• The korean journal of orthodontics
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• v.15 no.2
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• pp.197-209
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• 1985

To investigate the relationship between the pubertal spurt in body height and bone maturity of the hand-and-wrist in normal occlusion, the author X-rayed the hand-and-wrists of 1,141 students (male 614, female 527) and assessed their bone maturity. In this study, eleven skeletal stages were selected. The bones used to determine skeletal maturity were the ulnar sesamoid of the metacarpophalangeal joint of the first finger, the epiphyses of the proximal, middle, distal phalanges of the third finger, and middle phalanx of the fifth finger, and distal epiphysis of the radius. From the longitudinal data for height, an assessment was made of the change in growth velocity. The pubertal growth stage was divided into onset and peak height velocity phases. The results were as follows; 1. The onset of the pubertal growth was between the $PP_3=\;and\;MP_3=$ stage for boys, and between the $MP_3=\;and\;MP_5=$ stage for girls; the mean age of onset was 10.6 years for boys and 9.0 years for girls. 2. The peak height velocity was between the S and $MP_{3_{cap}}$ stage for boys, and between the $MP_{3_{cap}}$ and $MP_{5_{cap}}$ stage for girls; the mom age of peak height velocity was 12.5 years for boys and 10.9 years for girls. 3. As the stages of bone maturity progressed from $DP_{3u},\;to\;PP_{3u},\;MP_{3u}$, Ru, the peak height velocity had been reached, and the growth rate retarded, therefore the approach to full physical maturity was attained. 4. The evidence for the period of onset, peak height velocity and bone maturation suggested that girls were in advance of boys. During the latter part of pubertal growth, the rate of boys' bone maturation was faster than that of girls'.

• Phonetics and Speech Sciences
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• v.11 no.3
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• pp.31-38
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• 2019

The current electromagnetic articulography study analyzes several articulatory measures and examines whether, and if so, how they are interconnected, with a focus on cluster types and an additional consideration of speech rates and morphosyntactic contexts. Using articulatory data on non-assimilating contexts from three Seoul-Korean speakers, we examine how speaker-dependent gestural overlap between C1 and C2 in a low vowel context (/a/-to-/a/) and their resulting intergestural coordination are realized. Examining three C1C2 sequences (/k(#)t/, /k(#)p/, and /p(#)t/), we found that three normalized gestural overlap measures (movement onset lag, constriction onset lag, and constriction plateau lag) were correlated with one another for all speakers. Limiting the scope of analysis to C1 velar stop (/k(#)t/ and /k(#)p/), the results are recapitulated as follows. First, for two speakers (K1 and K3), i) longer normalized constriction plateau lags (i.e., less gestural overlap) were observed in the pre-/t/ context, compared to the pre-/p/ (/k(#)t/>/k(#)p/), ii) the tongue dorsum at the constriction offset of C1 in the pre-/t/ contexts was more anterior, and iii) these two variables are correlated. Second, the three speakers consistently showed greater horizontal distance between the vertical tongue dorsum and the vertical tongue tip position in /k(#)t/ sequences when it was measured at the time of constriction onset of C2 (/k(#)t/>/k(#)p/): the tongue tip completed its constriction onset by extending further forward in the pre-/t/ contexts than the uncontrolled tongue tip articulator in the pre-/p/ contexts (/k(#)t/>/k(#)p/). Finally, most speakers demonstrated less variability in the horizontal distance of the lingual-lingual sequences, which were taken as the active articulators (/k(#)t/=/k(#)p/ for K1; /k(#)t/

• Journal of the Korea Convergence Society
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• v.12 no.2
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• pp.61-66
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• 2021

This study aimed to investigate the effect of changes in pain on the autonomic nervous system and brain waves after inducing delayed-onset muscle soreness(DOMS). Based on voluntary participation, 28 participants with induced-DOMS were randomly divided into control(non-treatment, n=14) and experiment groups(transcutaneous electrical nerve stimulation (TENS) and kinesio taping, n=14). Intervention was performed from first day to fifth days after the onset of DOMS. Measurements were performed using the Visual Analogue Scale(VAS), Heart Rate Variability(HRV), and brain wave before DOMS induction, 24 hours after, fifth day after, and eighth day after. According to the study results, when DOMS occurred, the activity of the sympathetic nervous system was increased or the activity of the parasympathetic nervous system was suppressed, and reduction of pain due to interventions showed the opposite activity. A decreased in alpha was seen during pain, but was not significant. These results will help develop and study pain management and treatment strategies.

• Journal of Animal Reproduction and Biotechnology
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• v.36 no.1
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• pp.25-34
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• 2021

Kisspeptin is a key player in the central control of reproductive axis. Central administration of kisspeptin has been shown to advance puberty in rats. Stimulation of hypothalamic GnRH pulse generating mechanism by kisspeptin has been proposed to be the mechanism behind the onset of puberty. We hypothesized that chronic high doses of kisspeptin administration suppresses the reproductive axis and hence delays the pubertal onset. Hence, we investigated the effect of peripheral administration of chronic high doses of kisspeptin on pubertal onset, feed intake and body weight in female rats. Rats were treated with saline or kisspeptin (100 nmoles per day; intraperitoneal) for 26 days (day 25 to day 50 postnatal) and the day of vaginal opening was marked as day of puberty. Kisspeptin treated rats had delayed pubertal onset and reduced feed intake and body weight. Gonadal GPR54 mRNA was reduced suggesting that chronic high doses of kisspeptin may suppress the reproductive functions possibly by downregulation of GPR54 receptor. However, delay in puberty due to reduction in feed intake and body weight could not be ruled out in this study. Further, our study emphasizes the importance of dosage and duration of kisspeptin administration in the manipulation of reproductive axis. Our study, for the first time, suggests that kisspeptin and its analogues, if proven beneficial, could be used to treat precocious puberty in children. It appears that, though a promising tool for enhancing fertility, kisspeptin acts as a double-edged sword and has to be cautiously used to manipulate reproduction.

• Journal of Physiology & Pathology in Korean Medicine
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• v.35 no.1
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• pp.8-14
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• 2021

Shihogayonggolmoryo-tang (ST) is a Korean medical herb cocktail which has been used to treat anxiety induced insomnia. In this study, we will examine sleep-promoting and anti-anxiety effects of ST, and investigate its mechanism. ICR mice were divided into three groups for the first examination : control group (n=11), ST50 group (50 mg/kg, po, n=11), ST200 group (200 mg/kg, po, n=11). Sleep-promoting effect was confirmed by measuring the sleeping duration time and sleeping onset time after thiopental sodium treatment (50 mg/kg, ip). ICR mice were divided into five groups for the second examination : control group (n=11), ST200 group (200 mg/kg, po, n=11), ST200+Flumazenil group (ST 200 mg/kg, po, flumazenil 0.3 mg/kg, ip, n=11), diazepam group (1 mg/kg, ip, n=11), diazepam+flumazenil group (diazepam 1 mg/kg, ip, Flumazenil 0.3 mg/kg, ip, n=11). Anxiety behavior and sleep-promoting effect was confirmed by open field test and measuring the sleeping duration time and sleeping onset time. Expression levels of c-fos in tuberomammillary nucleus (TMN) and ventrolateral preoptic nucleus (VLPO) were analyzed by immunohistochemistry. ST treated group showed significantly decreased anxiety behavior and enhanced sleeping duration time and sleeping onset time concentration dependently. The expression of c-fos was significantly upregulated in VLPO as sleep-inducing center and TMN as downregulated in arousal center by ST treatment. In addition, all effects of ST were reversed by flumazenil. Our results suggest that ST has sleep-promoting and anti-anxiety effects through regulating arousal center (TMN) and sleep-inducing center (VLPO).

• Genomics & Informatics
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• v.18 no.3
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• pp.27.1-27.12
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• 2020

The prevalence of early-onset type 2 diabetes (EOT2D) is increasing in Asian countries. Genome-wide association studies performed in European and various other populations have identified associations of numerous variants with type 2 diabetes in adults. However, the genetic component of EOT2D which is still unexplored could have similarities with late-onset type 2 diabetes. Here in the present study we aim to identify the association of variants with EOT2D in South Indian population. Twenty-five variants from 18 gene loci were genotyped in 1,188 EOT2D and 1,183 normal glucose tolerant subjects using the MassARRAY technology. We confirm the association of the HHEX variant rs1111875 with EOT2D in this South Indian population and also the association of CDKN2A/2B (rs7020996) and TCF7L2 (rs4506565) with EOT2D. Logistic regression analyses of the TCF7L2 variant rs4506565(A/T), showed that the heterozygous and homozygous carriers for allele 'T' have odds ratios of 1.47 (95% confidence interval [CI], 1.17 to 1.83; p = 0.001) and 1.65 (95% CI, 1.18 to 2.28; p = 0.006) respectively, relative to AA homozygote. For the HHEX variant rs1111875 (T/C), heterozygous and homozygous carriers for allele 'C' have odds ratios of 1.13 (95% CI, 0.91 to 1.42; p = 0.27) and 1.58 (95% CI, 1.17 to 2.12; p = 0.003) respectively, relative to the TT homozygote. For CDKN2A/2B variant rs7020996, the heterozygous and homozygous carriers of allele 'C' were protective with odds ratios of 0.65 (95% CI, 0.51 to 0.83; p = 0.0004) and 0.62 (95% CI, 0.27 to 1.39; p = 0.24) respectively, relative to TT homozygote. This is the first study to report on the association of HHEX variant rs1111875 with EOT2D in this population.

• Journal of computational fluids engineering
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• v.16 no.2
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• pp.88-93
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• 2011

A numerical study of subcooled onset of nucleate boiling (ONB) in a micro-channel under pulsed heating using volume of fluids (VOF) model was conducted. The VOF simulation adopting the existing experimental condition is compared to the experimental data. The time to ONB was determined when the void fraction at the microheater surface first appeared. The theoretical superheat for homogeneous nucleation relatively predicts the transient ONB results of convective flow of water well based on local temperature distribution. It was found that once heat load increases at the heater, transient flow boiling starts to occur faster.

• English Language & Literature Teaching
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• v.11 no.1
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• pp.137-154
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• 2005

The purpose of this paper is to analyze vowel lengthening triggered by resyllabification. In general, short vowels become long when a following consonant is deleted, as shown in stehli 'steel' > st$\bar{e}$li and *fimf 'five' > five. We can account for the phenomenon in a straightforward way within the framework of CV phonology (Clements & Keyser, 1983) : deletion of a coda consonant C slot and then the preceding vowel spreads onto it, resulting in a long vowel. The analysis, however, cannot hold for words like ealhes 'temple', where deletion of an onset segment eventually triggers vowel lengthening in the preceding syllable. In order to account for this, I propose resyllabification. That is, ealhes first becomes eales by /h/-deletion. Next, the /l/ in coda is resyllabified as the onset of the following syllable, leaving its C slot unoccupied. Finally, the vowel spreads onto the empty slot, producing a long vowel.

• Phonetics and Speech Sciences
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• v.3 no.4
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• pp.23-31
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• 2011

This paper examines the production patterns of the acquisition of coda consonants in monosyllabic words in English-speaking children with cochlear implants. The data come from the transcribed speech of children with cochlear implants. This study poses three questions. First, do children with cochlear implants acquire onset consonants earlier than codas? Second, do children's productions have a bimoraic-sized constraint that maintains binary feet? Third, what patterns emerge from production of coda consonants? The results revealed that children with cochlear implants acquire onset consonants earlier than codas. With regard to the bimoraic-sized constraints, the productions of vowel type (i.e., monomoraic and bimoraic) were more accurate for monomoraic vowels than bimoraic ones for some children with cochlear implants, although accuracy in vowel productions showed high proportion regardless of vowel types. The variations of coda production exhibited individual differences. Some children produced less sonorant consonants with high frequency and others produced more sonorant ones. The results of this study were similar to those pertaining to children with normal hearing. In the process of coda consonant acquisition, the error patterns of prosody-sensitive production may be regarded as articulatory challenges to produce higher-level prosodic structures.

• Transactions of the Korean Society of Automotive Engineers
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• v.3 no.1
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• pp.13-19
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• 1995

The objective of this study is do obtain the relationship between the acoustic mode and cavity tone induced in a perforated tube exhaust muffler. First, the modal frequency for the axisymmetric radial mode and the mode shape have been computed using the impedance model for the perforated tube. Then, experiment has been perfonned for the onset frequencies of the cavity tone for various design parameters and through-flow. The theoretically obtained modal frequencies are well consistent with the measured onset frequencies of the cavity tone, showing that the cavity tone is induced by the axisymmetric radial mode. And it is found that the modal frequency of a perforated tube muffler is much lower than that of a simple expansion chamber.