• Archives of Pharmacal Research
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• v.28 no.8
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• pp.988-994
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• 2005

The purpose of the present study was to prepare multivesicular liposomes with a high drug loading capacity and to investigate its potential applicability in the oral delivery of a peptide, human epidermal growth factor (rhEGF). The multivesicular liposomes containing rhEGF was prepared by a two-step water-in-oil-in-water double emulsification process. The loading efficiency was increased as rhEGF concentration increased from 1 to 5mg/mL, reaching approximately $60\%$ at 5 mg/mL. Approximately $47\%$ and $35\%$ of rhEGF was released from the multivesicular liposomes within 6 h in simulated intra-gastric fluid (pH 1.2) and intra-intestinal fluid (pH 7.4), respectively. rhEGF-loaded multivesicular liposomes markedly suppressed the enzymatic degradation of the peptide in an incubation with the Caco-2 cell homogenate. However, the transport of rhEGF from the multivesicular liposomes to the basolateral side of Caco­2 cells was two times lower than that of the rhEGF in aqueous solution. The gastric ulcer healing effect of rhEGF-loaded multivesicular liposomes was significantly enhanced compared with that of rhEGF in aqueous solution; the healing effect of the liposomes was comparable to that of the cimetidine in rats. Collectively, these results indicate that rhEGF-loaded multivesicular liposomes may be used as a new strategy for the development of an oral delivery system in the treatment of peptic ulcer diseases.

• Journal of Biomedical Engineering Research
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• v.30 no.1
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• pp.89-93
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• 2009

Bone remodeling is a continuous process of skeletal renewal during which bone formation is tightly coupled to bone resorption. Mechanical loading is an important regulator of bone formation and resorption. In recent studies, neurotransmitters such as vasoactive intestinal peptide (VIP) were found to be present inside bone tissue and have been suggested to potentially regulate bone remodeling. In this study, our objective was to use a pre-established in vitro oscillatory fluid flow-induced shear stress mechanical loading system to quantify the effect of VIP on bone resorptive activity and investigate its combined effect with mechanical loading. VIP decreased osteoclastogenesis significantly decreased RANKL/OPG mRNA ration by approximately 90%. Combined VIP and mechanical loading further decreased RANKL/OPG ratio to approximately 95%. These results suggest that VIP present in bone tissue may synergistically act with mechanical loading to regulate bone remodeling via suppression of bone resorptive activities.

• 유체기계공업학회:학술대회논문집
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• 2004.12a
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• pp.166-171
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• 2004

The Rate-of-Loading(ROL) effect of motor operated gate valves causes a decrease in the thrust delivered at a specific torque by the actuator under dynamic flow ${\Delta}$P conditions as compared to the no-flow, static conditions. This effect needs to be studied for the quantitative evaluation of motor operated gate valve operability. This study is performed to verify the validity for the application of ROL in the evaluation of operability of motor operated gate valves for the opening stroke. The ROL is assessed on the basis of in-situ test data for the opening and closing strokes. The results show that the distribution of the ROL for the operling sake has a tendency to the negative value when DP is higher than 150psid.

• The KSFM Journal of Fluid Machinery
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• v.2 no.3 s.4
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• pp.17-23
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• 1999

In the present numerical analysis, investigation of the effect of blade loadings from design shape on the slip factor variation was studied. Both the Eckardt radial bladed impeller and the backswept impeller were analyzed. In addition, a new design of the blade profile was arbitrarily attempted to generate a center-loading pattern in the original backswept impeller. Three dimensional compressible Navier-Stokes flow analysis with the Baldwin-Lomax turbulence model was applied to get the numerical slip factor at each impeller exit plane using the mass-averaging technique. The numerical slip (actors are in good agreement with the experimental ones and the Wiesner's slip factors deviate further from the numerical and experimental ones in both backswept impellers. Deviation angles and meridional channel loadings are found in no relation with the trend of change of the slip factor. Blade-to-blade loadings in midspan location are, however, found to have a direct relationship, especially at the sections where maximum loadings we to be expected. That information can be utilized in establishing an improved expression for slip factors in the future.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2014.04a
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• pp.644-649
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• 2014

Analytical model is derived for the far-field acoustic radiation from machinery installed inside cylindrical shell. The analytical model includes the effect of fluid loading and interactions between periodic ring supports. Transmitted force from machine to a shell can be different by the impedance of shell. In this paper the transmitted force from machinery to a infinite shell through vibration isolator is considered by the impedance of shell. The effect of the shell impedance for acoustic radiation is investigated.

• Wind and Structures
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• v.1 no.4
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• pp.303-315
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• 1998

Full-scale measurements have been made to determine the increase in wind speed over two exposed embankments, one of $23^{\circ}$ slope and 4.7 m in height, the other of $24^{\circ}$ slope and 7.3 m in height. Measurements were made at heights of 5, 10 and 15 m above the upper edge of each embankment and at the same heights approximately 100 m upwind in the lower-level approach fetch. Despite the modest sizes of the embankments, the maximum recorded increase in mean wind speed was 28% and the minimum was 13%; these increase relate to increases in wind loads on structures erected at the top of the embankments of 64% and 28% respectively. The associated increases in gust speeds are estimated at 33% and 18%, which imply increases in gust loading of 77% and 39% respectively. These experimental results are compared with predictions obtained from a computational fluid dynamics (CFD) analysis, using three high Reynolds number eddy-viscosity models and estimates from the UK wind loading code, BS 6399: Part 2. The CFD results are generally in agreement with the experimental data, although near-ground effects on the embankment crest are poorly reproduced.

• Journal of the Society of Naval Architects of Korea
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• v.55 no.4
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• pp.281-288
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• 2018

Acoustic radiation efficiency is a crucial factor to estimate Underwater Radiated Noise (URN) of ships accurately. This paper describes a numerical method to analyse acoustic radiation efficiency of one side-wetted rectangular Mindlin plate with simply supported boundaries excited by a harmonic point force. Transverse displacements of plate and acoustic radiation pressures are evaluated by the mode superposition method. The acoustic radiation efficiencies analyzed by both Mindlin and thin plate theories show little differences at monopole and corner modes of low frequency regions but relatively large differences at edge and critical modes of high frequency regions. Especially, the critical frequency with the highest acoustic radiation efficiency evaluated by the Mindlin plate theory is higher than that of thin plate theory. In addition, the acoustic loading effect of fluid also increases bending wave-number of plate and its critical frequency. Finally, the acoustic radiation characteristics of plates with different aspect ratios and thicknesses through numerical analyses are investigated and discussed.

• Ocean Systems Engineering
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• v.12 no.1
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• pp.23-38
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• 2022

In this paper, a pitch-type wave energy converter (WEC-rotor) is investigated in irregular wave conditions for the real sea testing at the west coast of Jeju Island, South Korea. The present research builds on and extends our previous work on regular waves to irregular waves. The hydrodynamic characteristics of the WEC-rotor are assessed by establishing a quasi-two-dimensional numerical wave tank using computational fluid dynamics by solving the Reynolds-averaged Navier-Stokes equation. The numerical solution is validated with physical experiments, and the comparison shows good agreement. Furthermore, the hydrodynamic performance of the WEC-rotor is explored by investigating the effect of the power take-off (PTO) loading torque by one-way and two-way systems, the wave height, the wave period, operational and high sea wave conditions. Irrespective of the sea wave conditions, the absorbed power is quadratic in nature with the one-way and two-way PTO loading systems. The power absorption increases with the wave height, and the increment is rapid and mild in the two-way and one-way PTO loading torques, respectively. The pitch response amplitude operator increases as the wave period increases until the maximum value and then decreases. For a fixed PTO loading, the power and efficiency are higher in the two-way PTO loading system than in the one-way PTO loading system at different wave periods.

• Journal of the Korean Society of Visualization
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• v.18 no.3
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• pp.35-41
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• 2020

We conduct numerical simulations of the interaction of a deformable structure with two-phase compressible flow. The finite volume method (FVM) is used to simulate fluid phenomena including a shock wave, a gas bubble, and the deformation of free surface. The deformation of a floating structure is computed with the finite element method (FEM). The compressible two-phase volume of fluid (VOF) method is used for the generation and development of a cavitation bubble, and the immersed boundary method (IBM) is used to impose the effect of the structure on the fluid domain. The result of the simulation shows the generation of a shock wave, and the expansion of the bubble. Also, the deformation of the structure due to the hydrodynamic loading by the explosion is identified.

• 유체기계공업학회:학술대회논문집
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• 2002.12a
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• pp.131-136
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• 2002

A computational analysis using Reynolds stress model in FLUENT is conducted to give a clear understanding of the effect of blade loading on the structure of tip leakage flow in a forward-swept axial-flow fan at design condition ($\phi$=0.25) and off-design condition ($\phi$=0.21 and 0.30). The roll-up of tip leakage flow starts near the minimum static wall pressure position, and the tip leakage vortex developes along the centerline of the pressure trough within the blade passages. Near tip region, a reverse flow induced by tip leakage vortex has a blockage effect on the through-flow. As a result, high momentum region is observed below the tip leakage vortex. As the blade loading increases, the reverse flow region is more inclined toward circumferential direction and the onset position of the rolling-up of tip leakage flow moves upstream. Because the casing boundary layer becomes thicker, and the mixing between the through-flow and the leakage jet with the different flow direction is enforced, the streamwise vorticity decays more fast with blade loading increasing. The computational results show that a distinct tip leakage vortex is observed downstream of the blade trailing edge at $\phi$=0.30, but it is not observed at $\phi$=0.21 and 0.25.