tMCAO challenge. Similarly, suppressing $S1P_1$ activity with AUY954 administration inhibited M1-polarizatioin-relevant $NF-{\kappa}B$ activation in post-ischemic brain. Particularly, $NF-{\kappa}B$ activation was observed in activated microglia of post-ischemic brain and markedly attenuated by AUY954, indicating that M1 polarization through $S1P_1$ in post-ischemic brain mainly occurred in activated microglia. Suppressing $S1P_1$ activity with AUY954 also increased mRNA expression levels of M2 polarization markers in post-ischemic brain, further indicating that $S1P_1$ could also influence M2 polarization in post-ischemic brain. Finally, suppressing $S1P_1$ activity decreased phosphorylation of M1-relevant ERK1/2, p38, and JNK MAPKs, but increased phosphorylation of M2-relevant Akt, all of which were downstream pathways following $S1P_1$ activation. Overall, these results revealed $S1P_1$-regulated M1/M2 polarization toward brain damage as a pathogenesis of cerebral ischemia.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.38 no.6
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• pp.511-519
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• 2020

For camera calibration, a checkerboard is generally used to determine the principal point, focal length, and lens distortions. The checkerboard has a planar and three-dimensional shape, and camera calibration parameters are affected by the size of the checkerboard, the placement of the target, and the number of target points. In this study, the accuracies of the types of checkerboards were compared using checkpoints for stereo camera calibration, and the purpose of this study was to propose the best performance checkerboard. The checkerboard with large flat shape showed comparatively high accuracy through comparison with the check points. However, due to the size of the checkerboard, it was inconvenient to move and rotate, and there was a disadvantage in that it was difficult to shoot so that the target points could all appear in the stereo camera. The checkerboard, which was manufactured in a small size in a flat shape, was easy to move and rotate but had the lowest three-dimensional accuracy. The checkerboard with targets with height values had the hassle of having to determine the three-dimensional coordinates of the target points by using observation equipment for camera calibration, but it was small in size, convenient to move and rotate, and showed the highest three-dimensional accuracy.

• Parasites, Hosts and Diseases
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• v.58 no.6
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• pp.627-634
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• 2020

Belitung district in Bangka-Belitung Province, Indonesia with a population of 0.27 million is endemic for Brugia malayi and 5 rounds of mass drug administration (MDA) were completed by 2010. Based on the results of 3 transmission assessment surveys (TAS), the district is declared as achieving elimination of lymphatic filariasis (LF) in 2017. The findings of an independent survey conducted by the National Institute of Health Research and Development (NIHRD) in the same year showed microfilaria (Mf) prevalence of 1.3% in this district. In 2019, NIHRD conducted microfilaria survey in 2 villages in Belitung district. Screening of 311 and 360 individuals in Lasar and Suak Gual villages showed Mf prevalence of 5.1% and 2.2% with mean Mf density of 120 and 354 mf/ml in the respective villages. Mf prevalence was significantly higher among farmers and fishermen compared to others and the gender specific difference was not significant. The results of a questionnaire based interview showed that 62.4% of the respondents reported to have participated in MDA in Lasar while it was 57.7% in Suak Gual village. About 42% of the Mf positive cases did not participate in MDA. Environmental surveys identified many swampy areas supporting the breeding of Mansonia vector species. Persistence of infection is evident and in the event of successful TAS3 it is necessary to monitor the situation and plan for focal MDA. Appropriate surveillance strategies including xenomonitoring in post-MDA situations need to be developed to prevent resurgence of infection. Possible role of animal reservoirs is discussed.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.24 no.1
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• pp.7-18
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• 2021

Purpose: The long-term efficacy and safety of infliximab (IFX) in children with ulcerative colitis (UC) have not been well-evaluated. Here, we reviewed the long-term durability and safety of IFX in our single center pediatric cohort with UC. Methods: This retrospective study included 20 children with UC who were administered IFX. Results: For induction, 5 mg/kg IFX was administered at weeks 0, 2, and 6, followed by every 8 weeks for maintenance. The dose and interval of IFX were adjusted depending on clinical decisions. Corticosteroid (CS)-free remission without dose escalation (DE) occurred in 30% and 25% of patients at weeks 30 and 54, respectively. Patients who achieved CS-free remission without DE at week 30 sustained long-term IFX treatment without colectomy. However, one-third of the patients discontinued IFX treatment because of a primary nonresponse, and one-third experienced secondary loss of response (sLOR). IFX durability was higher in patients administered IFX plus azathioprine for >6 months. Four of five patients with very early onset UC had a primary nonresponse. Infusion reactions (IRs) occurred in 10 patients, resulting in discontinuation of IFX in four of these patients. No severe opportunistic infections occurred, except in one patient who developed acute focal bacterial nephritis. Three patients developed psoriasis-like lesions. Conclusion: IFX is relatively safe and effective for children with UC. Clinical remission at week 30 was associated with long-term durability of colectomy-free IFX treatment. However, approximately two-thirds of the patients were unable to continue IFX therapy because of primary nonresponse, sLOR, IRs, and other side effects.

• Journal of the Korean Society of Radiology
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• v.79 no.6
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• pp.340-347
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• 2018

Purpose: To evaluate value of image subtraction for identifying hepatocellular carcinoma (HCC) capsule on gadoxetic acid-enhanced MR images. Materials and Methods: This study involved 108 patients at risk of HCC preoperatively examined using gadoxetic acid-enhanced MRI with hepatic resection between May 2015 and February 2017. We evaluated qualities of subtraction images and presence of capsular appearance on portal venous or transitional phases conventional and subtraction images. We assessed effect of capsular appearance on subtraction images on HCC. Results: After excluding 1 patient who had treated by transarterial chemoembolization prior to surgery and 33 patients with unsatisfactory subtraction image qualities, 82 focal hepatic lesions (73 HCC, 5 non-HCC malignancies, and 4 benign) from 74 patients were analyzed. Regarding detection of capsules, sensitivity, accuracy, and area under the receiver operating characteristic curve (AUC) on subtraction images were significantly higher than those on conventional images (95.4%, 89.0%, and 0.80, respectively; p < 0.001), though specificities were same (64.7%). For diagnosis of HCC, sensitivity, accuracy, and AUC on subtraction images were significantly higher than on conventional images (82.2%, 79.3%, and 0.69, respectively; p = 0.011), though specificities were identical (55.6%). Conclusion: Portal venous or transitional phase gadoxetic acid-enhanced MRI subtraction images could improve detection of HCC capsule.

• (The)Study of the Eastern Classic
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• no.56
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• pp.117-146
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• 2014

A Collective intelligence as a means of creation of new knowledge is a keyword in the internet era. However, all parts of the collective intelligence is not useful. This paper examined the process of scattered historical data restoration by use of collective intelligence. and conditions for effective restoration. A restoration of historical data is the basis of research and uncovering the historical facts. In the past, some passionate researchers restored the historical data. However, its progress was slow and the amount of the restored data was not much. Moreover, the restoration itself was not easy even to verify the results. The internet made a number of researchers and the general public collaborate for restoration of historical data. Due to the collective intelligence of the internet, a possibility of historical data restoration increased. This paper examined the restoration process of the military examination roster(武科及第者) in Korean Historical Figures DB(韓國歷代人物綜合情報). The passionate users took part in the restoration in such a way to donate the old documents and inform the location of originals and articles of military examination. The results of the restoration were reliable. And this paper confirmed that passionate participants, competent and professional operators, and reliable focal point(Internet Community) should be added in order to more accurately restore the data.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.16 no.5
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• pp.93-106
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• 2006

With the rapid growth of the wireless Internet communication, a new generation of mobile devices have made possible the broad distribution of mobile digital contents, such as image, music, video, games and applications over the wireless Internet. Mobile devices are rapidly becoming the major means to extend communication channels without copy Protection, usage rule controlling and authentication. As a result, mobile digital contents may be illegally altered, copied and distributed among unauthorized mobile devices. In this paper, we take a look at Open Mobile Alliance (OMA) DRM v2.0 in general, its purpose and function. The OMA is uniquely the focal point for development of an open standard for mobile DRM. Next we introduces features for an active content and illustrates the difference between an active content and an inactive content. Enabling fast rendering of an active content, we propose an OMA-based DRM framework. This framework include the following: 1) Extending DCF Header for supporting an selective encryption, 2) Content encryption key management, 3) Rendering API for an active content. Experimental results show that the proposed framework is able to render an active content fast enough to satisfy Quality of Experience. %is framework has been proposed for a mobile device environment, but it is also applicable to other devices, such as portable media players, set-top boxes, or personal computer.

• Journal of The Korean Association For Science Education
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• v.41 no.1
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• pp.11-18
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• 2021

The purpose of this study is to analyze the questions generated by elementary school pre-service teachers when reading the teacher's guide for the refraction of light, and to analyze the difficulties in understanding the concept and in making instructional plans. A total of 592 meaningful questions were generated by 283 elementary school pre-service teachers after reading the teacher's guide of 'light and lens' unit in the 6th grade of the 2015 revised curriculum. Of these, 306 questions are for understanding the concept of physics and 286 are pedagogical questions. As a result of the analysis, in terms of understanding the concept of physics, the elementary school pre-service teachers encounter difficulties in understanding the concept of the 'cause' of the phenomenon suggested in the textbook, such as the cause of refraction, the reason for scattering light, and the cause of the image change depending on the focal length of the convex lens. In terms of instructional planning, it was followed by questions about how to explain concepts, questions about not being able to explain concepts to elementary school students and having to teach only phenomena, specific explanation methods for specific concepts, and experimental methods. Although the teacher's guide contains various explanations and supplementary materials to help teachers understand the concept, it can be seen that there are many elementary pre-service teachers who cannot answer questions about some concepts even after reading the guide. For concepts with a high frequency of questions, it is necessary to prepare a tutorial that is more understandable. In the instructional plan, there were many questions about teaching methods and experimental methods, so it is necessary to provide more examples and specific experimental methods for explaining concepts in the teacher's guide.

• The Journal of the Convergence on Culture Technology
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• v.7 no.1
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• pp.416-423
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• 2021

Drawing upon research in affect and social identity theory, this study examines when and how an individual's trait positive affect (TPA) exerts a significant effect on the person's organizational citizenship behavior directed toward individuals (OCBI). A moderated mediation model was tested by using the data of 293 employees nested in 66 work groups. Results demonstrate that the indirect effect of TPA on OCBI mediated by group identification (GI) is significantly positive only when perceived group positive affect (PGPA) is low, highlighting the substituting role of PGPA in the relationship between TPA and GI. The significant conditional indirect effects at the low level of PGPA suggest that TPA functions as significant, affective resources for enhancing GI and consequently increasing OCBI of the focal member when PGPA is low. By contrast, TPA's role in enhancing GI becomes redundant when PGPA is high. The current analysis reveals potential complementary functions of TPA and PGPA in explaining subsequent identity cognition and individual behavior.

• Korean Journal of Optics and Photonics
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• v.31 no.6
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• pp.281-289
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• 2020

This paper reports a slim mobile lens design using a hybrid refractive/diffractive optical element. Conventionally a wide field of view (FOV) camera-lens design adopts a retrofocus type having a negative (-) lens at the forefront, so that it improves in imaging performance over the wide FOV, but with the sacrifice of longer total track length (TTL). However, we chose a telephoto type as a baseline design layout having a positive (+) lens at the forefront, to achieving slimness, based on the specification analysis of 23 reported optical designs. Following preliminary optimization of a baseline design and aberration analysis based on Zernike-polynomial decomposition, we applied a hybrid refractive/diffractive element to effectively reduce the residual chromatic spherical aberration. The optimized optical design consists of 6 optical elements, including one hybrid element. It results in a very slim telephoto ratio of 1.7, having an f-number of 2.0, FOV of 90°, effective focal length of 2.23 mm, and TTL of 3.7 mm. Compared to a comparable conventional lens design with no hybrid elements, the hybrid design improved the value of the modulation transfer function (MTF) at a spatial frequency of 180 cycles/mm from 63% to 71-73% at zero field (0 F), and about 2-3% at 0.5, 0.7, and 0.9 fields. It was also found that a design with a hybrid lens with only two diffraction zones at the stop achieved the same performance improvement.