• 동의생리병리학회지
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• 제17권4호
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• pp.930-938
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• 2003

The purpose of the present study was to investigate the effects of Hyunhosaiksan (HHS) on antithrombotic actions which include blood activation, thrombus removal, warming of circulating blood, and the control of pain on abdomen and lower and upper burning spaces. HHS significantly inhibited platelet aggregation induced by ADP and epinephrine in a HHS dose-dependent manner when analyzed by the Sigmoid Emax model in WinNonlin. EC50 values of HHS were 1.71 ㎍/ml and 0.004 ㎍/ml for ADP and epinephrine respectively. In the vivo study, HHS inhibited pulmonary embolism induced by collagen and epinephrine, which was however statistically insignificant. HHS increased number of platelets, APTT and volume of fibrinogen significantly as compared with the control group in dextran-induced thrombus model. Furthermore, HHS stimulated levels of blood flow in vivo though its effect was not observed in vitro. These results suggest that Hyunhosaiksan (HHS) can be used for treating numerous diseases related with blood aggregation and circulation problems. Further systematic investigations on the synergic effects among drugs used in the oriental medicine as well as in the western medicine in relation to thrombosis therapy would provide an important insight into the potential therapeutic applications.

• Journal of Electrical Engineering and Technology
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• 제7권4호
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• pp.501-512
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• 2012

Social welfare maximization in a double-sided auction market is performed by implementing an aggregation-based particle swarm optimization (CAPSO) algorithm for optimal placement and sizing of one Static Synchronous Series Compensator (SSSC) device. Dallied simulation results (without/with line flow constraints and without/with SSSC) are generated to demonstrate the impact of SSSC on the congestion levels of the modified IEEE 14-bus test system. The proposed CAPSO algorithm employs conventional quadratic smooth and augmented quadratic nonsmooth generator cost curves with sine components to improve the accurate of the model by incorporating the valve loading effects. CAPSO also employs quadratic smooth consumer benefit functions. The proposed approach relies on particle swarm optimization to capture the near-optimal GenCos and DisCos, as well as the location and rating of SSSC while the Newton based load flow solution minimizes the mismatch equations. Simulation results of the proposed CAPSO algorithm are compared to solutions obtained by sequential quadratic programming (SQP) and a recently implemented Fuzzy based genetic algorithm (Fuzzy-GA). The main contributions are inclusion of customer benefit in the congestion management objective function, consideration of nonsmooth generator characteristics and the utilization of a coordinated aggregation-based PSO for locating/sizing of SSSC.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제10권1호
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• pp.79-95
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• 2016

In order to improve the Quality-of-Service (QoS) of latency sensitive applications in next-generation cellular networks, multi-path is adopted to transmit packet stream in real-time to achieve high-quality video transmission in heterogeneous wireless networks. However, multi-path also introduces two important challenges: out-of-order issue and reordering delay. In this paper, we propose a new architecture based on Software Defined Network (SDN) for flow aggregation and flow splitting, and then design a Multiple Access Radio Scheduling (MARS) scheme based on relative Round-Trip Time (RTT) measurement. The QoS metrics including end-to-end delay, throughput and the packet out-of-order problem at the receiver have been investigated using the extensive simulation experiments. The performance results show that this SDN architecture coupled with the proposed MARS scheme can reduce the end-to-end delay and the reordering delay time caused by packet out-of-order as well as achieve a better throughput than the existing SMOS and Round-Robin algorithms.

• 지질동맥경화학회지
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• 제7권2호
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• pp.88-97
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• 2018

The prevalence of atherothrombotic disease continues to rise, presenting an increasing number of challenges to modern society and creating interest in functional foods. Platelet activation, adhesion, and aggregation at vascular endothelial disruption sites are key events in atherothrombotic disease. Physiological challenges such as hyperlipidemia, obesity, and cigarette smoking are associated with vascular changes underlying platelet aggregation and inflammatory processes. However, it is difficult to determine the beneficial response of functional foods in healthy subjects. To address this problem, challenge models and high-risk models related to smokers, obesity, and dyslipidemia are proposed as sensitive measures to evaluate the effects of functional foods in healthy subjects. In this review, we construct a model to evaluate the effects of functional food such as natural products on blood flow based on a human intervention study.

• 대한한방부인과학회지
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• 제22권1호
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• pp.110-124
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• 2009

Purpose: This study was performed to evaluate anti-thrombotic effect of Jogantanggagambang extract (JGTG). Methods: Blood flow rate through the regular volume of glass tube after the blood was diluted five times with ACD solution. Antithrombotic effect was calculated as a percentage of the experimental animal figure protected from the paralysis of hind legs or death of the mouse that was caused from the administration of platelet aggregation regent. Results: 1. JGTG inhibited the platelet aggregation induced by ADP, epinephrine, collagen and arachidonic acid as compared with the control group. 2. JGTG inhibited pulmonary embolism induced by collagen and epinephrine (inhibitory rate is 37.5%). 3. JGTG increased platelet number and fibrinogen amount significantly and also JGTG shortened PT and APTT significantly as compared with the control group in thrombus model induced by dextran. 4. JGTG increased blood flow rate significantly as compared with the control group in vivo. Conclusion: These results suggest that JGTG can be used for treating various female diseases caused by thrombosis.

• 대한한방부인과학회지
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• 제22권1호
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• pp.79-94
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• 2009

Purpose: This study was performed to evaluate anti-thrombotic effect of Cheongyeoljohyeoltangkamibang extract (CYJHT). Methods: Blood flow rate through the regular volume of glass tube after the blood was diluted five times with ACD soulution. Antithrombotic effect was calculated as a percentage of the experimental animal figure protected from the paralysis of hind legs or death of the mouse that is caused from the administration of platelet aggregation regent. Results: 1. CYJHT inhibited the platelet aggregation induced by ADP, epinephrine, collagen and arachidonic acid as compared with the control group. 2. CYJHT inhibited pulmonary embolism induced by collagen and epinephrine (inhibitory rate is 50%). 3. CYJHT increased platelet number and fibrinogen amount significantly and also CYJHT shortened PT and APTT significantly as compared with the control group in thrombus model induced by dextran. 4. CYJHT increased blood flow rate insignificantly as compared with the control group in vivo. Conclusion: These results suggest that CYJHT can be useful in treating various female diseases caused by thrombosis, such as menstrual pain, menstrual disorder and so on.

• 대한교통학회지
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• 제23권3호
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• pp.109-123
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• 2005

본 논문에서는 지방부 간선도로에서 제공되는 단속류 구간통행시간 정보의 체계적인 수집 분석을 위해 현재 일부 국도에서 운영중인 차량번호판 매칭방식 AVI(자동차량인식장치 : Automated Vehicle Indentification)로부터 수집된 자료의 적합성분석 및 단속류 구간통행시간 자료의 적정집락간격(optimal aggregation interval)산정을 위한 통계적 결정방법을 연구하였다. 연구결과 차량번호판 매칭방식 AVI 수집자료는 통과위주의 대표차로상에서만 수집되기 때문에 차로간의 속도차가 크게 나타나는 단속류 구간에서는 전차로에 대한 통행시간 수집자료와 교통특성에 차이가 있으므로 현재의 차량번호판 매칭방식 ANI 표본수집 자료를 통해 산출된 구간통행기간을 구간의 대표값으로 적용하는 데에는 문제가 있어 이에 대한 추가적인 검토가 필요하다는 결론을 얻었다. 그리고, 단속류 구간의 통행시간 정보제공을 위한 수집자료의 적정집락간격 결정방법으로 점추정과 구간추정방법을 적용하여 모형을 개발하고, 이 모형을 적용한 결과 점추정모형이 구간추정모형보다 집락간격결정에 민감하고 보다 정확한 적정집락간격 선정이 가능한 것으로 밝혀졌으며, 단속류 구간의 적정집락간격은 5분으로 산정되어 현재 적용되고 있는 단속류 구간 5분 집락간격은 적정한 것으로 판단된다.

• 대한산업공학회지
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• 제28권1호
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• pp.1-13
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• 2002

We study a multi-component production/inventory system in which individual components are made to meet various demand types. We assume that the demands arrive according to a Poisson process, but there is a fixed probability that a demand requests a particular kit of different components. Each component is produced by a flow line with several stations. The production of each component is operated by the CONWIP control mechanism. To analyse this system, we propose an approximation method based on aggregation method. In application of the aggregation method, a product-form approximation technique as well as a matrix-geometric method is used. Comparisons with simulation show that the approximation method provides fairly good results.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1990년도 하계학술대회 논문집
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• pp.113-120
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• 1990

This paper presents a new aggregation method of induction motors for the load flow and transient stability analysis. The proposed method aggregates a group of motors into a single motor considering the variations of the system voltage and frequency so that the aggregated model represents the dynamic characteristics of the system accurately. The performance of the Method is shown by numerical simulation and is compared with that of LOADSYN algorithm.

• 대한한의학회지
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• 제31권2호
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• pp.167-176
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• 2010

Objectives: The purpose of this study was to report the effect of Kamitongkyung-tang on adenomyosis. Methods: Three women who were diagnosed with adenomyosis were enrolled in this study. They were supposed to have blood aggregation, so received oriental treatments to decrease blood aggregation and promote blood flow. They took Kamitongkyung-tang internally 3 times a day and were taken acupuncture therapy 3 times a week during about 3 months. Results: The most common symptoms of adenomyosis were menorrhagia and dysmenorrhea. After the treatment, symptoms of adenomyosis decreased and ultrasonography showed good results. Conclusion: These clinical cases indicated that Kamitongkyung-tang was effective in the treatment of adenomyosis. More clinical data and studies are needed about the treatment of adenomyosis.