• Journal of the Semiconductor & Display Technology
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• v.21 no.3
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• pp.101-104
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• 2022

Mist-CVD is known to have advantages of low cost and high productivity compared to ALD and PECVD methods. It is capable of reacting to the substrate by misting an aqueous solution using ultrasonic waves under vacuum-free conditions of atmospheric pressure. In particular, Ga₂O₃ is regarded as advanced power semiconductor material because of its high quality of transmittance, and excellent electrical conductivity through N-type doping. In this study, Computational Fluid Dynamics were used to predict the uniformity of the thin film on a large-area substrate. And also the deposition pattern and uniformity were analyzed using the flow velocity and particle tracking method. The uniformity was confirmed by quantifying the deposition cross section with an FIB-SEM, and the consistency of the uniformity prediction was secured through the analysis of the CFD distribution. With the analysis and experimental results, the match rate of deposition area was 80.14% and the match rate of deposition thickness was 55.32%. As the experimental and analysis results were consistent, it was confirmed that it is possible to predict the deposition thickness uniformity of Mist-CVD.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.34 no.6
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• pp.275-289
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• 2022

New businesses such as marine leisure and floating construction have recently flourished on the coast. As a result, consideration is given to a floating structure appropriate for marine environments. In this study, we applied a damping plate to increase the stability of a hybrid floating structure that was expanded by vertical and horizontal stacking of mobile unit modules. In the numerical analysis using ANSYS AQWA, the behavioral characteristics of the floating structure were analyzed according to the length change of the damping plate. However, the wave forces acting on a floating structure are excessively calculated by the resonance of fluid surrounded by the structure in the numerical analysis using potential flow. Therefore, we used the damping zone option of the ANSYS AQWA in the frequency domain analysis.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.36 no.2
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• pp.1-9
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• 2023

Objectives : This study used a network pharmacology approach to analyze the treatment mechanisms of Yijin-tang on Meniere's disease, and comparative analysis the treatment mechanisms of drugs recommended in the Meniere's disease treatment guidelines. Methods : We collected information on the recommended drugs from the Meniere's disease treatment guidelines and their target proteins were screened via the STITCH database. The intersection targets were obtained through Venny 2.1.0. Gene Ontology(GO) analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway analysis were performed using ClueGO. Results : The 7 proteins(TNF, CASP9, PARP1, CCL2, CFTR, NOS2, NOS1) were associated with both Yijin-tang and Meniere's disease related genes. The 10 proteins(AQP2, KCNE1, AQP1, AVP, ACE, HRH1, HRH3, NOS1, CA1, CFTR) were associated with both the recommended drugs in the guidelines and Meniere's disease related genes. The 2 proteins(CFTR, NOS1) were common across all three groups. Further, GO/KEGG pathway analysis of the collected proteins revealed that the common mechanisms of action between Yijin-tang and the recommended drugs in the guidelines were related to pathways involving immune dysfunction and disturbances in lymphatic fluid homeostasis. In addition, the recommended drugs in the guidelines appeared to act through mechanisms that improve blood flow through vasodilation. Conclusions : Pharmacological network analysis can help to explain the treatment mechanisms of Yijin-tang on Meniere's disease.

• Journal of the Society of Naval Architects of Korea
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• v.60 no.1
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• pp.1-9
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• 2023

In order to improve the propeller cavitation performance composed of Cavitation Inception Speed (CIS), cavitation extent and pressure fluctuation, it needs to improve the wake distribution that flows into the propeller. The warship propeller cavitation is strongly influenced by the wake created at the V-strut of various appendages. The inflow characteristics of the V-strut were investigated using Computational Fluid Dynamics (CFD) and the twisted angles of the V-strut were aligned with upstream flow. The resistance and self-propulsion tests for the model ship with the existing and modified V-struts were conducted in Towing Tank (TT), and wake distribution, CIS, cavitation observation and pressure fluctuation tests were conducted in Large Cavitation Tunnel (LCT). The propeller behind the modified V-strut showed better cavitation characteristics than that behind the existing V-strut. Another model test was conducted to investigate rudder cavitation performance by the change of the V-strut. The rudder cavitation characteristics were not improved by the change of the operating conditions. On the basis of the present study, it is thought that the stern appendages for better propeller cavitation performance would be developed.

• Nuclear Engineering and Technology
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• v.55 no.2
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• pp.460-474
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• 2023

A simple but accurate mathematical model is crucial for dynamic simulations and controller design of helical coil once-through steam generator (OTSG). This paper presents a three-region movable boundary dynamic model of the helical coil OTSG. Based on the secondary side fluid conditions, the OTSG is divided into subcooled region (two control volumes), two-phase region (two control volumes) and superheated region (three control volumes) with movable boiling boundaries between each region. The nonlinear dynamic model is derived based on mass, energy and momentum conservation equations. And the linear model is obtained by using the transfer function and state space transformation, which is a 37-order model of five input and three output. Validations are made under full-power steady-state condition and four transient conditions. Results show good agreements among the nonlinear model, linear model and the RELAP5 model, with acceptable errors. This model can be applied to dynamic simulations and controller design of helical coil OTSG with constant primary-side flow rate.

• Biomolecules & Therapeutics
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• v.31 no.4
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• pp.434-445
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• 2023

We investigated whether FTY-720 might have an effect on bleomycin-induced pulmonary fibrosis through inhibiting TGF-β1 pathway, and up-regulating autophagy. The pulmonary fibrosis was induced by bleomycin. FTY-720 (1 mg/kg) drug was intraperitoneally injected into mice. Histological changes and inflammatory factors were observed, and EMT and autophagy protein markers were studied by immunohistochemistry and immunofluorescence. The effects of bleomycin on MLE-12 cells were detected by MTT assay and flow cytometry, and the related molecular mechanisms were studied by Western Blot. FTY-720 considerably attenuated bleomycin-induced disorganization of alveolar tissue, extracellular collagen deposition, and α-SMA and E-cadherin levels in mice. The levels of IL-1β, TNF-α, and IL-6 cytokines were attenuated in bronchoalveolar lavage fluid, as well as protein content and leukocyte count. COL1A1 and MMP9 protein expressions in lung tissue were significantly reduced. Additionally, FTY-720 treatment effectively inhibited the expressions of key proteins in TGF-β1/TAK1/P38MAPK pathway and regulated autophagy proteins. Similar results were additionally found in cellular assays with mouse alveolar epithelial cells. Our study provides proof for a new mechanism for FTY-720 to suppress pulmonary fibrosis. FTY-720 is also a target for treating pulmonary fibrosis.

• Journal of Korea Water Resources Association
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• v.56 no.2
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• pp.125-137
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• 2023

In marine environments, plastics have become more abundant due to increasing plastic use. Especially, in coastal regions, particles may remain for a long time, and they interact with flows, wind, sand and human activities. This study aimed thus to observe how plastic debris interacts with and escape from sediments. A series of experiments were conducted in order to gain a better understanding of particle release from coastal sediments into water body. An oscillating water tunnel was built for the experiments, and used to generate oscillatory flows of relatively high Reynolds number and induce sediment transport. Spherical plastic particles of three different sizes was used in lieu of plastic debris in environments. It was observed that release of the particles was directly related to change of bedform, which is in turn determined by the flow condition. Also smaller particles tend to escape the sediment more readily. Critical values for dimensionless parameters are proposed.

• Journal of Korean Tunnelling and Underground Space Association
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• v.11 no.2
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• pp.141-150
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• 2009

When constructing a subsea tunnel in discontinuous rock mass, fluid flow in joints has a great influence on the behavior of the tunnel so that hydro-mechanical coupled analysis should be performed for the stability estimation. In practice, relaxed rock load is generally used for the design of tunnel concrete lining. In a continuum analysis, a method based on the distribution of local safety factor around a tunnel was proposed for the estimation of a potential relaxed zone. However, in the case of discontinuous rock mass in which joints are developed, the whole stability of tunnels depends on the behavior of the joints. In this study, therefore, a method is proposed for the estimation of a potential relaxed zone occurred by the excavation of a tunnel in discontinuous rock mass. The suggested method is validated by sensitivity analysis and the comparison with the results of continuum analysis.

• Design & Manufacturing
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• v.16 no.2
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• pp.33-38
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• 2022

Currently, Korea is an aging society, and it is expected to enter a super-aging society in about 4 years. Accordingly, many X-ray technologies are being developed. In X-rays, 99% of X-rays are converted into heat energy and 1% into light energy (X-rays). 99% of the thermal energy raises the temperature of the anode and its surroundings, and the cooling system is an important factor as overheating can affect the deterioration of X-ray quality and shortened lifespan. There is a method of forced air cooling using natural convection. Therefore, in this study, when X-rays were taken 5 times, Flow analysis was performed on heat removal according to temperature rise and cooling time for the heat generated at the anode of the X-ray tube (input power 60kW, 75kW, 90kW). Based on one-shot, the most rapid temperature rise section increased by more than 57% to 0.03 seconds, A constant temperature rises from 0.03 seconds to 0.1 seconds, It is judged that the temperature rises by about 8.2% or more at one time. After one-shot cooling, the cooling drops sharply from about 60% to 0.03 seconds, It is judged that the temperature has cooled by more than 86% compared to the temperature before shooting. One-shot is cooled by more than 86% with cooling time after 0.1 seconds, As the input power of the anode increases, the cooling temperature gradually increases. Since the tungsten of the anode target inside the X-ray tube may be damaged by thermal shock caused by a rapid temperature rise, an improvement method for removing thermal energy is required when using a high-input power supply.

• Journal of the Korean Geotechnical Society
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• v.39 no.11
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• pp.63-70
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• 2023

Underground carbon dioxide (CO₂) storage emerges as a pivotal strategy for mitigating atmospheric CO₂ emissions and addressing global warming concerns. This study investigates techniques to optimize storage efficiency in aquifers, which stand out for their superior capacity compared to other geological layers. The focus is on the application of nonionic and anionic surfactants to enhance CO₂ storage efficiency within confined spaces. A specialized micromodel facilitating fluid flow observation was employed for the evaluation. Experimental results revealed a noteworthy minimum 40% increase in storage efficiency at the lowest injection rate when utilizing nonionic and anionic surfactants, in comparison to pure water injection. Interestingly, no significant variations in storage efficiency were observed based on the ionicity and concentration of the surfactants under investigation. These findings have implications for guiding the selection and concentration determination of surfactants in future underground CO₂ storage endeavors.